Email Archive

Max Dose Tirzepatide, Retatrutide Horror Stories, BPC-157 Anhedonia, and More

Score 0.803 · Account tjphuhs@gmail.com · 4/3/2026, 6:08:01 PM

Max Dose Tirzepatide, Retatrutide Horror Stories, BPC-157 Anhedonia, and More from huntershealthhacks@mail.beehiiv.com on 2026-04-03T22:08:01.000Z Happy Friday and Happy Easter weekend to those of you celebrating! I just published the March 2026 Q&A episode. The podcast is now live on both [YouTube](https://www.youtube.com/watch?v=4igc2UpFr7Q) and [Spotify](https://open.spotify.com/episode/7Hp4gx4DNSSmXJAM8kliDO?si=1rcXny45TrapPzZsuSC2QA). If you haven't subscribed on both platforms yet, please

Max Dose Tirzepatide, Retatrutide Horror Stories, BPC-157 Anhedonia, and More

Score 0.782 · Account tjphuhs@gmail.com · 4/3/2026, 6:08:01 PM

Max Dose Tirzepatide, Retatrutide Horror Stories, BPC-157 Anhedonia, and More from huntershealthhacks@mail.beehiiv.com on 2026-04-03T22:08:01.000Z oxygen species buildup could be the culprit. * Peptides for social anxiety, confidence, and fear. Dihexa, Noopept, oxytocin, and why the chemical piece is only part of the equation. * Urolithin A and spermidine dosing for mitophagy and autophagy. Two of my favorite background players. ——————————————————————————— **Final Thoughts** To close this out on

Fwd: Compound Tirzepatide & Semaglutide Updates!

Score 0.647 · Account tjphuhs@gmail.com · 3/17/2026, 5:51:48 PM

Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z exclusive DDC list explained Novo’s lab findings 302% dose shocker Catalent’s contamination mess Lilly’s B12 tirzepatide bombshell Is the molecule changing? New oral GLP-1 contender MASSIVE: Compound Tirzepatide and Semaglutide Updates! Dave Knapp GLP-1 Industry Insider Episode Do you trust compounded GLP-1s based on real-world experience, or do findings like the ones discussed today change your p

GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching

Score 0.634 · Account tjphuhs@gmail.com · 4/4/2026, 8:24:03 PM

GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z and produce mood-adjacent effects through its central mechanism. Dosing being explored runs 500 mcg – 2 mg per research administration, administered 1–2 hours before the relevant observation window. Most community research starts at the lower end — 500 mcg to 1 mg — to assess tolerance before titrating up. Frequency is kept to a maximum of 2–3x per week to avoid the receptors

The Next Wave of GLP-1s Is Coming

Score 0.634 · Account tjphuhs@gmail.com · 3/31/2026, 6:05:53 PM

The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z approved doses in China are 4 mg and 6 mg per week. The titration protocol starts at 2 mg, then moves to 4 mg, then to 6 mg, with about four weeks between each step. The 9 mg dose is the highest studied in China's GLORY-2 trial. The US is evaluating doses up to 16 mg. Survodutide is also once weekly. Phase 3 target doses are 3.6 mg and 6.0 mg. Phase 2 used aggressive bi-weekly escalation and it

Reta

Score 0.632 · Account tjphuhs@gmail.com · 2/20/2026, 4:40:51 PM

Reta from tjphuhs@gmail.com on 2026-02-20T21:40:51.000Z Hey Dave, I started in compounded Tirzepatide then went to grey Reta. Been on Reta for about 6 months now and down a total of 107 lbs. Fee free to ask any question. TJ

Fwd: When Ozempic stops working (and what 10% of users already know)

Score 0.627 · Account tjphuhs@gmail.com · 3/17/2026, 2:05:41 PM

Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z to lose even 5% of body weight, the minimum threshold considered clinically meaningful. In the SURMOUNT-2 trial for tirzepatide, 17-21% of participants didn't hit that 5% mark. Why? Variants in the GLP-1 receptor gene affect how strongly the drug signals satiety. Gut microbiome composition also influences response. And if your metabolism is already adapted to caloric restrictio

When Ozempic stops working (and what 10% of users already know)

Score 0.626 · Account tjphuhs@gmail.com · 3/17/2026, 1:36:07 PM

When Ozempic stops working (and what 10% of users already know) from newsletter@seedoilscout.com on 2026-03-17T17:36:07.000Z tissue you need to age well. * Gastroparesis: The FDA added a warning about delayed gastric emptying ( https://www.fda.gov/safety/medical-product-safety-information/ozempic-semaglutide-marketed-type-2-diabetes-mellitus ) so severe it can cause bowel obstruction. Some users report symptoms persisting after stopping the drug. * Gallbladder disease: Clinical trials ( https://

Retatrutide Is Too Good… And That’s The Problem

Score 0.625 · Account tjphuhs@gmail.com · 3/24/2026, 9:24:24 PM

Retatrutide Is Too Good… And That’s The Problem from onthepen@substack.com on 2026-03-25T01:24:24.000Z View this post on the web at https://onthepen.substack.com/p/retatrutide-is-too-good-and-thats There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. From new signals out of Washington that could impact access, to powerful new data on next-generation treatments like retatrutide, to wher

Compound Tirzepatide & Semaglutide Updates!

Score 0.625 · Account tjphuhs@gmail.com · 3/17/2026, 4:03:46 PM

Compound Tirzepatide & Semaglutide Updates! from onthepen@substack.com on 2026-03-17T20:03:46.000Z View this post on the web at https://onthepen.substack.com/p/compound-tirzepatide-and-semaglutide Happy Spring Break to many of you! While Dave and I are taking a short break from MFW LIVE this week, the news is anything but quiet. Major developments are unfolding, and you can catch up on everything in the latest OTP podcast, where Dave breaks it all down. In today’s episode, Dave explores several

Sale Ends at Midnight!

Score 0.625 · Account tjphuhs@gmail.com · 5/11/2026, 9:24:49 AM

Sale Ends at Midnight! from info@citizenmeds.com on 2026-05-11T13:24:49.000Z Tirzepatide, Semaglutide, NAD+, Glutathione, MIC B12 and more!https://citizenmeds.com/weight-loss-injections/ https://citizenmeds.com/product/tirzepatide-injection/ https://citizenmeds.com/product/semaglutide-injection/ https://citizenmeds.com/product/nad-injection/ https://citizenmeds.com/weight-loss-injections/ https://citizenmeds.com/product/tirzepatide-injection/ https://www.instagram.com/citizenmeds/ https://citize

Fwd: Compound Tirzepatide & Semaglutide Updates!

Score 0.622 · Account tjphuhs@gmail.com · 3/17/2026, 5:51:48 PM

Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z TJ Begin forwarded message: From: Dave Knapp from On The Pen <onthepen@substack.com> Date: March 17, 2026 at 4:03:57 PM EDT To: tjphuhs@gmail.com Subject: Compound Tirzepatide & Semaglutide Updates! Reply-To: Dave Knapp from On The Pen <reply+35w1tf&4iwoe6&&9985d0eabdad8d3ee001e8d18022b7e3ec1f9e03481cf6e0f518cbf32ac3e62e@mg1.substack.com> Compound Tirzepatide & Semaglutide Updates! Happy Spring Br

Fwd: Retatrutide Is Too Good… And That’s The Problem

Score 0.621 · Account oc.tjphuhs@gmail.com · 3/24/2026, 10:14:11 PM

Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z quickly on multiple fronts. > We break it all down in this week’s episode, what’s changing, what it could mean for you, and what to keep an eye on next. > The Throttling of Compounded GLP-1sFDA vs Telehealth, What’s Really HappeningThe Truth About “Research Peptides”The Rule That Created the Black Market If You Rely on This, Here’s What’s ComingWhy They Want You Back on Branded DrugsRetatrutid

Fwd: Retatrutide Is Too Good… And That’s The Problem

Score 0.621 · Account tjphuhs@gmail.com · 3/24/2026, 10:14:11 PM

Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z quickly on multiple fronts. > We break it all down in this week’s episode, what’s changing, what it could mean for you, and what to keep an eye on next. > The Throttling of Compounded GLP-1sFDA vs Telehealth, What’s Really HappeningThe Truth About “Research Peptides”The Rule That Created the Black Market If You Rely on This, Here’s What’s ComingWhy They Want You Back on Branded DrugsRetatrutid

The Next Wave of GLP-1s Is Coming

Score 0.620 · Account tjphuhs@gmail.com · 3/31/2026, 6:05:53 PM

The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A

Fwd: When Ozempic stops working (and what 10% of users already know)

Score 0.615 · Account tjphuhs@gmail.com · 3/17/2026, 2:05:41 PM

Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z Rate Problem Retatrutide is Eli Lilly's triple agonist (GIP/GLP-1/glucagon). Early results: up to 24.2% weight loss at 48 weeks per the NEJM Phase 2 trial. But buried in the data: dose-dependent increases in heart rate peaking at 24 weeks. The glucagon receptor component is the likely culprit. At the 12mg dose, heart rate elevations were clinically notable. Users report resting

Your BPC-157 Experience Could Change FDA policy

Score 0.615 · Account tjphuhs@gmail.com · 3/26/2026, 6:02:51 PM

Your BPC-157 Experience Could Change FDA policy from huntershealthhacks@mail.beehiiv.com on 2026-03-26T22:02:51.000Z Happy Thursday! The FDA classified BPC-157 as a Category 2 bulk drug substance in 2023. Their reasoning? Insufficient evidence on whether it causes harm to humans. Meanwhile, hundreds of thousands of people have used BPC-157, including many of you reading this right now. And most of you walked away with zero adverse events and a healed injury. But as of now, we have no documented

Retatrutide Makes Me Hungrier?

Score 0.614 · Account tjphuhs@gmail.com · 4/29/2026, 6:04:32 PM

Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z more hunger. The TRIUMPH body composition data showed retatrutide doesn't actually preserve lean mass any better than other GLP-1 agents. The "muscle-sparing" marketing around glucagon doesn't hold up in the data. So if you're not training, eating protein, and optimizing your hormones, you'll lose muscle. And your hunger is going to climb. ——————————————————————————— **What I Would Do ** A few thi

Your BPC-157 Experience Could Change FDA policy

Score 0.614 · Account tjphuhs@gmail.com · 3/26/2026, 6:02:51 PM

Your BPC-157 Experience Could Change FDA policy from huntershealthhacks@mail.beehiiv.com on 2026-03-26T22:02:51.000Z peptide access is the absence of organized data from the people who actually use these compounds. We have the community. We have the experience. We've just never had a system to capture it in a way that regulators take seriously. Now we do. If BPC-157 helped you heal a torn tendon, recover from gut issues, bounce back from surgery, or anything else, your experience is valuable evi

Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine

Score 0.607 · Account tjphuhs@gmail.com · 4/24/2026, 9:05:46 AM

Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from derekpruski@substack.com on 2026-04-24T13:05:46.000Z of the next 12-18 months. The quintuple is the story of the early 2030s at the earliest. Many preclinical compounds never make it to humans. The history of drug development is full of animal models that looked amazing and then failed in translation. We should expect that possibility with any new molecule. The dysesthesia signal in retatrutide — the abnormal sensation s

Fwd: Retatrutide Is Too Good… And That’s The Problem

Score 0.607 · Account oc.tjphuhs@gmail.com · 3/24/2026, 10:14:11 PM

Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 24, 2026 at 9:24 PM -0400 To: tjphuhs@gmail.com Subject: Retatrutide Is Too Good… And That’s The Problem > There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. > ͏ ­͏ ­͏ ­͏ ­͏ ­

Fwd: Retatrutide Is Too Good… And That’s The Problem

Score 0.607 · Account tjphuhs@gmail.com · 3/24/2026, 10:14:11 PM

Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 24, 2026 at 9:24 PM -0400 To: tjphuhs@gmail.com Subject: Retatrutide Is Too Good… And That’s The Problem > There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. > ͏ ­͏ ­͏ ­͏ ­͏ ­

Two Vials of Tirzepatide Got Lost in the Mail for Two Years. Here's What the Data Showed.

Score 0.607 · Account tjphuhs@gmail.com · 5/9/2026, 7:49:04 AM

Two Vials of Tirzepatide Got Lost in the Mail for Two Years. Here's What the Data Showed. from derekpruski@substack.com on 2026-05-09T11:49:04.000Z View this post on the web at https://derekpruski.substack.com/p/two-vials-of-tirzepatide-got-lost A real-world stability test nobody planned for Peptide Crafters recently sent me a story I couldn’t pass up. Back in June 2024, they shipped an order containing two vials of tirzepatide. The package never made it. UPS lost it somewhere in the system, and

Fwd: Your BPC-157 Experience Could Change FDA policy

Score 0.606 · Account oc.tjphuhs@gmail.com · 3/26/2026, 7:29:23 PM

Fwd: Your BPC-157 Experience Could Change FDA policy from tjphuhs@gmail.com on 2026-03-26T23:29:23.000Z kind of data regulatory bodies actually take seriously. > There is a commission currently reviewing the Category 2 designation for several peptides. > The doctors on that commission need volume. > They need to show the FDA that real humans have used this compound, here's what happened, and here's the safety profile across a large population. > Good, bad, or neutral. All of it matters. > > What

Fwd: Your BPC-157 Experience Could Change FDA policy

Score 0.606 · Account tjphuhs@gmail.com · 3/26/2026, 7:29:23 PM

Fwd: Your BPC-157 Experience Could Change FDA policy from tjphuhs@gmail.com on 2026-03-26T23:29:23.000Z kind of data regulatory bodies actually take seriously. > There is a commission currently reviewing the Category 2 designation for several peptides. > The doctors on that commission need volume. > They need to show the FDA that real humans have used this compound, here's what happened, and here's the safety profile across a large population. > Good, bad, or neutral. All of it matters. > > What