View
Semantic Search: Why You Should NOT Refrigerate Amino Blends (Lipo-C, L-Carnitine, etc.)
Why You Should NOT Refrigerate Amino Blends (Lipo-C, L-Carnitine, etc.)
Score 0.920
· Account tjphuhs@gmail.com
· 4/7/2026, 2:03:33 PM
Why You Should NOT Refrigerate Amino Blends (Lipo-C, L-Carnitine, etc.) from derekpruski@substack.com on 2026-04-07T18:03:33.000Z View this post on the web at https://derekpruski.substack.com/p/why-you-should-not-refrigerate-amino This comes up constantly and the answer surprises most people: amino-based blends like Lipo-C, L-Carnitine, and similar compounded solutions are typically best stored at room temperature — refrigerating them can actually cause problems. I actually struggled a lot with
Why You Should NOT Refrigerate Amino Blends (Lipo-C, L-Carnitine, etc.)
Score 0.907
· Account tjphuhs@gmail.com
· 4/7/2026, 2:03:33 PM
Why You Should NOT Refrigerate Amino Blends (Lipo-C, L-Carnitine, etc.) from derekpruski@substack.com on 2026-04-07T18:03:33.000Z vial. Once a vial is opened and in active use, the preservative continues protecting the solution at room temperature across a normal use window. So what actually causes degradation? The real enemies of amino blends are: Light exposure — B12 in particular breaks down quickly when exposed to direct light. Keep vials away from windows and out of direct sunlight. Extreme
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12
Score 0.690
· Account tjphuhs@gmail.com
· 3/30/2026, 4:25:58 PM
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12 from derekpruski@substack.com on 2026-03-30T20:25:58.000Z processes NAD+ is a coenzyme required for energy production in every cell in the body. Research interest around NAD+ has expanded significantly in recent years, particularly around its decline with age and the downstream effects on cellular function and longevity B6 and methionine are studied as methylation cofactors — methylation being the process the body uses to reg
Why You Shouldn't Blend Your Own Peptides
Score 0.687
· Account tjphuhs@gmail.com
· 3/31/2026, 10:15:58 AM
Why You Shouldn't Blend Your Own Peptides from derekpruski@substack.com on 2026-03-31T14:15:58.000Z if the combined pH pushes GHK-Cu outside its stable window, you’re no longer working with an intact peptide. Bacteriostatic water isn’t a neutral variable Most people assume bac water is just water. It’s not — it contains 0.9% benzyl alcohol as a preservative, and its pH can shift differently depending on which peptide and environment it’s introduced into. A study looking at peptide crafter bacter
Complete Research Blend Breakdown: Amino Formulas
Score 0.686
· Account tjphuhs@gmail.com
· 4/3/2026, 3:49:26 PM
Complete Research Blend Breakdown: Amino Formulas from derekpruski@substack.com on 2026-04-03T19:49:26.000Z View this post on the web at https://derekpruski.substack.com/p/complete-research-blend-breakdown ⚠️ RESEARCH PURPOSES ONLY DISCLAIMER ⚠️ The information below is for educational and research purposes only. These are research compounds not approved for human consumption. This post discusses theoretical use cases and dosing protocols for research applications only. Always consult with a qua
Why You Shouldn't Blend Your Own Peptides
Score 0.685
· Account tjphuhs@gmail.com
· 3/31/2026, 10:15:58 AM
Why You Shouldn't Blend Your Own Peptides from derekpruski@substack.com on 2026-03-31T14:15:58.000Z View this post on the web at https://derekpruski.substack.com/p/why-you-shouldnt-blend-your-own-peptides Quick transparency note before we get into this: I’m actively working on putting together a more formal study on this topic. What I’m sharing here is based on current science and reasoning — the goal is to eventually confirm whether this is myth or reality with real data. But based on what we k
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12
Score 0.680
· Account tjphuhs@gmail.com
· 3/30/2026, 4:25:58 PM
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12 from derekpruski@substack.com on 2026-03-30T20:25:58.000Z View this post on the web at https://derekpruski.substack.com/p/peptira-just-dropped-3-new-amino If you’ve been following along, you know B12 is one of those things that shows up in virtually every amino blend on the market. The problem is that research levels tend to run significantly higher than what’s considered ideal, and for researchers trying to isolate variables
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.677
· Account tjphuhs@gmail.com
· 3/27/2026, 4:31:44 PM
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from derekpruski@substack.com on 2026-03-27T20:31:44.000Z body called NNMT that essentially drains your NAD+ supply by siphoning off the raw materials needed to make it. 5-Amino-1MQ blocks that enzyme. It’s not adding more NAD+ — it’s stopping the leak so the NAD+ you have (and are supplying with the first compound) sticks around longer and gets used productively. It also plays a role in how fat cells behave metabolically. Why These Three Toge
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Score 0.669
· Account tjphuhs@gmail.com
· 4/6/2026, 10:43:36 PM
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides from derekpruski@substack.com on 2026-04-07T02:43:36.000Z — 20mg Blood flow support. Substrate for nitric oxide synthase → produces NO → relaxes blood vessel walls → improves regional perfusion. Better delivery of everything else to metabolically active tissue. B5 — Dexpanthenol — 25mg CoA builder. Converts to Coenzyme A, which is required to activate fatty acids before carnitine can even transport them. B5 and carnitine are a pair —
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.667
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z does something useful. Together, they address the same system from three directions: > NAD+ and 5-Amino-1MQ work as a supply-and-preserve pair. You’re putting more NAD+ in while simultaneously slowing the rate it gets degraded. Without addressing the drain, supplementing NAD+ alone is less efficient — 5-Amino-1MQ closes that loop. > MOTS-c and NAD+ reinforce each other at the output level
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.667
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z does something useful. Together, they address the same system from three directions: > NAD+ and 5-Amino-1MQ work as a supply-and-preserve pair. You’re putting more NAD+ in while simultaneously slowing the rate it gets degraded. Without addressing the drain, supplementing NAD+ alone is less efficient — 5-Amino-1MQ closes that loop. > MOTS-c and NAD+ reinforce each other at the output level
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Score 0.666
· Account tjphuhs@gmail.com
· 4/6/2026, 10:43:36 PM
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides from derekpruski@substack.com on 2026-04-07T02:43:36.000Z View this post on the web at https://derekpruski.substack.com/p/lipo-c-a-cheaper-energy-alternative Research Use Only. Not Medical Advice. Educational Purposes Only. If you’ve been running mitochondrial peptides and hit a wall — or you’re looking for something that moves the needle on energy without the price tag — this one’s worth a look. Lipo-C was one of the biggest energy
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.658
· Account tjphuhs@gmail.com
· 3/27/2026, 4:31:44 PM
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from derekpruski@substack.com on 2026-03-27T20:31:44.000Z Vial contents: 100mg NAD+ / 10mg MOTS-c / 10mg 5-Amino-1MQ Add 3ml of bacteriostatic water to the vial. Store reconstituted vial refrigerated. Each 30-unit (0.3ml) research dose yields 1mg NAD+, 0.1mg MOTS-c, and 0.1mg 5-Amino-1MQ — a 10-1-1 ratio that keeps all three compounds proportional throughout the vial. Compound Summary NAD+ is the direct energy substrate — it supplies what mito
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.650
· Account tjphuhs@gmail.com
· 3/27/2026, 4:31:44 PM
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from derekpruski@substack.com on 2026-03-27T20:31:44.000Z View this post on the web at https://derekpruski.substack.com/p/nad-mots-c-5-amino-1mq-breaking-down For research purposes only. Not for human consumption. A lot of you have been asking about this one, so I figured we’d just walk through each component and explain how it works and whether the combination actually makes sense. By the end of this you’ll have a clear picture of what each c
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.648
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 27, 2026 at 4:32 PM -0400 To: tjphuhs@gmail.com Subject: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend > For research purposes only. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.648
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 27, 2026 at 4:32 PM -0400 To: tjphuhs@gmail.com Subject: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend > For research purposes only. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
What Do You Do When Your First Vial Is Running Low?
Score 0.636
· Account tjphuhs@gmail.com
· 3/15/2026, 10:50:16 AM
What Do You Do When Your First Vial Is Running Low? from derekpruski@substack.com on 2026-03-15T14:50:16.000Z cloudiness is a sign the peptide structure may be compromised. Gelling. Some lyophilized peptides are sensitive to environmental changes. Combining two solutions under different conditions can cause them to gel up or form aggregates — meaning the peptide is no longer properly dissolved and you can’t accurately dose it. None of those outcomes are what you want in a research setting where
Why COA Net Content Matters Even More With Peptide Blends
Score 0.634
· Account tjphuhs@gmail.com
· 4/14/2026, 1:08:09 AM
Why COA Net Content Matters Even More With Peptide Blends from derekpruski@substack.com on 2026-04-14T05:08:09.000Z a vendor isn’t testing their blends to the same standard as their singles, take note Simpler is almost always better when it comes to blend complexity All content is intended for research and educational purposes only. Not for human consumption. This is not medical advice. Always conduct your own due diligence. Unsubscribe https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9kZXJla3B
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.633
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.633
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the
Fwd: Breaking Down the Blend: Does GLOW or KLOW Actually Make Sense for Your Research?
Score 0.629
· Account tjphuhs@gmail.com
· 3/26/2026, 11:40:30 AM
Fwd: Breaking Down the Blend: Does GLOW or KLOW Actually Make Sense for Your Research? from tjphuhs@gmail.com on 2026-03-26T15:40:30.000Z logic to including them. The issue is cost. Running BPC-157 and TB-500 as part of a year-round skin protocol is expensive, and the incremental benefit over GHK-Cu alone likely doesn’t justify it for most research purposes. GHK-Cu is the primary driver. BPC and TB-500 are a nice addition for an acute phase, not a staple. > If the RS has healthy skin with no inf
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.625
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z what mitochondria need to produce ATP and activates repair proteins that depend on it. > MOTS-c is the capacity builder — it signals the body to create more mitochondria and become more metabolically efficient, amplifying what NAD+ can do. > 5-Amino-1MQ is the preservation mechanism — it blocks the enzyme that degrades NAD+ precursors, extending the effectiveness of the NAD+ being supplie
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.625
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z what mitochondria need to produce ATP and activates repair proteins that depend on it. > MOTS-c is the capacity builder — it signals the body to create more mitochondria and become more metabolically efficient, amplifying what NAD+ can do. > 5-Amino-1MQ is the preservation mechanism — it blocks the enzyme that degrades NAD+ precursors, extending the effectiveness of the NAD+ being supplie
Why SNAP-8 Is Typically Lyophilized - Despite Being Topical
Score 0.625
· Account tjphuhs@gmail.com
· 4/6/2026, 9:43:00 PM
Why SNAP-8 Is Typically Lyophilized - Despite Being Topical from derekpruski@substack.com on 2026-04-07T01:43:00.000Z View this post on the web at https://derekpruski.substack.com/p/why-snap-8-is-typically-lyophilized Ever wondered why SNAP8 (Acetyl Octapeptide-3) consistently arrives as freeze-dried powder while GHK-Cu and Syn-Ake come as raw powders? The molecular structure determines the optimal storage form - and understanding this affects both stability and your research safety. I’m going t
Breaking Down the Blend: Does GLOW or KLOW Actually Make Sense for Your Research?
Score 0.621
· Account tjphuhs@gmail.com
· 3/25/2026, 7:49:07 PM
Breaking Down the Blend: Does GLOW or KLOW Actually Make Sense for Your Research? from derekpruski@substack.com on 2026-03-25T23:49:07.000Z Now, BPC-157 and TB-500 do have a supporting role here. Both compounds can accelerate collagen synthesis and tissue remodeling — BPC-157 through angiogenesis and growth hormone receptor upregulation, TB-500 through actin regulation and cellular migration. So there is some logic to including them. The issue is cost. Running BPC-157 and TB-500 as part of a yea