Email Archive

Pinealon for Longevity

Score 0.838 · Account tjphuhs@gmail.com · 2/10/2026, 6:02:33 PM

Pinealon for Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-10T23:02:33.000Z expression through pathways like MAPK and ERK signaling. This is important because those pathways regulate cell survival, inflammation, and aging. One of the standout features of Pinealon is that it downregulates pro-apoptotic factors such as caspase-3 and p53 while upregulating antioxidant enzymes such as SOD2 and GPX. In plain English, it reduces programmed cell death in the brain and increases the brai

Pinealon for Longevity

Score 0.811 · Account tjphuhs@gmail.com · 2/10/2026, 6:02:33 PM

Pinealon for Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-10T23:02:33.000Z there’s a wide range of approaches. Most conservative protocols you’ll see online recommend 100–300 micrograms per day, injected subcutaneously for 10–20 days. That dose absolutely works for many people, especially if you’re just looking for subtle circadian or cognitive support. Personally, I like 2 mg per day, and I’ve used that dose for anywhere from 10 to 60 days depending on the situation. Shorter cy

Pinealon for Longevity

Score 0.756 · Account tjphuhs@gmail.com · 2/10/2026, 6:02:33 PM

Pinealon for Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-10T23:02:33.000Z Happy Tuesday! I just released a brand new deep-dive episode on Spotify, breaking down the underrated peptide Pinealon. Pinealon | The Underrated Peptide for Sleep, Stress, and Longevity: (https://open.spotify.com/episode/6r4jji1nEwaFYsF0GfJiaD?si=4_h_qZQqR1K_j8FTAZ7jIg) This is an update to a video I filmed years ago, and a lot has changed since then. Pinealon quietly improves how _everything_ works upst

Weirdly-Named Longevity Compound

Score 0.628 · Account tjphuhs@gmail.com · 3/17/2026, 6:04:04 PM

Weirdly-Named Longevity Compound from huntershealthhacks@mail.beehiiv.com on 2026-03-17T22:04:04.000Z only goal right now is putting on as much muscle as possible, maybe hold off. But for most of us who want to live long and live strong, this belongs in the stack. The product I personally use is [NAD Regen from Biostack Labs.](http://biostacklabs.com/hunter) One serving provides 5mg of spermidine, along with a few other solid ingredients. It's been my go-to through this past year, and I've been

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.584 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z you go with a generic UA product, look for: > > • > Urolithin A listed as the active ingredient (not “pomegranate extract” or “ellagitannin complex”) > • > A specified mg dose, 500 mg or 1000 mg per serving to match the trial doses > • > Third-party testing or COA available > • > A reputable brand with transparent sourcing > > Either way — verify the label says Urolithin A, not a precur

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.584 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z you go with a generic UA product, look for: > > • > Urolithin A listed as the active ingredient (not “pomegranate extract” or “ellagitannin complex”) > • > A specified mg dose, 500 mg or 1000 mg per serving to match the trial doses > • > Third-party testing or COA available > • > A reputable brand with transparent sourcing > > Either way — verify the label says Urolithin A, not a precur

Fwd: Spermidine, NAD+, and Longevity

Score 0.583 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: February 25, 2026 at 6:06:49 PM EST To: tjphuhs@gmail.com Subject: Spermidine, NAD+, and Longevity Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Spermidine, NAD+, and Longevity 96 Don't waste your NAD+! ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

Spermidine, NAD+, and Longevity

Score 0.583 · Account tjphuhs@gmail.com · 2/25/2026, 6:06:48 PM

Spermidine, NAD+, and Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-25T23:06:48.000Z Happy Wednesday! Over the past few weeks, I’ve gone deep down the rabbit hole on spermidine. Spermidine has been around for a while. It is a naturally occurring polyamine found in foods such as wheat germ, mushrooms, soybeans, and aged cheese. It also exists within every cell in our body, and like most things, endogenous levels decline with age. In animal models, spermidine consistently extends l

Primobolan - The Most Refined AAS

Score 0.579 · Account tjphuhs@gmail.com · 4/24/2026, 12:58:35 PM

Primobolan - The Most Refined AAS from hello@pctz.news on 2026-04-24T16:58:35.000Z mass while staying dry and healthy . Though often overshadowed by more aggressive compounds, Primo offers something unique: Steady progress with minimal risk . Want to know if it deserves a spot in your cycle? Let’s break it down: BENEFITS AND SIDE-EFFECTS OF PRIMOBOLAN Primobolan is a DHT-derived compound that doesn’t aromatize, meaning no estrogenic side effects : No water retention, no gynecomastia, and no bloa

Urolithin A: The Most Underrated Compound in Longevity

Score 0.577 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z in healthy elderly adults at 250–2000 mg single doses and 250/500/1000 mg/day for 28 days. Favorable safety profile at all doses. Bioavailable in plasma at all doses. Modulated mitochondrial gene expression in muscle biopsies at 500 and 1000 mg. Phase 2 in middle-aged adults (Singh et al., 2022, Cell Reports Medicine — the ATLAS trial). 88 sedentary middle-aged adults, 4 months of sup

Urolithin A: The Most Underrated Compound in Longevity

Score 0.575 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z Foundational mitophagy research Ryu D, Mouchiroud L, Andreux PA, et al. Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents. Nature Medicine. 2016;22(8):879-888. doi:10.1038/nm.4132 [ https://substack.com/redirect/123266d7-f61c-49ee-9bc7-5d377a6b5129?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Phase 1 human

Fwd: Weirdly-Named Longevity Compound

Score 0.570 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z https://pubmed.ncbi.nlm.nih.gov/29315079/ https://pubmed.ncbi.nlm.nih.gov/39405978/ https://pmc.ncbi.nlm.nih.gov/articles/PMC11587830/ Want more? Here’s how you can work with me: 👉Join my private coaching group, The AXION Collective: The AXION Collective 👉Try Zeroats, the world’s first sugar-free, naturally flavored oatmeal: Store: https://zeroats.com/ Amazon: https://a.co/d/2gq1zJ9 👉 Link To All My Old V

Fwd: Brain fog isn't normal—here's what fixes it

Score 0.570 · Account tjphuhs@gmail.com · 3/17/2026, 2:05:19 PM

Fwd: Brain fog isn't normal—here's what fixes it from tjphuhs@gmail.com on 2026-03-17T18:05:19.000Z for Sleep and Cognition How to restore deep sleep, mental sharpness, and protect against cognitive aging Does this sound familiar? You sleep 7-8 hours but wake up exhausted Brain fog slows you down at work Recovery takes longer than it used to Mental sharpness isn't what it was Sleep quality has quietly declined Here's the issue: as you age, your brain's repair pathways break down. Neurons can't r

Spermidine, NAD+, and Longevity

Score 0.570 · Account tjphuhs@gmail.com · 2/25/2026, 6:06:48 PM

Spermidine, NAD+, and Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-25T23:06:48.000Z NAD+ is metabolic fuel. It drives sirtuins, supports mitochondrial respiration, and assists DNA repair. When you supplement with exogenous NAD+ or high-dose precursors like NMN, you increase substrate availability. But here is the problem. If your mitochondria are dysfunctional, you are pouring premium fuel into a dirty engine. Spermidine enhances mitophagy. It improves mitochondrial quality cont

Urolithin A: The Most Underrated Compound in Longevity

Score 0.570 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z verify the label says Urolithin A, not a precursor complex. Things Worth Researching Further If you’re going down the rabbit hole, here’s what’s worth understanding more deeply. Mitophagy biology in general — PINK1/Parkin, BNIP3, NIX pathways. The hallmarks of aging (López-Otín et al.) and where mitochondrial dysfunction sits among them. Microbiome variability — why some people conver

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.568 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z medical advice, and this isn’t a recommendation to use UA personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who knows your situation. > If this was useful, share it with someone who’s been chasing the longevity rabbit hole and hasn’t come across UA yet — and let me know in the comments what underrated co

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.568 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z medical advice, and this isn’t a recommendation to use UA personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who knows your situation. > If this was useful, share it with someone who’s been chasing the longevity rabbit hole and hasn’t come across UA yet — and let me know in the comments what underrated co

Fwd: Weirdly-Named Longevity Compound

Score 0.567 · Account tjphuhs@gmail.com · 3/17/2026, 6:25:14 PM

Fwd: Weirdly-Named Longevity Compound from tjphuhs@gmail.com on 2026-03-17T22:25:14.000Z larger 12-month trial using only 0.9 milligrams per day showed no significant memory benefit. Blood spermidine levels didn't change in either group. The dose was probably just too low. When researchers examined higher doses in the range of 3.3 to 40 milligrams per day, no safety issues were observed. Side effects across trials were minimal. Some people reported minor joint and muscle issues. There was a sign

Fwd: Spermidine, NAD+, and Longevity

Score 0.566 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z Spermidine does not raise NAD+ levels directly and is not a precursor. But it does improve NAD+ efficiency and cellular resilience so that the NAD+ you are using actually produces meaningful longevity signaling. If you are using exogenous NAD+, adding spermidine makes mechanistic sense. Dosage Human trials have used a wide range of doses. Some plant-extract studies are in the 1-1.2 mg/day range. There are saf

Urolithin A: The Most Underrated Compound in Longevity

Score 0.566 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z https://substack.com/redirect/2e1d546d-6551-4992-b6ac-87f2c20b044b?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Heart failure (HFpEF) Urolithin A Restores Mitochondrial Function and Reverses Cardiac Remodeling in Heart Failure with Preserved Ejection Fraction. bioRxiv. 2025. Preprint [ https://substack.com/redirect/08b19280-c64c-4a6e-bb10-2ac4d5272df6?j=eyJ1Ijoi

Spermidine, NAD+, and Longevity

Score 0.565 · Account tjphuhs@gmail.com · 2/25/2026, 6:06:48 PM

Spermidine, NAD+, and Longevity from huntershealthhacks@mail.beehiiv.com on 2026-02-25T23:06:48.000Z effects. If you’re going to invest in NAD+, make sure you’re not pouring it into broken mitochondria. Fix the engine first, optimize mitochondrial quality control, and stop wasting your cellular currency! Best, Hunter Williams ——————————————————————————— **Further Reading** Here are several primary sources if you want to dig deeper: * [https://www.nature.com/articles/nm.4222](https://www.nature.c

Fwd: Spermidine, NAD+, and Longevity

Score 0.563 · Account tjphuhs@gmail.com · 2/26/2026, 12:36:17 AM

Fwd: Spermidine, NAD+, and Longevity from tjphuhs@gmail.com on 2026-02-26T05:36:17.000Z deserves your attention. Let’s break it down. How Spermidine Works Spermidine’s primary claim to fame is its ability to activate autophagy. Autophagy is the cellular cleanup process. It’s how your cells remove damaged proteins, dysfunctional mitochondria, and cellular debris. It is one of the most consistently associated mechanisms with lifespan extension across species. Spermidine induces autophagy independe

Fwd: longevity protocols for women

Score 0.563 · Account oc.tjphuhs@gmail.com · 3/16/2026, 10:42:39 AM

Fwd: longevity protocols for women from tjphuhs@gmail.com on 2026-03-16T14:42:39.000Z Supplements: + sodium 200 to 400 mg daily + potassium 200 to 400 mg daily + magnesium 100 to 200 mg daily + ashwagandha 300 to 600 mg and rhodiola 200 to 400 mg daily to support stress resilience and overall well-being during the luteal phase.* + melatonin 1 to 3 mg nightly to help improve sleep quality Late luteal phase (last week before your period): + light training only + prioritize recovery and self-care +

Fwd: longevity protocols for women

Score 0.563 · Account tjphuhs@gmail.com · 3/16/2026, 10:42:39 AM

Fwd: longevity protocols for women from tjphuhs@gmail.com on 2026-03-16T14:42:39.000Z Supplements: + sodium 200 to 400 mg daily + potassium 200 to 400 mg daily + magnesium 100 to 200 mg daily + ashwagandha 300 to 600 mg and rhodiola 200 to 400 mg daily to support stress resilience and overall well-being during the luteal phase.* + melatonin 1 to 3 mg nightly to help improve sleep quality Late luteal phase (last week before your period): + light training only + prioritize recovery and self-care +

Urolithin A: The Most Underrated Compound in Longevity

Score 0.560 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z stop efficiently clearing out damaged mitochondria. Dysfunctional mitochondria pile up, leak oxidative stress, fail to make energy efficiently, and contribute to nearly every “hallmark of aging” you can name. Mitophagy is the cellular cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control