Email Archive

Massive GLP-1 Data From ECO 2026

Score 0.674 · Account tjphuhs@gmail.com · 5/13/2026, 10:52:49 AM

Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z keeping what you lost, but stepping down to 5mg is viable for a meaningful subset. ATTAIN-MAINTAIN says switching from an injectable to a daily pill is a real option, not a theoretical one -- with results that vary depending on which injectable you came from and deserve to be understood on their own terms. The STEPUP sub-analysis says there is more efficacy headroom above the current Wegovy dose, and the body

Massive GLP-1 Data From ECO 2026

Score 0.670 · Account tjphuhs@gmail.com · 5/13/2026, 10:52:49 AM

Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z weeks. Two cohorts: those coming off Zepbound and those coming off Wegovy. 376 participants total. They started orforglipron at 12mg and titrated up every four weeks, targeting a maximum of 36mg. A rescue protocol allowed escalation or a switch from placebo to orforglipron after week 24 for anyone who regained more than half their original loss. One detail to keep in mind: there was a two-week screening gap b

Massive GLP-1 Data From ECO 2026

Score 0.647 · Account tjphuhs@gmail.com · 5/13/2026, 10:52:49 AM

Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z Wegovy and thinking about switching to Foundayo, the data is quite encouraging. If you are on Zepbound, the picture is still positive, but expect some drift and definitely factor that into the conversation with your doctor. On tolerability, the transition went relatively smoothly. GI effects were mild to moderate, discontinuation rates were low across all arms, and (perhaps most importantly) no liver safety c

Massive GLP-1 Data From ECO 2026

Score 0.634 · Account tjphuhs@gmail.com · 5/13/2026, 10:52:49 AM

Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z View this post on the web at https://onthepen.substack.com/p/massive-glp-1-data-from-eco-2026 We spent time on the podcast last week walking through what the European Congress on Obesity was likely to bring. The maintenance question was the one we flagged as most important -- not whether these drugs work, but what “staying on them” actually looks like for people navigating real lives, real costs, and real pre

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In

Score 0.625 · Account tjphuhs@gmail.com · 4/7/2026, 1:00:10 PM

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In

Score 0.625 · Account oc.tjphuhs@gmail.com · 4/7/2026, 1:00:10 PM

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio

Massive GLP-1 Data From ECO 2026

Score 0.620 · Account tjphuhs@gmail.com · 5/13/2026, 10:52:49 AM

Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z the data says that for about a third of people in that situation, it largely holds. That conversation with your doctor just got more grounded in evidence. The headline, though, is that the maximum tolerated dose performed best. If keeping as much of your loss as possible is the priority, the data says staying on your highest tolerated dose is still your best bet. The placebo arm tells a story this community a

Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This.

Score 0.617 · Account tjphuhs@gmail.com · 3/18/2026, 4:18:18 PM

Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This. from tjphuhs@gmail.com on 2026-03-18T20:18:18.000Z overthink it — just make sure there’s enough fuel in the tank before lights out. > As always, this is for research purposes only. All compounds are research use only, not for human consumption. > Drop any questions below — happy to help you troubleshoot. > Upgrade to paid > You're currently a free subscriber to Peptide Price. For the full experience, upgrade your subscription. > Upgra

Massive GLP-1 Data From ECO 2026

Score 0.616 · Account tjphuhs@gmail.com · 5/13/2026, 10:52:49 AM

Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z patients) reached 27.7% total body weight loss by week 72. Even the slower responders averaged 15.4%, which means the floor is higher than what most people experience at the current approved dose. Wegovy at 7.2mg is now approved in the US for prescription, and it was recently announced that it would be included in the medicare BRIDGE program beginning on July 1 of this year. 4. Viking’s dual agonist pill coul

GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In

Score 0.601 · Account tjphuhs@gmail.com · 3/28/2026, 1:38:29 PM

GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z expect at this stage. Rates of gestational diabetes, hypertensive disorders, preterm birth, and gestational weight gain were all over the place depending on the study, with no single direction that clearly stands out. Where this really lands for the OTP community is with Polycystic Ovary Syndrome, and this is not some small corner of the audience. This is a huge group of women who h

GLP-1s vs. Fertility

Score 0.600 · Account tjphuhs@gmail.com · 5/4/2026, 6:05:41 PM

GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z all. For couples whose fertility is being dragged down by metabolic dysfunction, GLP-1s are the most promising pharmacological lever I've seen in a decade. The female data on PCOS pregnancy rates is the strongest signal in the whole literature. The male data is catching up. The next 24 months of trial data will tell us a lot. I'll keep you posted on what we learn, on our journey, and on the science. GLP-1s

GLP-1 vs GLP-2 vs GLP-3

Score 0.594 · Account tjphuhs@gmail.com · 5/14/2026, 9:00:21 AM

GLP-1 vs GLP-2 vs GLP-3 from happy@happypeptides.com on 2026-05-14T13:00:21.000Z A simple comparison of the three. This email was sent to you as HTML-only. To view it, please visit: https://wfg.soundestlink.com/ce/v/68a8a1cb95c4ac11474be077/6a04d2931ac007f30c9a1cd2 ************************** Make sure you keep getting our latest offers and add happy@happypeptides.com to your address book. Unsubscribe https://wfg.soundestlink.com/contactsPreferences/v2/unsubscribe/?b=68a8a136cfa3b70cffc67e5f&c=68

The Next Wave of GLP-1s Is Coming

Score 0.593 · Account tjphuhs@gmail.com · 3/31/2026, 6:05:53 PM

The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In

Score 0.591 · Account tjphuhs@gmail.com · 4/7/2026, 1:00:10 PM

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z and this is not some small corner of the audience. This is a huge group of women who have spent years being told their condition was secondary to weight instead of something with its own biology and its own set of levers. In the review, GLP-1 therapies were associated with improvements in both metabolic and reproductive markers in women with PCOS, including signals around insulin r

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In

Score 0.591 · Account oc.tjphuhs@gmail.com · 4/7/2026, 1:00:10 PM

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z and this is not some small corner of the audience. This is a huge group of women who have spent years being told their condition was secondary to weight instead of something with its own biology and its own set of levers. In the review, GLP-1 therapies were associated with improvements in both metabolic and reproductive markers in women with PCOS, including signals around insulin r

😱 GLP-3 (RETA) vs MOTS-C 😱

Score 0.591 · Account tjphuhs@gmail.com · 2/11/2026, 10:30:15 AM

😱 GLP-3 (RETA) vs MOTS-C 😱 from info@somachems.com on 2026-02-11T15:30:15.000Z Take your metabolic research to the next level This email was sent to you as HTML-only. To view it, please visit: https://qfq.soundestlink.com/ce/v/68a3ebb905e51bffe64c8eaf/698c2a47dd9732c63e198315 ************************** Make sure you keep getting our latest offers and add info@somachems.com to your address book. Unsubscribe https://qfq.soundestlink.com/contactsPreferences/v2/unsubscribe/?b=686794eb7d5d9b4678a0b

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In

Score 0.589 · Account oc.tjphuhs@gmail.com · 4/7/2026, 1:00:10 PM

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In

Score 0.589 · Account tjphuhs@gmail.com · 4/7/2026, 1:00:10 PM

Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce

GLP-1 Access State of the Union

Score 0.588 · Account tjphuhs@gmail.com · 4/7/2026, 4:01:22 PM

GLP-1 Access State of the Union from onthepen@substack.com on 2026-04-07T20:01:22.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-access-state-of-the-union If you just look at the headlines, things look great for access to GLP-1 medications but for some of those already using these medications things are changing and getting tighter. Listen in as Dave breaks down the news of the week and puts it all in context. Watch or listen to this week’s podcast on Spotify! If you pre

GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In

Score 0.588 · Account tjphuhs@gmail.com · 3/28/2026, 1:38:29 PM

GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z ovulation becomes the outcome, the framing starts to move closer to what patients have been describing all along. Lactation is still largely an unknown, which is not surprising given how early this entire space is. There is one small pharmacokinetic study involving Semaglutide [ chatgpt://generic-entity?number=3 ] that did not detect transfer into breast milk, but the patient pool w

GLPs Are Back at Modern Aminos — Here’s Why

Score 0.585 · Account tjphuhs@gmail.com · 1/27/2026, 11:03:52 AM

GLPs Are Back at Modern Aminos — Here’s Why from cs@modernaminos.com on 2026-01-27T16:03:52.000Z Transparency first. Here’s why GLPs were removed, and why they’re now available again. This email was sent to you as HTML-only. To view it, please visit: https://glh.soundestlink.com/ce/v/68732f567657959f48cbbc66/6978e1a0a338842ab0915008 ************************** Make sure you keep getting our latest offers and add cs@modernaminos.com to your address book. Unsubscribe https://glh.soundestlink.com/co

Fwd: Compound Tirzepatide & Semaglutide Updates!

Score 0.583 · Account tjphuhs@gmail.com · 3/17/2026, 5:51:48 PM

Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z exclusive DDC list explained Novo’s lab findings 302% dose shocker Catalent’s contamination mess Lilly’s B12 tirzepatide bombshell Is the molecule changing? New oral GLP-1 contender MASSIVE: Compound Tirzepatide and Semaglutide Updates! Dave Knapp GLP-1 Industry Insider Episode Do you trust compounded GLP-1s based on real-world experience, or do findings like the ones discussed today change your p

The Next Wave of GLP-1s Is Coming

Score 0.582 · Account tjphuhs@gmail.com · 3/31/2026, 6:05:53 PM

The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z approved doses in China are 4 mg and 6 mg per week. The titration protocol starts at 2 mg, then moves to 4 mg, then to 6 mg, with about four weeks between each step. The 9 mg dose is the highest studied in China's GLORY-2 trial. The US is evaluating doses up to 16 mg. Survodutide is also once weekly. Phase 3 target doses are 3.6 mg and 6.0 mg. Phase 2 used aggressive bi-weekly escalation and it

New post in the group My Community (Members Only).

Score 0.580 · Account tjphuhs@gmail.com · 2/22/2026, 10:11:25 PM

New post in the group My Community (Members Only). from info@totalwellconnect.com on 2026-02-23T03:11:25.000Z NEW POST Hi there, bruno_tanya posted something in the group My Community (Members Only) . Stop by and leave a comment. Post: I am at paramount peptides and there is no Reta? Actually there is no Glp period what’s up? Click on the link below to open the message in a browser: https://thepeptidecommunity.com/so/tr/86d55f27-4ce2-40d2-8f3b-ac489f2ae1a4 You've received this email because you

When Ozempic stops working (and what 10% of users already know)

Score 0.579 · Account tjphuhs@gmail.com · 3/17/2026, 1:36:07 PM

When Ozempic stops working (and what 10% of users already know) from newsletter@seedoilscout.com on 2026-03-17T17:36:07.000Z Bottom Line *********** * About 10% of GLP-1 users are non-responders, and many more hit plateaus after 12 months. * After stopping semaglutide, people regain two-thirds of lost weight within a year. * Side effects include significant muscle loss, gallbladder disease, gastroparesis, pancreatitis risk, and thyroid concerns. * Retatrutide shows dose-dependent heart rate incr