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Semantic Search: we made a metabolic discovery
Just dropped: Most significant metabolic finding in years
Score 0.705
· Account tjphuhs@gmail.com
· 4/1/2026, 9:13:13 AM
Just dropped: Most significant metabolic finding in years from hello@drinklmnt.com on 2026-04-01T13:13:13.000Z access to the full draft — so you can review the findings, context, and early interpretations for yourself. [Read Summary](https://science.drinklmnt.com/did-you-know/preliminary-findings-pinkle-monade-doing-a-lot?utm_source=klaviyo&utm_medium=email&utm_campaign=weekly-newsletter&utm_term=just-dropped-most-significant-metabolic-finding-in-years&utm_content=blog) https://science.drinklmnt
we made a metabolic discovery
Score 0.702
· Account tjphuhs@gmail.com
· 3/22/2026, 11:00:22 PM
we made a metabolic discovery from hello@bryanjohnson.com on 2026-03-23T03:00:22.000Z [Blueprint Homepage](https://blueprint.bryanjohnson.com) Hi friend, This is email 3 in a 3-part series on magic mushrooms. In the last two emails, I shared why we began testing psilocybin as a potential longevity therapy, the scientific rationale behind it, and the fully quantified protocol measuring 249 biomarkers across three medically supervised doses ([read more here](https://blueprint.bryanjohnson.com/blog
we made a metabolic discovery
Score 0.694
· Account tjphuhs@gmail.com
· 3/22/2026, 11:00:22 PM
we made a metabolic discovery from hello@bryanjohnson.com on 2026-03-23T03:00:22.000Z cooled, showing cognitive effort and introspection + my arms cooled, showing peripheral vasoconstriction Overall, there was sympathetic activation, peripheral vasoconstriction, and increased cardiovascular load, leading to increased core and reduced peripheral blood flow. Around the peak (2.5 hrs), my heart rate was still elevated by 15 bpm (55 bpm to 70 bpm), and interestingly, my fingertip SpO₂ was decreased
Just dropped: Most significant metabolic finding in years
Score 0.678
· Account tjphuhs@gmail.com
· 4/1/2026, 9:13:13 AM
Just dropped: Most significant metabolic finding in years from hello@drinklmnt.com on 2026-04-01T13:13:13.000Z https://drinklmnt.com?utm_source=klaviyo&utm_medium=email&utm_campaign=&utm_term=&utm_content=universal-header-newsletter [MY ACCOUNT](https://drinklmnt.com/account/login?utm_source=klaviyo&utm_medium=email&utm_campaign=&utm_term=&utm_content=universal-header-newsletter) [DRINKLMNT.COM](https://drinklmnt.com?utm_source=klaviyo&utm_medium=email&utm_campaign=&utm_term=&utm_content=univers
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.661
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z a number of mitochondrial parameters — including redox handling, mitochondrial integrity, and OXPHOS efficiency — jointly indicating a mechanistic basis for the observed functional improvements. Breaking those terms down: Redox handling — how well the cell manages oxidative stress Mitochondrial integrity — the structural health of the mitochondria themselves OXPHOS efficiency
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.656
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z in mitochondrial DNA. Mitochondria produce it themselves. It belongs to a small class called mitochondrial-derived peptides (MDPs). What the research shows: Activates AMPK, the master energy sensor in cells. When AMPK is active, cells shift into “burn fuel, don’t store it” mode. Improves insulin sensitivity in preclinical models, meaning muscle cell
Metabolic Regulation Study Preparation
Score 0.653
· Account tjphuhs@gmail.com
· 3/23/2026, 9:02:21 AM
Metabolic Regulation Study Preparation from happy@happypeptides.com on 2026-03-23T13:02:21.000Z Transparent testing. Controlled research inputs. This email was sent to you as HTML-only. To view it, please visit: https://wfg.soundestlink.com/ce/v/68a8a1cb95c4ac11474be077/69bc39cb4616ceb9131f48af ************************** Make sure you keep getting our latest offers and add happy@happypeptides.com to your address book. Unsubscribe https://wfg.soundestlink.com/contactsPreferences/v2/unsubscribe/?b
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.647
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z pages, has described MOTS-c as promoting biogenesis — meaning it helps you grow more mitochondria. This study says that’s not what’s primarily happening. MOTS-c is making your existing mitochondria work better. Same number, higher output. Think of it like tuning an engine rather than adding more cylinders. How Does It Do That? The Two Pathways The researchers found that MOTS-
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.644
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.644
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.639
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 24, 2026 at 9:10 AM -0400 To: tjphuhs@gmail.com Subject: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine > Let’s talk about one of the biggest stories currently brewing in the obesity and metabolic disease space — Eli Lilly’s rumored quintup
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.639
· Account tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 24, 2026 at 9:10 AM -0400 To: tjphuhs@gmail.com Subject: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine > Let’s talk about one of the biggest stories currently brewing in the obesity and metabolic disease space — Eli Lilly’s rumored quintup
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.639
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.639
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.636
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z View this post on the web at https://derekpruski.substack.com/p/a-new-mots-c-study-just-dropped-heres A new peer-reviewed study on MOTS-c was published January 9th out of the University of Copenhagen, and I’ve seen a little chatter about it online — including Coach Cam touching on it on TikTok. I wanted to give my own read on it for the community, broken down in a way that ac
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Score 0.632
· Account tjphuhs@gmail.com
· 4/6/2026, 10:43:36 PM
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides from derekpruski@substack.com on 2026-04-07T02:43:36.000Z — 20mg Blood flow support. Substrate for nitric oxide synthase → produces NO → relaxes blood vessel walls → improves regional perfusion. Better delivery of everything else to metabolically active tissue. B5 — Dexpanthenol — 25mg CoA builder. Converts to Coenzyme A, which is required to activate fatty acids before carnitine can even transport them. B5 and carnitine are a pair —
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.626
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.626
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.624
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z track record of human trials. NMN’s evidence base is catching up fast — as of mid-2025, at least five NMN RCTs and ten NR RCTs have reported metabolic outcomes, with more on the way. What The Human Data Shows This is where the picture sharpens. We’re not just looking at rodents anymore. The head-to-head trial (Christen et al., 2025, Nature Metabolism). The fir
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.619
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z > Here’s a walkthrough to help you think about which direction matches your research interests. Read through top to bottom, stop at the first question where the answer is yes. > 1. Is your focus primarily metabolic pathways? (glucose handling, insulin sensitivity, AMPK signaling) > → MOTS-c is more targeted. Focus area: AMPK activation literature. Key
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.619
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z > Here’s a walkthrough to help you think about which direction matches your research interests. Read through top to bottom, stop at the first question where the answer is yes. > 1. Is your focus primarily metabolic pathways? (glucose handling, insulin sensitivity, AMPK signaling) > → MOTS-c is more targeted. Focus area: AMPK activation literature. Key
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.619
· Account tjphuhs@gmail.com
· 4/24/2026, 9:05:46 AM
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from derekpruski@substack.com on 2026-04-24T13:05:46.000Z View this post on the web at https://derekpruski.substack.com/p/eli-lillys-quintuple-agonist-the Let’s talk about one of the biggest stories currently brewing in the obesity and metabolic disease space — Eli Lilly’s rumored quintuple agonist. If you’ve been on peptide Twitter, Reddit, or Instagram the last few weeks, you’ve seen the hype. Animal data reportedly droppin
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Score 0.619
· Account tjphuhs@gmail.com
· 4/6/2026, 10:43:36 PM
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides from derekpruski@substack.com on 2026-04-07T02:43:36.000Z View this post on the web at https://derekpruski.substack.com/p/lipo-c-a-cheaper-energy-alternative Research Use Only. Not Medical Advice. Educational Purposes Only. If you’ve been running mitochondrial peptides and hit a wall — or you’re looking for something that moves the needle on energy without the price tag — this one’s worth a look. Lipo-C was one of the biggest energy
😱 GLP-3 (RETA) vs MOTS-C 😱
Score 0.619
· Account tjphuhs@gmail.com
· 2/11/2026, 10:30:15 AM
😱 GLP-3 (RETA) vs MOTS-C 😱 from info@somachems.com on 2026-02-11T15:30:15.000Z Take your metabolic research to the next level This email was sent to you as HTML-only. To view it, please visit: https://qfq.soundestlink.com/ce/v/68a3ebb905e51bffe64c8eaf/698c2a47dd9732c63e198315 ************************** Make sure you keep getting our latest offers and add info@somachems.com to your address book. Unsubscribe https://qfq.soundestlink.com/contactsPreferences/v2/unsubscribe/?b=686794eb7d5d9b4678a0b
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.618
· Account tjphuhs@gmail.com
· 4/24/2026, 9:05:46 AM
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from derekpruski@substack.com on 2026-04-24T13:05:46.000Z single dose and push efficacy into territory that previously only bariatric surgery could reach. ═══════════════════════════════ THE FIVE RECEPTORS AND WHY EACH MATTERS The rumored Lilly quintuple reportedly targets GLP-1, GIP, glucagon, amylin, and calcitonin. Let’s break down what each one actually does. GLP-1 (Glucagon-Like Peptide-1) This is the backbone of every m