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Semantic Search: The GLP-1 Moment Is Breaking the Healthcare System Wide Open
The GLP-1 Moment Is Breaking the Healthcare System Wide Open
Score 0.871
· Account tjphuhs@gmail.com
· 3/18/2026, 6:27:27 PM
The GLP-1 Moment Is Breaking the Healthcare System Wide Open from onthepen@substack.com on 2026-03-18T22:27:27.000Z View this post on the web at https://onthepen.substack.com/p/the-glp-1-moment-is-breaking-the I’ve said this a number of times, but it keeps proving itself out. GLP-1 medications are not just transforming lives, they’re transforming our healthcare system in a way we haven’t seen in decades, and it’s happening faster than most people realize. What started as a shortage story, and on
The GLP-1 Moment Is Breaking the Healthcare System Wide Open
Score 0.858
· Account tjphuhs@gmail.com
· 3/18/2026, 6:27:27 PM
The GLP-1 Moment Is Breaking the Healthcare System Wide Open from onthepen@substack.com on 2026-03-18T22:27:27.000Z are doing at the individual level is just as profound. They are increasingly looking like longevity drugs, fewer heart attacks and strokes, less inflammation, reduced cancer risk signals, meaningful diabetes improvement, and the list keeps growing. The impact of that alone is massively transformative and cannot be overstated. I’ve been digging into this more in recent conversations
GLP-1 Access State of the Union
Score 0.711
· Account tjphuhs@gmail.com
· 4/7/2026, 4:01:22 PM
GLP-1 Access State of the Union from onthepen@substack.com on 2026-04-07T20:01:22.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-access-state-of-the-union If you just look at the headlines, things look great for access to GLP-1 medications but for some of those already using these medications things are changing and getting tighter. Listen in as Dave breaks down the news of the week and puts it all in context. Watch or listen to this week’s podcast on Spotify! If you pre
BREAKING: Two Stories That Impact Compounded GLP-1
Score 0.699
· Account tjphuhs@gmail.com
· 4/30/2026, 10:32:22 PM
BREAKING: Two Stories That Impact Compounded GLP-1 from onthepen@substack.com on 2026-05-01T02:32:22.000Z The Reality for Patients Patients did not turn to compounded GLP-1s because they wanted a workaround. They turned to them because the branded medications were out of stock, out of reach, imprecisely dosed, or excluded by their insurance. Compounding was not a loophole. For hundreds of thousands of people, it was the only path forward. The FDA’s position is now clear. Affordability is not a c
The Last Time It “Worked” Before GLP-1
Score 0.692
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z in the middle of the night and went home. I say “finally” because it seems like every weigh loss story has a “finally”… This is the part right before the wheels come off. My wife ended up in the hospital for a full week, passing kidney stones one after another. I stayed with her the entire time. Inducing early labor was the big concern, so it was a terrifying time for us. The hospital was about an hour
The Last Time It “Worked” Before GLP-1
Score 0.679
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z the moment life got complicated, then you already understand why that matters. What is the moment where things fell apart for you, even when you were doing everything right? Unsubscribe https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9vbnRoZXBlbi5zdWJzdGFjay5jb20vYWN0aW9uL2Rpc2FibGVfZW1haWw_dG9rZW49ZXlKMWMyVnlYMmxrSWpveU56TTJNakl6T1Rnc0luQnZjM1JmYVdRaU9qRTVNemt3T1RJd05pd2lhV0YwSWpveE56YzFPVE16T0RNMExD
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.676
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.676
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
The Next Wave of GLP-1s Is Coming
Score 0.666
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z Happy Tuesday! There are two peptides quietly making waves in the clinical space that will demand all of our attention over the next 24 months. They don't work like semaglutide, they don't work like tirzepatide, and the clinical data is turning heads. I just dropped a brand new video breaking down survodutide and mazdutide. Survodutide & Mazdutide | The GLP-1/Glucagon Duo That Could Rival Reta:
Retatrutide Is Too Good… And That’s The Problem
Score 0.664
· Account tjphuhs@gmail.com
· 3/24/2026, 9:24:24 PM
Retatrutide Is Too Good… And That’s The Problem from onthepen@substack.com on 2026-03-25T01:24:24.000Z View this post on the web at https://onthepen.substack.com/p/retatrutide-is-too-good-and-thats There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. From new signals out of Washington that could impact access, to powerful new data on next-generation treatments like retatrutide, to wher
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.660
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.660
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce
The Next Wave of GLP-1s Is Coming
Score 0.658
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.657
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z ovulation becomes the outcome, the framing starts to move closer to what patients have been describing all along. Lactation is still largely an unknown, which is not surprising given how early this entire space is. There is one small pharmacokinetic study involving Semaglutide [ chatgpt://generic-entity?number=3 ] that did not detect transfer into breast milk, but the patient pool w
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.656
· Account tjphuhs@gmail.com
· 5/3/2026, 10:40:57 AM
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from onthepen@substack.com on 2026-05-03T14:40:57.000Z pharmacologically active cores of each drug while leaving off the fatty acid chains used for extended release. To the tail end of each peptide, they attached a short additional sequence that PapB could recognize and staple into a ring. When they added the enzyme, it completed the ring on all three analogs, every single time, with nothing left unreac
GLP-1 Shaming
Score 0.656
· Account tjphuhs@gmail.com
· 4/20/2026, 6:03:00 PM
GLP-1 Shaming from huntershealthhacks@mail.beehiiv.com on 2026-04-20T22:03:00.000Z and it shortens lives. ——————————————————————————— **Final Thoughts** If there is anyone who is a proponent of intelligent GLP-1 use, it’s me. I always say, these peptides should be used as a catalyst, then stack the rest of the lifestyle work to enhance results. Resistance training to protect lean mass. Protein intake high enough to keep you metabolically strong through the weight loss phase. Sleep well. Handle S
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.656
· Account oc.tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z time, with nothing left unreacted. In laboratory terms, that is a perfect result. > That closed ring at the tail end of the peptide does several things worth understanding. It blocks the exoproteases that would otherwise begin dismantling the key from that end. It also stiffens the tail of the molecule, reducing the kind of loose molecular movement
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.656
· Account tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z time, with nothing left unreacted. In laboratory terms, that is a perfect result. > That closed ring at the tail end of the peptide does several things worth understanding. It blocks the exoproteases that would otherwise begin dismantling the key from that end. It also stiffens the tail of the molecule, reducing the kind of loose molecular movement
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.655
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-pregnancy-fears-vs-reality If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversation matters. These are not casual medications for this community, they are often the first thing that actually moved the needle after y
GLP-1s vs. Addiction
Score 0.651
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z Happy Monday! I recently [read a very large study published in ](https://www.bmj.com/content/392/bmj-2025-086886)_[The BMJ](https://www.bmj.com/content/392/bmj-2025-086886)_ that provided the strongest signal yet that something tangible may be happening in the brain on GLP-1s. The study analyzed health records from more than 600,000 U.S. veterans with type 2 diabetes to examine whether GLP-1 drugs influence
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.650
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z of trying everything else. For many others, it was the first real hope offered, after the promises of metabolic surgeries failed to deliver as promised. > That is exactly why pregnancy can add such a complex layer to the journey, because the same medication that helped restore metabolic health is also restoring ovulation in ways many women using GLP-1 therapies did not necessarily
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.650
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z of trying everything else. For many others, it was the first real hope offered, after the promises of metabolic surgeries failed to deliver as promised. > That is exactly why pregnancy can add such a complex layer to the journey, because the same medication that helped restore metabolic health is also restoring ovulation in ways many women using GLP-1 therapies did not necessarily
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.647
· Account tjphuhs@gmail.com
· 5/3/2026, 10:40:57 AM
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from onthepen@substack.com on 2026-05-03T14:40:57.000Z Utah and co-founded a company called Sethera Therapeutics built around this enzyme platform. The research was funded by the National Institute of General Medical Sciences, part of the National Institutes of Health. This work is proof of concept, meaning it is a meaningful early step but not a finished drug. The GLP-1 analogs used in the experiments
GLP-1s vs. Fertility
Score 0.646
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z all. For couples whose fertility is being dragged down by metabolic dysfunction, GLP-1s are the most promising pharmacological lever I've seen in a decade. The female data on PCOS pregnancy rates is the strongest signal in the whole literature. The male data is catching up. The next 24 months of trial data will tell us a lot. I'll keep you posted on what we learn, on our journey, and on the science. GLP-1s
GLP-1s vs. Addiction
Score 0.645
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z what it does and does not prove. The research is observational. That means it identifies associations between GLP-1 drugs and addiction outcomes. It does not prove that the drugs directly caused the reduction in addiction risk. The study population also consisted mostly of older male veterans with type 2 diabetes. That population may not perfectly represent the broader public. Researchers also cannot fully