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Semantic Search: New Study Worth Knowing About: GLP-1s and Alzheimer's
New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.895
· Account tjphuhs@gmail.com
· 4/30/2026, 10:19:32 AM
New Study Worth Knowing About: GLP-1s and Alzheimer's from derekpruski@substack.com on 2026-04-30T14:19:32.000Z below. Disclaimer: This content is for research and educational purposes only and is not medical advice. All compounds discussed (peptides, GLP-1 receptor agonists, and related research chemicals) are referenced in the context of research use only (RUO) and the published scientific literature. Nothing in this post should be interpreted as a recommendation for human consumption, diagnos
New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.895
· Account tjphuhs@gmail.com
· 4/30/2026, 10:19:32 AM
New Study Worth Knowing About: GLP-1s and Alzheimer's from derekpruski@substack.com on 2026-04-30T14:19:32.000Z View this post on the web at https://derekpruski.substack.com/p/new-study-worth-knowing-about-glp A new research review just came out in Molecular and Cellular Neuroscience (April 2026) looking at how GLP-1 drugs — the same class as Ozempic, Wegovy, Mounjaro, and Trulicity — might affect Alzheimer’s disease. ScienceAlert covered it, but I wanted to dig into the actual paper and break i
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.893
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z in the community can follow along. > Link to the study: https://doi.org/10.1016/j.mcn.2026.104091 > ScienceAlert summary: https://www.sciencealert.com/weight-loss-drugs-may-reduce-buildup-of-alzheimers-proteins-major-review-finds > Upgrade to paid > A Quick Primer on Alzheimer’s > Alzheimer’s is defined by two specific things going wrong in the brain: > > 1. > Amyloid-beta plaques — stic
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.893
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z in the community can follow along. > Link to the study: https://doi.org/10.1016/j.mcn.2026.104091 > ScienceAlert summary: https://www.sciencealert.com/weight-loss-drugs-may-reduce-buildup-of-alzheimers-proteins-major-review-finds > Upgrade to paid > A Quick Primer on Alzheimer’s > Alzheimer’s is defined by two specific things going wrong in the brain: > > 1. > Amyloid-beta plaques — stic
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.878
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z wave of trials needs to recruit at-risk people before symptoms start — that’s where the real test happens. > This is one more data point worth tracking as the field develops. Stay measured, watch the next 2-3 years of trial readouts, and don’t get ahead of the evidence. > Drop questions or thoughts below. > Disclaimer: This content is for research and educational purposes only and is not
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.878
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z wave of trials needs to recruit at-risk people before symptoms start — that’s where the real test happens. > This is one more data point worth tracking as the field develops. Stay measured, watch the next 2-3 years of trial readouts, and don’t get ahead of the evidence. > Drop questions or thoughts below. > Disclaimer: This content is for research and educational purposes only and is not
New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.877
· Account tjphuhs@gmail.com
· 4/30/2026, 10:19:32 AM
New Study Worth Knowing About: GLP-1s and Alzheimer's from derekpruski@substack.com on 2026-04-30T14:19:32.000Z block the enzyme that creates tangles Tau gets converted into tangles by an enzyme called GSK-3β. GLP-1 drugs activate a signaling pathway (called PI3K/Akt) that inhibits GSK-3β. Less GSK-3β activity = less tau gunking up = fewer tangles forming inside neurons. 5. They help the brain clean itself out Your brain has its own waste-clearance system that flushes out toxic proteins. GLP-1 r
New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.873
· Account tjphuhs@gmail.com
· 4/30/2026, 10:19:32 AM
New Study Worth Knowing About: GLP-1s and Alzheimer's from derekpruski@substack.com on 2026-04-30T14:19:32.000Z gets exciting: 22 out of 30 studies showed reductions in amyloid-beta plaques 19 out of 30 studies showed reductions in tau tangles That’s about 73% showing plaque reduction and 63% showing tangle reduction. In research terms, that’s a strong, consistent signal — not a one-off finding. By drug: Liraglutide — the most studied of the four. The most consistent. Reduced both plaques AND ta
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.866
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z factory level. > 4. They block the enzyme that creates tangles > Tau gets converted into tangles by an enzyme called GSK-3β. GLP-1 drugs activate a signaling pathway (called PI3K/Akt) that inhibits GSK-3β. > Less GSK-3β activity = less tau gunking up = fewer tangles forming inside neurons. > 5. They help the brain clean itself out > Your brain has its own waste-clearance system that flus
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.866
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z factory level. > 4. They block the enzyme that creates tangles > Tau gets converted into tangles by an enzyme called GSK-3β. GLP-1 drugs activate a signaling pathway (called PI3K/Akt) that inhibits GSK-3β. > Less GSK-3β activity = less tau gunking up = fewer tangles forming inside neurons. > 5. They help the brain clean itself out > Your brain has its own waste-clearance system that flus
New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.863
· Account tjphuhs@gmail.com
· 4/30/2026, 10:19:32 AM
New Study Worth Knowing About: GLP-1s and Alzheimer's from derekpruski@substack.com on 2026-04-30T14:19:32.000Z the right one — prevention, not treatment. The researchers explicitly say these drugs may work as a preventative, not as a treatment for people who already have established cognitive impairment. That tracks with the human trial data — those trials enrolled people who already had Alzheimer’s. By that point, you may simply be too late. 3. The multi-mechanism story is genuinely promising.
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.863
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 30, 2026 at 10:19 AM -0400 To: tjphuhs@gmail.com Subject: New Study Worth Knowing About: GLP-1s and Alzheimer's > A new research review just came out in Molecular and Cellular Neuroscience (April 2026) looking at how GLP-1 drugs — the same class as Ozempic, Wegovy, Mounjaro, and T
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.863
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 30, 2026 at 10:19 AM -0400 To: tjphuhs@gmail.com Subject: New Study Worth Knowing About: GLP-1s and Alzheimer's > A new research review just came out in Molecular and Cellular Neuroscience (April 2026) looking at how GLP-1 drugs — the same class as Ozempic, Wegovy, Mounjaro, and T
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.858
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z That’s about 73% showing plaque reduction and 63% showing tangle reduction. In research terms, that’s a strong, consistent signal — not a one-off finding. > By drug: > > • > Liraglutide — the most studied of the four. The most consistent. Reduced both plaques AND tangles across multiple models. > • > Dulaglutide — fewer studies, but consistent. Reduced both plaques and tangles, and impro
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.858
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z That’s about 73% showing plaque reduction and 63% showing tangle reduction. In research terms, that’s a strong, consistent signal — not a one-off finding. > By drug: > > • > Liraglutide — the most studied of the four. The most consistent. Reduced both plaques AND tangles across multiple models. > • > Dulaglutide — fewer studies, but consistent. Reduced both plaques and tangles, and impro
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.856
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z development is full of compounds that worked beautifully in mice and failed in humans. Mouse models are typically genetically engineered to develop pathology fast — which doesn’t fully mirror what happens in a human brain over decades. > 2. The lead author’s framing is the right one — prevention, not treatment. The researchers explicitly say these drugs may work as a preventative, not as
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.856
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z development is full of compounds that worked beautifully in mice and failed in humans. Mouse models are typically genetically engineered to develop pathology fast — which doesn’t fully mirror what happens in a human brain over decades. > 2. The lead author’s framing is the right one — prevention, not treatment. The researchers explicitly say these drugs may work as a preventative, not as
GLP-1s vs. Addiction
Score 0.782
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z what it does and does not prove. The research is observational. That means it identifies associations between GLP-1 drugs and addiction outcomes. It does not prove that the drugs directly caused the reduction in addiction risk. The study population also consisted mostly of older male veterans with type 2 diabetes. That population may not perfectly represent the broader public. Researchers also cannot fully
GLP-1s vs. Addiction
Score 0.759
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z Happy Monday! I recently [read a very large study published in ](https://www.bmj.com/content/392/bmj-2025-086886)_[The BMJ](https://www.bmj.com/content/392/bmj-2025-086886)_ that provided the strongest signal yet that something tangible may be happening in the brain on GLP-1s. The study analyzed health records from more than 600,000 U.S. veterans with type 2 diabetes to examine whether GLP-1 drugs influence
TB-500 for Alzheimer's?
Score 0.732
· Account tjphuhs@gmail.com
· 3/30/2026, 6:07:48 PM
TB-500 for Alzheimer's? from huntershealthhacks@mail.beehiiv.com on 2026-03-30T22:07:48.000Z Happy Monday! Most people think of TB-500 as strictly a peptide for healing injuries, and rightfully so. However, [a new study just dropped in ](https://www.sciencedirect.com/science/article/abs/pii/S1567576925020867)_[International Immunopharmacology](https://www.sciencedirect.com/science/article/abs/pii/S1567576925020867)_ that examines TB-500 through the lens of brain function. And the results are wor
TB-500 for Alzheimer's?
Score 0.732
· Account tjphuhs@gmail.com
· 3/30/2026, 6:07:48 PM
TB-500 for Alzheimer's? from huntershealthhacks@mail.beehiiv.com on 2026-03-30T22:07:48.000Z 5xFAD mice. In the novel object recognition test, treated mice showed better ability to distinguish new objects from familiar ones. Their memory was measurably improved. Then the researchers examined what was happening in the brains of these mice. Analysis showed that glial activation was markedly reduced in treated mice. That means microglia and astrocytes were less inflamed. Neuronal apoptosis was also
GLP-1s vs. Addiction
Score 0.731
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z addiction medicine, it is rare to see a single intervention associated with improvements across multiple substances at the same time! ——————————————————————————— **What’s Going on in the Brain** To understand why these drugs might influence addiction, we have to look at where GLP-1 receptors exist in the body. Most people think of GLP-1 as a gut hormone. It is released after eating and helps regulate blood
Fwd: Urolithin A: The Most Underrated Compound in Longevity
Score 0.728
· Account oc.tjphuhs@gmail.com
· 5/2/2026, 4:58:06 PM
Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z doesn’t get enough attention. UA crosses the blood-brain barrier, and the preclinical neuroprotective data is genuinely impressive across multiple disease models. > Alzheimer’s disease (preclinical) > In multiple AD mouse models — APP/PS1, 3xTgAD, and DNA-repair-deficient ADP mice — UA treatment has been shown to: > > • > Reduce amyloid-beta plaque accumulation > • > Decrease tau hyperp
Fwd: Urolithin A: The Most Underrated Compound in Longevity
Score 0.728
· Account tjphuhs@gmail.com
· 5/2/2026, 4:58:06 PM
Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z doesn’t get enough attention. UA crosses the blood-brain barrier, and the preclinical neuroprotective data is genuinely impressive across multiple disease models. > Alzheimer’s disease (preclinical) > In multiple AD mouse models — APP/PS1, 3xTgAD, and DNA-repair-deficient ADP mice — UA treatment has been shown to: > > • > Reduce amyloid-beta plaque accumulation > • > Decrease tau hyperp
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.726
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z you want to start a task, finish a project, or feel rewarded after doing something. GLP-1 compounds can dial down dopamine activity in these areas — not dramatically, but enough that some RS subjects notice a consistent low-grade flatness that doesn’t go away on its own. The same mechanism making the compounds so effective at reducing compulsive eating can also reduce the brai