Email Archive

💪 The Muscle Test That Predicts Aging

Score 0.855 · Account tjphuhs@gmail.com · 4/28/2026, 11:10:49 AM

💪 The Muscle Test That Predicts Aging from newsletter@seedoilscout.com on 2026-04-28T15:10:49.000Z Three simple checks can forecast future independence. *********************** The Muscle Reserve Test *********************** ( https://eatartemis.com/products/heart-and-liver?utm_source=seedoilscout&utm_medium=newsletter&utm_campaign=sos_newsletter ) Artemis ( https://eatartemis.com/products/heart-and-liver?utm_source=seedoilscout&utm_medium=newsletter&utm_campaign=sos_newsletter ): The World's F

💪 The Muscle Test That Predicts Aging

Score 0.843 · Account tjphuhs@gmail.com · 4/28/2026, 11:10:49 AM

💪 The Muscle Test That Predicts Aging from newsletter@seedoilscout.com on 2026-04-28T15:10:49.000Z of future independence. * Grip, chair stands, and balance give a fast at-home reality check. * Aging muscle is more changeable than people assume. * Moderate calorie control can preserve muscle quality, but crash dieting can backfire. * A lot of muscle loss shows up during acute catabolic crises, like illness, hospitalization, surgery, or bed rest, which is exactly why reserve matters. * Strength

💪 The Muscle Test That Predicts Aging

Score 0.838 · Account tjphuhs@gmail.com · 4/28/2026, 11:10:49 AM

💪 The Muscle Test That Predicts Aging from newsletter@seedoilscout.com on 2026-04-28T15:10:49.000Z cut calories by about 12% over two years lost some lean mass, but preserved muscle quality and kept strength more stable than expected. Translation: the goal is not starvation, crash dieting, or getting smaller at all costs. The goal is improving the quality of the muscle you keep. ****************************** The minimum effective protocol ****************************** * Lift or carry somethin

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.688 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z What the Human Data Actually Shows > This is where UA separates itself from a lot of “promising” compounds. We have actual placebo-controlled human trials. > Phase 1 safety trial (Ryu et al., 2019). Tested in healthy elderly adults at 250–2000 mg single doses and 250/500/1000 mg/day for 28 days. Favorable safety profile at all doses. Bioavailable in plasma at all doses. Modulated mitoch

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.688 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z What the Human Data Actually Shows > This is where UA separates itself from a lot of “promising” compounds. We have actual placebo-controlled human trials. > Phase 1 safety trial (Ryu et al., 2019). Tested in healthy elderly adults at 250–2000 mg single doses and 250/500/1000 mg/day for 28 days. Favorable safety profile at all doses. Bioavailable in plasma at all doses. Modulated mitoch

Urolithin A: The Most Underrated Compound in Longevity

Score 0.686 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z in healthy elderly adults at 250–2000 mg single doses and 250/500/1000 mg/day for 28 days. Favorable safety profile at all doses. Bioavailable in plasma at all doses. Modulated mitochondrial gene expression in muscle biopsies at 500 and 1000 mg. Phase 2 in middle-aged adults (Singh et al., 2022, Cell Reports Medicine — the ATLAS trial). 88 sedentary middle-aged adults, 4 months of sup

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.685 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control systems in the body. > UA is one of the only known compounds that directly and reliably induces mitophagy in humans at oral doses. That alone would be remarkable. But the downstream effects of restoring mitophagy ripple through nearly ev

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.685 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control systems in the body. > UA is one of the only known compounds that directly and reliably induces mitophagy in humans at oral doses. That alone would be remarkable. But the downstream effects of restoring mitophagy ripple through nearly ev

Urolithin A: The Most Underrated Compound in Longevity

Score 0.681 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z Foundational mitophagy research Ryu D, Mouchiroud L, Andreux PA, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine. 2016;22(8):879-888. doi:10.1038/nm.4132 [ https://substack.com/redirect/123266d7-f61c-49ee-9bc7-5d377a6b5129?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Phase 1 human

Urolithin A: The Most Underrated Compound in Longevity

Score 0.680 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z stop efficiently clearing out damaged mitochondria. Dysfunctional mitochondria pile up, leak oxidative stress, fail to make energy efficiently, and contribute to nearly every “hallmark of aging” you can name. Mitophagy is the cellular cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control

7 science-backed exercises that reverse aging

Score 0.676 · Account tjphuhs@gmail.com · 5/12/2026, 12:31:36 PM

7 science-backed exercises that reverse aging from dan@highperformancefounder.com on 2026-05-12T16:31:36.000Z healthy knees, and a lower body that picks things up off the ground for the next 40 years. Beginner: kettlebell deadlift. Push your hips back, drive the floor away. Three sets of eight. ​Intermediate: kettlebell swing. Two or three sets of 10 to 20. ​Advanced: trap bar deadlift and low back extensions. The hinge is the lift that ages best. Done right, it's a strength move you keep doing

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.674 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z medical advice, and this isn’t a recommendation to use UA personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who knows your situation. > If this was useful, share it with someone who’s been chasing the longevity rabbit hole and hasn’t come across UA yet — and let me know in the comments what underrated co

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.674 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z medical advice, and this isn’t a recommendation to use UA personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who knows your situation. > If this was useful, share it with someone who’s been chasing the longevity rabbit hole and hasn’t come across UA yet — and let me know in the comments what underrated co

7 science-backed exercises that reverse aging

Score 0.666 · Account tjphuhs@gmail.com · 5/12/2026, 12:31:36 PM

7 science-backed exercises that reverse aging from dan@highperformancefounder.com on 2026-05-12T16:31:36.000Z ​ Read this on Dango.co ( https://986419df.click.convertkit-mail4.com/75u5errzkps8h6736ndtzhw4qp7rkbnhndd4v/p8heh9h4oe35zkcq/aHR0cHM6Ly93d3cuZGFuZ28uY28vYmxvZy83LXNjaWVuY2UtYmFja2VkLWV4ZXJjaXNlcy10aGF0LXJldmVyc2UtYWdpbmc= )​ A few months ago, a client named Robert told me something I haven’t been able to shake. He’s 58, fell on a ski trip, and couldn’t get up without help. He said the wo

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.664 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z you go with a generic UA product, look for: > > • > Urolithin A listed as the active ingredient (not “pomegranate extract” or “ellagitannin complex”) > • > A specified mg dose, 500 mg or 1000 mg per serving to match the trial doses > • > Third-party testing or COA available > • > A reputable brand with transparent sourcing > > Either way — verify the label says Urolithin A, not a precur

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.664 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z you go with a generic UA product, look for: > > • > Urolithin A listed as the active ingredient (not “pomegranate extract” or “ellagitannin complex”) > • > A specified mg dose, 500 mg or 1000 mg per serving to match the trial doses > • > Third-party testing or COA available > • > A reputable brand with transparent sourcing > > Either way — verify the label says Urolithin A, not a precur

Urolithin A: The Most Underrated Compound in Longevity

Score 0.661 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z verify the label says Urolithin A, not a precursor complex. Things Worth Researching Further If you’re going down the rabbit hole, here’s what’s worth understanding more deeply. Mitophagy biology in general — PINK1/Parkin, BNIP3, NIX pathways. The hallmarks of aging (López-Otín et al.) and where mitochondrial dysfunction sits among them. Microbiome variability — why some people conver

Fwd: The Future of Peptides, Longevity, and Human Performance

Score 0.656 · Account tjphuhs@gmail.com · 3/20/2026, 10:03:01 PM

Fwd: The Future of Peptides, Longevity, and Human Performance from tjphuhs@gmail.com on 2026-03-21T02:03:01.000Z 10 to 15 years > • > KLP-1 (Klotho Protein Peptide 1), the new molecule Alex calls the closest thing to a "does everything" peptide. We're talking HRV improvement, fat loss, libido, skin quality, hair quality, recovery, and more > • > VD-11, a new peptide derived from salamander regeneration research that heightened Alex's senses so much he could smell his kid's diaper from a differen

Fwd: The Future of Peptides, Longevity, and Human Performance

Score 0.656 · Account oc.tjphuhs@gmail.com · 3/20/2026, 10:03:01 PM

Fwd: The Future of Peptides, Longevity, and Human Performance from tjphuhs@gmail.com on 2026-03-21T02:03:01.000Z 10 to 15 years > • > KLP-1 (Klotho Protein Peptide 1), the new molecule Alex calls the closest thing to a "does everything" peptide. We're talking HRV improvement, fat loss, libido, skin quality, hair quality, recovery, and more > • > VD-11, a new peptide derived from salamander regeneration research that heightened Alex's senses so much he could smell his kid's diaper from a differen

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.656 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z conversation alongside them: Urolithin A. > Upgrade to paid > If you’ve been around the research community long enough, you’ve heard of NAD+, rapamycin, metformin, GLP-1s, GHK-Cu, MOTS-c, SS-31. All of them have legitimate mechanisms. Urolithin A — UA from here on — quietly checks more boxes than almost anything I’ve come across, and I rarely see it discussed at the depth it deserves. >

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.656 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z conversation alongside them: Urolithin A. > Upgrade to paid > If you’ve been around the research community long enough, you’ve heard of NAD+, rapamycin, metformin, GLP-1s, GHK-Cu, MOTS-c, SS-31. All of them have legitimate mechanisms. Urolithin A — UA from here on — quietly checks more boxes than almost anything I’ve come across, and I rarely see it discussed at the depth it deserves. >

See What’s New on WHOOP

Score 0.653 · Account tjphuhs@gmail.com · 2/25/2026, 5:20:00 PM

See What’s New on WHOOP from reply@official.whoop.com on 2026-02-25T22:20:00.000Z Labs, letting members see how key biomarkers align with each Healthspan contributor. AI guidance helps you understand the connections between metrics, so you can focus on what moves long-term health forward. <https://www.whoop.com/thelocker/10-biomarkers-that-matter-most-for-your-health/> Input to Insight Upload a photo or talk to text with WHOOP AI - from breaking down meals to understanding your equipment. Turn r

7 science-backed exercises that reverse aging

Score 0.653 · Account tjphuhs@gmail.com · 5/12/2026, 12:31:36 PM

7 science-backed exercises that reverse aging from dan@highperformancefounder.com on 2026-05-12T16:31:36.000Z want. Hang every day, and your body slowly uncurls. You start to stand like someone who owns the room again. -------------------- #2 - The Asian Squat -------------------- ​ This isn't an exercise. It's the human resting position your body was designed for. A study in the European Journal of Preventive Cardiology found that adults who struggled to sit down and rise from the floor without

The Future of Peptides, Longevity, and Human Performance

Score 0.651 · Account tjphuhs@gmail.com · 3/20/2026, 7:16:14 PM

The Future of Peptides, Longevity, and Human Performance from huntershealthhacks@mail.beehiiv.com on 2026-03-20T23:16:14.000Z for couples trying to get pregnant. Vaginal biome, sperm motility, senescent cell clearance, and more * The postpartum protocol for women, including SS-31, saffron, oxaloacetate, and why most postpartum advice on the internet is wrong * Non-androgenic muscle builders for women and men. Growth hormone, injectable oxytocin, insulin as a longevity compound, and why myostatin

Fwd: The Future of Peptides, Longevity, and Human Performance

Score 0.650 · Account tjphuhs@gmail.com · 3/20/2026, 10:03:01 PM

Fwd: The Future of Peptides, Longevity, and Human Performance from tjphuhs@gmail.com on 2026-03-21T02:03:01.000Z the Peptide Cheat Sheet: > > • > Peptide Cheat Sheet > > 👉All my daily essentials on Amazon > > • > Amazon Storefront > > 👉Get discounts on your favorite peptides and research chemicals: > > • > PEPTIDES > • > BioLongevity Labs (use code hunterw for 15% off): https://biolongevitylabs.com/ > > 👉10% off the BEST workout supplements from Unmatched Supps (pre-workout, whey protein, cre