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NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.887
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z View this post on the web at https://derekpruski.substack.com/p/nmn-vs-nr-a-deep-dive-for-researchers Read this first: Everything below is for research and educational purposes only. Nothing here is medical advice. If you’re considering anything for personal use, that’s a conversation for a qualified clinician — not a Substack post. The Landscape The NAD+ conv
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.859
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z NMN and NR worth understanding deeply — even if the subQ NAD+ literature has been a letdown. This is for research and educational purposes only. Nothing in this post is medical advice, and this isn’t a recommendation to use NMN, NR, or any NAD+ format personally. If the topic is of interest for any non-research reason, that’s a conversation for a qualified med
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.858
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z keeping NAD+ high over time. This is the key context for anyone reading the NAD+ literature. Weak results from subQ NAD+ research aren’t evidence that NAD+ doesn’t matter. They’re evidence that the delivery format probably isn’t doing what the marketing claims. NMN vs NR — What They Actually Are NR (nicotinamide riboside) is nicotinamide attached to a ribose s
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.851
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z track record of human trials. NMN’s evidence base is catching up fast — as of mid-2025, at least five NMN RCTs and ten NR RCTs have reported metabolic outcomes, with more on the way. What The Human Data Shows This is where the picture sharpens. We’re not just looking at rodents anymore. The head-to-head trial (Christen et al., 2025, Nature Metabolism). The fir
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.840
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z Levels in Hospitalized Patients With COVID-19 and Acute Kidney Injury. 2025. NR muscle and bone function trial (Mayo Clinic, NCT03818802): Link [ https://substack.com/redirect/9737018a-4061-459d-b557-f2b4b2758ccc?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] NR functional capacity in older veterans (NCT04691986): Link [ https://substack.c
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.836
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z a noisier regulatory history: NMN. They mostly converge. Product Suggestions Here are some good suggestions from products off Amazon. NR: Option 1 [ https://substack.com/redirect/cc11084b-8946-4ee1-92cb-88a534bd1170?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Option 2 [ https://substack.com/redirect/0d8335b6-57e8-4ebe-b292-16d87ad30def?
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.833
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z with both, safety is good at doses up to 2 g/day, and downstream effects are real but modest. The honest takeaway from the literature: a big chunk of the disappointment in NAD+ outcomes probably comes down to the wrong precursor (oral nicotinamide alone isn’t great), the wrong delivery format (subQ NAD+ may not actually do what the marketing claims), or expect
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.824
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z mg in healthy Japanese men. Long-term trials have used 250 mg/day to 1250 mg/day for 4-12 weeks. 500-1000 mg/day is where most positive results come from. The 250 mg/day older-men trial showed effects but smaller ones. Time course is similar to NR — NAD+ rises in days, functional changes show up at 6-12 weeks and beyond. Timing. Both NMN and NR have been used
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.809
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z The supplement world mostly lives in the last two. Everything else is either old news (niacin) or impractical (tryptophan loading). The SubQ NAD+ Debate This is the elephant in the room, and it’s why a lot of researchers feel the broader NAD+ story isn’t delivering. The pro-subQ argument is simple: oral NAD+ has terrible bioavailability (often cited at 2-10%),
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.714
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z research is more nuanced and mostly preclinical. Can they be studied together? Mechanistically they don’t conflict, and there’s some theoretical rationale for why they might be complementary (signal plus substrate). But from a research design standpoint, studying both at once means you can’t tell which compound is driving any observed effect. One va
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.692
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z at the signaling layer, NAD+ at the substrate layer. The “anti-aging” framing in marketing is usually oversimplified. The research is more nuanced and mostly preclinical. > Can they be studied together? > Mechanistically they don’t conflict, and there’s some theoretical rationale for why they might be complementary (signal plus substrate). But from a
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.692
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z at the signaling layer, NAD+ at the substrate layer. The “anti-aging” framing in marketing is usually oversimplified. The research is more nuanced and mostly preclinical. > Can they be studied together? > Mechanistically they don’t conflict, and there’s some theoretical rationale for why they might be complementary (signal plus substrate). But from a
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.686
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 24, 2026 at 1:18 PM -0400 To: tjphuhs@gmail.com Subject: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds > I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one res
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.686
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 24, 2026 at 1:18 PM -0400 To: tjphuhs@gmail.com Subject: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds > I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one res
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.685
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z to Research Radar. For the full experience, upgrade your subscription. > Upgrade to paid > > Share > > > Like > Comment > Restack > > © 2026 Derek Pruski > 548 Market Street PMB 72296, San Francisco, CA 94104 > Unsubscribe
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.685
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z to Research Radar. For the full experience, upgrade your subscription. > Upgrade to paid > > Share > > > Like > Comment > Restack > > © 2026 Derek Pruski > 548 Market Street PMB 72296, San Francisco, CA 94104 > Unsubscribe
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.675
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-vs-nad-the-beginners-guide I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one research protocols should implement first. This post breaks down what each one actually does, how they differ, and gives you a simple decision tree to think throu
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.665
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z Here’s a walkthrough to help you think about which direction matches your research interests. Read through top to bottom, stop at the first question where the answer is yes. 1. Is your focus primarily metabolic pathways? (glucose handling, insulin sensitivity, AMPK signaling) → MOTS-c is more targeted. Focus area: AMPK activation literature. Key mod
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.665
· Account tjphuhs@gmail.com
· 3/27/2026, 4:31:44 PM
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from derekpruski@substack.com on 2026-03-27T20:31:44.000Z body called NNMT that essentially drains your NAD+ supply by siphoning off the raw materials needed to make it. 5-Amino-1MQ blocks that enzyme. It’s not adding more NAD+ — it’s stopping the leak so the NAD+ you have (and are supplying with the first compound) sticks around longer and gets used productively. It also plays a role in how fat cells behave metabolically. Why These Three Toge
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.658
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z > Here’s a walkthrough to help you think about which direction matches your research interests. Read through top to bottom, stop at the first question where the answer is yes. > 1. Is your focus primarily metabolic pathways? (glucose handling, insulin sensitivity, AMPK signaling) > → MOTS-c is more targeted. Focus area: AMPK activation literature. Key
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.658
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z > Here’s a walkthrough to help you think about which direction matches your research interests. Read through top to bottom, stop at the first question where the answer is yes. > 1. Is your focus primarily metabolic pathways? (glucose handling, insulin sensitivity, AMPK signaling) > → MOTS-c is more targeted. Focus area: AMPK activation literature. Key
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.656
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.656
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.653
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.653
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm