View
Semantic Search: Inside Mitochondrial B12
Inside Mitochondrial B12
Score 0.759
· Account tjphuhs@gmail.com
· 4/8/2026, 7:01:21 AM
Inside Mitochondrial B12 from support@simplepeptide.com on 2026-04-08T11:01:21.000Z A closer look at its role in mitochondrial and metabolic research This email was sent to you as HTML-only. To view it, please visit: https://ptv.soundestlink.com/ce/v/6864b11c9f318c74accf8c6b/69d56585f78b9ef697c62836 ************************** Make sure you keep getting our latest offers and add support@simplepeptide.com to your address book. Unsubscribe https://ptv.soundestlink.com/contactsPreferences/v2/unsubsc
New Product: Mitochondrial B12
Score 0.678
· Account tjphuhs@gmail.com
· 4/9/2026, 7:06:17 AM
New Product: Mitochondrial B12 from support@simplepeptide.com on 2026-04-09T11:06:17.000Z A closer look at its role in mitochondrial and metabolic research This email was sent to you as HTML-only. To view it, please visit: https://ptv.soundestlink.com/ce/v/6864b11c9f318c74accf8c6b/69d636772ee3c1bbc4ee1af6 ************************** Make sure you keep getting our latest offers and add support@simplepeptide.com to your address book. Unsubscribe https://ptv.soundestlink.com/contactsPreferences/v2/u
Do You Actually Need SS-31 for Mitochondrial Repair?
Score 0.594
· Account tjphuhs@gmail.com
· 4/2/2026, 3:03:01 PM
Do You Actually Need SS-31 for Mitochondrial Repair? from derekpruski@substack.com on 2026-04-02T19:03:01.000Z — the wall where all the energy production actually happens. Cardiolipin’s job is to hold everything in place. It keeps the energy-producing proteins organized, maintains the physical structure of the membrane, and supports the courier proteins that shuttle electrons through the process. When cardiolipin gets damaged by excess free radicals, the whole system starts to fall apart. The pr
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12
Score 0.589
· Account tjphuhs@gmail.com
· 3/30/2026, 4:25:58 PM
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12 from derekpruski@substack.com on 2026-03-30T20:25:58.000Z processes NAD+ is a coenzyme required for energy production in every cell in the body. Research interest around NAD+ has expanded significantly in recent years, particularly around its decline with age and the downstream effects on cellular function and longevity B6 and methionine are studied as methylation cofactors — methylation being the process the body uses to reg
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.584
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z in mitochondrial DNA. Mitochondria produce it themselves. It belongs to a small class called mitochondrial-derived peptides (MDPs). What the research shows: Activates AMPK, the master energy sensor in cells. When AMPK is active, cells shift into “burn fuel, don’t store it” mode. Improves insulin sensitivity in preclinical models, meaning muscle cell
Do You Actually Need SS-31 for Mitochondrial Repair?
Score 0.582
· Account tjphuhs@gmail.com
· 4/2/2026, 3:03:01 PM
Do You Actually Need SS-31 for Mitochondrial Repair? from derekpruski@substack.com on 2026-04-02T19:03:01.000Z View this post on the web at https://derekpruski.substack.com/p/do-you-actually-need-ss-31-for-mitochondrial Everyone always brings up SS-31 when mitochondrial stacks come up. It’s almost reflexive — someone mentions fatigue or recovery issues, and SS-31 gets thrown into the conversation immediately. But here’s the question nobody actually stops to ask first: how do you know if your mit
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides
Score 0.577
· Account tjphuhs@gmail.com
· 4/6/2026, 10:43:36 PM
Lipo-C: A Cheaper Energy Alternative To Mitochondrial Peptides from derekpruski@substack.com on 2026-04-07T02:43:36.000Z — 20mg Blood flow support. Substrate for nitric oxide synthase → produces NO → relaxes blood vessel walls → improves regional perfusion. Better delivery of everything else to metabolically active tissue. B5 — Dexpanthenol — 25mg CoA builder. Converts to Coenzyme A, which is required to activate fatty acids before carnitine can even transport them. B5 and carnitine are a pair —
Do You Actually Need SS-31 for Mitochondrial Repair?
Score 0.570
· Account tjphuhs@gmail.com
· 4/2/2026, 3:03:01 PM
Do You Actually Need SS-31 for Mitochondrial Repair? from derekpruski@substack.com on 2026-04-02T19:03:01.000Z organs in the body and can’t store ATP reserves the way muscle can. It needs a constant, reliable supply — so when mitochondrial output drops, cognitive performance often takes the first visible hit. Metabolic sluggishness. Difficulty losing fat despite controlled intake. Energy dips after eating. Poor glucose handling. When energy production at the cellular level is inefficient, your m
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.570
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.570
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.565
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.565
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z every cell in your body. Their job is to take the food you eat and convert it into usable energy. When they work well, you feel it — better energy, better metabolism, better recovery. When they decline, everything suffers. > This blend targets mitochondrial function from three different angles at the same time. Each compound has its own job, but they work together in a way that makes the
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.560
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-vs-nad-the-beginners-guide I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one research protocols should implement first. This post breaks down what each one actually does, how they differ, and gives you a simple decision tree to think throu
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12
Score 0.559
· Account tjphuhs@gmail.com
· 3/30/2026, 4:25:58 PM
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12 from derekpruski@substack.com on 2026-03-30T20:25:58.000Z View this post on the web at https://derekpruski.substack.com/p/peptira-just-dropped-3-new-amino If you’ve been following along, you know B12 is one of those things that shows up in virtually every amino blend on the market. The problem is that research levels tend to run significantly higher than what’s considered ideal, and for researchers trying to isolate variables
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.556
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z mitochondria are the bottleneck. SS-31 is a precision tool, not a generic “feel better” peptide. In conditions where mitochondrial dysfunction is genuinely the upstream driver — Barth syndrome, certain kidney injuries, dry AMD, mitochondrial disease — the effects are real. In conditions where mitochondria are downstream of bigger problems, SS-31 can support but won’t
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.554
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z a number of mitochondrial parameters — including redox handling, mitochondrial integrity, and OXPHOS efficiency — jointly indicating a mechanistic basis for the observed functional improvements. Breaking those terms down: Redox handling — how well the cell manages oxidative stress Mitochondrial integrity — the structural health of the mitochondria themselves OXPHOS efficiency
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.552
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z View this post on the web at https://derekpruski.substack.com/p/ss-31-the-mitochondrial-peptide-with Research and educational purposes only. Nothing in this piece is medical advice. If you’re considering anything personally, that’s a conversation for a qualified clinician. Most of the SS-31 conversation in the peptide world stops at one sentence: “it repairs mitochond
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.547
· Account oc.tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z what mitochondria need to produce ATP and activates repair proteins that depend on it. > MOTS-c is the capacity builder — it signals the body to create more mitochondria and become more metabolically efficient, amplifying what NAD+ can do. > 5-Amino-1MQ is the preservation mechanism — it blocks the enzyme that degrades NAD+ precursors, extending the effectiveness of the NAD+ being supplie
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.547
· Account tjphuhs@gmail.com
· 3/27/2026, 4:33:04 PM
Fwd: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from tjphuhs@gmail.com on 2026-03-27T20:33:04.000Z what mitochondria need to produce ATP and activates repair proteins that depend on it. > MOTS-c is the capacity builder — it signals the body to create more mitochondria and become more metabolically efficient, amplifying what NAD+ can do. > 5-Amino-1MQ is the preservation mechanism — it blocks the enzyme that degrades NAD+ precursors, extending the effectiveness of the NAD+ being supplie
Do You Actually Need SS-31 for Mitochondrial Repair?
Score 0.547
· Account tjphuhs@gmail.com
· 4/2/2026, 3:03:01 PM
Do You Actually Need SS-31 for Mitochondrial Repair? from derekpruski@substack.com on 2026-04-02T19:03:01.000Z despite doing everything right, recovery is clearly impaired, and both mental and physical fatigue show up together in a pattern that doesn’t resolve — that’s when mitochondrial repair becomes worth exploring seriously in a research context. If you’re just beat up from a hard cut and a heavy training load, more food and sleep will do more for you than any peptide. Start there first. For
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.546
· Account tjphuhs@gmail.com
· 3/27/2026, 4:31:44 PM
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from derekpruski@substack.com on 2026-03-27T20:31:44.000Z View this post on the web at https://derekpruski.substack.com/p/nad-mots-c-5-amino-1mq-breaking-down For research purposes only. Not for human consumption. A lot of you have been asking about this one, so I figured we’d just walk through each component and explain how it works and whether the combination actually makes sense. By the end of this you’ll have a clear picture of what each c
Urolithin A: The Most Underrated Compound in Longevity
Score 0.544
· Account tjphuhs@gmail.com
· 5/2/2026, 11:16:56 AM
Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z stop efficiently clearing out damaged mitochondria. Dysfunctional mitochondria pile up, leak oxidative stress, fail to make energy efficiently, and contribute to nearly every “hallmark of aging” you can name. Mitophagy is the cellular cleanup process that selectively removes damaged mitochondria so new, healthy ones can take their place. It’s one of the most important quality-control
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize
Score 0.543
· Account tjphuhs@gmail.com
· 5/6/2026, 2:59:21 PM
SS-31: The Mitochondrial Peptide With Way More Uses Than People Realize from derekpruski@substack.com on 2026-05-06T18:59:21.000Z tools. And that’s why it deserves to be understood for more than just “it helps mitochondria.” This is for research and educational purposes only. Nothing in this piece is medical advice, and this isn’t a recommendation to use SS-31 personally. If you’re interested in the topic for any non-research reason, that’s a conversation for a qualified medical professional who
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.539
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z pages, has described MOTS-c as promoting biogenesis — meaning it helps you grow more mitochondria. This study says that’s not what’s primarily happening. MOTS-c is making your existing mitochondria work better. Same number, higher output. Think of it like tuning an engine rather than adding more cylinders. How Does It Do That? The Two Pathways The researchers found that MOTS-
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.536
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >