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Semantic Search: PE-22-28 for Depression
PE-22-28 for Depression
Score 0.797
· Account tjphuhs@gmail.com
· 5/12/2026, 6:04:07 PM
PE-22-28 for Depression from huntershealthhacks@mail.beehiiv.com on 2026-05-12T22:04:07.000Z with some nootropic benefit on top. Depression is multifaceted. You can have perfect bloodwork and still be depressed. You can have a perfect lifestyle and still struggle. Most of the time, it's a combination of hormones, inflammation, lifestyle, stress, and circumstance. PE-22-28 alone won't fix any of that. But it can do something an SSRI struggles to do, which is help someone get out of the hole fast
PE-22-28 for Depression
Score 0.757
· Account tjphuhs@gmail.com
· 5/12/2026, 6:04:07 PM
PE-22-28 for Depression from huntershealthhacks@mail.beehiiv.com on 2026-05-12T22:04:07.000Z PE-22-28 has no significant effects on TREK-2, TRAAK, TRESK, or TASK-1 channels. No effect on hERG cardiac channels either. That means no heart rate, blood pressure, or cardiac rhythm issues. **Important caveat.** All of this is preclinical. There are no human trials yet. My experience is anecdotal, and the wider human use data is basically nonexistent. ——————————————————————————— **Benefits** What does
PE-22-28 for Depression
Score 0.715
· Account tjphuhs@gmail.com
· 5/12/2026, 6:04:07 PM
PE-22-28 for Depression from huntershealthhacks@mail.beehiiv.com on 2026-05-12T22:04:07.000Z Happy Tuesday! In today’s new podcast, I sat down to cover one of the market's underrated peptides, **PE-22-28**. If you struggle with depression, anxiety, or just want a peptide that lifts mood without the SSRI baggage, this one is worth a listen. Youtube: This Peptide Works 10X Faster Than SSRIs (Here's How) (https://youtu.be/4FZ_bKCeUro) Watch on YouTube: [https://youtu.be/4FZ_bKCeUro](https://youtu.b
Thymosin Alpha-1 For Depression?
Score 0.628
· Account tjphuhs@gmail.com
· 2/18/2026, 6:06:20 PM
Thymosin Alpha-1 For Depression? from huntershealthhacks@mail.beehiiv.com on 2026-02-18T23:06:20.000Z a knowledgeable provider. Address the immune system. Support the brain by stabilizing the environment around it. Hopefully, this approach will be where the future of mental health is headed! Best, Hunter Williams ——— You are reading a plain text version of this post. For the best experience, copy and paste this link in your browser to view the post online: https://huntershealthhacks.beehiiv.com/
Thymosin Alpha-1 For Depression?
Score 0.608
· Account tjphuhs@gmail.com
· 2/18/2026, 6:06:20 PM
Thymosin Alpha-1 For Depression? from huntershealthhacks@mail.beehiiv.com on 2026-02-18T23:06:20.000Z sufficient consistent signaling to shift patterns without inducing overactivation. Eight weeks allows for meaningful immune remodeling. Remember, T-cell dynamics and cytokine environments do not change overnight. I prefer subcutaneous administration. After eight weeks, reassess. Some individuals may not need continuous use. Others with deeper immune dysfunction may benefit from periodic cycles.
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.599
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z enzymes responsible for making it. For GLP-1 anhedonia, where the problem is the brain’s reward output being turned down, this is a potentially meaningful distinction. Rather than forcing a dopamine spike, Bromantane may help restore the brain’s natural capacity to generate it. Research is also exploring its potential to reduce fatigue without overstimulation, support motivati
Thymosin Alpha-1 For Depression?
Score 0.580
· Account tjphuhs@gmail.com
· 2/18/2026, 6:06:20 PM
Thymosin Alpha-1 For Depression? from huntershealthhacks@mail.beehiiv.com on 2026-02-18T23:06:20.000Z It alters motivation and reward circuitry. It changes how the brain interprets stress. When immune cells are chronically activated, they produce cytokines that can cross the blood brain barrier. Those cytokines influence the hypothalamic-pituitary-adrenal axis. They shift tryptophan metabolism away from serotonin production toward neurotoxic metabolites. You can throw SSRIs at that system and so
Thymosin Alpha-1 For Depression?
Score 0.574
· Account tjphuhs@gmail.com
· 2/18/2026, 6:06:20 PM
Thymosin Alpha-1 For Depression? from huntershealthhacks@mail.beehiiv.com on 2026-02-18T23:06:20.000Z Happy Wednesday! I was digging through recent literature this week and came across a [2025 human study](https://pmc.ncbi.nlm.nih.gov/articles/PMC11762651/) that immediately caught my attention. ([Click here to read it](https://pmc.ncbi.nlm.nih.gov/articles/PMC11762651/)) It looked at thymosin alpha-1 in patients with common variable immune deficiency who were also dealing with depression. And wh
Tesofensine: What’s Worth Knowing About The Mechanism, The Side Effects, And The GLP-1 Washout Question
Score 0.566
· Account tjphuhs@gmail.com
· 5/11/2026, 1:40:19 PM
Tesofensine: What’s Worth Knowing About The Mechanism, The Side Effects, And The GLP-1 Washout Question from derekpruski@substack.com on 2026-05-11T17:40:19.000Z of major depression on the highest dose. The 1mg group also showed measurable increases in anger and hostility on standardized mood tests. Worth pausing on that 12-18% number. That’s roughly one in seven trial participants. And these were screened populations — meaning the trials excluded people with prior depression, anxiety disorders,
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.555
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z you want to start a task, finish a project, or feel rewarded after doing something. GLP-1 compounds can dial down dopamine activity in these areas — not dramatically, but enough that some RS subjects notice a consistent low-grade flatness that doesn’t go away on its own. The same mechanism making the compounds so effective at reducing compulsive eating can also reduce the brai
BPC-157 for Your Brain?
Score 0.553
· Account tjphuhs@gmail.com
· 4/6/2026, 6:06:08 PM
BPC-157 for Your Brain? from huntershealthhacks@mail.beehiiv.com on 2026-04-06T22:06:08.000Z than most pharmaceuticals. Those typically force one system in one direction. ——————————————————————————— **Why This Matters ** Modern psychiatric treatment is built on a simple model. Target one neurotransmitter. Push it in one direction. SSRIs increase serotonin availability. Stimulants increase dopamine. Benzodiazepines enhance GABA activity. But the model has obvious gaps. Side effects are common. Wi
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.547
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z and produce mood-adjacent effects through its central mechanism. Dosing being explored runs 500 mcg – 2 mg per research administration, administered 1–2 hours before the relevant observation window. Most community research starts at the lower end — 500 mcg to 1 mg — to assess tolerance before titrating up. Frequency is kept to a maximum of 2–3x per week to avoid the receptors
The Brain Peptide You Don't Know About
Score 0.542
· Account tjphuhs@gmail.com
· 1/27/2026, 6:09:49 PM
The Brain Peptide You Don't Know About from huntershealthhacks@mail.beehiiv.com on 2026-01-27T23:09:49.000Z HUNTER20 at [Soma Chems to try it out.](https://somachems.com/product/p21/) ——————————————————————————— **Final Thoughts** P21 fits best for people who care about long-term brain health and want something that supports the system rather than blasting it. If you have a demanding work schedule, a high cognitive load, and you want more clarity without leaning on stimulants, P21 is interesting
Tesofensine: What’s Worth Knowing About The Mechanism, The Side Effects, And The GLP-1 Washout Question
Score 0.536
· Account tjphuhs@gmail.com
· 5/11/2026, 1:40:19 PM
Tesofensine: What’s Worth Knowing About The Mechanism, The Side Effects, And The GLP-1 Washout Question from derekpruski@substack.com on 2026-05-11T17:40:19.000Z head-to-head comparisons are limited. What the trials don’t tell us as clearly: how many people dropped out specifically because of mood-related side effects, what happens to mood and cardiovascular markers over multi-year exposure, and how the compound performs in populations with psychiatric or cardiovascular history (since those popu
Tesofensine: What’s Worth Knowing About The Mechanism, The Side Effects, And The GLP-1 Washout Question
Score 0.532
· Account tjphuhs@gmail.com
· 5/11/2026, 1:40:19 PM
Tesofensine: What’s Worth Knowing About The Mechanism, The Side Effects, And The GLP-1 Washout Question from derekpruski@substack.com on 2026-05-11T17:40:19.000Z what’s actually going on. Running a different appetite suppressant through the window means you never see baseline. You’re just swapping one suppressing drug for another. None of this means tesofensine during washout is automatically a bad call. Some protocols do this and it works fine. The point is that the choice involves more variabl
Fwd: What Is Serotonin Syndrome?
Score 0.531
· Account tjphuhs@gmail.com
· 4/27/2026, 11:24:40 AM
Fwd: What Is Serotonin Syndrome? from tjphuhs@gmail.com on 2026-04-27T15:24:40.000Z SSRIs, supplements, even some over-the-counter meds count. > 3. Methylene blue deserves extra respect. If you’re on any psychiatric medication, this one is a hard stop without a doctor’s guidance. > 4. Start low, go slow. Lower doses give your body time to react before things escalate. > 5. Know the early symptoms. Catching it early means it’s easy to reverse — just stop the compound. Catching it late is a much b
Fwd: What Is Serotonin Syndrome?
Score 0.531
· Account oc.tjphuhs@gmail.com
· 4/27/2026, 11:24:40 AM
Fwd: What Is Serotonin Syndrome? from tjphuhs@gmail.com on 2026-04-27T15:24:40.000Z SSRIs, supplements, even some over-the-counter meds count. > 3. Methylene blue deserves extra respect. If you’re on any psychiatric medication, this one is a hard stop without a doctor’s guidance. > 4. Start low, go slow. Lower doses give your body time to react before things escalate. > 5. Know the early symptoms. Catching it early means it’s easy to reverse — just stop the compound. Catching it late is a much b
What If You Could Lose Weight Effortlessly?
Score 0.531
· Account tjphuhs@gmail.com
· 5/12/2026, 4:57:19 PM
What If You Could Lose Weight Effortlessly? from fchsupportnany@qzqizyrfuybrwnbuyfwyqyxs.com on 2026-05-12T20:57:19.000Z DirectMeds - Affordable GLP-1 meds Are You Paying "Mortgage Money" for GLP-1 meds? A healthier you starts here with transparent, affordable pricing. TAP YOUR GOAL! 10 — 25 lbs 25 — 50 lbs 50 — 75 lbs 75 — 100 lbs 100+ lbs Ditch the Delays Sick of being just another number? Our nursing team provides full-time support and real-time online chats. Lower Your Costs Programs start a
Fwd: ROP TERM FOR SON UP TO AGE 65 (33 Year term)
Score 0.530
· Account tjphuhs@gmail.com
· 1/27/2026, 12:48:02 PM
Fwd: ROP TERM FOR SON UP TO AGE 65 (33 Year term) from kbourdeau@peodepot.com on 2026-01-27T17:48:02.000Z These are interesting options. If you outlive the term you get a good chunk of your premium back. *Kim Bourdeau* *727-773-6460* *kbourdeau@peodepot.com <kbourdeau@peodepot.com>* *kbourdeau@biginsagency.com <kbourdeau@biginsagency.com>* *Payroll Administration - Human Resource Support * *Benefits - Workers' Compensation * *What is a PEO? ANSWER <http://peodepot.com/videos/discover-the-benefit
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.526
· Account tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z study population that was predominantly White. The researchers themselves are careful to say that larger, more diverse studies are needed before anyone should consider using this drug off-label for AUD. > Upgrade to paid > This is just the beginning. Eli Lilly has a dual GLP-1/GIP co-agonist called brenipatide that is being looked at for a whole host of nueralogical d
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.526
· Account oc.tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z study population that was predominantly White. The researchers themselves are careful to say that larger, more diverse studies are needed before anyone should consider using this drug off-label for AUD. > Upgrade to paid > This is just the beginning. Eli Lilly has a dual GLP-1/GIP co-agonist called brenipatide that is being looked at for a whole host of nueralogical d
Fwd: When Ozempic stops working (and what 10% of users already know)
Score 0.525
· Account tjphuhs@gmail.com
· 3/17/2026, 2:05:41 PM
Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z to lose even 5% of body weight, the minimum threshold considered clinically meaningful. In the SURMOUNT-2 trial for tirzepatide, 17-21% of participants didn't hit that 5% mark. Why? Variants in the GLP-1 receptor gene affect how strongly the drug signals satiety. Gut microbiome composition also influences response. And if your metabolism is already adapted to caloric restrictio
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.525
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z > • > News-Medical coverage: “New quintuple agonist shows promise for treating obesity and type 2 diabetes.” September 21, 2025. news-medical.net > • > Andreassen KV, et al. Research on Dual Amylin and Calcitonin Receptor Agonists (DACRAs, KBP-042, KBP-089) — various publications > • > Eli Lilly pipeline page (no quintuple currently listed): lilly.com/science/research-de
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.525
· Account tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z > • > News-Medical coverage: “New quintuple agonist shows promise for treating obesity and type 2 diabetes.” September 21, 2025. news-medical.net > • > Andreassen KV, et al. Research on Dual Amylin and Calcitonin Receptor Agonists (DACRAs, KBP-042, KBP-089) — various publications > • > Eli Lilly pipeline page (no quintuple currently listed): lilly.com/science/research-de
If you want to lose 20 pounds of fat by the summer, copy this:
Score 0.525
· Account tjphuhs@gmail.com
· 3/31/2026, 11:05:52 AM
If you want to lose 20 pounds of fat by the summer, copy this: from dan@highperformancefounder.com on 2026-03-31T15:05:52.000Z Read this on Dango.co ( https://986419df.click.convertkit-mail4.com/r8u4dll95mhoh3d83vpu2hdn22pxlc7h38870/l2hehmhl2qxmewh6/aHR0cHM6Ly93d3cuZGFuZ28uY28vYmxvZy9pZi15b3Utd2FudC10by1sb3NlLTIwLXBvdW5kcy1vZi1mYXQtYnktdGhlLXN1bW1lci1jb3B5LXRoaXM= ) Jeff came to us last April. He got on a Zoom call with 25 pounds to lose and a waistline that kept getting bigger despite everyt