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Semantic Search: POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means
Score 0.870
· Account tjphuhs@gmail.com
· 4/13/2026, 11:17:06 AM
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means from derekpruski@substack.com on 2026-04-13T15:17:06.000Z View this post on the web at https://derekpruski.substack.com/p/pots-mecfs-and-long-covid-are-being Before diving in: all content shared here is for educational and research purposes only. This is not medical advice. Always do your own research and consult a qualified professional. A new review paper just dropped in February 2026 in the journal ImmunoTargets and
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means
Score 0.823
· Account tjphuhs@gmail.com
· 4/13/2026, 11:17:06 AM
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means from derekpruski@substack.com on 2026-04-13T15:17:06.000Z immune modulation, and autonomic support are being explored with such interest. This isn’t a treatment paper — it’s a classification and mechanistic review. But the mechanistic detail is dense and worth understanding, especially for anyone researching inflammation, immune dysregulation, or autonomic health. Full citation: Blitshteyn S, Doherty TA, Steinman L. Pos
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means
Score 0.816
· Account tjphuhs@gmail.com
· 4/13/2026, 11:17:06 AM
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means from derekpruski@substack.com on 2026-04-13T15:17:06.000Z the cellular level across the entire body. One small study cited in the paper found that time-restricted eating over six months improved heart rate, energy levels, and mitochondrial function in POTS patients — an interesting finding worth watching. 5. Cerebral Hypoperfusion This simply means not enough blood is getting to the brain. The paper identifies this as a
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means
Score 0.809
· Account tjphuhs@gmail.com
· 4/13/2026, 11:17:06 AM
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means from derekpruski@substack.com on 2026-04-13T15:17:06.000Z that was once dismissed as “hysterical paralysis” before it was properly understood as a neuroimmune disease. They’re arguing POTS, ME/CFS, and Long COVID are following the same pattern. So What Is Actually Going On in the Body? This is where it gets really interesting. The paper identifies several overlapping biological mechanisms across all three conditions. Le
PCOS Has A New Name: Meet PMOS (Polyendocrine Metabolic Ovarian Syndrome)
Score 0.667
· Account tjphuhs@gmail.com
· 5/12/2026, 9:13:06 PM
PCOS Has A New Name: Meet PMOS (Polyendocrine Metabolic Ovarian Syndrome) from derekpruski@substack.com on 2026-05-13T01:13:06.000Z is regular. You see it as a long-term health condition with cardiovascular and metabolic implications, not just a fertility issue. What Didn’t Change The diagnosis itself stayed exactly the same. You still need two out of three of these: Irregular or absent ovulation High androgens (testosterone-type hormones) Polycystic ovaries on ultrasound, or elevated AMH (a hor
PCOS Has A New Name: Meet PMOS (Polyendocrine Metabolic Ovarian Syndrome)
Score 0.638
· Account tjphuhs@gmail.com
· 5/12/2026, 9:13:06 PM
PCOS Has A New Name: Meet PMOS (Polyendocrine Metabolic Ovarian Syndrome) from derekpruski@substack.com on 2026-05-13T01:13:06.000Z View this post on the web at https://derekpruski.substack.com/p/pcos-has-a-new-name-meet-pmos-polyendocrine Everything below is for research and educational purposes only. Nothing here is medical advice. If this affects you personally, talk to a qualified clinician. The Update If you saw my earlier PCOS post — there’s a major update. As of May 12, 2026, PCOS has off
PCOS Has A New Name: Meet PMOS (Polyendocrine Metabolic Ovarian Syndrome)
Score 0.636
· Account tjphuhs@gmail.com
· 5/12/2026, 9:13:06 PM
PCOS Has A New Name: Meet PMOS (Polyendocrine Metabolic Ovarian Syndrome) from derekpruski@substack.com on 2026-05-13T01:13:06.000Z means cycles become irregular or skip entirely. The trap: all four problems make each other worse Insulin resistance drives high testosterone. High testosterone makes insulin resistance worse. The scrambled brain signals push both of them further. The ovaries get caught in the middle. The ovaries aren’t broken. They’re responding exactly the way you’d expect them to
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.630
· Account tjphuhs@gmail.com
· 3/19/2026, 8:54:05 AM
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from tjphuhs@gmail.com on 2026-03-19T12:54:05.000Z more interesting topics I’ve been sitting on for a while, and it keeps coming up enough in research circles that it deserves a thorough breakdown. > Long COVID has affected a significant number of people, and conventional medicine has largely struggled to explain why some individuals never fully recover. What’s emerging from the research, however, points toward a very
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.630
· Account oc.tjphuhs@gmail.com
· 3/19/2026, 8:54:05 AM
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from tjphuhs@gmail.com on 2026-03-19T12:54:05.000Z more interesting topics I’ve been sitting on for a while, and it keeps coming up enough in research circles that it deserves a thorough breakdown. > Long COVID has affected a significant number of people, and conventional medicine has largely struggled to explain why some individuals never fully recover. What’s emerging from the research, however, points toward a very
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.619
· Account tjphuhs@gmail.com
· 3/19/2026, 8:54:05 AM
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from tjphuhs@gmail.com on 2026-03-19T12:54:05.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 19, 2026 at 7:37 AM -0400 To: tjphuhs@gmail.com Subject: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests > This post is for educational and informational purposes only. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.619
· Account oc.tjphuhs@gmail.com
· 3/19/2026, 8:54:05 AM
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from tjphuhs@gmail.com on 2026-03-19T12:54:05.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 19, 2026 at 7:37 AM -0400 To: tjphuhs@gmail.com Subject: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests > This post is for educational and informational purposes only. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.616
· Account tjphuhs@gmail.com
· 3/19/2026, 7:37:26 AM
Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from derekpruski@substack.com on 2026-03-19T11:37:26.000Z View this post on the web at https://derekpruski.substack.com/p/long-covid-and-mitochondrial-peptides This post is for educational and informational purposes only. None of this is medical advice, none of this is intended to diagnose or treat any disease or condition, and none of this should be taken as a recommendation to use any compound for any purpose. All compoun
PCOS Has A New Name: Meet PMOS (Polyendocrine Metabolic Ovarian Syndrome)
Score 0.614
· Account tjphuhs@gmail.com
· 5/12/2026, 9:13:06 PM
PCOS Has A New Name: Meet PMOS (Polyendocrine Metabolic Ovarian Syndrome) from derekpruski@substack.com on 2026-05-13T01:13:06.000Z Guideline (Monash): Monash Centre for Health Research & Implementation — PCOS Guideline [ https://substack.com/redirect/9193435f-47f9-4a3a-b6d4-09e336327e38?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] WHO PCOS Fact Sheet: World Health Organization — Polycystic Ovary Syndrome [ https://substack.com/redirect/0e65eafc-5cc8-46c9-821e-1ab6cb2b983e
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.608
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most cases — preserved. > This article is for research and educational purposes only. The compounds and protocols discussed are intended for in vitro and laboratory research use. Nothing in this article constitutes medical advice, clinical guidance, or
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.608
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most cases — preserved. > This article is for research and educational purposes only. The compounds and protocols discussed are intended for in vitro and laboratory research use. Nothing in this article constitutes medical advice, clinical guidance, or
The GLP-1 Moment Is Breaking the Healthcare System Wide Open
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· Account tjphuhs@gmail.com
· 3/18/2026, 6:27:27 PM
The GLP-1 Moment Is Breaking the Healthcare System Wide Open from onthepen@substack.com on 2026-03-18T22:27:27.000Z are doing at the individual level is just as profound. They are increasingly looking like longevity drugs, fewer heart attacks and strokes, less inflammation, reduced cancer risk signals, meaningful diabetes improvement, and the list keeps growing. The impact of that alone is massively transformative and cannot be overstated. I’ve been digging into this more in recent conversations
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.601
· Account tjphuhs@gmail.com
· 4/25/2026, 2:00:53 PM
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from derekpruski@substack.com on 2026-04-25T18:00:53.000Z onset to be delayed, expect peaks to be softer, and don’t interpret a delayed onset as a failure of the protocol. The compound is in circulation. It’s just taking a longer path to get there. Understanding the mechanism is the difference between confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.598
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z > The compounds where this PK shift becomes noteworthy in the published literature are the ones where timing of the peak is part of the mechanism, or where a sharp Cmax is what produces the intended effect: > Fast-onset agents where the curve shape is the effect — the onset profile changes, and the shifted Tmax can create the impression that something isn’t working wh
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.598
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z > The compounds where this PK shift becomes noteworthy in the published literature are the ones where timing of the peak is part of the mechanism, or where a sharp Cmax is what produces the intended effect: > Fast-onset agents where the curve shape is the effect — the onset profile changes, and the shifted Tmax can create the impression that something isn’t working wh
Mold Toxicity & Peptides: A Comprehensive Walkthrough
Score 0.597
· Account tjphuhs@gmail.com
· 4/28/2026, 7:52:08 PM
Mold Toxicity & Peptides: A Comprehensive Walkthrough from derekpruski@substack.com on 2026-04-28T23:52:08.000Z Works This is where binders, sauna, glutathione support, and all the standard detox protocols suddenly start producing results in weeks instead of years. The immune system can recognize what to clear, the mitochondria have the energy to push toxins out of cells, and the barriers hold so you don’t re-absorb what you just excreted. This is also where addressing chronic infections fits —
Mold Toxicity & Peptides: A Comprehensive Walkthrough
Score 0.595
· Account tjphuhs@gmail.com
· 4/28/2026, 7:52:08 PM
Mold Toxicity & Peptides: A Comprehensive Walkthrough from derekpruski@substack.com on 2026-04-28T23:52:08.000Z crash hard. The immune system never actually got rebuilt — it got pharmacologically suppressed into a temporary equilibrium. The crash threshold stays low. There’s also the sinus colonization issue layered on top. VIP nasal sprayed into a colonized sinus isn’t reaching what it’s supposed to reach, and may actually be feeding the wrong response. The research-informed alternative is what
180M People. Same Vaccine Pattern.
Score 0.590
· Account tjphuhs@gmail.com
· 3/24/2026, 8:02:56 AM
180M People. Same Vaccine Pattern. from support@twc.health on 2026-03-24T12:02:56.000Z Real-world data shows elevated cardiac and neurological events post-rollout This email was sent to you as HTML-only. To view it, please visit: https://arn.soundestlink.com/ce/v/66f59766ed7d70230df9f78b/69c194efe4d6dbb3e428e188 ************************** Make sure you keep getting our latest offers and add support@twc.health to your address book. Unsubscribe https://arn.soundestlink.com/contactsPreferences/v2/u
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.588
· Account tjphuhs@gmail.com
· 4/25/2026, 2:00:53 PM
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from derekpruski@substack.com on 2026-04-25T18:00:53.000Z how much compound actually entered systemic circulation, tends to be similar across most studied agents. That last point is the one most people miss. Slower does not mean less. For most orally administered compounds, the full dose still reaches circulation; it just arrives on a delayed, smoothed-out timeline. Where the Kinetics Actually Matter The compounds where th
Fwd: Reta vs. Cancer
Score 0.582
· Account tjphuhs@gmail.com
· 2/26/2026, 12:51:09 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z at lower doses, these metabolic changes may be meaningful. Non-Cancer-Favoring Terrain Cancer develops within biological terrain. A body with high fasting glucose A body with elevated insulin A body with systemic inflammation A body with immune dysfunction These conditions create fertile ground for pathological growth. Retatrutide appears to influence multiple pathways simultaneously. It improves glucose regulation, flattens
PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching
Score 0.582
· Account tjphuhs@gmail.com
· 5/12/2026, 12:13:59 PM
PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z Is Currently Managed This is the conventional medicine approach, based on the 2023 international evidence-based guideline. Knowing this matters because it’s the foundation that peptide research is being layered onto. Lifestyle modification. Always first-line, always non-negotiable. Diet (no single “best” diet — sustainable, individualized matters mo