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Semantic Search: MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.861
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z outcome data. And if the primary goal is metabolic health or body composition rather than maximum hypertrophy, the timing concern becomes much less relevant. The AMPK/mTOR tension matters most when you’re trying to squeeze every bit of muscle growth out of training. Bottom Line The rest-day scheduling approach is a smart way to think about MOTS-c for anyone training har
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.846
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z composition, the metabolic improvements, without actively fighting the 24 to 48 hour recovery window that determines whether training turns into muscle. The old bodybuilding instinct to use rest days for body composition work wasn’t wrong in spirit. It was just missing a piece of the puzzle about recovery biology. Rest-day MOTS-c scheduling is an updated version of that
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.843
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z with that framework is it glosses over what’s actually happening in your muscles during those rest days. Muscle recovery and protein synthesis don’t shut off the moment you rack your last set. The mTOR response runs strong for roughly 24 to 48 hours after training. So your rest day isn’t really a “nothing is happening” day from a recovery standpoint, it’s often the day
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.817
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-on-rest-days-the-scheduling Research use only. This content is intended for educational and informational purposes within a research context. Not for human consumption. Not medical advice. No dosing recommendations are provided or implied. If you’ve been around the research space for any length of ti
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.731
· Account tjphuhs@gmail.com
· 3/21/2026, 8:24:20 AM
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from derekpruski@substack.com on 2026-03-21T12:24:20.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-and-morning-workout-timing Not medical advice, not personal advice. For educational purposes only. All use cases discussed are strictly research use only. If a researcher is using MOTS-c and also hitting the gym in the morning, timing matters. Here’s why — broken down in plain language. First, What Is MOTS
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.719
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z this needs to be stated clearly because it gets misunderstood constantly. > Activating AMPK does not completely shut off mTOR. It does not eliminate muscle growth. > The relationship between these two pathways is nuanced — it depends on how strongly each is activated, the researcher’s nutrition status, training intensity, recovery, and a range of other factors. A research subje
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.716
· Account tjphuhs@gmail.com
· 3/21/2026, 8:24:20 AM
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from derekpruski@substack.com on 2026-03-21T12:24:20.000Z capacity with no interference. Step 3 — Remain in a fasted or semi-fasted state for roughly 2–4 hours. This gives the acute AMPK signaling window time to normalize. Step 4 — Break the fast with a solid meal. Protein, carbohydrates, adequate calories. This refuels glycogen stores, raises circulating amino acid availability, and shifts the hormonal environment toward anabolism.
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.715
· Account tjphuhs@gmail.com
· 3/21/2026, 8:24:20 AM
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from derekpruski@substack.com on 2026-03-21T12:24:20.000Z on mTOR. Biologically this makes sense — the body doesn’t want to be building expensive new muscle tissue when it thinks it’s in an energy-deficient state. These two pathways actively suppress each other, which is why administering a potent AMPK activator right before resistance training creates a potential conflict worth thinking about. The Important Nuance Before getting in
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.713
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 21, 2026 at 8:24 AM -0400 To: tjphuhs@gmail.com Subject: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown > Not medical advice, not personal advice. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.712
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z acid availability, and shifts the hormonal environment toward anabolism. > Step 5 — Train. With MOTS-c out of the acute signaling window and the body adequately refueled, resistance training can potently stimulate mTOR without meaningful AMPK interference. The anabolic response to training is uncompromised. > The end result is two clean, well-supported signaling environments —
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.694
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z — often called the “powerhouse of the cell.” MOTS-c is essentially a signal that mitochondria send out to communicate with the rest of the body about energy status. > In research, it has shown strong effects on metabolism, insulin sensitivity, fat utilization, and cellular energy regulation. > Two Pathways You Need to Understand > To understand why timing matters, a researcher
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.622
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z pages, has described MOTS-c as promoting biogenesis — meaning it helps you grow more mitochondria. This study says that’s not what’s primarily happening. MOTS-c is making your existing mitochondria work better. Same number, higher output. Think of it like tuning an engine rather than adding more cylinders. How Does It Do That? The Two Pathways The researchers found that MOTS-
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.615
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z a number of mitochondrial parameters — including redox handling, mitochondrial integrity, and OXPHOS efficiency — jointly indicating a mechanistic basis for the observed functional improvements. Breaking those terms down: Redox handling — how well the cell manages oxidative stress Mitochondrial integrity — the structural health of the mitochondria themselves OXPHOS efficiency
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.615
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z View this post on the web at https://derekpruski.substack.com/p/a-new-mots-c-study-just-dropped-heres A new peer-reviewed study on MOTS-c was published January 9th out of the University of Copenhagen, and I’ve seen a little chatter about it online — including Coach Cam touching on it on TikTok. I wanted to give my own read on it for the community, broken down in a way that ac
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria?
Score 0.609
· Account tjphuhs@gmail.com
· 4/5/2026, 1:05:35 PM
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria? from derekpruski@substack.com on 2026-04-05T17:05:35.000Z a well-defined signaling mechanism makes it clearer that SS-31 is filling a different role entirely — structural stabilization at the membrane level that MOTS-c doesn’t address. They’re not competing compounds. They’re targeting different layers of the same problem, which is exactly why they’re frequently discussed together in mitochondrial health research. As always — for resea
Do You Actually Need SS-31 for Mitochondrial Repair?
Score 0.605
· Account tjphuhs@gmail.com
· 4/2/2026, 3:03:01 PM
Do You Actually Need SS-31 for Mitochondrial Repair? from derekpruski@substack.com on 2026-04-02T19:03:01.000Z to build up over years — through aging, sustained oxidative damage, long histories of calorie cycling, or significant illness. If you’re deep in a cut, training hard, and have a history of restrict and binge cycles — you’re most likely dealing with stress, not dysfunction. Stress resolves with recovery. Dysfunction requires more targeted intervention. Treating one like the other just ad
GHK-Cu: Morning or Night — Does Timing Matter for Your Research?
Score 0.599
· Account tjphuhs@gmail.com
· 4/7/2026, 11:20:35 AM
GHK-Cu: Morning or Night — Does Timing Matter for Your Research? from derekpruski@substack.com on 2026-04-07T15:20:35.000Z shown the ability to upregulate superoxide dismutase (SOD) and other protective enzymes. Superoxide dismutase is one of the body’s most important internal antioxidant enzymes — its job is to neutralize free radicals, which are unstable molecules that damage cells over time. Upregulating SOD means the body is producing more of its own natural defense against that damage Gene
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.598
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z to Research Radar. For the full experience, upgrade your subscription. > Upgrade to paid > > Share > > > Like > Comment > Restack > > © 2026 Derek Pruski > 548 Market Street PMB 72296, San Francisco, CA 94104 > Unsubscribe
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.598
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z to Research Radar. For the full experience, upgrade your subscription. > Upgrade to paid > > Share > > > Like > Comment > Restack > > © 2026 Derek Pruski > 548 Market Street PMB 72296, San Francisco, CA 94104 > Unsubscribe
Weekly Luxe Letter
Score 0.598
· Account tjphuhs@gmail.com
· 3/29/2026, 8:01:14 AM
Weekly Luxe Letter from diane@premierchoicefitness.ccsend.com on 2026-03-29T12:01:14.000Z Email from Luxeworks Fitness Trainer Tip of the week Weekly Luxe Letter 3/29/26 💪 TRAINER TIP: 💪 “Do’s & Don’ts of Your Workout Routine” If you want better results, start treating your workouts with intention. Here’s something you should focus on this week: DO: ✔ Take 5–10 minutes to warm up—this sets the tone for your entire workout ✔ Slow down and focus on your form before thinking about increasing weig
GHK-Cu: Morning or Night — Does Timing Matter for Your Research?
Score 0.597
· Account tjphuhs@gmail.com
· 4/7/2026, 11:20:35 AM
GHK-Cu: Morning or Night — Does Timing Matter for Your Research? from derekpruski@substack.com on 2026-04-07T15:20:35.000Z throughout the day, reaching its lowest point in the evening and overnight. The reason this matters for GHK-Cu research is that cortisol at elevated levels is catabolic and pro-inflammatory. Catabolic means it breaks things down rather than building them up. It is essentially the opposite of a repair signal. Cortisol works against many of the same pathways GHK-Cu is research
Re:
Score 0.597
· Account tjphuhs@gmail.com
· 3/25/2026, 8:41:10 AM
Re: from tjphuhs@gmail.com on 2026-03-25T12:41:10.000Z a question for you. So I’m not trying to rush the dosage but there’s little time before spring break it’s like around March 30 for us so I was wondering if I could do the doses like Monday and Thursday every week instead of doing it like every 4 days just do it two days a week and skip saturday and Sunday. It’ll still be consistent but would that be bad?
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.595
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 24, 2026 at 1:18 PM -0400 To: tjphuhs@gmail.com Subject: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds > I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one res
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.595
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 24, 2026 at 1:18 PM -0400 To: tjphuhs@gmail.com Subject: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds > I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one res
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria?
Score 0.593
· Account tjphuhs@gmail.com
· 4/5/2026, 1:05:35 PM
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria? from derekpruski@substack.com on 2026-04-05T17:05:35.000Z stabilizes it. It’s a physical repair and protection mechanism at the membrane level. The Key Difference Between the Two This is the part that answers the original question. Both MOTS-c and SS-31 improve existing mitochondria and reduce ROS. On the surface that looks redundant. But the way they do it couldn’t be more different: MOTS-c works like software — it sends a signal thro