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Semantic Search: The Next Wave of GLP-1s Is Coming
The Next Wave of GLP-1s Is Coming
Score 0.771
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A
The Next Wave of GLP-1s Is Coming
Score 0.745
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z Happy Tuesday! There are two peptides quietly making waves in the clinical space that will demand all of our attention over the next 24 months. They don't work like semaglutide, they don't work like tirzepatide, and the clinical data is turning heads. I just dropped a brand new video breaking down survodutide and mazdutide. Survodutide & Mazdutide | The GLP-1/Glucagon Duo That Could Rival Reta:
The Next Wave of GLP-1s Is Coming
Score 0.729
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z approved doses in China are 4 mg and 6 mg per week. The titration protocol starts at 2 mg, then moves to 4 mg, then to 6 mg, with about four weeks between each step. The 9 mg dose is the highest studied in China's GLORY-2 trial. The US is evaluating doses up to 16 mg. Survodutide is also once weekly. Phase 3 target doses are 3.6 mg and 6.0 mg. Phase 2 used aggressive bi-weekly escalation and it
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.703
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.703
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This.
Score 0.694
· Account tjphuhs@gmail.com
· 3/18/2026, 4:18:18 PM
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This. from tjphuhs@gmail.com on 2026-03-18T20:18:18.000Z overthink it — just make sure there’s enough fuel in the tank before lights out. > As always, this is for research purposes only. All compounds are research use only, not for human consumption. > Drop any questions below — happy to help you troubleshoot. > Upgrade to paid > You're currently a free subscriber to Peptide Price. For the full experience, upgrade your subscription. > Upgra
GLP-1 Access State of the Union
Score 0.688
· Account tjphuhs@gmail.com
· 4/7/2026, 4:01:22 PM
GLP-1 Access State of the Union from onthepen@substack.com on 2026-04-07T20:01:22.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-access-state-of-the-union If you just look at the headlines, things look great for access to GLP-1 medications but for some of those already using these medications things are changing and getting tighter. Listen in as Dave breaks down the news of the week and puts it all in context. Watch or listen to this week’s podcast on Spotify! If you pre
The GLP-1 Moment Is Breaking the Healthcare System Wide Open
Score 0.683
· Account tjphuhs@gmail.com
· 3/18/2026, 6:27:27 PM
The GLP-1 Moment Is Breaking the Healthcare System Wide Open from onthepen@substack.com on 2026-03-18T22:27:27.000Z View this post on the web at https://onthepen.substack.com/p/the-glp-1-moment-is-breaking-the I’ve said this a number of times, but it keeps proving itself out. GLP-1 medications are not just transforming lives, they’re transforming our healthcare system in a way we haven’t seen in decades, and it’s happening faster than most people realize. What started as a shortage story, and on
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.680
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z wave of trials needs to recruit at-risk people before symptoms start — that’s where the real test happens. > This is one more data point worth tracking as the field develops. Stay measured, watch the next 2-3 years of trial readouts, and don’t get ahead of the evidence. > Drop questions or thoughts below. > Disclaimer: This content is for research and educational purposes only and is not
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.680
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z wave of trials needs to recruit at-risk people before symptoms start — that’s where the real test happens. > This is one more data point worth tracking as the field develops. Stay measured, watch the next 2-3 years of trial readouts, and don’t get ahead of the evidence. > Drop questions or thoughts below. > Disclaimer: This content is for research and educational purposes only and is not
Retatrutide Is Too Good… And That’s The Problem
Score 0.679
· Account tjphuhs@gmail.com
· 3/24/2026, 9:24:24 PM
Retatrutide Is Too Good… And That’s The Problem from onthepen@substack.com on 2026-03-25T01:24:24.000Z View this post on the web at https://onthepen.substack.com/p/retatrutide-is-too-good-and-thats There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. From new signals out of Washington that could impact access, to powerful new data on next-generation treatments like retatrutide, to wher
GLP-1s vs. Fertility
Score 0.678
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z all. For couples whose fertility is being dragged down by metabolic dysfunction, GLP-1s are the most promising pharmacological lever I've seen in a decade. The female data on PCOS pregnancy rates is the strongest signal in the whole literature. The male data is catching up. The next 24 months of trial data will tell us a lot. I'll keep you posted on what we learn, on our journey, and on the science. GLP-1s
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This.
Score 0.671
· Account tjphuhs@gmail.com
· 3/18/2026, 4:18:18 PM
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This. from tjphuhs@gmail.com on 2026-03-18T20:18:18.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 18, 2026 at 3:44 PM -0400 To: tjphuhs@gmail.com Subject: Waking Up at 2–3am While Researching a GLP-1? Read This. > If you’re researching a GLP-1 like tirzepatide or retatrutide and you’re randomly waking up at 2 or 3 in the morning unable to fall back asleep — this post is for
GLP-1 vs GLP-2 vs GLP-3
Score 0.669
· Account tjphuhs@gmail.com
· 5/14/2026, 9:00:21 AM
GLP-1 vs GLP-2 vs GLP-3 from happy@happypeptides.com on 2026-05-14T13:00:21.000Z A simple comparison of the three. This email was sent to you as HTML-only. To view it, please visit: https://wfg.soundestlink.com/ce/v/68a8a1cb95c4ac11474be077/6a04d2931ac007f30c9a1cd2 ************************** Make sure you keep getting our latest offers and add happy@happypeptides.com to your address book. Unsubscribe https://wfg.soundestlink.com/contactsPreferences/v2/unsubscribe/?b=68a8a136cfa3b70cffc67e5f&c=68
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.667
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.667
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce
Fwd: Compound Tirzepatide & Semaglutide Updates!
Score 0.666
· Account tjphuhs@gmail.com
· 3/17/2026, 5:51:48 PM
Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z exclusive DDC list explained Novo’s lab findings 302% dose shocker Catalent’s contamination mess Lilly’s B12 tirzepatide bombshell Is the molecule changing? New oral GLP-1 contender MASSIVE: Compound Tirzepatide and Semaglutide Updates! Dave Knapp GLP-1 Industry Insider Episode Do you trust compounded GLP-1s based on real-world experience, or do findings like the ones discussed today change your p
GLPs Are Back at Modern Aminos — Here’s Why
Score 0.666
· Account tjphuhs@gmail.com
· 1/27/2026, 11:03:52 AM
GLPs Are Back at Modern Aminos — Here’s Why from cs@modernaminos.com on 2026-01-27T16:03:52.000Z Transparency first. Here’s why GLPs were removed, and why they’re now available again. This email was sent to you as HTML-only. To view it, please visit: https://glh.soundestlink.com/ce/v/68732f567657959f48cbbc66/6978e1a0a338842ab0915008 ************************** Make sure you keep getting our latest offers and add cs@modernaminos.com to your address book. Unsubscribe https://glh.soundestlink.com/co
The Next Wave of GLP-1s Is Coming
Score 0.665
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z restores mitochondrial function. These are effects that GLP-1 agonism alone cannot replicate. When glucagon agonism is combined with GLP-1 agonism in a single molecule, the GLP-1 component counterbalances the glucose-raising effect of glucagon. No increased risk of hyperglycemia has been observed in trials of either compound. ——————————————————————————— **The Benefits ** The weight loss numbers
GLP-1s vs. Addiction
Score 0.661
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z Happy Monday! I recently [read a very large study published in ](https://www.bmj.com/content/392/bmj-2025-086886)_[The BMJ](https://www.bmj.com/content/392/bmj-2025-086886)_ that provided the strongest signal yet that something tangible may be happening in the brain on GLP-1s. The study analyzed health records from more than 600,000 U.S. veterans with type 2 diabetes to examine whether GLP-1 drugs influence
Massive GLP-1 Data From ECO 2026
Score 0.661
· Account tjphuhs@gmail.com
· 5/13/2026, 10:52:49 AM
Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z keeping what you lost, but stepping down to 5mg is viable for a meaningful subset. ATTAIN-MAINTAIN says switching from an injectable to a daily pill is a real option, not a theoretical one -- with results that vary depending on which injectable you came from and deserve to be understood on their own terms. The STEPUP sub-analysis says there is more efficacy headroom above the current Wegovy dose, and the body
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors?
Score 0.659
· Account oc.tjphuhs@gmail.com
· 3/15/2026, 2:45:56 PM
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors? from tjphuhs@gmail.com on 2026-03-15T18:45:56.000Z Week > Week 0 - Administration stops > Plasma levels begin their slow decline. Receptors are getting their first break from continuous stimulation, but clearance is far from complete and meaningful resensitization hasn’t started. > Weeks 1-2 > Significant compound is still circulating. Appetite will likely begin creeping back up and gastric emptying will start accelerating
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.657
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z and produce mood-adjacent effects through its central mechanism. Dosing being explored runs 500 mcg – 2 mg per research administration, administered 1–2 hours before the relevant observation window. Most community research starts at the lower end — 500 mcg to 1 mg — to assess tolerance before titrating up. Frequency is kept to a maximum of 2–3x per week to avoid the receptors
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.657
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z expect at this stage. Rates of gestational diabetes, hypertensive disorders, preterm birth, and gestational weight gain were all over the place depending on the study, with no single direction that clearly stands out. Where this really lands for the OTP community is with Polycystic Ovary Syndrome, and this is not some small corner of the audience. This is a huge group of women who h
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.657
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-pregnancy-fears-vs-reality If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversation matters. These are not casual medications for this community, they are often the first thing that actually moved the needle after y