Email Archive

Fwd: Spermidine, NAD+, and Longevity

Score 0.885 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z Spermidine does not raise NAD+ levels directly and is not a precursor. But it does improve NAD+ efficiency and cellular resilience so that the NAD+ you are using actually produces meaningful longevity signaling. If you are using exogenous NAD+, adding spermidine makes mechanistic sense. Dosage Human trials have used a wide range of doses. Some plant-extract studies are in the 1-1.2 mg/day range. There are saf

Spermidine, NAD+, and Longevity

Score 0.881 · Account tjphuhs@gmail.com · 2/25/2026, 6:06:48 PM

Spermidine, NAD+, and Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-25T23:06:48.000Z NAD+ is metabolic fuel. It drives sirtuins, supports mitochondrial respiration, and assists DNA repair. When you supplement with exogenous NAD+ or high-dose precursors like NMN, you increase substrate availability. But here is the problem. If your mitochondria are dysfunctional, you are pouring premium fuel into a dirty engine. Spermidine enhances mitophagy. It improves mitochondrial quality cont

Spermidine, NAD+, and Longevity

Score 0.854 · Account tjphuhs@gmail.com · 2/25/2026, 6:06:48 PM

Spermidine, NAD+, and Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-25T23:06:48.000Z Happy Wednesday! Over the past few weeks, I’ve gone deep down the rabbit hole on spermidine. Spermidine has been around for a while. It is a naturally occurring polyamine found in foods such as wheat germ, mushrooms, soybeans, and aged cheese. It also exists within every cell in our body, and like most things, endogenous levels decline with age. In animal models, spermidine consistently extends l

Fwd: Spermidine, NAD+, and Longevity

Score 0.853 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z deserves your attention. Let’s break it down. How Spermidine Works Spermidine’s primary claim to fame is its ability to activate autophagy. Autophagy is the cellular cleanup process. It’s how your cells remove damaged proteins, dysfunctional mitochondria, and cellular debris. It is one of the most consistently associated mechanisms with lifespan extension across species. Spermidine induces autophagy independe

Fwd: Spermidine, NAD+, and Longevity

Score 0.847 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: February 25, 2026 at 6:06:49 PM EST To: tjphuhs@gmail.com Subject: Spermidine, NAD+, and Longevity Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Spermidine, NAD+, and Longevity 96 Don't waste your NAD+! ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

Spermidine, NAD+, and Longevity

Score 0.832 · Account tjphuhs@gmail.com · 2/25/2026, 6:06:48 PM

Spermidine, NAD+, and Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-25T23:06:48.000Z effects. If you’re going to invest in NAD+, make sure you’re not pouring it into broken mitochondria. Fix the engine first, optimize mitochondrial quality control, and stop wasting your cellular currency! Best, Hunter Williams ——————————————————————————— **Further Reading** Here are several primary sources if you want to dig deeper: * [https://www.nature.com/articles/nm.4222](https://www.nature.c

Fwd: Weirdly-Named Longevity Compound

Score 0.776 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z was originally discovered in semen. That's where the name comes from. But spermidine exists in nearly every cell in your body. It's not a sperm-specific compound. Spermidine is a type of molecule called a polyamine. It's small and positively charged. It plays a role in cell growth, stress response, immune signaling, and gene activity. Your body makes it naturally. It also breaks it down naturally. When the b

Fwd: Spermidine, NAD+, and Longevity

Score 0.765 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z the Peptide Cheat Sheet: Peptide Cheat Sheet 👉All my daily essentials on Amazon Amazon Storefront 👉Get discounts on your favorite peptides and research chemicals: PEPTIDES BioLongevity Labs (use code hunterw for 15% off): https://biolongevitylabs.com/ 👉10% off the BEST workout supplements from Unmatched Supps (pre-workout, whey protein, creatine, EAAs, electrolytes - use code HUNTERW at checkout): https://

Weirdly-Named Longevity Compound

Score 0.759 · Account tjphuhs@gmail.com · 3/17/2026, 6:04:04 PM

Weirdly-Named Longevity Compound from huntershealthhacks@mail.beehiiv.com on 2026-03-17T22:04:04.000Z Happy Tuesday! Last month, I [published an email ](https://huntershealthhacks.beehiiv.com/p/spermidine-nad-and-longevity)on some interesting research around spermidine. Today, I just dropped a brand new video on Spotify, breaking down spermidine. The video goes deep into the research. This email will give you the highlights. Spermidine for Longevity: (https://open.spotify.com/episode/1hZCBd6gyHx

Weirdly-Named Longevity Compound

Score 0.759 · Account tjphuhs@gmail.com · 3/17/2026, 6:04:04 PM

Weirdly-Named Longevity Compound from huntershealthhacks@mail.beehiiv.com on 2026-03-17T22:04:04.000Z only goal right now is putting on as much muscle as possible, maybe hold off. But for most of us who want to live long and live strong, this belongs in the stack. The product I personally use is [NAD Regen from Biostack Labs.](http://biostacklabs.com/hunter) One serving provides 5mg of spermidine, along with a few other solid ingredients. It's been my go-to through this past year, and I've been

Fwd: Weirdly-Named Longevity Compound

Score 0.753 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z larger 12-month trial using only 0.9 milligrams per day showed no significant memory benefit. Blood spermidine levels didn't change in either group. The dose was probably just too low. When researchers examined higher doses in the range of 3.3 to 40 milligrams per day, no safety issues were observed. Side effects across trials were minimal. Some people reported minor joint and muscle issues. There was a sign

Weirdly-Named Longevity Compound

Score 0.741 · Account tjphuhs@gmail.com · 3/17/2026, 6:04:04 PM

Weirdly-Named Longevity Compound from huntershealthhacks@mail.beehiiv.com on 2026-03-17T22:04:04.000Z fasting. That rise appears to be required for lasting longevity benefits. So, taking spermidine is essentially giving your body a fasting signal without actually fasting. ——————————————————————————— **What Does the Research Say?** Human evidence falls into two buckets. Observational studies and intervention trials. On the observational side, people who eat more spermidine-rich foods have around

Fwd: Weirdly-Named Longevity Compound

Score 0.718 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: March 17, 2026 at 6:04:57 PM EDT To: tjphuhs@gmail.com Subject: Weirdly-Named Longevity Compound Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Weirdly-Named Longevity Compound 96 New video on spermidine is live! ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds

Score 0.669 · Account oc.tjphuhs@gmail.com · 4/24/2026, 1:28:54 PM

Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >

Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds

Score 0.669 · Account tjphuhs@gmail.com · 4/24/2026, 1:28:54 PM

Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >

NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend

Score 0.668 · Account tjphuhs@gmail.com · 3/27/2026, 4:31:44 PM

NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from derekpruski@substack.com on 2026-03-27T20:31:44.000Z Vial contents: 100mg NAD+ / 10mg MOTS-c / 10mg 5-Amino-1MQ Add 3ml of bacteriostatic water to the vial. Store reconstituted vial refrigerated. Each 30-unit (0.3ml) research dose yields 1mg NAD+, 0.1mg MOTS-c, and 0.1mg 5-Amino-1MQ — a 10-1-1 ratio that keeps all three compounds proportional throughout the vial. Compound Summary NAD+ is the direct energy substrate — it supplies what mito

Urolithin A: The Most Underrated Compound in Longevity

Score 0.667 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z verify the label says Urolithin A, not a precursor complex. Things Worth Researching Further If you’re going down the rabbit hole, here’s what’s worth understanding more deeply. Mitophagy biology in general — PINK1/Parkin, BNIP3, NIX pathways. The hallmarks of aging (López-Otín et al.) and where mitochondrial dysfunction sits among them. Microbiome variability — why some people conver

Urolithin A: The Most Underrated Compound in Longevity

Score 0.666 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z in healthy elderly adults at 250–2000 mg single doses and 250/500/1000 mg/day for 28 days. Favorable safety profile at all doses. Bioavailable in plasma at all doses. Modulated mitochondrial gene expression in muscle biopsies at 500 and 1000 mg. Phase 2 in middle-aged adults (Singh et al., 2022, Cell Reports Medicine — the ATLAS trial). 88 sedentary middle-aged adults, 4 months of sup

NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+

Score 0.664 · Account tjphuhs@gmail.com · 5/11/2026, 10:07:04 AM

NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z The supplement world mostly lives in the last two. Everything else is either old news (niacin) or impractical (tryptophan loading). The SubQ NAD+ Debate This is the elephant in the room, and it’s why a lot of researchers feel the broader NAD+ story isn’t delivering. The pro-subQ argument is simple: oral NAD+ has terrible bioavailability (often cited at 2-10%),

MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds

Score 0.664 · Account tjphuhs@gmail.com · 4/24/2026, 1:18:04 PM

MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z in mitochondrial DNA. Mitochondria produce it themselves. It belongs to a small class called mitochondrial-derived peptides (MDPs). What the research shows: Activates AMPK, the master energy sensor in cells. When AMPK is active, cells shift into “burn fuel, don’t store it” mode. Improves insulin sensitivity in preclinical models, meaning muscle cell

NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+

Score 0.664 · Account tjphuhs@gmail.com · 5/11/2026, 10:07:04 AM

NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z mg in healthy Japanese men. Long-term trials have used 250 mg/day to 1250 mg/day for 4-12 weeks. 500-1000 mg/day is where most positive results come from. The 250 mg/day older-men trial showed effects but smaller ones. Time course is similar to NR — NAD+ rises in days, functional changes show up at 6-12 weeks and beyond. Timing. Both NMN and NR have been used

Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend

Score 0.659 · Account tjphuhs@gmail.com · 3/27/2026, 4:33:04 PM

Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the

Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend

Score 0.659 · Account oc.tjphuhs@gmail.com · 3/27/2026, 4:33:04 PM

Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the

Urolithin A: The Most Underrated Compound in Longevity

Score 0.658 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z stop efficiently clearing out damaged mitochondria. Dysfunctional mitochondria pile up, leak oxidative stress, fail to make energy efficiently, and contribute to nearly every “hallmark of aging” you can name. Mitophagy is the cellular cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control

NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+

Score 0.653 · Account tjphuhs@gmail.com · 5/11/2026, 10:07:04 AM

NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z View this post on the web at https://derekpruski.substack.com/p/nmn-vs-nr-a-deep-dive-for-researchers Read this first: Everything below is for research and educational purposes only. Nothing here is medical advice. If you’re considering anything for personal use, that’s a conversation for a qualified clinician — not a Substack post. The Landscape The NAD+ conv