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Semantic Search: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.863
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.863
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.846
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-pregnancy-fears-vs-reality If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversation matters. These are not casual medications for this community, they are often the first thing that actually moved the needle after y
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.813
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z ovulation becomes the outcome, the framing starts to move closer to what patients have been describing all along. Lactation is still largely an unknown, which is not surprising given how early this entire space is. There is one small pharmacokinetic study involving Semaglutide [ chatgpt://generic-entity?number=3 ] that did not detect transfer into breast milk, but the patient pool w
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.812
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.812
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z There is one small pharmacokinetic study involving Semaglutide that did not detect transfer into breast milk, but the patient pool was small, and more studies will likely be necessary for many clinicians to feel comfortable giving GLP-1 use during lactation the “thumbs up”. > READ ABOUT THE LACTATION STUDY > The biggest gap across all of this is duration, and that is where the unce
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.812
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z of trying everything else. For many others, it was the first real hope offered, after the promises of metabolic surgeries failed to deliver as promised. > That is exactly why pregnancy can add such a complex layer to the journey, because the same medication that helped restore metabolic health is also restoring ovulation in ways many women using GLP-1 therapies did not necessarily
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.812
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z of trying everything else. For many others, it was the first real hope offered, after the promises of metabolic surgeries failed to deliver as promised. > That is exactly why pregnancy can add such a complex layer to the journey, because the same medication that helped restore metabolic health is also restoring ovulation in ways many women using GLP-1 therapies did not necessarily
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.808
· Account tjphuhs@gmail.com
· 3/28/2026, 1:38:29 PM
GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from onthepen@substack.com on 2026-03-28T17:38:29.000Z expect at this stage. Rates of gestational diabetes, hypertensive disorders, preterm birth, and gestational weight gain were all over the place depending on the study, with no single direction that clearly stands out. Where this really lands for the OTP community is with Polycystic Ovary Syndrome, and this is not some small corner of the audience. This is a huge group of women who h
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.802
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z and this is not some small corner of the audience. This is a huge group of women who have spent years being told their condition was secondary to weight instead of something with its own biology and its own set of levers. In the review, GLP-1 therapies were associated with improvements in both metabolic and reproductive markers in women with PCOS, including signals around insulin r
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.802
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z and this is not some small corner of the audience. This is a huge group of women who have spent years being told their condition was secondary to weight instead of something with its own biology and its own set of levers. In the review, GLP-1 therapies were associated with improvements in both metabolic and reproductive markers in women with PCOS, including signals around insulin r
GLP-1s vs. Fertility
Score 0.719
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z all. For couples whose fertility is being dragged down by metabolic dysfunction, GLP-1s are the most promising pharmacological lever I've seen in a decade. The female data on PCOS pregnancy rates is the strongest signal in the whole literature. The male data is catching up. The next 24 months of trial data will tell us a lot. I'll keep you posted on what we learn, on our journey, and on the science. GLP-1s
GLP-1s vs. Fertility
Score 0.707
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z Happy Monday! Taylor and I are trying to have a baby. As I do with most everything in my life, I research as much as I can to achieve the desired outcome. Studies I used to skim now feel much more personal. And the one that's been on my mind lately is from Dr. Shanna Swan. If you haven't read her book _Countdown_, here's the short version. Sperm concentration in Western men decreased by more than 50% betwee
GLP-1s vs. Fertility
Score 0.685
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z but the question is whether the clinical data back it up. ——————————————————————————— **The Male Data** In a 2023 trial, La Vignera and colleagues gave liraglutide to obese men with metabolic hypogonadism and severe erectile dysfunction. After 4 months, semen concentration, motility, and morphology all significantly improved. Erectile function scores improved more than with conventional fertility treatment
GLP-1s vs. Fertility
Score 0.678
· Account tjphuhs@gmail.com
· 5/4/2026, 6:05:41 PM
GLP-1s vs. Fertility from huntershealthhacks@mail.beehiiv.com on 2026-05-04T22:05:41.000Z ovarian steroidogenesis, granulosa cell biology, and the FSH-cAMP-BMP signaling pathway. It's likely a direct ovarian effect layered on top of metabolic improvement. ——————————————————————————— **Microdosing for Fertility** Here's where I'm going to get speculative. Most of the GLP-1 fertility research uses standard or high doses. The kind aimed at meaningful weight loss. 1mg semaglutide weekly. 3mg liraglu
Massive GLP-1 Data From ECO 2026
Score 0.671
· Account tjphuhs@gmail.com
· 5/13/2026, 10:52:49 AM
Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z keeping what you lost, but stepping down to 5mg is viable for a meaningful subset. ATTAIN-MAINTAIN says switching from an injectable to a daily pill is a real option, not a theoretical one -- with results that vary depending on which injectable you came from and deserve to be understood on their own terms. The STEPUP sub-analysis says there is more efficacy headroom above the current Wegovy dose, and the body
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.665
· Account tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z is real and meaningful. The appetite suppression is genuine, the metabolic effects are genuine, and for many researchers the long-term results are significant. The point isn’t to discredit the compounds — it’s to set realistic expectations so people don’t get discouraged when their first week looks different from someone else’s highlight reel. Stop Comparing Y
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.665
· Account oc.tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z is real and meaningful. The appetite suppression is genuine, the metabolic effects are genuine, and for many researchers the long-term results are significant. The point isn’t to discredit the compounds — it’s to set realistic expectations so people don’t get discouraged when their first week looks different from someone else’s highlight reel. Stop Comparing Y
Massive GLP-1 Data From ECO 2026
Score 0.657
· Account tjphuhs@gmail.com
· 5/13/2026, 10:52:49 AM
Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z Wegovy and thinking about switching to Foundayo, the data is quite encouraging. If you are on Zepbound, the picture is still positive, but expect some drift and definitely factor that into the conversation with your doctor. On tolerability, the transition went relatively smoothly. GI effects were mild to moderate, discontinuation rates were low across all arms, and (perhaps most importantly) no liver safety c
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This.
Score 0.654
· Account tjphuhs@gmail.com
· 3/18/2026, 4:18:18 PM
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This. from tjphuhs@gmail.com on 2026-03-18T20:18:18.000Z overthink it — just make sure there’s enough fuel in the tank before lights out. > As always, this is for research purposes only. All compounds are research use only, not for human consumption. > Drop any questions below — happy to help you troubleshoot. > Upgrade to paid > You're currently a free subscriber to Peptide Price. For the full experience, upgrade your subscription. > Upgra
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.652
· Account tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z TJ Begin forwarded message: From: Derek from Peptide Price <derekpruski@substack.com> Date: March 16, 2026 at 10:25:49 AM EDT To: tjphuhs@gmail.com Subject: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. Reply-To: Derek from Peptide Price <reply+35so0v&4iwoe6&&82edb6be5b009f85c0744544f02d4a5269faf369ed1e663207a198ec47c9f0d9@m
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.652
· Account oc.tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z TJ Begin forwarded message: From: Derek from Peptide Price <derekpruski@substack.com> Date: March 16, 2026 at 10:25:49 AM EDT To: tjphuhs@gmail.com Subject: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. Reply-To: Derek from Peptide Price <reply+35so0v&4iwoe6&&82edb6be5b009f85c0744544f02d4a5269faf369ed1e663207a198ec47c9f0d9@m
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.651
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z and produce mood-adjacent effects through its central mechanism. Dosing being explored runs 500 mcg – 2 mg per research administration, administered 1–2 hours before the relevant observation window. Most community research starts at the lower end — 500 mcg to 1 mg — to assess tolerance before titrating up. Frequency is kept to a maximum of 2–3x per week to avoid the receptors
Massive GLP-1 Data From ECO 2026
Score 0.648
· Account tjphuhs@gmail.com
· 5/13/2026, 10:52:49 AM
Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z weeks. Two cohorts: those coming off Zepbound and those coming off Wegovy. 376 participants total. They started orforglipron at 12mg and titrated up every four weeks, targeting a maximum of 36mg. A rescue protocol allowed escalation or a switch from placebo to orforglipron after week 24 for anyone who regained more than half their original loss. One detail to keep in mind: there was a two-week screening gap b
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.644
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z wave of trials needs to recruit at-risk people before symptoms start — that’s where the real test happens. > This is one more data point worth tracking as the field develops. Stay measured, watch the next 2-3 years of trial readouts, and don’t get ahead of the evidence. > Drop questions or thoughts below. > Disclaimer: This content is for research and educational purposes only and is not