Email Archive

Fwd: Weirdly-Named Longevity Compound

Score 0.765 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: March 17, 2026 at 6:04:57 PM EDT To: tjphuhs@gmail.com Subject: Weirdly-Named Longevity Compound Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Weirdly-Named Longevity Compound 96 New video on spermidine is live! ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

Weirdly-Named Longevity Compound

Score 0.739 · Account tjphuhs@gmail.com · 3/17/2026, 6:04:04 PM

Weirdly-Named Longevity Compound from huntershealthhacks@mail.beehiiv.com on 2026-03-17T22:04:04.000Z only goal right now is putting on as much muscle as possible, maybe hold off. But for most of us who want to live long and live strong, this belongs in the stack. The product I personally use is [NAD Regen from Biostack Labs.](http://biostacklabs.com/hunter) One serving provides 5mg of spermidine, along with a few other solid ingredients. It's been my go-to through this past year, and I've been

Weirdly-Named Longevity Compound

Score 0.731 · Account tjphuhs@gmail.com · 3/17/2026, 6:04:04 PM

Weirdly-Named Longevity Compound from huntershealthhacks@mail.beehiiv.com on 2026-03-17T22:04:04.000Z Happy Tuesday! Last month, I [published an email ](https://huntershealthhacks.beehiiv.com/p/spermidine-nad-and-longevity)on some interesting research around spermidine. Today, I just dropped a brand new video on Spotify, breaking down spermidine. The video goes deep into the research. This email will give you the highlights. Spermidine for Longevity: (https://open.spotify.com/episode/1hZCBd6gyHx

Fwd: Weirdly-Named Longevity Compound

Score 0.710 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z was originally discovered in semen. That's where the name comes from. But spermidine exists in nearly every cell in your body. It's not a sperm-specific compound. Spermidine is a type of molecule called a polyamine. It's small and positively charged. It plays a role in cell growth, stress response, immune signaling, and gene activity. Your body makes it naturally. It also breaks it down naturally. When the b

Urolithin A: The Most Underrated Compound in Longevity

Score 0.702 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z verify the label says Urolithin A, not a precursor complex. Things Worth Researching Further If you’re going down the rabbit hole, here’s what’s worth understanding more deeply. Mitophagy biology in general — PINK1/Parkin, BNIP3, NIX pathways. The hallmarks of aging (López-Otín et al.) and where mitochondrial dysfunction sits among them. Microbiome variability — why some people conver

Fwd: Weirdly-Named Longevity Compound

Score 0.693 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z https://pubmed.ncbi.nlm.nih.gov/29315079/ https://pubmed.ncbi.nlm.nih.gov/39405978/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11587830/ Want more? Here’s how you can work with me: 👉Join my private coaching group, The AXION Collective: The AXION Collective 👉Try Zeroats, the world’s first sugar-free, naturally flavored oatmeal: Store: https://zeroats.com/ Amazon: https://a.co/d/2gq1zJ9 👉 Link To All My Old V

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.686 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z you go with a generic UA product, look for: > > • > Urolithin A listed as the active ingredient (not “pomegranate extract” or “ellagitannin complex”) > • > A specified mg dose, 500 mg or 1000 mg per serving to match the trial doses > • > Third-party testing or COA available > • > A reputable brand with transparent sourcing > > Either way — verify the label says Urolithin A, not a precur

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.686 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z you go with a generic UA product, look for: > > • > Urolithin A listed as the active ingredient (not “pomegranate extract” or “ellagitannin complex”) > • > A specified mg dose, 500 mg or 1000 mg per serving to match the trial doses > • > Third-party testing or COA available > • > A reputable brand with transparent sourcing > > Either way — verify the label says Urolithin A, not a precur

Fwd: Spermidine, NAD+, and Longevity

Score 0.676 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: February 25, 2026 at 6:06:49 PM EST To: tjphuhs@gmail.com Subject: Spermidine, NAD+, and Longevity Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Spermidine, NAD+, and Longevity 96 Don't waste your NAD+! ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

Spermidine, NAD+, and Longevity

Score 0.673 · Account tjphuhs@gmail.com · 2/25/2026, 6:06:48 PM

Spermidine, NAD+, and Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-25T23:06:48.000Z Happy Wednesday! Over the past few weeks, I’ve gone deep down the rabbit hole on spermidine. Spermidine has been around for a while. It is a naturally occurring polyamine found in foods such as wheat germ, mushrooms, soybeans, and aged cheese. It also exists within every cell in our body, and like most things, endogenous levels decline with age. In animal models, spermidine consistently extends l

Urolithin A: The Most Underrated Compound in Longevity

Score 0.671 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z https://substack.com/redirect/2e1d546d-6551-4992-b6ac-87f2c20b044b?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Heart failure (HFpEF) Urolithin A Restores Mitochondrial Function and Reverses Cardiac Remodeling in Heart Failure with Preserved Ejection Fraction. bioRxiv. 2025. Preprint [ https://substack.com/redirect/08b19280-c64c-4a6e-bb10-2ac4d5272df6?j=eyJ1Ijoi

Urolithin A: The Most Underrated Compound in Longevity

Score 0.671 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z View this post on the web at https://derekpruski.substack.com/p/urolithin-a-the-most-underrated-compound Research and educational purposes only. Nothing in this piece is medical advice. If you’re considering anything personally, that’s a conversation for a qualified clinician. I want to talk about something that isn’t a peptide but probably deserves a permanent spot in the longevity c

Weirdly-Named Longevity Compound

Score 0.668 · Account tjphuhs@gmail.com · 3/17/2026, 6:04:04 PM

Weirdly-Named Longevity Compound from huntershealthhacks@mail.beehiiv.com on 2026-03-17T22:04:04.000Z fasting. That rise appears to be required for lasting longevity benefits. So, taking spermidine is essentially giving your body a fasting signal without actually fasting. ——————————————————————————— **What Does the Research Say?** Human evidence falls into two buckets. Observational studies and intervention trials. On the observational side, people who eat more spermidine-rich foods have around

Urolithin A: The Most Underrated Compound in Longevity

Score 0.664 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z Foundational mitophagy research Ryu D, Mouchiroud L, Andreux PA, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine. 2016;22(8):879-888. doi:10.1038/nm.4132 [ https://substack.com/redirect/123266d7-f61c-49ee-9bc7-5d377a6b5129?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Phase 1 human

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.661 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z medical advice, and this isn’t a recommendation to use UA personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who knows your situation. > If this was useful, share it with someone who’s been chasing the longevity rabbit hole and hasn’t come across UA yet — and let me know in the comments what underrated co

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.661 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z medical advice, and this isn’t a recommendation to use UA personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who knows your situation. > If this was useful, share it with someone who’s been chasing the longevity rabbit hole and hasn’t come across UA yet — and let me know in the comments what underrated co

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.661 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z all downstream of mitochondrial decline. A compound that addresses the upstream cause has multi-system effects. > The human data is real. This isn’t a “rodents only” story. We have multiple placebo-controlled human trials with measured outcomes in muscle biopsies, plasma biomarkers, and functional performance. > It pairs logically with other interventions. It doesn’t compete with peptid

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.661 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z all downstream of mitochondrial decline. A compound that addresses the upstream cause has multi-system effects. > The human data is real. This isn’t a “rodents only” story. We have multiple placebo-controlled human trials with measured outcomes in muscle biopsies, plasma biomarkers, and functional performance. > It pairs logically with other interventions. It doesn’t compete with peptid

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.657 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: May 2, 2026 at 11:17 AM -0400 To: tjphuhs@gmail.com Subject: Urolithin A: The Most Underrated Compound in Longevity > A postbiotic that targets the upstream cause of aging — and why almost nobody in the peptide world is talking about it > ͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.657 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: May 2, 2026 at 11:17 AM -0400 To: tjphuhs@gmail.com Subject: Urolithin A: The Most Underrated Compound in Longevity > A postbiotic that targets the upstream cause of aging — and why almost nobody in the peptide world is talking about it > ͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­͏ ­

Fwd: Weirdly-Named Longevity Compound

Score 0.655 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z larger 12-month trial using only 0.9 milligrams per day showed no significant memory benefit. Blood spermidine levels didn't change in either group. The dose was probably just too low. When researchers examined higher doses in the range of 3.3 to 40 milligrams per day, no safety issues were observed. Side effects across trials were minimal. Some people reported minor joint and muscle issues. There was a sign

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.654 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z conversation alongside them: Urolithin A. > Upgrade to paid > If you’ve been around the research community long enough, you’ve heard of NAD+, rapamycin, metformin, GLP-1s, GHK-Cu, MOTS-c, SS-31. All of them have legitimate mechanisms. Urolithin A — UA from here on — quietly checks more boxes than almost anything I’ve come across, and I rarely see it discussed at the depth it deserves. >

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.654 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z conversation alongside them: Urolithin A. > Upgrade to paid > If you’ve been around the research community long enough, you’ve heard of NAD+, rapamycin, metformin, GLP-1s, GHK-Cu, MOTS-c, SS-31. All of them have legitimate mechanisms. Urolithin A — UA from here on — quietly checks more boxes than almost anything I’ve come across, and I rarely see it discussed at the depth it deserves. >

Fwd: Spermidine, NAD+, and Longevity

Score 0.645 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z deserves your attention. Let’s break it down. How Spermidine Works Spermidine’s primary claim to fame is its ability to activate autophagy. Autophagy is the cellular cleanup process. It’s how your cells remove damaged proteins, dysfunctional mitochondria, and cellular debris. It is one of the most consistently associated mechanisms with lifespan extension across species. Spermidine induces autophagy independe

Urolithin A: The Most Underrated Compound in Longevity

Score 0.645 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z in healthy elderly adults at 250–2000 mg single doses and 250/500/1000 mg/day for 28 days. Favorable safety profile at all doses. Bioavailable in plasma at all doses. Modulated mitochondrial gene expression in muscle biopsies at 500 and 1000 mg. Phase 2 in middle-aged adults (Singh et al., 2022, Cell Reports Medicine — the ATLAS trial). 88 sedentary middle-aged adults, 4 months of sup