Email Archive

Introducing Peptidology: Testing Taken To A New Level

Score 0.830 · Account tjphuhs@gmail.com · 3/24/2026, 11:15:15 AM

Introducing Peptidology: Testing Taken To A New Level from derekpruski@substack.com on 2026-03-24T15:15:15.000Z View this post on the web at https://derekpruski.substack.com/p/introducing-peptidology-testing-taken Without question the best-tested company I’ve come across in this space — and one of the first to do it at this level. Peptidology takes a different approach to the research space. Their goal is to do the maximum amount of testing possible to ensure their products are the highest quali

Introducing Peptidology: Testing Taken To A New Level

Score 0.777 · Account tjphuhs@gmail.com · 3/24/2026, 11:15:15 AM

Introducing Peptidology: Testing Taken To A New Level from derekpruski@substack.com on 2026-03-24T15:15:15.000Z sold. They’re spending over $2,000 in testing per batch, and for future batches they’re sending in up to 20 vials for sterility testing alone. That’s not a vendor cutting corners to move product fast. That’s a vendor that’s built their entire operation around getting it right. Code DEREK is live at Peptidology for 15% off. https://peptidology.co/?ref=mxxyvdne [ https://substack.com/red

Peptidology Just Upgraded Their Testing Standard and Their Discount

Score 0.768 · Account tjphuhs@gmail.com · 4/8/2026, 12:15:30 PM

Peptidology Just Upgraded Their Testing Standard and Their Discount from derekpruski@substack.com on 2026-04-08T16:15:30.000Z View this post on the web at https://derekpruski.substack.com/p/peptidology-just-upgraded-their-testing Peptidology Just Upgraded Their Testing Standard + 25% Off Sale Got a message with some details worth sharing. Peptidology has a large inventory, and it’s worth being transparent about where things stand — some products in their catalog currently only have 2x sterility

Peptidology Just Upgraded Their Testing Standard and Their Discount

Score 0.752 · Account tjphuhs@gmail.com · 4/8/2026, 12:15:30 PM

Peptidology Just Upgraded Their Testing Standard and Their Discount from derekpruski@substack.com on 2026-04-08T16:15:30.000Z that can identify contamination faster than traditional incubation. Running sterility at two independent labs, something no one else in the space is doing right now. The upgrade from 4 to 15 samples at Eagle is the biggest single jump in the new standard — 15 vials across two labs means a much higher level of confidence in the result. Most vendors in this space run a puri

Peptidology Just Upgraded Their Testing Standard and Their Discount

Score 0.750 · Account tjphuhs@gmail.com · 4/8/2026, 12:15:30 PM

Peptidology Just Upgraded Their Testing Standard and Their Discount from derekpruski@substack.com on 2026-04-08T16:15:30.000Z is a test a lot of vendors skip entirely. ICP-MS Heavy Metals ICP-MS (Inductively Coupled Plasma Mass Spectrometry) screens for toxic heavy metals: lead, arsenic, cadmium, mercury, and chromium. These can enter a product through the raw materials used in synthesis or through manufacturing equipment. You won’t taste or see them, and they won’t show up on a purity test — wh

New Testing Standards at Southern Aminos

Score 0.687 · Account tjphuhs@gmail.com · 3/30/2026, 3:53:11 PM

New Testing Standards at Southern Aminos from derekpruski@substack.com on 2026-03-30T19:53:11.000Z Reaction) for sterility testing. PCR is a molecular method that detects the DNA or RNA of bacteria, fungi, and other contaminants directly, without waiting for them to grow in a culture. It’s a different methodology than the culture-based approach and operates on a faster timeline. Worth noting: PCR-based sterility is not currently a recognized compendial standard in the way USP 71 is — meaning it

What’s new on peptideprice: payment filters and sterility testing tiers

Score 0.675 · Account tjphuhs@gmail.com · 5/10/2026, 6:08:49 PM

What’s new on peptideprice: payment filters and sterility testing tiers from derekpruski@substack.com on 2026-05-10T22:08:49.000Z — USP 71. This is the gold standard. Two-week growth test. Worth a full point in the testing score. Sterility (PCR / rapid) — DNA-based, hours instead of weeks. Newer technology, but still a real sterility check. Worth half a point. Bioburden (5 Day) — USP 61. This is not a sterility test. It counts microbes but doesn’t prove sterility. Worth half a point. The filters

New Testing Standards at Southern Aminos

Score 0.669 · Account tjphuhs@gmail.com · 3/30/2026, 3:53:11 PM

New Testing Standards at Southern Aminos from derekpruski@substack.com on 2026-03-30T19:53:11.000Z View this post on the web at https://derekpruski.substack.com/p/new-testing-standards-at-southern Most vendors send one vial to a lab and call it a day. Southern Aminos is now running full testing across 10 vials per batch — and closing in on a 6.5/7 score on the PeptidePrice.store testing standard. That’s not a small thing. Here’s exactly what that means for your research. What Does “Full Peptide

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching

Score 0.665 · Account tjphuhs@gmail.com · 5/12/2026, 12:13:59 PM

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z “BPC-157 treats PCOS” claim. It’s a “the upstream amplifier of inflammation in PCOS partially originates in the gut, and BPC-157 has research evidence for restoring gut barrier function” claim. KPV (lysine-proline-valine). A C-terminal tripeptide derived from alpha-MSH. Potent anti-inflammatory, immune-modulating, and antimicrobial activity, particu

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.

Score 0.658 · Account tjphuhs@gmail.com · 5/3/2026, 2:45:39 PM

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z a finished drug. The GLP-1 analogs used in the experiments were stripped of their fatty acid chains, so they are not identical to the medications currently on the market. Whether PapB can be applied to the full clinical compounds, and whether the ring-shaped structures it creates show meaningfully better performance in animal studies or human trial

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.

Score 0.658 · Account oc.tjphuhs@gmail.com · 5/3/2026, 2:45:39 PM

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z a finished drug. The GLP-1 analogs used in the experiments were stripped of their fatty acid chains, so they are not identical to the medications currently on the market. Whether PapB can be applied to the full clinical compounds, and whether the ring-shaped structures it creates show meaningfully better performance in animal studies or human trial

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching

Score 0.651 · Account tjphuhs@gmail.com · 5/12/2026, 12:13:59 PM

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z 2025. Full text [ https://substack.com/redirect/43449217-f376-4861-a38e-9e1cbd27451b?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Kisspeptin improving ovarian insulin resistance (2026) Kisspeptin improves local ovarian insulin resistance in PCOS by modulating the PI3K/AKT/GLUT4 signaling pathway. PLOS One. 2026. Full text [ ht

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching

Score 0.648 · Account tjphuhs@gmail.com · 5/12/2026, 12:13:59 PM

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z kinds of mechanisms peptide research is good at addressing. That’s not a coincidence. PCOS sits at the intersection of metabolic, inflammatory, and endocrine dysfunction. Any therapeutic class that targets those layers will eventually have something to say about PCOS. The fact that incretin peptides are already moving into mainstream PCOS care after

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching

Score 0.647 · Account tjphuhs@gmail.com · 5/12/2026, 12:13:59 PM

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z accelerates fat breakdown for fuel. In a 2025 scoping review, the triple agonist class produced the largest improvements in weight loss and insulin sensitivity in PCOS-relevant research compared to GLP-1 and dual agonists. Retatrutide is still pre-FDA approval but is moving through trials. What the literature shows specifically for PCOS Significant

A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.

Score 0.644 · Account tjphuhs@gmail.com · 5/3/2026, 10:40:57 AM

A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from onthepen@substack.com on 2026-05-03T14:40:57.000Z Utah and co-founded a company called Sethera Therapeutics built around this enzyme platform. The research was funded by the National Institute of General Medical Sciences, part of the National Institutes of Health. This work is proof of concept, meaning it is a meaningful early step but not a finished drug. The GLP-1 analogs used in the experiments

Research Radar Ep. 1: Payments, Peptides & Proper Testing

Score 0.644 · Account tjphuhs@gmail.com · 4/3/2026, 10:19:48 AM

Research Radar Ep. 1: Payments, Peptides & Proper Testing from derekpruski@substack.com on 2026-04-03T14:19:48.000Z View this post on the web at https://derekpruski.substack.com/p/research-radar-ep-1-payments-peptides Topic 1: Payment processing in the research space One of the most persistent behind-the-scenes headaches for research companies right now is payment processing. Vendors have been cycling through as many as seven different processors trying to find one that’s both reliable and will

Past, Present, and Future: How to Verify a Clean Manufacturing Process

Score 0.643 · Account tjphuhs@gmail.com · 3/26/2026, 12:51:37 PM

Past, Present, and Future: How to Verify a Clean Manufacturing Process from derekpruski@substack.com on 2026-03-26T16:51:37.000Z manufacturing byproducts, USP 61 looks at living organisms that could be introduced during filling, storage, or handling. This is the forward-looking test. A product can be clean at the time of manufacture and still pick up contamination later. USP 61 is the standard microbial quality test used broadly across non-sterile pharmaceutical products and is what most researc

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching

Score 0.642 · Account tjphuhs@gmail.com · 5/12/2026, 12:13:59 PM

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z Is Currently Managed This is the conventional medicine approach, based on the 2023 international evidence-based guideline. Knowing this matters because it’s the foundation that peptide research is being layered onto. Lifestyle modification. Always first-line, always non-negotiable. Diet (no single “best” diet — sustainable, individualized matters mo

The Test That's Actually Failing - 3 of 6 Failed Sterility at 99.8%

Score 0.641 · Account tjphuhs@gmail.com · 3/26/2026, 8:49:21 AM

The Test That's Actually Failing - 3 of 6 Failed Sterility at 99.8% from derekpruski@substack.com on 2026-03-26T12:49:21.000Z are completely separate things. A peptide can be analytically perfect and still have microbial contamination introduced during manufacturing. The argument “if purity is high, everything else is fine” doesn’t hold. Sterility failures don’t automatically mean a vendor has bad practices. It means contamination is hard to eliminate entirely and even harder to detect consisten

The Next Wave of GLP-1s Is Coming

Score 0.639 · Account tjphuhs@gmail.com · 3/31/2026, 6:05:53 PM

The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z Happy Tuesday! There are two peptides quietly making waves in the clinical space that will demand all of our attention over the next 24 months. They don't work like semaglutide, they don't work like tirzepatide, and the clinical data is turning heads. I just dropped a brand new video breaking down survodutide and mazdutide. Survodutide & Mazdutide | The GLP-1/Glucagon Duo That Could Rival Reta:

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.

Score 0.639 · Account tjphuhs@gmail.com · 5/3/2026, 2:45:39 PM

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z time, with nothing left unreacted. In laboratory terms, that is a perfect result. > That closed ring at the tail end of the peptide does several things worth understanding. It blocks the exoproteases that would otherwise begin dismantling the key from that end. It also stiffens the tail of the molecule, reducing the kind of loose molecular movement

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.

Score 0.639 · Account oc.tjphuhs@gmail.com · 5/3/2026, 2:45:39 PM

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z time, with nothing left unreacted. In laboratory terms, that is a perfect result. > That closed ring at the tail end of the peptide does several things worth understanding. It blocks the exoproteases that would otherwise begin dismantling the key from that end. It also stiffens the tail of the molecule, reducing the kind of loose molecular movement

What’s new on peptideprice: payment filters and sterility testing tiers

Score 0.638 · Account tjphuhs@gmail.com · 5/10/2026, 6:08:49 PM

What’s new on peptideprice: payment filters and sterility testing tiers from derekpruski@substack.com on 2026-05-10T22:08:49.000Z View this post on the web at https://derekpruski.substack.com/p/whats-new-on-peptideprice-payment A weekend of updates to make vendor comparison faster and more accurate. Spent this weekend pushing a round of updates to peptideprice.store [ https://substack.com/redirect/f76f57e4-54d0-49b1-9ca5-4e6208a623c9?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching

Score 0.636 · Account tjphuhs@gmail.com · 5/12/2026, 12:13:59 PM

PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z These don’t address the underlying PCOS biology but may have relevance for the psychological burden. Tesofensine. Not a peptide, but worth flagging — it’s a triple monoamine reuptake inhibitor in development for obesity that’s showing strong weight loss data and may be relevant for PCOS patients who don’t tolerate GLP-1 agonists. The Honest Big Pict

Fwd: Past, Present, and Future: How to Verify a Clean Manufacturing Process

Score 0.634 · Account oc.tjphuhs@gmail.com · 3/26/2026, 1:28:59 PM

Fwd: Past, Present, and Future: How to Verify a Clean Manufacturing Process from tjphuhs@gmail.com on 2026-03-26T17:28:59.000Z 71 > In plain English: “Can we confirm there are absolutely zero viable microorganisms present?” > USP 71 is the sterility test — it goes a step further than USP 61 by attempting to confirm the complete absence of viable microorganisms. This is the standard applied to products intended for injectable research and is used for injectable research compounds, biologics, and