View
Semantic Search: Retatrutide Is Too Good… And That’s The Problem
Retatrutide Is Too Good… And That’s The Problem
Score 0.750
· Account tjphuhs@gmail.com
· 3/24/2026, 9:24:24 PM
Retatrutide Is Too Good… And That’s The Problem from onthepen@substack.com on 2026-03-25T01:24:24.000Z View this post on the web at https://onthepen.substack.com/p/retatrutide-is-too-good-and-thats There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. From new signals out of Washington that could impact access, to powerful new data on next-generation treatments like retatrutide, to wher
Fwd: Retatrutide Is Too Good… And That’s The Problem
Score 0.747
· Account oc.tjphuhs@gmail.com
· 3/24/2026, 10:14:11 PM
Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z quickly on multiple fronts. > We break it all down in this week’s episode, what’s changing, what it could mean for you, and what to keep an eye on next. > The Throttling of Compounded GLP-1sFDA vs Telehealth, What’s Really HappeningThe Truth About “Research Peptides”The Rule That Created the Black Market If You Rely on This, Here’s What’s ComingWhy They Want You Back on Branded DrugsRetatrutid
Fwd: Retatrutide Is Too Good… And That’s The Problem
Score 0.747
· Account tjphuhs@gmail.com
· 3/24/2026, 10:14:11 PM
Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z quickly on multiple fronts. > We break it all down in this week’s episode, what’s changing, what it could mean for you, and what to keep an eye on next. > The Throttling of Compounded GLP-1sFDA vs Telehealth, What’s Really HappeningThe Truth About “Research Peptides”The Rule That Created the Black Market If You Rely on This, Here’s What’s ComingWhy They Want You Back on Branded DrugsRetatrutid
Fwd: Retatrutide Is Too Good… And That’s The Problem
Score 0.713
· Account oc.tjphuhs@gmail.com
· 3/24/2026, 10:14:11 PM
Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 24, 2026 at 9:24 PM -0400 To: tjphuhs@gmail.com Subject: Retatrutide Is Too Good… And That’s The Problem > There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. > ͏ ͏ ͏ ͏ ͏
Fwd: Retatrutide Is Too Good… And That’s The Problem
Score 0.713
· Account tjphuhs@gmail.com
· 3/24/2026, 10:14:11 PM
Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 24, 2026 at 9:24 PM -0400 To: tjphuhs@gmail.com Subject: Retatrutide Is Too Good… And That’s The Problem > There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. > ͏ ͏ ͏ ͏ ͏
Retatrutide Makes Me Hungrier?
Score 0.679
· Account tjphuhs@gmail.com
· 4/29/2026, 6:04:32 PM
Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z more hunger. The TRIUMPH body composition data showed retatrutide doesn't actually preserve lean mass any better than other GLP-1 agents. The "muscle-sparing" marketing around glucagon doesn't hold up in the data. So if you're not training, eating protein, and optimizing your hormones, you'll lose muscle. And your hunger is going to climb. ——————————————————————————— **What I Would Do ** A few thi
Retatrutide Makes Me Hungrier?
Score 0.661
· Account tjphuhs@gmail.com
· 4/29/2026, 6:04:32 PM
Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z modest, around r=0.28. That means appetite suppression accounts for less than 10% of the weight-loss variance. So the play is to lean into the protein, the training, HRT, and the lifestyle work. The peptide is doing its job. Your job is to give it the inputs that let the weight loss show up on the scale. Best, Hunter Williams ——————————————————————————— **Further Reading** * [Why Am I So Hungry on
Retatrutide Makes Me Hungrier?
Score 0.650
· Account tjphuhs@gmail.com
· 4/29/2026, 6:04:32 PM
Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z Happy Wednesday! An excellent reader question landed in my inbox this week. It's one I'm hearing more often these days. “_"I've noticed a significant increase in hunger while taking retatrutide, but interestingly, I'm not experiencing weight gain, just not seeing any weight loss either. Is this something you've seen before, and are there ways to improve results in a situation like this?"_“ — The s
Orforglipron: Does It Work? Yes. Is It Better Than Subq? Not Even Close.
Score 0.644
· Account tjphuhs@gmail.com
· 4/23/2026, 2:51:24 PM
Orforglipron: Does It Work? Yes. Is It Better Than Subq? Not Even Close. from derekpruski@substack.com on 2026-04-23T18:51:24.000Z Versus Retatrutide (Triple Agonist) This is where the gap becomes absurd. Subq retatrutide at 12 mg delivered 28.7% weight loss at 68 weeks in TRIUMPH-4. Break that down further: 58.6% of participants on 12 mg achieved at least 25% weight loss 39.4% achieved at least 30% 23.7% achieved at least 35% Orforglipron 36 mg: 12.4%. Retatrutide is in a different universe — r
Retatrutide Makes Me Hungrier?
Score 0.643
· Account tjphuhs@gmail.com
· 4/29/2026, 6:04:32 PM
Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z a drug. Up to 28.7% at 68 weeks in TRIUMPH-4. That kind of rapid loss triggers a maximal counter-regulatory response. Your body interprets it as starvation and ramps up hunger drive to defend its weight. Lilly hasn't measured ghrelin or leptin in any published retatrutide trial. They don't track "increased appetite" as a reportable side effect. So this whole counter-regulatory mechanism is invisib
Reta vs. Cancer
Score 0.639
· Account tjphuhs@gmail.com
· 2/24/2026, 6:06:31 PM
Reta vs. Cancer from huntershealthhacks@mail.beehiiv.com on 2026-02-24T23:06:31.000Z that metabolism and cancer are closely linked. Elevated insulin. Elevated glucose. Chronic inflammation. Visceral adiposity. Impaired immune surveillance. These factors create conditions that favor tumor growth. If a compound improves glucose control, lowers inflammatory tone, enhances insulin sensitivity, and potentially influences immune function, it is reasonable to consider that it could support a less cance
Fwd: Reta vs. Cancer
Score 0.637
· Account tjphuhs@gmail.com
· 2/26/2026, 12:51:09 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z or appetite suppression. The dose used did not significantly affect body weight, yet tumor growth decreased meaningfully. Retatrutide’s benefits go far beyond cosmetic fat loss. They are metabolic. They are immunologic. They may even profoundly reshape the body's internal terrain. FYI, BioLongevity Labs is running a storewide sale where everything is 30% off. Use code HUNTERW to get an additional 15% off. The Study The resea
Fwd: Reta vs. Cancer
Score 0.634
· Account tjphuhs@gmail.com
· 2/26/2026, 12:56:32 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z broadly influence chronic disease pathways, including those involved in tumor biology. If low-dose retatrutide can meaningfully reduce tumor progression in an aggressive cancer model without causing weight loss, that suggests its metabolic influence runs deeper than body composition changes alone. That opens the door to considering this molecule within a broader longevity framework. Final Thoughts We are still early in the r
Reta vs. Cancer
Score 0.633
· Account tjphuhs@gmail.com
· 2/24/2026, 6:06:31 PM
Reta vs. Cancer from huntershealthhacks@mail.beehiiv.com on 2026-02-24T23:06:31.000Z Happy Tuesday! I recently came across [a preclinical study presented at the Society for Immunotherapy of Cancer](https://jitc.bmj.com/content/13/Suppl_2/A752) that genuinely made me pause([click here to read it](https://jitc.bmj.com/content/13/Suppl_2/A752)). The researchers looked at retatrutide and tested it in a mouse model of pancreatic cancer. The results were striking to say the least. Tumor growth was red
Reta vs. Cancer
Score 0.631
· Account tjphuhs@gmail.com
· 2/24/2026, 6:06:31 PM
Reta vs. Cancer from huntershealthhacks@mail.beehiiv.com on 2026-02-24T23:06:31.000Z stress without excessive suppression of appetite or energy, that becomes a sustainable strategy. Consistency matters more than intensity. Subtle improvements maintained over the years can compound in powerful ways. ——————————————————————————— **Reta Beyond Fat Loss** For years, I have emphasized that GLP-1 agents are metabolic regulators rather than simple fat loss drugs. Retatrutide extends that concept because
He took Retatrutide 40mg and Proved a Point
Score 0.631
· Account tjphuhs@gmail.com
· 5/5/2026, 7:44:17 PM
He took Retatrutide 40mg and Proved a Point from onthepen@substack.com on 2026-05-05T23:44:17.000Z View this post on the web at https://onthepen.substack.com/p/he-took-retatrutide-40mg-and-proved Forty milligrams of Retatrutide. That’s the number and the mistake that sets the tone for this week’s episode. A 32-year-old man bought the drug online, started at 10 milligrams, quickly escalated to 20, and then accidentally dosed twice in back-to-back days. You can imagine how that ended, and we break
Fwd: Reta vs. Cancer
Score 0.625
· Account tjphuhs@gmail.com
· 2/26/2026, 12:56:32 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z a frontline immune checkpoint cancer therapy in reducing tumor growth in this model. Interestingly, this study was not centered on dramatic weight loss or appetite suppression. The dose used did not significantly affect body weight, yet tumor growth decreased meaningfully. Retatrutide’s benefits go far beyond cosmetic fat loss. They are metabolic. They are immunologic. They may even profoundly reshape the body's internal ter
Max Dose Tirzepatide, Retatrutide Horror Stories, BPC-157 Anhedonia, and More
Score 0.619
· Account tjphuhs@gmail.com
· 4/3/2026, 6:08:01 PM
Max Dose Tirzepatide, Retatrutide Horror Stories, BPC-157 Anhedonia, and More from huntershealthhacks@mail.beehiiv.com on 2026-04-03T22:08:01.000Z Happy Friday and Happy Easter weekend to those of you celebrating! I just published the March 2026 Q&A episode. The podcast is now live on both [YouTube](https://www.youtube.com/watch?v=4igc2UpFr7Q) and [Spotify](https://open.spotify.com/episode/7Hp4gx4DNSSmXJAM8kliDO?si=1rcXny45TrapPzZsuSC2QA). If you haven't subscribed on both platforms yet, please
Non-GLP Fat Loss Compounds Ranked
Score 0.614
· Account tjphuhs@gmail.com
· 5/5/2026, 6:03:45 PM
Non-GLP Fat Loss Compounds Ranked from huntershealthhacks@mail.beehiiv.com on 2026-05-05T22:03:45.000Z Happy Tuesday! Most folks would agree that the GLPs are the kings of fat loss, with retatrutide holding the title belt. But what if GLPs are not on the table for you? What if you are cycling off? What if you want to stack other compounds so you don’t have to crank your GLP dose into the stratosphere? I just dropped a brand-new video and podcast episode where I rank **20 non-GLP-1 fat-loss**** c
Fwd: Reta vs. Cancer
Score 0.614
· Account tjphuhs@gmail.com
· 2/26/2026, 12:51:09 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z at lower doses, these metabolic changes may be meaningful. Non-Cancer-Favoring Terrain Cancer develops within biological terrain. A body with high fasting glucose A body with elevated insulin A body with systemic inflammation A body with immune dysfunction These conditions create fertile ground for pathological growth. Retatrutide appears to influence multiple pathways simultaneously. It improves glucose regulation, flattens
The Next Wave of GLP-1s Is Coming
Score 0.613
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z fat and energy expenditure benefits that GIP agonism simply does not. Retatrutide is still king on paper. It hits all three receptors and delivers the most weight loss. But survodutide and mazdutide are not far behind. And for people who need an alternative, or who want to cycle compounds to maintain receptor sensitivity, these fill a real gap. ——————————————————————————— **They're Not the Same
Fwd: Reta vs. Cancer
Score 0.611
· Account tjphuhs@gmail.com
· 2/26/2026, 12:56:32 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z improves insulin sensitivity and reduces hyperglycemia. That shift may reduce the availability of fuel and the growth signals that tumors rely on. Even at lower doses, these metabolic changes may be meaningful. Non-Cancer-Favoring Terrain Cancer develops within biological terrain. A body with high fasting glucose A body with elevated insulin A body with systemic inflammation A body with immune dysfunction These conditions cr
Stuck on Reta?
Score 0.607
· Account tjphuhs@gmail.com
· 5/8/2026, 8:19:55 PM
Stuck on Reta? from huntershealthhacks@mail.beehiiv.com on 2026-05-09T00:19:55.000Z biggest topics we get asked about. One listener was on MK-677, sleeping great, but binge eating and worried about insulin resistance. Taylor walks through what she actually recommends for women in this stage, why progesterone is doing more heavy lifting than most people realize, where MK-777 fits in, and the role minerals play that almost nobody talks about. I also get on my soapbox about sunlight, EMFs, and the
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.604
· Account tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z sits well behind all of these. > ═══════════════════════════════ > WHY TIME IS THE KEY VARIABLE > Here’s what matters most for anyone following this story. The excitement is warranted, but the timeline is not short. > If animal data drops at ADA in 5 weeks, that’s mouse data. From mouse preclinical to approved human drug is historically 8-12 years. Even in this accelerat
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.604
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z sits well behind all of these. > ═══════════════════════════════ > WHY TIME IS THE KEY VARIABLE > Here’s what matters most for anyone following this story. The excitement is warranted, but the timeline is not short. > If animal data drops at ADA in 5 weeks, that’s mouse data. From mouse preclinical to approved human drug is historically 8-12 years. Even in this accelerat