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Semantic Search: GLPs Are Back at Modern Aminos — Here’s Why
GLPs Are Back at Modern Aminos — Here’s Why
Score 0.838
· Account tjphuhs@gmail.com
· 1/27/2026, 11:03:52 AM
GLPs Are Back at Modern Aminos — Here’s Why from cs@modernaminos.com on 2026-01-27T16:03:52.000Z Transparency first. Here’s why GLPs were removed, and why they’re now available again. This email was sent to you as HTML-only. To view it, please visit: https://glh.soundestlink.com/ce/v/68732f567657959f48cbbc66/6978e1a0a338842ab0915008 ************************** Make sure you keep getting our latest offers and add cs@modernaminos.com to your address book. Unsubscribe https://glh.soundestlink.com/co
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.703
· Account tjphuhs@gmail.com
· 4/25/2026, 3:54:50 PM
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z conditions longer, protein denaturation by pepsin has more time to occur. Whether this translates to meaningfully better downstream amino acid absorption is less clear in the human data, but mechanistically it’s plausible. Fat digestion timing shifts. Fats normally slow gastric emptying on their own as a feedback signal. On a GLP-1, that signal is layered on top of
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.698
· Account tjphuhs@gmail.com
· 5/3/2026, 10:40:57 AM
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from onthepen@substack.com on 2026-05-03T14:40:57.000Z View this post on the web at https://onthepen.substack.com/p/a-molecular-stapler-could-make-glp The body has always known something drug developers are still learning: shape matters. Not just the shape of a molecule as it enters a receptor, but the shape it holds after hours in the bloodstream, after the body has done everything it does to break thi
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.697
· Account tjphuhs@gmail.com
· 5/3/2026, 10:40:57 AM
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from onthepen@substack.com on 2026-05-03T14:40:57.000Z Utah and co-founded a company called Sethera Therapeutics built around this enzyme platform. The research was funded by the National Institute of General Medical Sciences, part of the National Institutes of Health. This work is proof of concept, meaning it is a meaningful early step but not a finished drug. The GLP-1 analogs used in the experiments
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.696
· Account oc.tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z time, with nothing left unreacted. In laboratory terms, that is a perfect result. > That closed ring at the tail end of the peptide does several things worth understanding. It blocks the exoproteases that would otherwise begin dismantling the key from that end. It also stiffens the tail of the molecule, reducing the kind of loose molecular movement
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.696
· Account tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z time, with nothing left unreacted. In laboratory terms, that is a perfect result. > That closed ring at the tail end of the peptide does several things worth understanding. It blocks the exoproteases that would otherwise begin dismantling the key from that end. It also stiffens the tail of the molecule, reducing the kind of loose molecular movement
Why Researchers Trust Modern Aminos 🧪
Score 0.694
· Account tjphuhs@gmail.com
· 2/14/2026, 12:46:49 AM
Why Researchers Trust Modern Aminos 🧪 from cs@modernaminos.com on 2026-02-14T05:46:49.000Z 96 Why Researchers Trust Modern Aminos 🧪 Third-party tested. Lightning fast shipping. Real people ready to help — 24/7. ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.693
· Account tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z a finished drug. The GLP-1 analogs used in the experiments were stripped of their fatty acid chains, so they are not identical to the medications currently on the market. Whether PapB can be applied to the full clinical compounds, and whether the ring-shaped structures it creates show meaningfully better performance in animal studies or human trial
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.693
· Account oc.tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z a finished drug. The GLP-1 analogs used in the experiments were stripped of their fatty acid chains, so they are not identical to the medications currently on the market. Whether PapB can be applied to the full clinical compounds, and whether the ring-shaped structures it creates show meaningfully better performance in animal studies or human trial
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.690
· Account tjphuhs@gmail.com
· 4/24/2026, 9:05:46 AM
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from derekpruski@substack.com on 2026-04-24T13:05:46.000Z single dose and push efficacy into territory that previously only bariatric surgery could reach. ═══════════════════════════════ THE FIVE RECEPTORS AND WHY EACH MATTERS The rumored Lilly quintuple reportedly targets GLP-1, GIP, glucagon, amylin, and calcitonin. Let’s break down what each one actually does. GLP-1 (Glucagon-Like Peptide-1) This is the backbone of every m
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.689
· Account tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z the drugs work. But the question researchers keep returning to is whether they can work better, last longer, and hold their shape more completely against the body’s own cleanup systems. > A team at the University of Utah thinks a bacterial enzyme that almost no one was paying attention to might be part of the answer. > The lock, the key, and what h
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.689
· Account oc.tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z the drugs work. But the question researchers keep returning to is whether they can work better, last longer, and hold their shape more completely against the body’s own cleanup systems. > A team at the University of Utah thinks a bacterial enzyme that almost no one was paying attention to might be part of the answer. > The lock, the key, and what h
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.688
· Account tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z actually does. > GLP-1 (Glucagon-Like Peptide-1) > This is the backbone of every modern weight loss drug, from semaglutide forward. GLP-1 stimulates insulin release when blood sugar is high, suppresses glucagon (preventing unnecessary sugar release from the liver), and slows gastric emptying so you feel full longer. It also acts directly on the brain’s appetite centers i
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.688
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z actually does. > GLP-1 (Glucagon-Like Peptide-1) > This is the backbone of every modern weight loss drug, from semaglutide forward. GLP-1 stimulates insulin release when blood sugar is high, suppresses glucagon (preventing unnecessary sugar release from the liver), and slows gastric emptying so you feel full longer. It also acts directly on the brain’s appetite centers i
Fwd: Compound Tirzepatide & Semaglutide Updates!
Score 0.685
· Account tjphuhs@gmail.com
· 3/17/2026, 5:51:48 PM
Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z exclusive DDC list explained Novo’s lab findings 302% dose shocker Catalent’s contamination mess Lilly’s B12 tirzepatide bombshell Is the molecule changing? New oral GLP-1 contender MASSIVE: Compound Tirzepatide and Semaglutide Updates! Dave Knapp GLP-1 Industry Insider Episode Do you trust compounded GLP-1s based on real-world experience, or do findings like the ones discussed today change your p
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12
Score 0.684
· Account tjphuhs@gmail.com
· 3/30/2026, 4:25:58 PM
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12 from derekpruski@substack.com on 2026-03-30T20:25:58.000Z processes NAD+ is a coenzyme required for energy production in every cell in the body. Research interest around NAD+ has expanded significantly in recent years, particularly around its decline with age and the downstream effects on cellular function and longevity B6 and methionine are studied as methylation cofactors — methylation being the process the body uses to reg
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.683
· Account tjphuhs@gmail.com
· 5/3/2026, 10:40:57 AM
A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from onthepen@substack.com on 2026-05-03T14:40:57.000Z pharmacologically active cores of each drug while leaving off the fatty acid chains used for extended release. To the tail end of each peptide, they attached a short additional sequence that PapB could recognize and staple into a ring. When they added the enzyme, it completed the ring on all three analogs, every single time, with nothing left unreac
The Next Wave of GLP-1s Is Coming
Score 0.679
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z Happy Tuesday! There are two peptides quietly making waves in the clinical space that will demand all of our attention over the next 24 months. They don't work like semaglutide, they don't work like tirzepatide, and the clinical data is turning heads. I just dropped a brand new video breaking down survodutide and mazdutide. Survodutide & Mazdutide | The GLP-1/Glucagon Duo That Could Rival Reta:
💝 My Favorite Peptides for MOMS!!
Score 0.678
· Account tjphuhs@gmail.com
· 5/10/2026, 9:23:48 AM
💝 My Favorite Peptides for MOMS!! from jeff@projectbiohacked.com on 2026-05-10T13:23:48.000Z Lets lower inflammation, let's sleep, let's recover, let's dial things in and let weight do what its going to do. *What Ive seen GLPs do for chronic inflammation is life changing for many individuals,* what it does for REVERSING insulin resistance is unmatched. Which of course both of these benefits often times result in weight loss. I wont go deep down the rabbit hole here but I just dont want to prese
The Next Wave of GLP-1s Is Coming
Score 0.676
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12
Score 0.675
· Account tjphuhs@gmail.com
· 3/30/2026, 4:25:58 PM
Peptira Just Dropped 3 New Amino Blends — And None of Them Contain B12 from derekpruski@substack.com on 2026-03-30T20:25:58.000Z View this post on the web at https://derekpruski.substack.com/p/peptira-just-dropped-3-new-amino If you’ve been following along, you know B12 is one of those things that shows up in virtually every amino blend on the market. The problem is that research levels tend to run significantly higher than what’s considered ideal, and for researchers trying to isolate variables
Do GLP-1s Kill Your Testosterone?
Score 0.675
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z The Ranger and Marine studies show 20-60% increases. So even if total testosterone looks “fine” on paper, free testosterone — the active fraction — can be dramatically lower because more of the total is bound up. If your RS pulls labs and only checks total T, the picture looks better than it is. Always pull total T, free T, and SHBG together. Otherwise you’re guessing. Section 5: Why it’s not just hormone
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.673
· Account oc.tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: May 3, 2026 at 10:41 AM -0400 To: tjphuhs@gmail.com Subject: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. > The body has always known something drug developers are still learning: shape matters. > ͏
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria.
Score 0.673
· Account tjphuhs@gmail.com
· 5/3/2026, 2:45:39 PM
Fwd: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. from tjphuhs@gmail.com on 2026-05-03T18:45:39.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: May 3, 2026 at 10:41 AM -0400 To: tjphuhs@gmail.com Subject: A Molecular Stapler Could Make GLP-1 Drugs Last Longer. Scientists Borrowed It From Bacteria. > The body has always known something drug developers are still learning: shape matters. > ͏
Retatrutide Is Too Good… And That’s The Problem
Score 0.673
· Account tjphuhs@gmail.com
· 3/24/2026, 9:24:24 PM
Retatrutide Is Too Good… And That’s The Problem from onthepen@substack.com on 2026-03-25T01:24:24.000Z View this post on the web at https://onthepen.substack.com/p/retatrutide-is-too-good-and-thats There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. From new signals out of Washington that could impact access, to powerful new data on next-generation treatments like retatrutide, to wher