View
Semantic Search: Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Score 0.897
· Account tjphuhs@gmail.com
· 4/6/2026, 10:43:36 PM
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides from derekpruski@substack.com on 2026-04-07T02:43:36.000Z View this post on the web at https://derekpruski.substack.com/p/lipo-c-a-cheaper-energy-alternative Research Use Only. Not Medical Advice. Educational Purposes Only. If you’ve been running mitochondrial peptides and hit a wall — or you’re looking for something that moves the needle on energy without the price tag — this one’s worth a look. Lipo-C was one of the biggest energy
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Score 0.821
· Account tjphuhs@gmail.com
· 4/6/2026, 10:43:36 PM
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides from derekpruski@substack.com on 2026-04-07T02:43:36.000Z — 20mg Blood flow support. Substrate for nitric oxide synthase → produces NO → relaxes blood vessel walls → improves regional perfusion. Better delivery of everything else to metabolically active tissue. B5 — Dexpanthenol — 25mg CoA builder. Converts to Coenzyme A, which is required to activate fatty acids before carnitine can even transport them. B5 and carnitine are a pair —
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.701
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z mitochondria are the bottleneck. SS-31 is a precision tool, not a generic “feel better” peptide. In conditions where mitochondrial dysfunction is genuinely the upstream driver — Barth syndrome, certain kidney injuries, dry AMD, mitochondrial disease — the effects are real. In conditions where mitochondria are downstream of bigger problems, SS-31 can support but won’t
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.700
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z in mitochondrial DNA. Mitochondria produce it themselves. It belongs to a small class called mitochondrial-derived peptides (MDPs). What the research shows: Activates AMPK, the master energy sensor in cells. When AMPK is active, cells shift into “burn fuel, don’t store it” mode. Improves insulin sensitivity in preclinical models, meaning muscle cell
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.683
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z what mitochondria need to produce ATP and activates repair proteins that depend on it. > MOTS-c is the capacity builder — it signals the body to create more mitochondria and become more metabolically efficient, amplifying what NAD+ can do. > 5-Amino-1MQ is the preservation mechanism — it blocks the enzyme that degrades NAD+ precursors, extending the effectiveness of the NAD+ being supplie
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.683
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z what mitochondria need to produce ATP and activates repair proteins that depend on it. > MOTS-c is the capacity builder — it signals the body to create more mitochondria and become more metabolically efficient, amplifying what NAD+ can do. > 5-Amino-1MQ is the preservation mechanism — it blocks the enzyme that degrades NAD+ precursors, extending the effectiveness of the NAD+ being supplie
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.681
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z View this post on the web at https://derekpruski.substack.com/p/ss-31-the-mitochondrial-peptide-with Research and educational purposes only. Nothing in this piece is medical advice. If you’re considering anything personally, that’s a conversation for a qualified clinician. Most of the SS-31 conversation in the peptide world stops at one sentence: “it repairs mitochond
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.681
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.681
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
I Want to Rewrite the Narrative on SS-31 — Yes It’s an Energy Peptide, But That’s Not the Full Story
Score 0.680
· Account tjphuhs@gmail.com
· 3/29/2026, 10:36:40 PM
I Want to Rewrite the Narrative on SS-31 — Yes It’s an Energy Peptide, But That’s Not the Full Story from derekpruski@substack.com on 2026-03-30T02:36:40.000Z SS-31 doesn’t have that problem. Here’s why: There is no acute stimulatory effect No hormone release is triggered No nervous system activation occurs It works at the structural level inside the cell membrane — a process that has no relationship to time of day Because of this, SS-31 has timing flexibility that most energy-adjacent peptides
Do You Actually Need SS-31 for Mitochondrial Repair?
Score 0.679
· Account tjphuhs@gmail.com
· 4/2/2026, 3:03:01 PM
Do You Actually Need SS-31 for Mitochondrial Repair? from derekpruski@substack.com on 2026-04-02T19:03:01.000Z — the wall where all the energy production actually happens. Cardiolipin’s job is to hold everything in place. It keeps the energy-producing proteins organized, maintains the physical structure of the membrane, and supports the courier proteins that shuttle electrons through the process. When cardiolipin gets damaged by excess free radicals, the whole system starts to fall apart. The pr
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.677
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z brain concentrations achieved with subcutaneous dosing are lower than other tissues. Use this section as a “promising direction” rather than “established outcome.” The Less-Discussed Applications A quick rundown of areas where SS-31 has preclinical research that almost never gets talked about: Hearing loss. SS-31 has been studied for noise-induced and age-related hear
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.673
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-vs-nad-the-beginners-guide I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one research protocols should implement first. This post breaks down what each one actually does, how they differ, and gives you a simple decision tree to think throu
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.672
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z tools. And that’s why it deserves to be understood for more than just “it helps mitochondria.” This is for research and educational purposes only. Nothing in this piece is medical advice, and this isn’t a recommendation to use SS-31 personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who
I Want to Rewrite the Narrative on SS-31 — Yes It’s an Energy Peptide, But That’s Not the Full Story
Score 0.669
· Account tjphuhs@gmail.com
· 3/29/2026, 10:36:40 PM
I Want to Rewrite the Narrative on SS-31 — Yes It’s an Energy Peptide, But That’s Not the Full Story from derekpruski@substack.com on 2026-03-30T02:36:40.000Z View this post on the web at https://derekpruski.substack.com/p/i-want-to-rewrite-the-narrative-on SS-31 gets filed under “energy peptides” in almost every conversation I see. That label isn’t completely wrong — but it’s incomplete enough that it’s leading researchers to approach it the wrong way, time it wrong, and draw the wrong conclusi
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.666
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.666
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.658
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z the body. Vision is metabolically expensive. Every time a photon hits a photoreceptor, mitochondria have to fire to convert that signal into something the brain can read. As mitochondria age, the photoreceptors start dying, and you get age-related macular degeneration (AMD). The ReCLAIM trials SS-31 has been studied in a series of clinical trials for dry AMD with nonc
Do You Actually Need SS-31 for Mitochondrial Repair?
Score 0.657
· Account tjphuhs@gmail.com
· 4/2/2026, 3:03:01 PM
Do You Actually Need SS-31 for Mitochondrial Repair? from derekpruski@substack.com on 2026-04-02T19:03:01.000Z to build up over years — through aging, sustained oxidative damage, long histories of calorie cycling, or significant illness. If you’re deep in a cut, training hard, and have a history of restrict and binge cycles — you’re most likely dealing with stress, not dysfunction. Stress resolves with recovery. Dysfunction requires more targeted intervention. Treating one like the other just ad
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.652
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.652
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.651
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z its open-label extension. Long-term treatment (48 weeks) showed significant improvements in: 6-minute walk test performance Cardiac stroke volume Barth Syndrome Symptom Assessment scores SS-31 received orphan drug designation for Barth syndrome and is now FDA-approved as Forzinity — making it one of the very few peptides to make it through to actual approval. HFpEF (h
New Product: Mitochondrial B12
Score 0.648
· Account tjphuhs@gmail.com
· 4/9/2026, 7:06:17 AM
New Product: Mitochondrial B12 from support@simplepeptide.com on 2026-04-09T11:06:17.000Z A closer look at its role in mitochondrial and metabolic research This email was sent to you as HTML-only. To view it, please visit: https://ptv.soundestlink.com/ce/v/6864b11c9f318c74accf8c6b/69d636772ee3c1bbc4ee1af6 ************************** Make sure you keep getting our latest offers and add support@simplepeptide.com to your address book. Unsubscribe https://ptv.soundestlink.com/contactsPreferences/v2/u
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.644
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z pages, has described MOTS-c as promoting biogenesis — meaning it helps you grow more mitochondria. This study says that’s not what’s primarily happening. MOTS-c is making your existing mitochondria work better. Same number, higher output. Think of it like tuning an engine rather than adding more cylinders. How Does It Do That? The Two Pathways The researchers found that MOTS-
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.643
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z Here’s a walkthrough to help you think about which direction matches your research interests. Read through top to bottom, stop at the first question where the answer is yes. 1. Is your focus primarily metabolic pathways? (glucose handling, insulin sensitivity, AMPK signaling) → MOTS-c is more targeted. Focus area: AMPK activation literature. Key mod