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Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.906
· Account tjphuhs@gmail.com
· 3/19/2026, 7:37:26 AM
Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from derekpruski@substack.com on 2026-03-19T11:37:26.000Z View this post on the web at https://derekpruski.substack.com/p/long-covid-and-mitochondrial-peptides This post is for educational and informational purposes only. None of this is medical advice, none of this is intended to diagnose or treat any disease or condition, and none of this should be taken as a recommendation to use any compound for any purpose. All compoun
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.892
· Account oc.tjphuhs@gmail.com
· 3/19/2026, 8:54:05 AM
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from tjphuhs@gmail.com on 2026-03-19T12:54:05.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 19, 2026 at 7:37 AM -0400 To: tjphuhs@gmail.com Subject: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests > This post is for educational and informational purposes only. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.892
· Account tjphuhs@gmail.com
· 3/19/2026, 8:54:05 AM
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from tjphuhs@gmail.com on 2026-03-19T12:54:05.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 19, 2026 at 7:37 AM -0400 To: tjphuhs@gmail.com Subject: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests > This post is for educational and informational purposes only. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.887
· Account oc.tjphuhs@gmail.com
· 3/19/2026, 8:54:05 AM
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from tjphuhs@gmail.com on 2026-03-19T12:54:05.000Z more interesting topics I’ve been sitting on for a while, and it keeps coming up enough in research circles that it deserves a thorough breakdown. > Long COVID has affected a significant number of people, and conventional medicine has largely struggled to explain why some individuals never fully recover. What’s emerging from the research, however, points toward a very
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests
Score 0.887
· Account tjphuhs@gmail.com
· 3/19/2026, 8:54:05 AM
Fwd: Long COVID & Mitochondrial Peptides: What the Research Actually Suggests from tjphuhs@gmail.com on 2026-03-19T12:54:05.000Z more interesting topics I’ve been sitting on for a while, and it keeps coming up enough in research circles that it deserves a thorough breakdown. > Long COVID has affected a significant number of people, and conventional medicine has largely struggled to explain why some individuals never fully recover. What’s emerging from the research, however, points toward a very
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.781
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z mitochondria are the bottleneck. SS-31 is a precision tool, not a generic “feel better” peptide. In conditions where mitochondrial dysfunction is genuinely the upstream driver — Barth syndrome, certain kidney injuries, dry AMD, mitochondrial disease — the effects are real. In conditions where mitochondria are downstream of bigger problems, SS-31 can support but won’t
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.774
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z View this post on the web at https://derekpruski.substack.com/p/ss-31-the-mitochondrial-peptide-with Research and educational purposes only. Nothing in this piece is medical advice. If you’re considering anything personally, that’s a conversation for a qualified clinician. Most of the SS-31 conversation in the peptide world stops at one sentence: “it repairs mitochond
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.766
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z brain concentrations achieved with subcutaneous dosing are lower than other tissues. Use this section as a “promising direction” rather than “established outcome.” The Less-Discussed Applications A quick rundown of areas where SS-31 has preclinical research that almost never gets talked about: Hearing loss. SS-31 has been studied for noise-induced and age-related hear
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.766
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z tools. And that’s why it deserves to be understood for more than just “it helps mitochondria.” This is for research and educational purposes only. Nothing in this piece is medical advice, and this isn’t a recommendation to use SS-31 personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.762
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z its open-label extension. Long-term treatment (48 weeks) showed significant improvements in: 6-minute walk test performance Cardiac stroke volume Barth Syndrome Symptom Assessment scores SS-31 received orphan drug designation for Barth syndrome and is now FDA-approved as Forzinity — making it one of the very few peptides to make it through to actual approval. HFpEF (h
Mold Toxicity & Peptides: A Comprehensive Walkthrough
Score 0.738
· Account tjphuhs@gmail.com
· 4/28/2026, 7:52:08 PM
Mold Toxicity & Peptides: A Comprehensive Walkthrough from derekpruski@substack.com on 2026-04-28T23:52:08.000Z works, but it’s downstream — you’re catching toxins after they’re already loose, hoping to clear them faster than they’re being released. It can take 5 to 8 years on this approach, and a lot of people stall out. The newer framework looks upstream — fix the immune system and mitochondria first, then detox. The logic: If your immune system is broken, it can’t recognize or clear what’s co
Mold Toxicity & Peptides: A Comprehensive Walkthrough
Score 0.732
· Account tjphuhs@gmail.com
· 4/28/2026, 7:52:08 PM
Mold Toxicity & Peptides: A Comprehensive Walkthrough from derekpruski@substack.com on 2026-04-28T23:52:08.000Z already running. It’s an offensive weapon. You don’t deploy offense before the defense is built. Research dosing in the literature varies considerably. The principle that holds across the published work: start at a fraction of the target dose and titrate up. If an RS reacts to half a Peptide-S capsule, they’re going to react to LL-37 — period. Some research protocols start at 10% of th
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.732
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z the body. Vision is metabolically expensive. Every time a photon hits a photoreceptor, mitochondria have to fire to convert that signal into something the brain can read. As mitochondria age, the photoreceptors start dying, and you get age-related macular degeneration (AMD). The ReCLAIM trials SS-31 has been studied in a series of clinical trials for dry AMD with nonc
Mold Toxicity & Peptides: A Comprehensive Walkthrough
Score 0.732
· Account tjphuhs@gmail.com
· 4/28/2026, 7:52:08 PM
Mold Toxicity & Peptides: A Comprehensive Walkthrough from derekpruski@substack.com on 2026-04-28T23:52:08.000Z killing those organisms. That’s why it’s often staged later, not first Layer 3 — Rebuild the Immune System Now that the barriers hold, you can push TH1 up and pull TH2 down without the system rebelling. Thymogen Alpha-1 / Thymosin Alpha-1 class — the cornerstone for raising TH1. Used internationally in research for respiratory infections, immune deficiency, and as a cancer adjunct TB-4
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.729
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z one of the most underrated areas of SS-31 research, and it makes total sense once you understand the kidney’s biology. Why kidneys are mitochondria-dependent. The kidney is one of the most metabolically demanding organs in the body. Specifically, the proximal tubules — the part of the nephron responsible for reabsorbing nutrients, electrolytes, and water back into the
Mold Toxicity & Peptides: A Comprehensive Walkthrough
Score 0.725
· Account tjphuhs@gmail.com
· 4/28/2026, 7:52:08 PM
Mold Toxicity & Peptides: A Comprehensive Walkthrough from derekpruski@substack.com on 2026-04-28T23:52:08.000Z can work. The “arginine salt” version of certain peptides looks similar on a label but doesn’t survive — it’s marketed as “stable” but functionally less effective. Section 5: The Layered Research Framework This is the sequencing that’s emerging from clinical observation. Each layer prepares the system for the next. Skipping ahead causes problems — running offensive peptides before defe
Zombie Cells vs. FOXO4-DRI
Score 0.723
· Account tjphuhs@gmail.com
· 2/13/2026, 6:06:10 PM
Zombie Cells vs. FOXO4-DRI from huntershealthhacks@mail.beehiiv.com on 2026-02-13T23:06:10.000Z company is developing advanced versions of this peptide and moving toward clinical phases. The animal evidence is compelling and consistent across tissues, but human data remains pending. ——————————————————————————— **Dosage ** In animal studies, dosing was approximately 5 mg/kg administered intravenously or intraperitoneally every other day. In human experimentation circles, one common approach is 3
PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching
Score 0.723
· Account tjphuhs@gmail.com
· 5/12/2026, 12:13:59 PM
PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z dysfunction in ovarian granulosa cells is one of the more recent additions to the PCOS pathophysiology picture, and it opens up a different category of peptide research. MOTS-c. A mitochondria-derived 16-amino acid peptide encoded by mitochondrial 12S rRNA. It improves insulin sensitivity, increases mitochondrial efficiency, and modulates metabolic
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.721
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z in mitochondrial DNA. Mitochondria produce it themselves. It belongs to a small class called mitochondrial-derived peptides (MDPs). What the research shows: Activates AMPK, the master energy sensor in cells. When AMPK is active, cells shift into “burn fuel, don’t store it” mode. Improves insulin sensitivity in preclinical models, meaning muscle cell
I Want to Rewrite the Narrative on SS-31 — Yes It’s an Energy Peptide, But That’s Not the Full Story
Score 0.721
· Account tjphuhs@gmail.com
· 3/29/2026, 10:36:40 PM
I Want to Rewrite the Narrative on SS-31 — Yes It’s an Energy Peptide, But That’s Not the Full Story from derekpruski@substack.com on 2026-03-30T02:36:40.000Z SS-31 doesn’t have that problem. Here’s why: There is no acute stimulatory effect No hormone release is triggered No nervous system activation occurs It works at the structural level inside the cell membrane — a process that has no relationship to time of day Because of this, SS-31 has timing flexibility that most energy-adjacent peptides
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.721
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z Integr Neurosci. 2021;15:747901. Full text [ https://substack.com/redirect/b5dbd811-3f64-4b52-9c6c-c088c0c3f253?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Aging skeletal muscle Campbell MD, Marcinek DJ, et al. Improving mitochondrial function with SS-31 reverses age-related redox stress and improves exercise tolerance in aged mice. Free Radic
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.719
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z View this post on the web at https://derekpruski.substack.com/p/a-new-mots-c-study-just-dropped-heres A new peer-reviewed study on MOTS-c was published January 9th out of the University of Copenhagen, and I’ve seen a little chatter about it online — including Coach Cam touching on it on TikTok. I wanted to give my own read on it for the community, broken down in a way that ac
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Score 0.718
· Account tjphuhs@gmail.com
· 4/6/2026, 10:43:36 PM
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides from derekpruski@substack.com on 2026-04-07T02:43:36.000Z View this post on the web at https://derekpruski.substack.com/p/lipo-c-a-cheaper-energy-alternative Research Use Only. Not Medical Advice. Educational Purposes Only. If you’ve been running mitochondrial peptides and hit a wall — or you’re looking for something that moves the needle on energy without the price tag — this one’s worth a look. Lipo-C was one of the biggest energy
PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching
Score 0.715
· Account tjphuhs@gmail.com
· 5/12/2026, 12:13:59 PM
PCOS: What It Actually Is, How It’s Managed Now, And The Peptide Mechanisms Worth Watching from derekpruski@substack.com on 2026-05-12T16:13:59.000Z These don’t address the underlying PCOS biology but may have relevance for the psychological burden. Tesofensine. Not a peptide, but worth flagging — it’s a triple monoamine reuptake inhibitor in development for obesity that’s showing strong weight loss data and may be relevant for PCOS patients who don’t tolerate GLP-1 agonists. The Honest Big Pict
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means
Score 0.714
· Account tjphuhs@gmail.com
· 4/13/2026, 11:17:06 AM
POTS, ME/CFS, and Long COVID Are Being Reclassified — Here's What That Means from derekpruski@substack.com on 2026-04-13T15:17:06.000Z the cellular level across the entire body. One small study cited in the paper found that time-restricted eating over six months improved heart rate, energy levels, and mitochondrial function in POTS patients — an interesting finding worth watching. 5. Cerebral Hypoperfusion This simply means not enough blood is getting to the brain. The paper identifies this as a