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MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.810
· Account tjphuhs@gmail.com
· 3/21/2026, 8:24:20 AM
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from derekpruski@substack.com on 2026-03-21T12:24:20.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-and-morning-workout-timing Not medical advice, not personal advice. For educational purposes only. All use cases discussed are strictly research use only. If a researcher is using MOTS-c and also hitting the gym in the morning, timing matters. Here’s why — broken down in plain language. First, What Is MOTS
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.805
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 21, 2026 at 8:24 AM -0400 To: tjphuhs@gmail.com Subject: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown > Not medical advice, not personal advice. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.772
· Account tjphuhs@gmail.com
· 3/21/2026, 8:24:20 AM
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from derekpruski@substack.com on 2026-03-21T12:24:20.000Z capacity with no interference. Step 3 — Remain in a fasted or semi-fasted state for roughly 2–4 hours. This gives the acute AMPK signaling window time to normalize. Step 4 — Break the fast with a solid meal. Protein, carbohydrates, adequate calories. This refuels glycogen stores, raises circulating amino acid availability, and shifts the hormonal environment toward anabolism.
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.755
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z this needs to be stated clearly because it gets misunderstood constantly. > Activating AMPK does not completely shut off mTOR. It does not eliminate muscle growth. > The relationship between these two pathways is nuanced — it depends on how strongly each is activated, the researcher’s nutrition status, training intensity, recovery, and a range of other factors. A research subje
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.754
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z acid availability, and shifts the hormonal environment toward anabolism. > Step 5 — Train. With MOTS-c out of the acute signaling window and the body adequately refueled, resistance training can potently stimulate mTOR without meaningful AMPK interference. The anabolic response to training is uncompromised. > The end result is two clean, well-supported signaling environments —
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.742
· Account tjphuhs@gmail.com
· 3/21/2026, 8:24:20 AM
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from derekpruski@substack.com on 2026-03-21T12:24:20.000Z on mTOR. Biologically this makes sense — the body doesn’t want to be building expensive new muscle tissue when it thinks it’s in an energy-deficient state. These two pathways actively suppress each other, which is why administering a potent AMPK activator right before resistance training creates a potential conflict worth thinking about. The Important Nuance Before getting in
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.738
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z — often called the “powerhouse of the cell.” MOTS-c is essentially a signal that mitochondria send out to communicate with the rest of the body about energy status. > In research, it has shown strong effects on metabolism, insulin sensitivity, fat utilization, and cellular energy regulation. > Two Pathways You Need to Understand > To understand why timing matters, a researcher
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.708
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z outcome data. And if the primary goal is metabolic health or body composition rather than maximum hypertrophy, the timing concern becomes much less relevant. The AMPK/mTOR tension matters most when you’re trying to squeeze every bit of muscle growth out of training. Bottom Line The rest-day scheduling approach is a smart way to think about MOTS-c for anyone training har
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.685
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z composition, the metabolic improvements, without actively fighting the 24 to 48 hour recovery window that determines whether training turns into muscle. The old bodybuilding instinct to use rest days for body composition work wasn’t wrong in spirit. It was just missing a piece of the puzzle about recovery biology. Rest-day MOTS-c scheduling is an updated version of that
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.673
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z with that framework is it glosses over what’s actually happening in your muscles during those rest days. Muscle recovery and protein synthesis don’t shut off the moment you rack your last set. The mTOR response runs strong for roughly 24 to 48 hours after training. So your rest day isn’t really a “nothing is happening” day from a recovery standpoint, it’s often the day
Fwd: my morning routine (2026)
Score 0.669
· Account tjphuhs@gmail.com
· 3/24/2026, 8:50:44 AM
Fwd: my morning routine (2026) from tjphuhs@gmail.com on 2026-03-24T12:50:44.000Z ---------- Forwarded message ---------- From: Bryan Johnson <hello@bryanjohnson.com> Date: Mar 24, 2026 at 8:15 AM -0400 To: tjphuhs@gmail.com Subject: my morning routine (2026) > 13 steps ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
my morning routine (2026)
Score 0.657
· Account tjphuhs@gmail.com
· 3/24/2026, 8:15:25 AM
my morning routine (2026) from hello@bryanjohnson.com on 2026-03-24T12:15:25.000Z [Blueprint Homepage](https://blueprint.bryanjohnson.com) Hi friend, My daily routine takes 4 hours 46 min… but it used to take longer. When I started Blueprint several years ago, my routine was pretty complicated. Recently, my team and I have dramatically simplified it. We scrutinized every step to determine whether or not it belonged in the routine. Here’s what I’m currently doing each morning. https://blueprint.b
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.647
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-on-rest-days-the-scheduling Research use only. This content is intended for educational and informational purposes within a research context. Not for human consumption. Not medical advice. No dosing recommendations are provided or implied. If you’ve been around the research space for any length of ti
Fwd: my morning routine (2026)
Score 0.644
· Account tjphuhs@gmail.com
· 3/24/2026, 8:50:44 AM
Fwd: my morning routine (2026) from tjphuhs@gmail.com on 2026-03-24T12:50:44.000Z Blueprint several years ago, my routine was pretty complicated. Recently, my team and I have dramatically simplified it. > > We scrutinized every step to determine whether or not it belonged in the routine. > > Here’s what I’m currently doing each morning. > Bedtime > > In bed by 8:30 pm. > > Every day starts the night before. Sleep is my #1 life priority because high-quality rest makes hard things easy and impossi
my morning routine (2026)
Score 0.634
· Account tjphuhs@gmail.com
· 3/24/2026, 8:15:25 AM
my morning routine (2026) from hello@bryanjohnson.com on 2026-03-24T12:15:25.000Z training (2x/week) - + I'll rotate listening to music, a book, podcast, or educational video. + On the weekends, I'll hike, play pickleball, ride a bike, climb, etc. - #7: Sauna - + I sauna for 20 min daily. - + 200°F (93°C) + core temp post sauna (ear) 102.4°F (39°C) + ice packs on the boys to protect fertility markers + wool hat for the head + recently, as an experiment, I introduced face and neck cooling to prot
Fwd: my morning routine (2026)
Score 0.633
· Account tjphuhs@gmail.com
· 3/24/2026, 8:50:44 AM
Fwd: my morning routine (2026) from tjphuhs@gmail.com on 2026-03-24T12:50:44.000Z > • > + I exercise for 90 min. My workout is a mixture of: > • + cardio > + strength training > + balance and stretching > + high-intensity interval training (2x/week) > • > + I'll rotate listening to music, a book, podcast, or educational video. > > + On the weekends, I'll hike, play pickleball, ride a bike, climb, etc. > > > • #7: Sauna > • > + I sauna for 20 min daily. > • + 200°F (93°C) > + core temp post sauna
Morning Briefing
Score 0.619
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 1:41:54 PM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-17T17:41:54.000Z Attached is your morning briefing PDF.
Morning Briefing
Score 0.619
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 1:42:37 PM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-17T17:42:37.000Z Attached is your morning briefing PDF.
Morning Briefing
Score 0.618
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 6:24:17 AM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-17T10:24:17.000Z Attached is your morning briefing PDF.
Morning Briefing
Score 0.618
· Account tjphuhs@gmail.com
· 3/17/2026, 6:24:17 AM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-17T10:24:17.000Z Attached is your morning briefing PDF.
Morning Briefing
Score 0.616
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 12:24:19 PM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-17T16:24:19.000Z Attached is your morning briefing PDF.
Morning Briefing
Score 0.616
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 12:34:56 PM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-17T16:34:56.000Z Attached is your morning briefing PDF.
Morning Briefing
Score 0.616
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 12:23:25 PM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-17T16:23:25.000Z Attached is your morning briefing PDF.
Morning Briefing
Score 0.616
· Account oc.tjphuhs@gmail.com
· 3/18/2026, 5:45:35 AM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-18T09:45:35.000Z Attached is your morning briefing PDF.
Morning Briefing
Score 0.616
· Account tjphuhs@gmail.com
· 3/18/2026, 5:45:35 AM
Morning Briefing from oc.tjphuhs@gmail.com on 2026-03-18T09:45:35.000Z Attached is your morning briefing PDF.