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GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.906
· Account tjphuhs@gmail.com
· 4/25/2026, 2:00:53 PM
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from derekpruski@substack.com on 2026-04-25T18:00:53.000Z View this post on the web at https://derekpruski.substack.com/p/glp-1s-and-slowed-gastric-emptying One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — it’s the gut motility piece. And it’s the piece that generates the most confusion when researchers start asking how other orally administered
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.899
· Account tjphuhs@gmail.com
· 4/25/2026, 2:00:53 PM
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from derekpruski@substack.com on 2026-04-25T18:00:53.000Z onset to be delayed, expect peaks to be softer, and don’t interpret a delayed onset as a failure of the protocol. The compound is in circulation. It’s just taking a longer path to get there. Understanding the mechanism is the difference between confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.897
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z misinformation floating around — most of it landing on the wrong side of “things won’t absorb.” That’s not what the literature shows. What the literature shows is more nuanced, and understanding the mechanism makes the picture a lot clearer. > The Mechanism > GLP-1 receptor agonists slow gastric emptying through a few overlapping pathways. > The receptors are densely
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.897
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z misinformation floating around — most of it landing on the wrong side of “things won’t absorb.” That’s not what the literature shows. What the literature shows is more nuanced, and understanding the mechanism makes the picture a lot clearer. > The Mechanism > GLP-1 receptor agonists slow gastric emptying through a few overlapping pathways. > The receptors are densely
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.887
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most cases — preserved. > This article is for research and educational purposes only. The compounds and protocols discussed are intended for in vitro and laboratory research use. Nothing in this article constitutes medical advice, clinical guidance, or
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.887
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most cases — preserved. > This article is for research and educational purposes only. The compounds and protocols discussed are intended for in vitro and laboratory research use. Nothing in this article constitutes medical advice, clinical guidance, or
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.882
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 2:01 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption > One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — i
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.882
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 2:01 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption > One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — i
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.870
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z > The compounds where this PK shift becomes noteworthy in the published literature are the ones where timing of the peak is part of the mechanism, or where a sharp Cmax is what produces the intended effect: > Fast-onset agents where the curve shape is the effect — the onset profile changes, and the shifted Tmax can create the impression that something isn’t working wh
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.870
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z > The compounds where this PK shift becomes noteworthy in the published literature are the ones where timing of the peak is part of the mechanism, or where a sharp Cmax is what produces the intended effect: > Fast-onset agents where the curve shape is the effect — the onset profile changes, and the shifted Tmax can create the impression that something isn’t working wh
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.869
· Account tjphuhs@gmail.com
· 4/25/2026, 2:00:53 PM
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from derekpruski@substack.com on 2026-04-25T18:00:53.000Z how much compound actually entered systemic circulation, tends to be similar across most studied agents. That last point is the one most people miss. Slower does not mean less. For most orally administered compounds, the full dose still reaches circulation; it just arrives on a delayed, smoothed-out timeline. Where the Kinetics Actually Matter The compounds where th
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.839
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z means “you digest your food better” — and like most popular claims, it’s partially true, partially misleading, and worth unpacking properly. > Let’s walk through it. > The Mechanism Recap > Quick refresher from Part 1: GLP-1 receptor agonists slow gastric emptying by reducing antral contractility, increasing pyloric tone, and dampening the migrating motor complex. Fo
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.839
· Account tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z means “you digest your food better” — and like most popular claims, it’s partially true, partially misleading, and worth unpacking properly. > Let’s walk through it. > The Mechanism Recap > Quick refresher from Part 1: GLP-1 receptor agonists slow gastric emptying by reducing antral contractility, increasing pyloric tone, and dampening the migrating motor complex. Fo
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.838
· Account tjphuhs@gmail.com
· 4/25/2026, 3:54:50 PM
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z conditions longer, protein denaturation by pepsin has more time to occur. Whether this translates to meaningfully better downstream amino acid absorption is less clear in the human data, but mechanistically it’s plausible. Fat digestion timing shifts. Fats normally slow gastric emptying on their own as a feedback signal. On a GLP-1, that signal is layered on top of
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.836
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z wrong on GLP-1 protocols isn’t usually absorption — it’s the dramatic reduction in intake that gets ignored because the appetite suppression is doing its job. > Pay attention to what you’re putting in. Slowed gastric emptying is doing interesting things to the timing, but it can’t manufacture nutrition out of food that isn’t there. > This article is for research and
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.836
· Account tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z wrong on GLP-1 protocols isn’t usually absorption — it’s the dramatic reduction in intake that gets ignored because the appetite suppression is doing its job. > Pay attention to what you’re putting in. Slowed gastric emptying is doing interesting things to the timing, but it can’t manufacture nutrition out of food that isn’t there. > This article is for research and
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.833
· Account tjphuhs@gmail.com
· 4/25/2026, 3:54:50 PM
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z The framing from Part 1 applies here too: slower does not mean less, but it also doesn’t mean more. The kinetics shift; the totals mostly don’t. Where things actually go wrong on GLP-1 protocols isn’t usually absorption — it’s the dramatic reduction in intake that gets ignored because the appetite suppression is doing its job. Pay attention to what you’re putting i
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.832
· Account tjphuhs@gmail.com
· 4/25/2026, 3:54:50 PM
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z View this post on the web at https://derekpruski.substack.com/p/glp-1s-and-slowed-gastric-emptying-4ec After the first post on medication absorption, a lot of you asked the natural follow-up question: what about food? What about nutrients? If gastric emptying is slowed dramatically, are we actually absorbing more from our meals because food sits in the stomach long
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.816
· Account tjphuhs@gmail.com
· 4/25/2026, 3:54:50 PM
GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from derekpruski@substack.com on 2026-04-25T19:54:50.000Z about dramatically reduced intake, layered on top of slightly altered absorption conditions, layered on top of pre-existing borderline status in the general population. The reduced intake piece is doing the heavy lifting. If someone’s eating 40% less food across the board, they’re getting 40% less of everything in that food. That’s not an absorption problem — that’
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.810
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 3:55 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? > After the first post on medication absorption, a lot of you asked the natural follow-up question: what about food? > ͏ ͏ ͏
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.810
· Account tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 3:55 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? > After the first post on medication absorption, a lot of you asked the natural follow-up question: what about food? > ͏ ͏ ͏
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.804
· Account tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z on top of an already-slowed system. Fat-heavy meals can sit particularly long, which is part of why high-fat meals tend to produce the worst GI side effects on these protocols. > Specific Nutrient Issues That Have Popped Up > This is where the rubber meets the road. Across the broader GLP-1 user base — both clinical and community-reported — certain nutrient deficienc
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.804
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z on top of an already-slowed system. Fat-heavy meals can sit particularly long, which is part of why high-fat meals tend to produce the worst GI side effects on these protocols. > Specific Nutrient Issues That Have Popped Up > This is where the rubber meets the road. Across the broader GLP-1 user base — both clinical and community-reported — certain nutrient deficienc
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.801
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z they’re getting 40% less of everything in that food. That’s not an absorption problem — that’s an intake problem. But the two get conflated constantly. > So Is It True That You “Digest Better”? > Partially. The longer gastric residence time does likely improve mechanical and chemical breakdown of food, particularly proteins. That’s the legitimate kernel. > What it do
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption?
Score 0.801
· Account tjphuhs@gmail.com
· 4/25/2026, 9:07:43 PM
Fwd: GLP-1s and Slowed Gastric Emptying Part 2: What About Nutrient Absorption? from tjphuhs@gmail.com on 2026-04-26T01:07:43.000Z they’re getting 40% less of everything in that food. That’s not an absorption problem — that’s an intake problem. But the two get conflated constantly. > So Is It True That You “Digest Better”? > Partially. The longer gastric residence time does likely improve mechanical and chemical breakdown of food, particularly proteins. That’s the legitimate kernel. > What it do