Email Archive

Macaulay Culkin Explains Why Catherine O'Hara's Death 'Hit Me Pretty Good'

Score 0.868 · Account tjphuhs@gmail.com · 5/13/2026, 3:57:46 PM

Macaulay Culkin Explains Why Catherine O'Hara's Death 'Hit Me Pretty Good' from tampabaysmix@e.iheart.com on 2026-05-13T19:57:46.000Z iHeart Daily 96 Plus, Kimberly Van Der Beek shares life update months after husband James' death‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ &zwn

Martin Short Breaks Silence On Daughter Katherine's Death: 'A Nightmare'

Score 0.640 · Account tjphuhs@gmail.com · 5/11/2026, 3:52:18 PM

Martin Short Breaks Silence On Daughter Katherine's Death: 'A Nightmare' from tampabaysmix@e.iheart.com on 2026-05-11T19:52:18.000Z iHeart Daily 96 Plus, Rita Wilson opens up about new album inspired by breast cancer battle‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ &zwn

How AI is bringing dead voices back

Score 0.562 · Account tjphuhs@gmail.com · 5/14/2026, 7:10:37 AM

How AI is bringing dead voices back from hello@snacks.robinhood.com on 2026-05-14T11:10:37.000Z sent the company’s valuation soaring . But AI is far from a pure boon for estates. CMG Worldwide, a legacy management firm with a client list including Jim Henson, Andre the Giant, and James Dean, refers to AI as an “unprecedented threat.” And Zelda Williams, film director and daughter of Robin Williams, urged fans in a story on Instagram to stop sending her AI-generated videos of her father. “I concu

How AI is bringing dead voices back

Score 0.550 · Account tjphuhs@gmail.com · 5/14/2026, 7:10:37 AM

How AI is bringing dead voices back from hello@snacks.robinhood.com on 2026-05-14T11:10:37.000Z 96 AI is giving life to a resurrection economy (Getty Images)   Presented by Hey Snackers, What are the most popular baby names? New data from the Social Security Administration found that Olivia and Liam were again the top picks for baby girls and boys — marking the seventh straight year that Olivia’s been No. 1 for girls, and the ninth where Liam has been the top pick for American boys. We cha

Open Tab: Esther Perel

Score 0.547 · Account tjphuhs@gmail.com · 5/12/2026, 12:04:35 PM

Open Tab: Esther Perel from on+open-tab@substack.com on 2026-05-12T16:04:35.000Z ask them, what did the tarot reader say? Bring me the astrology chart. Let’s read it together. Maybe they see something you don’t see. Don’t be so insecure. So now I say to my students, do the same with AI. Don’t just have them tell you. Ask them, what did ChatGPT say? Bring it to me. Open your phone. Let’s read it together. And make it useful for the work you’re doing. You want to learn to say something? Tell the c

Fwd: Reta vs. Cancer

Score 0.544 · Account tjphuhs@gmail.com · 2/26/2026, 12:56:32 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z TJ Begin forwarded message: From: TJ Bourdeau <tjphuhs@gmail.com> Date: February 26, 2026 at 12:51:11 AM EST To: uncontrolledtrial@gmail.com Subject: Fwd: Reta vs. Cancer TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: February 24, 2026 at 6:06:32 PM EST To: tjphuhs@gmail.com Subject: Reta vs. Cancer Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Reta vs. Cancer 96 New stud

Fwd: Reta vs. Cancer

Score 0.541 · Account tjphuhs@gmail.com · 2/26/2026, 12:51:09 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z model without causing weight loss, that suggests its metabolic influence runs deeper than body composition changes alone. That opens the door to considering this molecule within a broader longevity framework. Final Thoughts We are still early in the research. Human data will be essential before drawing firm conclusions. Even so, the data's direction is compelling. Improving metabolic signaling alone influenced tumor biology

GHK-Cu Beyond Beauty

Score 0.541 · Account tjphuhs@gmail.com · 4/27/2026, 6:03:47 PM

GHK-Cu Beyond Beauty from huntershealthhacks@mail.beehiiv.com on 2026-04-27T22:03:47.000Z trial 2, and then it faded. Females got nothing. Now here's where it gets interesting. When they examined the hippocampal tissue itself, intranasal mice showed increased synaptophysin levels in females, a marker of synapse health. Both sexes showed reduced GFAP, a marker of brain inflammation and astrocyte activation. The RNA sequencing told an even bigger story. Intranasal GHK-Cu suppressed mTOR signaling,

Fwd: Reta vs. Cancer

Score 0.538 · Account tjphuhs@gmail.com · 2/26/2026, 12:51:09 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: February 24, 2026 at 6:06:32 PM EST To: tjphuhs@gmail.com Subject: Reta vs. Cancer Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Reta vs. Cancer 96 New study just released ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

Open Tab: Esther Perel

Score 0.536 · Account tjphuhs@gmail.com · 5/12/2026, 12:04:35 PM

Open Tab: Esther Perel from on+open-tab@substack.com on 2026-05-12T16:04:35.000Z then depending on whichever way they learn, I say, and what was it? What’s one thing that has actually been useful for you? And then I can handle it. Then I feel like there is substance here. FOOTNOTES Temple Bar [ https://substack.com/redirect/0b74a544-6e36-4e0f-82b7-5c22119c1757?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ], 332 Hudson St., New York—SoHo fixture with a long bar and low lighti

GHK-Cu Beyond Beauty

Score 0.536 · Account tjphuhs@gmail.com · 4/27/2026, 6:03:47 PM

GHK-Cu Beyond Beauty from huntershealthhacks@mail.beehiiv.com on 2026-04-27T22:03:47.000Z the move. The data here is mouse data, but the mechanism makes sense. Direct nose to brain delivery. Sustained exposure. Suppression of the same pathways that rapamycin hits. This also reframes how we should think about GHK-Cu in general. It's an endogenous tripeptide that declines with age. It modulates inflammation, senescence pathways, and, apparently, mitochondrial and growth signaling in the brain. ———

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.536 · Account oc.tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control systems in the body. > UA is one of the only known compounds that directly and reliably induces mitophagy in humans at oral doses. That alone would be remarkable. But the downstream effects of restoring mitophagy ripple through nearly ev

Fwd: Urolithin A: The Most Underrated Compound in Longevity

Score 0.536 · Account tjphuhs@gmail.com · 5/2/2026, 4:58:06 PM

Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control systems in the body. > UA is one of the only known compounds that directly and reliably induces mitophagy in humans at oral doses. That alone would be remarkable. But the downstream effects of restoring mitophagy ripple through nearly ev

GHK-Cu: Morning or Night — Does Timing Matter for Your Research?

Score 0.535 · Account tjphuhs@gmail.com · 4/7/2026, 11:20:35 AM

GHK-Cu: Morning or Night — Does Timing Matter for Your Research? from derekpruski@substack.com on 2026-04-07T15:20:35.000Z shown the ability to upregulate superoxide dismutase (SOD) and other protective enzymes. Superoxide dismutase is one of the body’s most important internal antioxidant enzymes — its job is to neutralize free radicals, which are unstable molecules that damage cells over time. Upregulating SOD means the body is producing more of its own natural defense against that damage Gene

5-Bullet Friday — Art Thieves, At-Home Brain Stimulation, Dwarkesh’s Origin Story, and Tide Shifts

Score 0.534 · Account tjphuhs@gmail.com · 5/8/2026, 7:51:46 PM

5-Bullet Friday — Art Thieves, At-Home Brain Stimulation, Dwarkesh’s Origin Story, and Tide Shifts from tim@fourhourbody.com on 2026-05-08T23:51:46.000Z ( https://click.fourhourmail.com/4zu36wwe44tehpem92zixh699qn49h5h704/z2hghnhexq576obp/aHR0cHM6Ly9hcmNoaXZlLmlzL1dXcGZ3 ).) ​ One excerpt from the latter: ​ “Various efforts within the psychopharmacology society aim to make deprescribing part of regular medical practice. One group is proposing the creation of a new insurance code so that doctors

GHK-Cu: Morning or Night — Does Timing Matter for Your Research?

Score 0.534 · Account tjphuhs@gmail.com · 4/7/2026, 11:20:35 AM

GHK-Cu: Morning or Night — Does Timing Matter for Your Research? from derekpruski@substack.com on 2026-04-07T15:20:35.000Z View this post on the web at https://derekpruski.substack.com/p/ghk-cu-morning-or-night-does-timing This is one of the more common questions that comes up with GHK-Cu, and it’s worth breaking down properly. The short answer is that timing likely does matter — and once you understand the mechanisms, the reasoning becomes pretty clear. What Is GHK-Cu and Why Are Researchers In

'America's Government Teacher' who maligned Charlie Kirk right after his assassination wants you to know she's the victim

Score 0.530 · Account tjphuhs@gmail.com · 5/11/2026, 11:32:17 AM

'America's Government Teacher' who maligned Charlie Kirk right after his assassination wants you to know she's the victim from updates@mail.conservativereview.com on 2026-05-11T15:32:17.000Z 96 Your update for Monday, May 11, 2026 &#8202; 'America's Government Teacher' who maligned Charlie Kirk right after his assassination wants you to know she's the victim &#8202; Trump says Ukraine and Russia agreed to 3-day ceasefire just ahead of Soviet WW2 military parade &#8202; Utah Supreme Court justice

Fwd: Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast.

Score 0.530 · Account tjphuhs@gmail.com · 3/17/2026, 3:31:51 PM

Fwd: Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast. from tjphuhs@gmail.com on 2026-03-17T19:31:51.000Z doesn’t exist for Ipamorelin in humans. But the mechanism is there, the cortisol problem is largely absent, and the GH response is real. MK-677 (Ibutamoren) MK-677 is the outlier of the group. It’s taken orally — no injection required — and has a half-life of around 24 hours, meaning it keeps GH and IGF-1 elevated throughout the day rather than producing discrete pulses. It actu

Fwd: Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast.

Score 0.530 · Account tjphuhs@gmail.com · 3/17/2026, 3:31:51 PM

Fwd: Does Tesamorelin Have a Monopoly on Visceral Fat? Not So Fast. from tjphuhs@gmail.com on 2026-03-17T19:31:51.000Z sustained signaling. CJC-1295 CJC-1295 comes in two versions and they behave very differently, so it’s worth separating them. CJC-1295 without DAC — sometimes called Mod GRF 1-29 — has a half-life of around 30 minutes, putting it in the same range as Tesamorelin. It produces a pulsatile GH response and is typically dosed multiple times per day. CJC-1295 with DAC is a different a

GHK-Cu: What Happens at the Cellular Level When a Protocol Ends?

Score 0.529 · Account tjphuhs@gmail.com · 4/10/2026, 2:26:57 PM

GHK-Cu: What Happens at the Cellular Level When a Protocol Ends? from derekpruski@substack.com on 2026-04-10T18:26:57.000Z View this post on the web at https://derekpruski.substack.com/p/ghk-cu-what-happens-at-the-cellular For research use only. Not for human consumption. What is GHK-Cu? GHK-Cu (glycyl-L-histidyl-L-lysine-copper) is a naturally occurring copper peptide first isolated from plasma in 1973. It is found naturally in the body and has been studied extensively in research settings. Rat

Urolithin A: The Most Underrated Compound in Longevity

Score 0.529 · Account tjphuhs@gmail.com · 5/2/2026, 11:16:56 AM

Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z stop efficiently clearing out damaged mitochondria. Dysfunctional mitochondria pile up, leak oxidative stress, fail to make energy efficiently, and contribute to nearly every “hallmark of aging” you can name. Mitophagy is the cellular cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control

Reta vs. Cancer

Score 0.528 · Account tjphuhs@gmail.com · 2/24/2026, 6:06:31 PM

Reta vs. Cancer from huntershealthhacks@mail.beehiiv.com on 2026-02-24T23:06:31.000Z that metabolism and cancer are closely linked. Elevated insulin. Elevated glucose. Chronic inflammation. Visceral adiposity. Impaired immune surveillance. These factors create conditions that favor tumor growth. If a compound improves glucose control, lowers inflammatory tone, enhances insulin sensitivity, and potentially influences immune function, it is reasonable to consider that it could support a less cance

Why Your Peptide Stings

Score 0.527 · Account tjphuhs@gmail.com · 4/28/2026, 6:04:33 PM

Why Your Peptide Stings from huntershealthhacks@mail.beehiiv.com on 2026-04-28T22:04:33.000Z Happy Tuesday! Today, I just released the April 2026 solo Q&A episode. I covered 37 questions around women's health, men's health, GLPs, growth hormone peptides, bio-regulators, and a few tough ones on disease states that I had to think hard about. Youtube: April 2026 Solo Q&A — Every Question Answered | Hunter Williams (https://youtu.be/HIxxh_uZCuw) Watch on YouTube: [https://youtu.be/HIxxh_uZCuw](https

5-Bullet Friday — Art Thieves, At-Home Brain Stimulation, Dwarkesh’s Origin Story, and Tide Shifts

Score 0.527 · Account tjphuhs@gmail.com · 5/8/2026, 7:51:46 PM

5-Bullet Friday — Art Thieves, At-Home Brain Stimulation, Dwarkesh’s Origin Story, and Tide Shifts from tim@fourhourbody.com on 2026-05-08T23:51:46.000Z a {text-decoration: none;} *************** 5-Bullet Friday *************** The latest from author and investor Tim Ferriss ( https://click.fourhourmail.com/4zu36wwe44tehpem92zixh699qn49h5h704/6qheh8hlemxwznao/aHR0cHM6Ly90aW0uYmxvZy8= ) Hi All! Here is your weekly dose of 5-Bullet Friday, a list of what I’m pondering and exploring. This issue is

The Last Time It “Worked” Before GLP-1

Score 0.527 · Account tjphuhs@gmail.com · 4/11/2026, 2:56:58 PM

The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z in the middle of the night and went home. I say “finally” because it seems like every weigh loss story has a “finally”… This is the part right before the wheels come off. My wife ended up in the hospital for a full week, passing kidney stones one after another. I stayed with her the entire time. Inducing early labor was the big concern, so it was a terrifying time for us. The hospital was about an hour