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Semantic Search: GLP-1s vs. Fertility
GLP-1s vs. Fertility
Score 0.805
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z Happy Monday! Taylor and I are trying to have a baby. As I do with most everything in my life, I research as much as I can to achieve the desired outcome. Studies I used to skim now feel much more personal. And the one that's been on my mind lately is from Dr. Shanna Swan. If you haven't read her book _Countdown_, here's the short version. Sperm concentration in Western men decreased by more than 50% betwee
GLP-1s vs. Fertility
Score 0.777
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z all. For couples whose fertility is being dragged down by metabolic dysfunction, GLP-1s are the most promising pharmacological lever I've seen in a decade. The female data on PCOS pregnancy rates is the strongest signal in the whole literature. The male data is catching up. The next 24 months of trial data will tell us a lot. I'll keep you posted on what we learn, on our journey, and on the science. GLP-1s
GLP-1s vs. Fertility
Score 0.776
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z ovarian steroidogenesis, granulosa cell biology, and the FSH-cAMP-BMP signaling pathway. It's likely a direct ovarian effect layered on top of metabolic improvement. ——————————————————————————— **Microdosing for Fertility** Here's where I'm going to get speculative. Most of the GLP-1 fertility research uses standard or high doses. The kind aimed at meaningful weight loss. 1mg semaglutide weekly. 3mg liraglu
GLP-1s vs. Fertility
Score 0.756
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z but the question is whether the clinical data back it up. ——————————————————————————— **The Male Data** In a 2023 trial, La Vignera and colleagues gave liraglutide to obese men with metabolic hypogonadism and severe erectile dysfunction. After 4 months, semen concentration, motility, and morphology all significantly improved. Erectile function scores improved more than with conventional fertility treatment
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.734
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.734
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.721
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-pregnancy-fears-vs-reality If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversation matters. These are not casual medications for this community, they are often the first thing that actually moved the needle after y
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.712
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z of trying everything else. For many others, it was the first real hope offered, after the promises of metabolic surgeries failed to deliver as promised. > That is exactly why pregnancy can add such a complex layer to the journey, because the same medication that helped restore metabolic health is also restoring ovulation in ways many women using GLP-1 therapies did not necessarily
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.712
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z of trying everything else. For many others, it was the first real hope offered, after the promises of metabolic surgeries failed to deliver as promised. > That is exactly why pregnancy can add such a complex layer to the journey, because the same medication that helped restore metabolic health is also restoring ovulation in ways many women using GLP-1 therapies did not necessarily
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.696
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z and this is not some small corner of the audience. This is a huge group of women who have spent years being told their condition was secondary to weight instead of something with its own biology and its own set of levers. In the review, GLP-1 therapies were associated with improvements in both metabolic and reproductive markers in women with PCOS, including signals around insulin r
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.696
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z and this is not some small corner of the audience. This is a huge group of women who have spent years being told their condition was secondary to weight instead of something with its own biology and its own set of levers. In the review, GLP-1 therapies were associated with improvements in both metabolic and reproductive markers in women with PCOS, including signals around insulin r
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.690
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z expect at this stage. Rates of gestational diabetes, hypertensive disorders, preterm birth, and gestational weight gain were all over the place depending on the study, with no single direction that clearly stands out. Where this really lands for the OTP community is with Polycystic Ovary Syndrome, and this is not some small corner of the audience. This is a huge group of women who h
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.685
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.685
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.673
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z ovulation becomes the outcome, the framing starts to move closer to what patients have been describing all along. Lactation is still largely an unknown, which is not surprising given how early this entire space is. There is one small pharmacokinetic study involving Semaglutide [ chatgpt://generic-entity?number=3 ] that did not detect transfer into breast milk, but the patient pool w
GLP-1 vs GLP-2 vs GLP-3
Score 0.652
· Account tjphuhs@gmail.com
· 5/14/2026, 9:00:21 AM
GLP-1 vs GLP-2 vs GLP-3 from happy@happypeptides.com on 2026-05-14T13:00:21.000Z A simple comparison of the three. This email was sent to you as HTML-only. To view it, please visit: https://wfg.soundestlink.com/ce/v/68a8a1cb95c4ac11474be077/6a04d2931ac007f30c9a1cd2 ************************** Make sure you keep getting our latest offers and add happy@happypeptides.com to your address book. Unsubscribe https://wfg.soundestlink.com/contactsPreferences/v2/unsubscribe/?b=68a8a136cfa3b70cffc67e5f&c=68
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.648
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z and produce mood-adjacent effects through its central mechanism. Dosing being explored runs 500 mcg – 2 mg per research administration, administered 1–2 hours before the relevant observation window. Most community research starts at the lower end — 500 mcg to 1 mg — to assess tolerance before titrating up. Frequency is kept to a maximum of 2–3x per week to avoid the receptors
The Next Wave of GLP-1s Is Coming
Score 0.645
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A
The Next Wave of GLP-1s Is Coming
Score 0.639
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z fat and energy expenditure benefits that GIP agonism simply does not. Retatrutide is still king on paper. It hits all three receptors and delivers the most weight loss. But survodutide and mazdutide are not far behind. And for people who need an alternative, or who want to cycle compounds to maintain receptor sensitivity, these fill a real gap. ——————————————————————————— **They're Not the Same
Do GLP-1s Kill Your Testosterone?
Score 0.639
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z then signals back to the hypothalamus to slow GnRH release, suppressing the whole axis from the top. Insulin resistance. Impairs Leydig cell function and HPG signaling. Chronic inflammation. Adipose tissue releases inflammatory cytokines that further suppress the axis. This is the population the GLP-1 trials are studying. So the starting line for these studies is already low T, and the question becomes: d
Do GLP-1s Kill Your Testosterone?
Score 0.638
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z (STEP 1) Tirzepatide: ~21% loss at 72 weeks (SURMOUNT-1) Peptide-R (triple-agonist): ~24% at 48 weeks (phase 2), and 28.7% at 68 weeks in the recent phase 3 TRIUMPH-4 readout. Placebo-adjusted: 26.6%. Once weight loss gets that aggressive, you’re no longer just dropping fat — you’re forcing the body into sustained caloric deficit territory that the HPG axis interprets as famine. And the famine response is
Do GLP-1s Kill Your Testosterone?
Score 0.638
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z None of this is medical advice. Anyone running these compounds in any human capacity should be working with a clinician monitoring full labs (total T, free T, LH, FSH, SHBG, estradiol, prolactin, fasting insulin, cortisol, full thyroid panel). If your RS is obese and on a moderate dose The data suggests testosterone will likely improve as weight comes off. The intervention is mostly hands-off: stay the co
Do GLP-1s Kill Your Testosterone?
Score 0.634
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z The Ranger and Marine studies show 20-60% increases. So even if total testosterone looks “fine” on paper, free testosterone — the active fraction — can be dramatically lower because more of the total is bound up. If your RS pulls labs and only checks total T, the picture looks better than it is. Always pull total T, free T, and SHBG together. Otherwise you’re guessing. Section 5: Why it’s not just hormone
Autoimmune, Fertility, and GLP-1s
Score 0.632
· Account tjphuhs@gmail.com
· 4/24/2026, 6:05:34 PM
Autoimmune, Fertility, and GLP-1s from huntershealthhacks@mail.beehiiv.com on 2026-04-24T22:05:34.000Z I'd actually use if I wanted a proactive anti-cancer cycle once or twice a year. ——————————————————————————— **Healthy seniors and statins.** I told the story of Taylor's dad. 80 pounds overweight, A1C of nine or ten, on statins for "perfect cholesterol." I told him to throw the statins in the trash and start testosterone. Three months later, his A1C dropped two points, and his cholesterol stay
Massive GLP-1 Data From ECO 2026
Score 0.632
· Account tjphuhs@gmail.com
· 5/13/2026, 10:52:49 AM
Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z weeks. Two cohorts: those coming off Zepbound and those coming off Wegovy. 376 participants total. They started orforglipron at 12mg and titrated up every four weeks, targeting a maximum of 36mg. A rescue protocol allowed escalation or a switch from placebo to orforglipron after week 24 for anyone who regained more than half their original loss. One detail to keep in mind: there was a two-week screening gap b