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Semantic Search: The Last Time It “Worked” Before GLP-1
The Last Time It “Worked” Before GLP-1
Score 0.791
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z the moment life got complicated, then you already understand why that matters. What is the moment where things fell apart for you, even when you were doing everything right? Unsubscribe https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9vbnRoZXBlbi5zdWJzdGFjay5jb20vYWN0aW9uL2Rpc2FibGVfZW1haWw_dG9rZW49ZXlKMWMyVnlYMmxrSWpveU56TTJNakl6T1Rnc0luQnZjM1JmYVdRaU9qRTVNemt3T1RJd05pd2lhV0YwSWpveE56YzFPVE16T0RNMExD
The Last Time It “Worked” Before GLP-1
Score 0.779
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z View this post on the web at https://onthepen.substack.com/p/the-last-time-it-worked-before-glp I’ve battled obesity my entire adult life. Not in a casual way, and not in a “I should probably lose a few pounds” kind of way, but in a way where it becomes part of how you think, how you plan your day, and how the world and people around you start to see you and treat you. I remember the last time my weight
The Last Time It “Worked” Before GLP-1
Score 0.778
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z in the middle of the night and went home. I say “finally” because it seems like every weigh loss story has a “finally”… This is the part right before the wheels come off. My wife ended up in the hospital for a full week, passing kidney stones one after another. I stayed with her the entire time. Inducing early labor was the big concern, so it was a terrifying time for us. The hospital was about an hour
When Ozempic stops working (and what 10% of users already know)
Score 0.685
· Account tjphuhs@gmail.com
· 3/17/2026, 1:36:07 PM
When Ozempic stops working (and what 10% of users already know) from newsletter@seedoilscout.com on 2026-03-17T17:36:07.000Z Bottom Line *********** * About 10% of GLP-1 users are non-responders, and many more hit plateaus after 12 months. * After stopping semaglutide, people regain two-thirds of lost weight within a year. * Side effects include significant muscle loss, gallbladder disease, gastroparesis, pancreatitis risk, and thyroid concerns. * Retatrutide shows dose-dependent heart rate incr
GLP-1 Access State of the Union
Score 0.674
· Account tjphuhs@gmail.com
· 4/7/2026, 4:01:22 PM
GLP-1 Access State of the Union from onthepen@substack.com on 2026-04-07T20:01:22.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-access-state-of-the-union If you just look at the headlines, things look great for access to GLP-1 medications but for some of those already using these medications things are changing and getting tighter. Listen in as Dave breaks down the news of the week and puts it all in context. Watch or listen to this week’s podcast on Spotify! If you pre
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This.
Score 0.671
· Account tjphuhs@gmail.com
· 3/18/2026, 4:18:18 PM
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This. from tjphuhs@gmail.com on 2026-03-18T20:18:18.000Z overthink it — just make sure there’s enough fuel in the tank before lights out. > As always, this is for research purposes only. All compounds are research use only, not for human consumption. > Drop any questions below — happy to help you troubleshoot. > Upgrade to paid > You're currently a free subscriber to Peptide Price. For the full experience, upgrade your subscription. > Upgra
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.668
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.668
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
The Next Wave of GLP-1s Is Coming
Score 0.666
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors?
Score 0.660
· Account oc.tjphuhs@gmail.com
· 3/15/2026, 2:45:56 PM
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors? from tjphuhs@gmail.com on 2026-03-15T18:45:56.000Z Week > Week 0 - Administration stops > Plasma levels begin their slow decline. Receptors are getting their first break from continuous stimulation, but clearance is far from complete and meaningful resensitization hasn’t started. > Weeks 1-2 > Significant compound is still circulating. Appetite will likely begin creeping back up and gastric emptying will start accelerating
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.660
· Account tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z larger. What Actually Happens When Someone Starts a GLP-1 GLP-1 compounds work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity. The appetite suppression in particular is real and meaningful — most people naturally and significantly reduce how much food they’re eating, often without even trying. Here’s where it gets interest
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.660
· Account oc.tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z larger. What Actually Happens When Someone Starts a GLP-1 GLP-1 compounds work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity. The appetite suppression in particular is real and meaningful — most people naturally and significantly reduce how much food they’re eating, often without even trying. Here’s where it gets interest
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors?
Score 0.655
· Account oc.tjphuhs@gmail.com
· 3/15/2026, 2:45:56 PM
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors? from tjphuhs@gmail.com on 2026-03-15T18:45:56.000Z > Upgrade to paid > First, Why Do Receptors Desensitize In The First Place? > GLP-1 receptors aren’t just in your stomach - they’re distributed throughout your gut, brain, and nervous system. When a long-acting GLP-1 compound is being administered week after week, those receptors are receiving a continuous, sustained signal. Over time the body does what it always does - it
GLPs Are Back at Modern Aminos — Here’s Why
Score 0.654
· Account tjphuhs@gmail.com
· 1/27/2026, 11:03:52 AM
GLPs Are Back at Modern Aminos — Here’s Why from cs@modernaminos.com on 2026-01-27T16:03:52.000Z Transparency first. Here’s why GLPs were removed, and why they’re now available again. This email was sent to you as HTML-only. To view it, please visit: https://glh.soundestlink.com/ce/v/68732f567657959f48cbbc66/6978e1a0a338842ab0915008 ************************** Make sure you keep getting our latest offers and add cs@modernaminos.com to your address book. Unsubscribe https://glh.soundestlink.com/co
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors?
Score 0.652
· Account oc.tjphuhs@gmail.com
· 3/15/2026, 2:45:56 PM
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors? from tjphuhs@gmail.com on 2026-03-15T18:45:56.000Z > > • > Lower research amounts → 6-8 weeks minimum > • > Moderate research amounts → 8 weeks as the general gold standard > • > Higher research amounts → 8-12 weeks to allow adequate receptor recovery > > On Reintroduction: Don’t Jump Back To Your Previous Amount > This part matters as much as the washout itself. When reintroducing after a 6-12 week break, re-titrate from t
GLP-1 vs GLP-2 vs GLP-3
Score 0.650
· Account tjphuhs@gmail.com
· 5/14/2026, 9:00:21 AM
GLP-1 vs GLP-2 vs GLP-3 from happy@happypeptides.com on 2026-05-14T13:00:21.000Z A simple comparison of the three. This email was sent to you as HTML-only. To view it, please visit: https://wfg.soundestlink.com/ce/v/68a8a1cb95c4ac11474be077/6a04d2931ac007f30c9a1cd2 ************************** Make sure you keep getting our latest offers and add happy@happypeptides.com to your address book. Unsubscribe https://wfg.soundestlink.com/contactsPreferences/v2/unsubscribe/?b=68a8a136cfa3b70cffc67e5f&c=68
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This.
Score 0.649
· Account tjphuhs@gmail.com
· 3/18/2026, 4:18:18 PM
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This. from tjphuhs@gmail.com on 2026-03-18T20:18:18.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 18, 2026 at 3:44 PM -0400 To: tjphuhs@gmail.com Subject: Waking Up at 2–3am While Researching a GLP-1? Read This. > If you’re researching a GLP-1 like tirzepatide or retatrutide and you’re randomly waking up at 2 or 3 in the morning unable to fall back asleep — this post is for
The GLP-1 Dose Escalation Trap
Score 0.647
· Account tjphuhs@gmail.com
· 4/2/2026, 3:26:42 PM
The GLP-1 Dose Escalation Trap from onthepen@substack.com on 2026-04-02T19:26:42.000Z View this post on the web at https://onthepen.substack.com/p/the-glp-1-dose-escalation-trap Something isn’t quite adding up, and if you’re on a GLP-1, you’ve probably felt it. You started the medication, followed the protocol exactly, and for a brief stretch, it worked the way you were told it would. Until it didn’t. The experience changed, for some it was quickly, others more subtly. One week felt controlled a
The GLP-1 Moment Is Breaking the Healthcare System Wide Open
Score 0.646
· Account tjphuhs@gmail.com
· 3/18/2026, 6:27:27 PM
The GLP-1 Moment Is Breaking the Healthcare System Wide Open from onthepen@substack.com on 2026-03-18T22:27:27.000Z View this post on the web at https://onthepen.substack.com/p/the-glp-1-moment-is-breaking-the I’ve said this a number of times, but it keeps proving itself out. GLP-1 medications are not just transforming lives, they’re transforming our healthcare system in a way we haven’t seen in decades, and it’s happening faster than most people realize. What started as a shortage story, and on
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.645
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z and produce mood-adjacent effects through its central mechanism. Dosing being explored runs 500 mcg – 2 mg per research administration, administered 1–2 hours before the relevant observation window. Most community research starts at the lower end — 500 mcg to 1 mg — to assess tolerance before titrating up. Frequency is kept to a maximum of 2–3x per week to avoid the receptors
Massive GLP-1 Data From ECO 2026
Score 0.645
· Account tjphuhs@gmail.com
· 5/13/2026, 10:52:49 AM
Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z weeks. Two cohorts: those coming off Zepbound and those coming off Wegovy. 376 participants total. They started orforglipron at 12mg and titrated up every four weeks, targeting a maximum of 36mg. A rescue protocol allowed escalation or a switch from placebo to orforglipron after week 24 for anyone who regained more than half their original loss. One detail to keep in mind: there was a two-week screening gap b
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.643
· Account tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z a finished drug. The GLP-1 analogs used in the experiments were stripped of their fatty acid chains, so they are not identical to the medications currently on the market. Whether PapB can be applied to the full clinical compounds, and whether the ring-shaped structures it creates show meaningfully better performance in animal studies or human trial
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.643
· Account oc.tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z a finished drug. The GLP-1 analogs used in the experiments were stripped of their fatty acid chains, so they are not identical to the medications currently on the market. Whether PapB can be applied to the full clinical compounds, and whether the ring-shaped structures it creates show meaningfully better performance in animal studies or human trial
GLP-1s vs. Fertility
Score 0.641
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z all. For couples whose fertility is being dragged down by metabolic dysfunction, GLP-1s are the most promising pharmacological lever I've seen in a decade. The female data on PCOS pregnancy rates is the strongest signal in the whole literature. The male data is catching up. The next 24 months of trial data will tell us a lot. I'll keep you posted on what we learn, on our journey, and on the science. GLP-1s
Do GLP-1s Kill Your Testosterone?
Score 0.639
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z 4-6+ weeks off before considering bridge protocols, eating at maintenance, sleep dialed in, training volume normalized. If labs at the 6-week mark still show suppression, then the kisspeptin / gonadorelin / enclomiphene logic comes in for a structured restart. What I’d avoid: bridging directly from one heavy compound into another targeting the same metabolic receptors, or stacking exogenous testosterone w