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Semantic Search: TRT vs. Fertility
TRT vs. Fertility
Score 0.806
· Account tjphuhs@gmail.com
· 2/6/2026, 6:04:34 PM
TRT vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-02-06T23:04:34.000Z It may help preserve some testicular size, but it does not reliably maintain intratesticular testosterone or sperm production. For older men who are done having children and simply want to avoid extreme testicular atrophy on a budget, gonadorelin can make sense. For men prioritizing fertility, it’s not comparable to hCG. ——————————————————————————— **Final Thoughts** There’s a big myth out there that needs to
TRT vs. Fertility
Score 0.763
· Account tjphuhs@gmail.com
· 2/6/2026, 6:04:34 PM
TRT vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-02-06T23:04:34.000Z next few years. It can help maintain LH and FSH output while testosterone is introduced, which may prevent a complete shutdown. Where I personally become cautious is long-term use. I don’t view enclomiphene as a long-term solution. There is some concern around visual disturbances with chronic SERM use, and it requires a functional pituitary to work well. In my own case, likely due to prior concussions, it didn
TRT vs. Fertility
Score 0.756
· Account tjphuhs@gmail.com
· 2/6/2026, 6:04:34 PM
TRT vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-02-06T23:04:34.000Z Happy Friday! I just dropped a brand-new long-form episode on Spotify breaking down fertility while on testosterone replacement therapy. Best Fertility Add-Ons for TRT : (https://open.spotify.com/episode/1dS0vfCH45vWUQD7wrzZFN?si=LuhhCDshTmegjaZ2XJi2_Q) This is something Taylor and I are navigating in real time right now as we think seriously about starting a family, so this wasn’t a theoretical episode for me
TRT vs. Fertility
Score 0.745
· Account tjphuhs@gmail.com
· 2/6/2026, 6:04:34 PM
TRT vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-02-06T23:04:34.000Z ranges from 75 to 150 IU 2-3 times per week. I’m currently running 75 IU three times per week alongside hCG. The results are often dramatic. Improved sperm count, motility, and morphology. Faster recovery of spermatogenesis. In many cases, men who were previously azoospermic recover viable sperm within months on hCG plus hMG. The downside is cost. hMG is expensive. It’s injectable. It’s not something you run i
Fwd: Women and Testosterone
Score 0.671
· Account tjphuhs@gmail.com
· 4/24/2026, 9:43:00 AM
Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z are low, testosterone might matter more than any supplement, stack, or peptide you're currently chasing. > > Mood and Cognition > Depression improved in 70.8% of women. Irritability in 69%. Anhedonia, which is the clinical term for loss of pleasure, improved in 67.5%. > These are numbers that would get a psychiatric drug fast-tracked for emergency approval. > Testosterone modulates dopamine and serotonin directly. > W
Fwd: Women and Testosterone
Score 0.671
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:43:00 AM
Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z are low, testosterone might matter more than any supplement, stack, or peptide you're currently chasing. > > Mood and Cognition > Depression improved in 70.8% of women. Irritability in 69%. Anhedonia, which is the clinical term for loss of pleasure, improved in 67.5%. > These are numbers that would get a psychiatric drug fast-tracked for emergency approval. > Testosterone modulates dopamine and serotonin directly. > W
Women and Testosterone
Score 0.670
· Account tjphuhs@gmail.com
· 4/23/2026, 6:06:24 PM
Women and Testosterone from huntershealthhacks@mail.beehiiv.com on 2026-04-23T22:06:24.000Z month. They didn't show meaningful improvement until the 4 to 6-month mark. Why? Because brain tissue takes longer to remodel than energy metabolism does. Testosterone supports hippocampal neurogenesis and BDNF expression, but growing new neurons is not a 30-day process. This is the reason so many women try TRT for 12 weeks, don't feel a cognitive shift, and quit. They stopped three months before the brai
GLP-1s vs. Fertility
Score 0.669
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z but the question is whether the clinical data back it up. ——————————————————————————— **The Male Data** In a 2023 trial, La Vignera and colleagues gave liraglutide to obese men with metabolic hypogonadism and severe erectile dysfunction. After 4 months, semen concentration, motility, and morphology all significantly improved. Erectile function scores improved more than with conventional fertility treatment
GLP-1s vs. Fertility
Score 0.667
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z ovarian steroidogenesis, granulosa cell biology, and the FSH-cAMP-BMP signaling pathway. It's likely a direct ovarian effect layered on top of metabolic improvement. ——————————————————————————— **Microdosing for Fertility** Here's where I'm going to get speculative. Most of the GLP-1 fertility research uses standard or high doses. The kind aimed at meaningful weight loss. 1mg semaglutide weekly. 3mg liraglu
Fwd: Women and Testosterone
Score 0.661
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:43:00 AM
Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z progesterone matter. I'm not arguing against them. But they cannot do what testosterone does. They operate on different receptors and different pathways. > Women who do BHRT with only estrogen and progesterone are running a hormone protocol with a missing pillar. > > The Study > Researchers tracked 332 women on individualized testosterone replacement therapy. > Ages ranged from 27 to 78, with an average of 45. A subse
Fwd: Women and Testosterone
Score 0.661
· Account tjphuhs@gmail.com
· 4/24/2026, 9:43:00 AM
Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z progesterone matter. I'm not arguing against them. But they cannot do what testosterone does. They operate on different receptors and different pathways. > Women who do BHRT with only estrogen and progesterone are running a hormone protocol with a missing pillar. > > The Study > Researchers tracked 332 women on individualized testosterone replacement therapy. > Ages ranged from 27 to 78, with an average of 45. A subse
GLP-1s vs. Fertility
Score 0.660
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z Happy Monday! Taylor and I are trying to have a baby. As I do with most everything in my life, I research as much as I can to achieve the desired outcome. Studies I used to skim now feel much more personal. And the one that's been on my mind lately is from Dr. Shanna Swan. If you haven't read her book _Countdown_, here's the short version. Sperm concentration in Western men decreased by more than 50% betwee
Women and Testosterone
Score 0.656
· Account tjphuhs@gmail.com
· 4/23/2026, 6:06:24 PM
Women and Testosterone from huntershealthhacks@mail.beehiiv.com on 2026-04-23T22:06:24.000Z also got paired blood work at baseline and 12 weeks. The protocol was simple. Start with a blood test, administer a low physiologic dose, retest, and then adjust. Then target the upper end of the premenopausal range, 25 to 50 ng/dL total testosterone (still too low in my opinion, but better than nothing). Delivery options were topical cream, oral troches, or subcutaneous injections. Women rated change acr
Fwd: Women and Testosterone
Score 0.654
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:43:00 AM
Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z 5.4% of women reported significant improvement in quality of life. > At greater than 12 months, 51.5% did. And not a single woman in the 12+ month group reported no change. > The benefits compound. > Most published trials on testosterone in women run 12 to 24 weeks. The study authors specifically called this out as a problem. These are trial windows that cut off just as the deeper benefits are starting to show. > If y
Fwd: Women and Testosterone
Score 0.654
· Account tjphuhs@gmail.com
· 4/24/2026, 9:43:00 AM
Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z 5.4% of women reported significant improvement in quality of life. > At greater than 12 months, 51.5% did. And not a single woman in the 12+ month group reported no change. > The benefits compound. > Most published trials on testosterone in women run 12 to 24 weeks. The study authors specifically called this out as a problem. These are trial windows that cut off just as the deeper benefits are starting to show. > If y
Hematocrit on HRT
Score 0.631
· Account tjphuhs@gmail.com
· 3/10/2026, 6:05:09 PM
Hematocrit on HRT from huntershealthhacks@mail.beehiiv.com on 2026-03-10T22:05:09.000Z that creates huge peaks. Maybe they have untreated sleep apnea. Maybe they are inflamed and insulin-resistant. Maybe they got their labs after sauna and cardio and came in dehydrated. Those are the kinds of things I would want to address first. I would much rather adjust the testosterone protocol, improve metabolic health, and get more consistent lab conditions before I default to pulling blood out of the body
Fwd: Women and Testosterone
Score 0.621
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:43:00 AM
Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z ---------- Forwarded message ---------- From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: Apr 23, 2026 at 6:06 PM -0400 To: tjphuhs@gmail.com <tjphuhs@gmail.com> Subject: Women and Testosterone > Fascinating new study released > April 23, 2026 | Read online > Women and Testosterone > Fascinating new study released > > > > Happy Thursday! > FYI, in case you missed it, I launched a giveaway yesterday to
Fwd: Women and Testosterone
Score 0.621
· Account tjphuhs@gmail.com
· 4/24/2026, 9:43:00 AM
Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z ---------- Forwarded message ---------- From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: Apr 23, 2026 at 6:06 PM -0400 To: tjphuhs@gmail.com <tjphuhs@gmail.com> Subject: Women and Testosterone > Fascinating new study released > April 23, 2026 | Read online > Women and Testosterone > Fascinating new study released > > > > Happy Thursday! > FYI, in case you missed it, I launched a giveaway yesterday to
Do GLP-1s Kill Your Testosterone?
Score 0.621
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z The Ranger and Marine studies show 20-60% increases. So even if total testosterone looks “fine” on paper, free testosterone — the active fraction — can be dramatically lower because more of the total is bound up. If your RS pulls labs and only checks total T, the picture looks better than it is. Always pull total T, free T, and SHBG together. Otherwise you’re guessing. Section 5: Why it’s not just hormone
Do GLP-1s Kill Your Testosterone?
Score 0.620
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z (STEP 1) Tirzepatide: ~21% loss at 72 weeks (SURMOUNT-1) Peptide-R (triple-agonist): ~24% at 48 weeks (phase 2), and 28.7% at 68 weeks in the recent phase 3 TRIUMPH-4 readout. Placebo-adjusted: 26.6%. Once weight loss gets that aggressive, you’re no longer just dropping fat — you’re forcing the body into sustained caloric deficit territory that the HPG axis interprets as famine. And the famine response is
Women and Testosterone
Score 0.620
· Account tjphuhs@gmail.com
· 4/23/2026, 6:06:24 PM
Women and Testosterone from huntershealthhacks@mail.beehiiv.com on 2026-04-23T22:06:24.000Z still feel off, ask for a testosterone panel that INCLUDES free testosterone. Don't accept "normal for your age" as an answer without seeing a number. A woman at 50 with the testosterone of a 50-year-old is a woman running on half of what she had at 25. That's not normal! I favor injections, but in this study, the other delivery mechanisms worked too. Pick what fits your lifestyle best. Testosterone is fo
Do GLP-1s Kill Your Testosterone?
Score 0.616
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z None of this is medical advice. Anyone running these compounds in any human capacity should be working with a clinician monitoring full labs (total T, free T, LH, FSH, SHBG, estradiol, prolactin, fasting insulin, cortisol, full thyroid panel). If your RS is obese and on a moderate dose The data suggests testosterone will likely improve as weight comes off. The intervention is mostly hands-off: stay the co
GLP-1s vs. Fertility
Score 0.613
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z all. For couples whose fertility is being dragged down by metabolic dysfunction, GLP-1s are the most promising pharmacological lever I've seen in a decade. The female data on PCOS pregnancy rates is the strongest signal in the whole literature. The male data is catching up. The next 24 months of trial data will tell us a lot. I'll keep you posted on what we learn, on our journey, and on the science. GLP-1s
Do GLP-1s Kill Your Testosterone?
Score 0.610
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z then signals back to the hypothalamus to slow GnRH release, suppressing the whole axis from the top. Insulin resistance. Impairs Leydig cell function and HPG signaling. Chronic inflammation. Adipose tissue releases inflammatory cytokines that further suppress the axis. This is the population the GLP-1 trials are studying. So the starting line for these studies is already low T, and the question becomes: d
Sterility Testing vs. Bioburden Testing — These Are Not the Same Thing
Score 0.610
· Account tjphuhs@gmail.com
· 3/24/2026, 2:28:13 PM
Sterility Testing vs. Bioburden Testing — These Are Not the Same Thing from derekpruski@substack.com on 2026-03-24T18:28:13.000Z people who understand the difference, the harder it is for the wrong standard to fly under the radar. All research compounds are for research use only and not for human consumption. Unsubscribe https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9kZXJla3BydXNraS5zdWJzdGFjay5jb20vYWN0aW9uL2Rpc2FibGVfZW1haWw_dG9rZW49ZXlKMWMyVnlYMmxrSWpveU56TTJNakl6T1Rnc0luQnZjM1JmYVdRaU9qR