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Semantic Search: Phases 1 and 2
Phases 1 and 2
Score 0.771
· Account tjphuhs@gmail.com
· 2/23/2026, 11:07:28 PM
Phases 1 and 2 from noralouj@gmail.com on 2026-02-24T04:07:28.000Z gluteresetphase1.pdf <https://drive.google.com/file/d/1ZfBqX5wRap7xu_deKKNWB1HOrxrEUlcp/view?usp=drive_web> gluteresetphase2.pdf <https://drive.google.com/file/d/1Ajgl0Fe7pyeKgUZvvKmHtiY3ig5QwhZB/view?usp=drive_web>
Fwd: Phases 1 and 2
Score 0.694
· Account tjphuhs@gmail.com
· 2/23/2026, 11:13:25 PM
Fwd: Phases 1 and 2 from tjphuhs@gmail.com on 2026-02-24T04:13:25.000Z TJ Begin forwarded message: From: Nora Jamieson <noralouj@gmail.com> Date: February 23, 2026 at 11:07:41 PM EST To: T <tjphuhs@gmail.com> Subject: Phases 1 and 2 gluteresetphase1.pdf gluteresetphase2.pdf
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.560
· Account tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z TJ Begin forwarded message: From: Derek from Peptide Price <derekpruski@substack.com> Date: March 17, 2026 at 2:35:48 PM EDT To: tjphuhs@gmail.com Subject: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds Reply-To: Derek from Peptide Price <reply+35vwkb&4iwoe6&&9a37b440eaa19e66b34a088ebedada07af9e3dc1f17602c464d22c4118ef1002@mg1.substack.com>
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.560
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z TJ Begin forwarded message: From: Derek from Peptide Price <derekpruski@substack.com> Date: March 17, 2026 at 2:35:48 PM EDT To: tjphuhs@gmail.com Subject: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds Reply-To: Derek from Peptide Price <reply+35vwkb&4iwoe6&&9a37b440eaa19e66b34a088ebedada07af9e3dc1f17602c464d22c4118ef1002@mg1.substack.com>
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.553
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z of that, the functional impact is minimal. MT2 produces the same tanning effect, plus appetite suppression that some research subjects find significant, plus pro-erectile and libido-related effects driven by MC4R activity. You’re essentially getting multiple systems activated from a single compound. The tradeoff is side effects. Nausea with MT2 is common, particularly
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.553
· Account tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z of that, the functional impact is minimal. MT2 produces the same tanning effect, plus appetite suppression that some research subjects find significant, plus pro-erectile and libido-related effects driven by MC4R activity. You’re essentially getting multiple systems activated from a single compound. The tradeoff is side effects. Nausea with MT2 is common, particularly
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.551
· Account tjphuhs@gmail.com
· 3/17/2026, 2:35:41 PM
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from derekpruski@substack.com on 2026-03-17T18:35:41.000Z same breadth is what drives the more pronounced side effects. Think of it this way: MT1 is a targeted signal to your melanocytes. MT2 is a louder, less specific signal that hits multiple systems at once. What That Looks Like in Practice MT1 produces a gradual, even tan. Existing freckles and moles will darken — this is expected, since those areas already have higher
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.533
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z Electrolyte disturbances are common, especially during dose escalation. Reduced food intake means reduced potassium intake (most people get the majority of their potassium from food, not supplements), and reduced sodium intake combined with any GI losses can produce real symptoms — lightheadedness on standing, fatigue, headaches, muscle weakness. The “GLP-1 keto flu”
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.533
· Account tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z Electrolyte disturbances are common, especially during dose escalation. Reduced food intake means reduced potassium intake (most people get the majority of their potassium from food, not supplements), and reduced sodium intake combined with any GI losses can produce real symptoms — lightheadedness on standing, fatigue, headaches, muscle weakness. The “GLP-1 keto flu”
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.532
· Account tjphuhs@gmail.com
· 4/25/2026, 3:54:50 PM
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z sleep disturbances, or muscle twitches. Multifactorial — reduced food intake, increased GI losses (especially during dose escalation when GI side effects are worst), and the fact that magnesium is one of the most common borderline-low nutrients in the general population even before adding a GLP-1. Potassium and sodium. Electrolyte disturbances are common, especiall
The Next Wave of GLP-1s Is Coming
Score 0.530
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z approved doses in China are 4 mg and 6 mg per week. The titration protocol starts at 2 mg, then moves to 4 mg, then to 6 mg, with about four weeks between each step. The 9 mg dose is the highest studied in China's GLORY-2 trial. The US is evaluating doses up to 16 mg. Survodutide is also once weekly. Phase 3 target doses are 3.6 mg and 6.0 mg. Phase 2 used aggressive bi-weekly escalation and it
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.529
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z as synthetic analogs of alpha-melanocyte stimulating hormone — α-MSH — a naturally occurring peptide your body already produces. α-MSH plays a central role in regulating pigmentation, appetite, inflammation, and sexual function by binding to a family of receptors called melanocortin receptors (MC1R through MC5R). The researchers weren’t trying to create a tanning pept
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.529
· Account tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z as synthetic analogs of alpha-melanocyte stimulating hormone — α-MSH — a naturally occurring peptide your body already produces. α-MSH plays a central role in regulating pigmentation, appetite, inflammation, and sexual function by binding to a family of receptors called melanocortin receptors (MC1R through MC5R). The researchers weren’t trying to create a tanning pept
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.529
· Account tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z wrong on GLP-1 protocols isn’t usually absorption — it’s the dramatic reduction in intake that gets ignored because the appetite suppression is doing its job. > Pay attention to what you’re putting in. Slowed gastric emptying is doing interesting things to the timing, but it can’t manufacture nutrition out of food that isn’t there. > This article is for research and
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.529
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z wrong on GLP-1 protocols isn’t usually absorption — it’s the dramatic reduction in intake that gets ignored because the appetite suppression is doing its job. > Pay attention to what you’re putting in. Slowed gastric emptying is doing interesting things to the timing, but it can’t manufacture nutrition out of food that isn’t there. > This article is for research and
5 protocols that claim to regrow hair
Score 0.528
· Account tjphuhs@gmail.com
· 3/30/2026, 3:30:22 PM
5 protocols that claim to regrow hair from hello@bryanjohnson.com on 2026-03-30T19:30:22.000Z [Blueprint Homepage](https://blueprint.bryanjohnson.com) Hi friend, Up to 50% of hair loss goes unnoticed. It’s not a problem that announces itself. It advances quietly for years before it's visible. By age 20, ~20% of men have some visible hair loss. By age 50, up to 40% of women have noticeable hair loss. Many people start addressing hair loss after the best window for intervention has already passed.
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.525
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z on top of an already-slowed system. Fat-heavy meals can sit particularly long, which is part of why high-fat meals tend to produce the worst GI side effects on these protocols. > Specific Nutrient Issues That Have Popped Up > This is where the rubber meets the road. Across the broader GLP-1 user base — both clinical and community-reported — certain nutrient deficienc
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.525
· Account tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z on top of an already-slowed system. Fat-heavy meals can sit particularly long, which is part of why high-fat meals tend to produce the worst GI side effects on these protocols. > Specific Nutrient Issues That Have Popped Up > This is where the rubber meets the road. Across the broader GLP-1 user base — both clinical and community-reported — certain nutrient deficienc
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.524
· Account tjphuhs@gmail.com
· 3/17/2026, 2:35:41 PM
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from derekpruski@substack.com on 2026-03-17T18:35:41.000Z per week MT2: Start: 0.1–0.25mg to assess tolerance Loading: 0.25–0.5mg daily for 1–3 weeks Maintenance: 0.5mg 1–2x per week MT2 achieves a comparable tan at lower doses and less frequent intervals. The convenience advantage is real. Whether it outweighs the side effect profile depends on what you’re optimizing for. How to Choose MT1 makes more sense if tanning is y
Fwd: Compound Tirzepatide & Semaglutide Updates!
Score 0.523
· Account tjphuhs@gmail.com
· 3/17/2026, 5:51:48 PM
Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z exclusive DDC list explained Novo’s lab findings 302% dose shocker Catalent’s contamination mess Lilly’s B12 tirzepatide bombshell Is the molecule changing? New oral GLP-1 contender MASSIVE: Compound Tirzepatide and Semaglutide Updates! Dave Knapp GLP-1 Industry Insider Episode Do you trust compounded GLP-1s based on real-world experience, or do findings like the ones discussed today change your p
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.523
· Account tjphuhs@gmail.com
· 4/25/2026, 3:54:50 PM
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z conditions longer, protein denaturation by pepsin has more time to occur. Whether this translates to meaningfully better downstream amino acid absorption is less clear in the human data, but mechanistically it’s plausible. Fat digestion timing shifts. Fats normally slow gastric emptying on their own as a feedback signal. On a GLP-1, that signal is layered on top of
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.523
· Account tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z compound with more clinical data behind it. It costs more per dose and requires more frequent administration — those are the real tradeoffs. MT2 makes more sense if you want the broader effect profile, if dosing convenience matters, or if you’ve used it before and handle it well. It’s also more cost-effective. Combining them is an option some people use to get the tan
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.523
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z compound with more clinical data behind it. It costs more per dose and requires more frequent administration — those are the real tradeoffs. MT2 makes more sense if you want the broader effect profile, if dosing convenience matters, or if you’ve used it before and handle it well. It’s also more cost-effective. Combining them is an option some people use to get the tan
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.521
· Account tjphuhs@gmail.com
· 4/24/2026, 9:05:46 AM
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from derekpruski@substack.com on 2026-04-24T13:05:46.000Z still mouse data Mouse-to-market is typically 8-12 years Retatrutide is what’s actually arriving soon Eloralintide is what’s actually advancing through Phase 3 for amylin The quintuple, if real, is a late-decade story The most important thing to do right now is stay curious and stay patient. Let the science play out. Don’t build expectations around compounds that haven
The Next Wave of GLP-1s Is Coming
Score 0.520
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A