Email Archive

What emulsifiers actually do to your gut lining

Score 0.857 · Account tjphuhs@gmail.com · 5/11/2026, 6:30:40 PM

What emulsifiers actually do to your gut lining from hello@lineageprovisions.com on 2026-05-11T22:30:40.000Z [What's Actually Destroying Your Gut](https://lineageprovisions.com/collect= ions/all) [What's Actually Destroying Your Gut](https://lineageprovisions.com/collect= ions/all) [What's Actually Destroying Your Gut](https://pmc.ncbi.nlm.nih.gov/articles= /PMC4910713/) [What's Actually Destroying Your Gut](https://pmc.ncbi.nlm.nih.gov/articles= /PMC4808858/) [What's Actually Destroying Your Gu

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption

Score 0.652 · Account oc.tjphuhs@gmail.com · 4/25/2026, 9:08:09 PM

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 2:01 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption > One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — i

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption

Score 0.652 · Account tjphuhs@gmail.com · 4/25/2026, 9:08:09 PM

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 2:01 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption > One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — i

GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption

Score 0.652 · Account tjphuhs@gmail.com · 4/25/2026, 2:00:53 PM

GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from derekpruski@substack.com on 2026-04-25T18:00:53.000Z View this post on the web at https://derekpruski.substack.com/p/glp-1s-and-slowed-gastric-emptying One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — it’s the gut motility piece. And it’s the piece that generates the most confusion when researchers start asking how other orally administered

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption

Score 0.643 · Account oc.tjphuhs@gmail.com · 4/25/2026, 9:08:09 PM

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z misinformation floating around — most of it landing on the wrong side of “things won’t absorb.” That’s not what the literature shows. What the literature shows is more nuanced, and understanding the mechanism makes the picture a lot clearer. > The Mechanism > GLP-1 receptor agonists slow gastric emptying through a few overlapping pathways. > The receptors are densely

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption

Score 0.643 · Account tjphuhs@gmail.com · 4/25/2026, 9:08:09 PM

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z misinformation floating around — most of it landing on the wrong side of “things won’t absorb.” That’s not what the literature shows. What the literature shows is more nuanced, and understanding the mechanism makes the picture a lot clearer. > The Mechanism > GLP-1 receptor agonists slow gastric emptying through a few overlapping pathways. > The receptors are densely

Tesofensine: What’s Worth Knowing About The Mechanism, The Side Effects, And The GLP-1 Washout Question

Score 0.642 · Account tjphuhs@gmail.com · 5/11/2026, 1:40:19 PM

Tesofensine: What’s Worth Knowing About The Mechanism, The Side Effects, And The GLP-1 Washout Question from derekpruski@substack.com on 2026-05-11T17:40:19.000Z they work in the gut — slowing digestion, increasing fullness, etc. That’s part of it. But research over the last few years has shown they also have significant effects in the brain. GLP-1 receptors are present in brain regions that control: Reward and motivation (the dopamine system) Mood Cravings and food noise Some addictive behavior

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption

Score 0.640 · Account tjphuhs@gmail.com · 4/25/2026, 9:08:09 PM

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most cases — preserved. > This article is for research and educational purposes only. The compounds and protocols discussed are intended for in vitro and laboratory research use. Nothing in this article constitutes medical advice, clinical guidance, or

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption

Score 0.640 · Account oc.tjphuhs@gmail.com · 4/25/2026, 9:08:09 PM

Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most cases — preserved. > This article is for research and educational purposes only. The compounds and protocols discussed are intended for in vitro and laboratory research use. Nothing in this article constitutes medical advice, clinical guidance, or

Can BPC-157 Blunt the Effects of Alcohol? The Angiogenesis Angle

Score 0.631 · Account tjphuhs@gmail.com · 5/14/2026, 11:46:54 AM

Can BPC-157 Blunt the Effects of Alcohol? The Angiogenesis Angle from derekpruski@substack.com on 2026-05-14T15:46:54.000Z then into acetate, which gets cleared from the body. The speed and efficiency of this entire process depends heavily on blood flow. The liver needs strong, consistent blood perfusion to filter alcohol efficiently. The stomach and gut need healthy vasculature to manage absorption without taking damage. And the brain — which is where you actually feel intoxication — is affecte

Fwd: Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast.

Score 0.631 · Account tjphuhs@gmail.com · 3/17/2026, 3:31:51 PM

Fwd: Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast. from tjphuhs@gmail.com on 2026-03-17T19:31:51.000Z secretagogue, not just Tesamorelin. When growth hormone rises in your body, it activates an enzyme called hormone-sensitive lipase. That enzyme breaks down stored triglycerides — the form fat is stored in — into free fatty acids that your body can actually use for energy. That process is called lipolysis, and it’s the fundamental mechanism through which GH drives fat loss. Here’

GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption

Score 0.629 · Account tjphuhs@gmail.com · 4/25/2026, 2:00:53 PM

GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from derekpruski@substack.com on 2026-04-25T18:00:53.000Z onset to be delayed, expect peaks to be softer, and don’t interpret a delayed onset as a failure of the protocol. The compound is in circulation. It’s just taking a longer path to get there. Understanding the mechanism is the difference between confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most

Fwd: I took 6 tablespoons of this every day for 21 days and it changed everything

Score 0.629 · Account tjphuhs@gmail.com · 3/17/2026, 11:45:55 AM

Fwd: I took 6 tablespoons of this every day for 21 days and it changed everything from tjphuhs@gmail.com on 2026-03-17T15:45:55.000Z Supplementation and Gut Health. (2024). Psyllium husk positively alters gut microbiota, decreases inflammation, and has bowel-regulatory action. Gastroenterology . https://www.gastrojournal.org/article/S0016-5085(23)05241-1/fulltext Reynolds, A., Mann, J., Cummings, J., Winter, N., Mete, E., & Te Morenga, L. (2019). Carbohydrate quality and human health: a series o

Fwd: Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast.

Score 0.627 · Account tjphuhs@gmail.com · 3/17/2026, 3:31:51 PM

Fwd: Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast. from tjphuhs@gmail.com on 2026-03-17T19:31:51.000Z things: “this compound has been studied for visceral fat” and “this compound burns visceral fat.” Those aren’t the same statement. Not even close. So let’s actually pull this apart. Upgrade to paid What Is Visceral Fat, and Why Does It Matter? Before anything else, it helps to understand what we’re actually talking about. Your body stores fat in two main places. Subcutaneous fat

Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast.

Score 0.622 · Account tjphuhs@gmail.com · 3/17/2026, 2:53:19 PM

Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast. from derekpruski@substack.com on 2026-03-17T18:53:19.000Z say “Tesamorelin is the only peptide with evidence for visceral fat reduction,” what they’re really saying — whether they realize it or not — is “Tesamorelin is the only peptide that a pharmaceutical company had sufficient financial incentive to study for visceral fat reduction.” That’s a funding gap. Not necessarily a biology gap. How Growth Hormone Actually Burns Visceral Fa

Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast.

Score 0.619 · Account tjphuhs@gmail.com · 3/17/2026, 2:53:19 PM

Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast. from derekpruski@substack.com on 2026-03-17T18:53:19.000Z View this post on the web at https://derekpruski.substack.com/p/does-tesamorelin-have-a-monopoly There’s a claim that gets repeated constantly in the peptide research space: “Tesamorelin is the only peptide proven to burn visceral fat.” And if you’ve spent any time researching GH secretagogues, you’ve probably accepted this as settled fact and moved on. I did for a while too.

Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?

Score 0.617 · Account oc.tjphuhs@gmail.com · 4/25/2026, 9:07:43 PM

Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z means “you digest your food better” — and like most popular claims, it’s partially true, partially misleading, and worth unpacking properly. > Let’s walk through it. > The Mechanism Recap > Quick refresher from Part 1: GLP-1 receptor agonists slow gastric emptying by reducing antral contractility, increasing pyloric tone, and dampening the migrating motor complex. Fo

Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?

Score 0.617 · Account tjphuhs@gmail.com · 4/25/2026, 9:07:43 PM

Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z means “you digest your food better” — and like most popular claims, it’s partially true, partially misleading, and worth unpacking properly. > Let’s walk through it. > The Mechanism Recap > Quick refresher from Part 1: GLP-1 receptor agonists slow gastric emptying by reducing antral contractility, increasing pyloric tone, and dampening the migrating motor complex. Fo

GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?

Score 0.617 · Account tjphuhs@gmail.com · 4/25/2026, 3:54:50 PM

GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z View this post on the web at https://derekpruski.substack.com/p/glp-1s-and-slowed-gastric-emptying-4ec After the first post on medication absorption, a lot of you asked the natural follow-up question: what about food? What about nutrients? If gastric emptying is slowed dramatically, are we actually absorbing more from our meals because food sits in the stomach long

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.

Score 0.615 · Account oc.tjphuhs@gmail.com · 5/3/2026, 2:45:39 PM

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: May 3, 2026 at 10:41 AM -0400 To: tjphuhs@gmail.com Subject: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. > The body has always known something drug developers are still learning: shape matters. > ͏

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.

Score 0.615 · Account tjphuhs@gmail.com · 5/3/2026, 2:45:39 PM

Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: May 3, 2026 at 10:41 AM -0400 To: tjphuhs@gmail.com Subject: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. > The body has always known something drug developers are still learning: shape matters. > ͏

Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?

Score 0.614 · Account tjphuhs@gmail.com · 4/25/2026, 9:07:43 PM

Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 3:55 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? > After the first post on medication absorption, a lot of you asked the natural follow-up question: what about food? > ͏ ­͏ ­͏ ­

Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?

Score 0.614 · Account oc.tjphuhs@gmail.com · 4/25/2026, 9:07:43 PM

Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 3:55 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? > After the first post on medication absorption, a lot of you asked the natural follow-up question: what about food? > ͏ ­͏ ­͏ ­

A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.

Score 0.613 · Account tjphuhs@gmail.com · 5/3/2026, 10:40:57 AM

A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from onthepen@substack.com on 2026-05-03T14:40:57.000Z View this post on the web at https://onthepen.substack.com/p/a-molecular-stapler-could-make-glp The body has always known something drug developers are still learning: shape matters. Not just the shape of a molecule as it enters a receptor, but the shape it holds after hours in the bloodstream, after the body has done everything it does to break thi

GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?

Score 0.613 · Account tjphuhs@gmail.com · 4/25/2026, 3:54:50 PM

GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z conditions longer, protein denaturation by pepsin has more time to occur. Whether this translates to meaningfully better downstream amino acid absorption is less clear in the human data, but mechanistically it’s plausible. Fat digestion timing shifts. Fats normally slow gastric emptying on their own as a feedback signal. On a GLP-1, that signal is layered on top of