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People mistakenly believe peptides are only good.
Score 0.864
· Account tjphuhs@gmail.com
· 5/8/2026, 4:10:03 PM
People mistakenly believe peptides are only good. from bryanjohns0n@substack.com on 2026-05-08T20:10:03.000Z View this post on the web at https://bryanjohns0n.substack.com/p/people-mistakenly-believe-peptides People mistakenly believe peptides are only good. Peptides can be bad, too. They can cause adverse effects. Some dangerous. I did a peptide experiment and measured its effects in my body. The results are complicated. I tried a peptide called CJC-1295. It pushed my growth hormone up by ~8x.
People mistakenly believe peptides are only good.
Score 0.810
· Account tjphuhs@gmail.com
· 5/8/2026, 4:10:03 PM
People mistakenly believe peptides are only good. from bryanjohns0n@substack.com on 2026-05-08T20:10:03.000Z was wrecked and I felt continuously awful. My REM sleep dropped by 23%. REM is when your brain processes memories and repairs itself. Less time for my brain to repair itself. During the experiment, I never felt rested and always fatigued. Why we chose CJC-1295 with DAC. Some will say we picked the wrong peptide. They will say I should have used a different version, CJC-1295 without DAC, m
The Most Overrated Peptides
Score 0.740
· Account tjphuhs@gmail.com
· 4/7/2026, 6:03:43 PM
The Most Overrated Peptides from huntershealthhacks@mail.beehiiv.com on 2026-04-07T22:03:43.000Z Happy Tuesday! I just dropped a brand new podcast on [YouTube](https://youtu.be/ODWpYYPTB_8) and [Spotify](https://open.spotify.com/episode/2rgubyfKMo6O6ITPfGQf9J?si=Kvee606jRrGoQqJCtxYPqw). Youtube: These Peptides Are Overrated (Here's What Actually Works) (https://youtu.be/ODWpYYPTB_8) This one might ruffle some feathers. I break down the five most overrated peptides. And before anyone gets fired u
Everyone's injecting peptides. Almost no one is measuring what they actually do.
Score 0.737
· Account tjphuhs@gmail.com
· 4/23/2026, 4:30:59 PM
Everyone's injecting peptides. Almost no one is measuring what they actually do. from bryanjohns0n@substack.com on 2026-04-23T20:30:59.000Z View this post on the web at https://bryanjohns0n.substack.com/p/everyones-injecting-peptides-almost I'm stacking two peptides with opposite side effects and testing whether the downsides cancel while the benefits don't. Tirzepatide didn't work for me. I'm already top 1% on glucose control and body composition, so the marginal upside was small. And even at 2
GLP-1 Shaming
Score 0.734
· Account tjphuhs@gmail.com
· 4/20/2026, 6:03:00 PM
GLP-1 Shaming from huntershealthhacks@mail.beehiiv.com on 2026-04-20T22:03:00.000Z Happy Monday! Peptides are all the rage these days. It seems like everyone and their neighbor is jumping on the optimization train. But are peptides and HRT cheating? I don’t think so. In fact, specifically referring to GLP-1s, I would argue that you are using one of the most powerful longevity tools we have ever discovered. But try telling that to the neighbor who gives you the side-eye at the mailbox. Or the cow
The Most Overrated Peptides
Score 0.727
· Account tjphuhs@gmail.com
· 4/7/2026, 6:03:43 PM
The Most Overrated Peptides from huntershealthhacks@mail.beehiiv.com on 2026-04-07T22:03:43.000Z they are working for you. And I am definitely not telling companies to stop selling them. What I am saying is that, for most people, better tools are available right now. Same price range. Better results. Better mechanisms. Better long-term outcomes. If you are curious, go test these peptides yourself. Maybe you get a great result and prove me wrong. That is part of the fun of this space. We are all
Fwd: Everyone's injecting peptides. Almost no one is measuring what they actually do.
Score 0.721
· Account tjphuhs@gmail.com
· 4/24/2026, 9:43:16 AM
Fwd: Everyone's injecting peptides. Almost no one is measuring what they actually do. from tjphuhs@gmail.com on 2026-04-24T13:43:16.000Z return to baseline in a couple weeks, not worth it. > > So I'm testing whether I can stack two peptides with opposite side effects and get the best of both worlds. > > Tirzepatide: metabolic optimization, yet raises my HR and can disrupt my sleep. > > CJC-1295 (a GHRH agonist that drives my own GH and IGF-1): growth and repair, but can blunt my glucose control
Fwd: Everyone's injecting peptides. Almost no one is measuring what they actually do.
Score 0.721
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:43:16 AM
Fwd: Everyone's injecting peptides. Almost no one is measuring what they actually do. from tjphuhs@gmail.com on 2026-04-24T13:43:16.000Z return to baseline in a couple weeks, not worth it. > > So I'm testing whether I can stack two peptides with opposite side effects and get the best of both worlds. > > Tirzepatide: metabolic optimization, yet raises my HR and can disrupt my sleep. > > CJC-1295 (a GHRH agonist that drives my own GH and IGF-1): growth and repair, but can blunt my glucose control
The Most Overrated Peptides
Score 0.719
· Account tjphuhs@gmail.com
· 4/7/2026, 6:03:43 PM
The Most Overrated Peptides from huntershealthhacks@mail.beehiiv.com on 2026-04-07T22:03:43.000Z in the pituitary and stimulate growth hormone release. They were popular in early peptide communities because they were inexpensive and readily available. The problem? GHRP-6 can cause ravenous, near-uncontrollable hunger within 15 to 20 minutes of injection. That is the opposite of what most people want when they're trying to manage body composition. It also significantly elevates prolactin and cort
Fwd: Everyone's injecting peptides. Almost no one is measuring what they actually do.
Score 0.712
· Account tjphuhs@gmail.com
· 4/24/2026, 9:43:16 AM
Fwd: Everyone's injecting peptides. Almost no one is measuring what they actually do. from tjphuhs@gmail.com on 2026-04-24T13:43:16.000Z ---------- Forwarded message ---------- From: Bryan Johnson from Bryan Johnson <bryanjohns0n@substack.com> Date: Apr 23, 2026 at 4:32 PM -0400 To: tjphuhs@gmail.com Subject: Everyone's injecting peptides. Almost no one is measuring what they actually do. > I'm stacking two peptides with opposite side effects and testing whether the downsides cancel while the be
Fwd: Everyone's injecting peptides. Almost no one is measuring what they actually do.
Score 0.712
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:43:16 AM
Fwd: Everyone's injecting peptides. Almost no one is measuring what they actually do. from tjphuhs@gmail.com on 2026-04-24T13:43:16.000Z ---------- Forwarded message ---------- From: Bryan Johnson from Bryan Johnson <bryanjohns0n@substack.com> Date: Apr 23, 2026 at 4:32 PM -0400 To: tjphuhs@gmail.com Subject: Everyone's injecting peptides. Almost no one is measuring what they actually do. > I'm stacking two peptides with opposite side effects and testing whether the downsides cancel while the be
Why Peptide Cycles Look Like a Slope, Not a Light Switch
Score 0.703
· Account tjphuhs@gmail.com
· 3/29/2026, 9:14:23 PM
Why Peptide Cycles Look Like a Slope, Not a Light Switch from derekpruski@substack.com on 2026-03-30T01:14:23.000Z View this post on the web at https://derekpruski.substack.com/p/why-peptide-cycles-look-like-a-slope Most researchers picture peptide effects like flipping a switch. You dose, it works. You stop, it’s done. That mental model is going to set you up for frustration. The reality is much closer to a slow incline and a slow decline — a gradual ramp up, a peak somewhere in the middle, and
The data grey-market peptide vendors don't want you to see
Score 0.703
· Account tjphuhs@gmail.com
· 2/18/2026, 1:25:10 PM
The data grey-market peptide vendors don't want you to see from info@marekhealth.com on 2026-02-18T18:25:10.000Z http://marekhealth.com https://marekhealth.com/blog/is-your-chinese-peptides-dealer-poisoning-you https://marekhealth.com/ Semaglutide and BPC-157 are game changers... if they’re real. We’re in the middle of a medical revolution. Peptides like Semaglutide and BPC-157 are helping people lose fat, heal faster, and feel better. But there is a massive, dangerous shadow hanging over this i
The Most Overrated Peptides
Score 0.703
· Account tjphuhs@gmail.com
· 4/7/2026, 6:03:43 PM
The Most Overrated Peptides from huntershealthhacks@mail.beehiiv.com on 2026-04-07T22:03:43.000Z was FDA-approved in 1997 and became the most commonly prescribed growth hormone secretagogue in anti-aging clinics for years. The problem is we have so many better options now. Sermorelin does stimulate GH release, and there is real clinical data behind it. But the half-life is very short, and the GH pulse it produces is brief and relatively weak. Many users report underwhelming results even after mo
Why You Shouldn't Blend Your Own Peptides
Score 0.702
· Account tjphuhs@gmail.com
· 3/31/2026, 10:15:58 AM
Why You Shouldn't Blend Your Own Peptides from derekpruski@substack.com on 2026-03-31T14:15:58.000Z View this post on the web at https://derekpruski.substack.com/p/why-you-shouldnt-blend-your-own-peptides Quick transparency note before we get into this: I’m actively working on putting together a more formal study on this topic. What I’m sharing here is based on current science and reasoning — the goal is to eventually confirm whether this is myth or reality with real data. But based on what we k
Men vs. Women Peptide Dosing
Score 0.698
· Account tjphuhs@gmail.com
· 1/28/2026, 6:03:37 PM
Men vs. Women Peptide Dosing from huntershealthhacks@mail.beehiiv.com on 2026-01-28T23:03:37.000Z always mean more benefit. Sometimes it just means more side effects, more water retention, more appetite changes, more cost, more noise. That’s why “standard” protocols tend to cluster around similar mcg or mg ranges. They’re trying to hit a practical sweet spot. Strong enough to create a biological shift, conservative enough to avoid running the pathway too hard. You can see this logic in clinical
Fwd: Men vs. Women Peptide Dosing
Score 0.697
· Account tjphuhs@gmail.com
· 2/26/2026, 1:00:26 AM
Fwd: Men vs. Women Peptide Dosing from tjphuhs@gmail.com on 2026-02-26T06:00:26.000Z your fuel tank, whereas peptides are more like tune-ups for every other area of your car. They bind to receptors, activate a signal, and trigger downstream cascades. Once you understand that, the unisex dosing makes a lot more sense. So today, I’ll break down the real reason protocols often look identical across men and women, and then I’ll give you the exceptions so you don’t walk away thinking it’s always one-
Fwd: Men vs. Women Peptide Dosing
Score 0.694
· Account tjphuhs@gmail.com
· 2/26/2026, 1:00:26 AM
Fwd: Men vs. Women Peptide Dosing from tjphuhs@gmail.com on 2026-02-26T06:00:26.000Z cascade, not “replace” sex hormones Many peptides hit a threshold where a higher dose gives less extra benefit Real clinical research often uses unified dosing and watches outcomes, not gender labels Now the exceptions, because there are always exceptions. If a peptide or compound causes side effects that are consistently more severe in one group, dose titration is warranted. GLP-1 nausea sensitivity is a common
PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching
Score 0.694
· Account tjphuhs@gmail.com
· 5/12/2026, 12:13:59 PM
PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z These don’t address the underlying PCOS biology but may have relevance for the psychological burden. Tesofensine. Not a peptide, but worth flagging — it’s a triple monoamine reuptake inhibitor in development for obesity that’s showing strong weight loss data and may be relevant for PCOS patients who don’t tolerate GLP-1 agonists. The Honest Big Pict
Mold Toxicity & Peptides: A Comprehensive Walkthrough
Score 0.692
· Account tjphuhs@gmail.com
· 4/28/2026, 7:52:08 PM
Mold Toxicity & Peptides: A Comprehensive Walkthrough from derekpruski@substack.com on 2026-04-28T23:52:08.000Z works, but it’s downstream — you’re catching toxins after they’re already loose, hoping to clear them faster than they’re being released. It can take 5 to 8 years on this approach, and a lot of people stall out. The newer framework looks upstream — fix the immune system and mitochondria first, then detox. The logic: If your immune system is broken, it can’t recognize or clear what’s co
Men vs. Women Peptide Dosing
Score 0.691
· Account tjphuhs@gmail.com
· 1/28/2026, 6:03:37 PM
Men vs. Women Peptide Dosing from huntershealthhacks@mail.beehiiv.com on 2026-01-28T23:03:37.000Z Happy Wednesday! Today, I will address a question I get pretty regularly from readers. “Hunter, why do peptide protocols always seem to use the same dose for men and women? Shouldn’t a 220-pound guy take way more than a 130-pound woman?“ — Totally fair question, because we’ve all been trained to think dosing = body size. And for some things, that’s true. But peptides play by a different set of rules
Why You Shouldn't Blend Your Own Peptides
Score 0.688
· Account tjphuhs@gmail.com
· 3/31/2026, 10:15:58 AM
Why You Shouldn't Blend Your Own Peptides from derekpruski@substack.com on 2026-03-31T14:15:58.000Z if the combined pH pushes GHK-Cu outside its stable window, you’re no longer working with an intact peptide. Bacteriostatic water isn’t a neutral variable Most people assume bac water is just water. It’s not — it contains 0.9% benzyl alcohol as a preservative, and its pH can shift differently depending on which peptide and environment it’s introduced into. A study looking at peptide crafter bacter
Fwd: Men vs. Women Peptide Dosing
Score 0.688
· Account tjphuhs@gmail.com
· 2/26/2026, 1:00:26 AM
Fwd: Men vs. Women Peptide Dosing from tjphuhs@gmail.com on 2026-02-26T06:00:26.000Z dosing.” Pharmacokinetics Many people assume that women and men metabolize substances differently. Sometimes that’s true with specific oral drugs, especially when liver enzyme differences matter. But most popular peptides are injected (or nasal), and they’re cleared by pathways that don’t reliably split by sex in a way that forces dosing differences. Instead, what matters more is stuff like: injection route and
Why Some Peptides Sting More Than Others: The pH Explanation
Score 0.688
· Account tjphuhs@gmail.com
· 3/28/2026, 11:54:20 AM
Why Some Peptides Sting More Than Others: The pH Explanation from derekpruski@substack.com on 2026-03-28T15:54:20.000Z and feel milder. Others sit lower and sting more. Tesamorelin — approximately 4.5 to 6.0 Tesamorelin is a 44 amino acid GHRH analog — meaning it mimics the hormone that signals the pituitary to release growth hormone. Its solutions typically land in the 4.5 to 6.0 range. At the higher end of that window it begins approaching a more tolerable distance from tissue pH, which is why
Men vs. Women Peptide Dosing
Score 0.687
· Account tjphuhs@gmail.com
· 1/28/2026, 6:03:37 PM
Men vs. Women Peptide Dosing from huntershealthhacks@mail.beehiiv.com on 2026-01-28T23:03:37.000Z Again, protocols don’t split into “men vs women,” because the goal is to shift immune behavior, not set sex-specific hormone levels. Cognition peptides like Semax and Selank? Same story. Semax is linked in research to changes in neurotrophic signaling like BDNF/TrkB, and Selank has published work on immune/cytokine modulation in anxious patients. Those systems don’t require gender dosing by default.