Email Archive

Fwd: Women and Testosterone

Score 0.808 · Account tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z ---------- Forwarded message ---------- From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: Apr 23, 2026 at 6:06 PM -0400 To: tjphuhs@gmail.com <tjphuhs@gmail.com> Subject: Women and Testosterone > Fascinating new study released > April 23, 2026 | Read online > Women and Testosterone > Fascinating new study released > > > > Happy Thursday! > FYI, in case you missed it, I launched a giveaway yesterday to

Fwd: Women and Testosterone

Score 0.808 · Account oc.tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z ---------- Forwarded message ---------- From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: Apr 23, 2026 at 6:06 PM -0400 To: tjphuhs@gmail.com <tjphuhs@gmail.com> Subject: Women and Testosterone > Fascinating new study released > April 23, 2026 | Read online > Women and Testosterone > Fascinating new study released > > > > Happy Thursday! > FYI, in case you missed it, I launched a giveaway yesterday to

Fwd: Women and Testosterone

Score 0.799 · Account tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z progesterone matter. I'm not arguing against them. But they cannot do what testosterone does. They operate on different receptors and different pathways. > Women who do BHRT with only estrogen and progesterone are running a hormone protocol with a missing pillar. > > The Study > Researchers tracked 332 women on individualized testosterone replacement therapy. > Ages ranged from 27 to 78, with an average of 45. A subse

Fwd: Women and Testosterone

Score 0.799 · Account oc.tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z progesterone matter. I'm not arguing against them. But they cannot do what testosterone does. They operate on different receptors and different pathways. > Women who do BHRT with only estrogen and progesterone are running a hormone protocol with a missing pillar. > > The Study > Researchers tracked 332 women on individualized testosterone replacement therapy. > Ages ranged from 27 to 78, with an average of 45. A subse

Fwd: Women and Testosterone

Score 0.798 · Account oc.tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z are low, testosterone might matter more than any supplement, stack, or peptide you're currently chasing. > > Mood and Cognition > Depression improved in 70.8% of women. Irritability in 69%. Anhedonia, which is the clinical term for loss of pleasure, improved in 67.5%. > These are numbers that would get a psychiatric drug fast-tracked for emergency approval. > Testosterone modulates dopamine and serotonin directly. > W

Fwd: Women and Testosterone

Score 0.798 · Account tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z are low, testosterone might matter more than any supplement, stack, or peptide you're currently chasing. > > Mood and Cognition > Depression improved in 70.8% of women. Irritability in 69%. Anhedonia, which is the clinical term for loss of pleasure, improved in 67.5%. > These are numbers that would get a psychiatric drug fast-tracked for emergency approval. > Testosterone modulates dopamine and serotonin directly. > W

Women and Testosterone

Score 0.771 · Account tjphuhs@gmail.com · 4/23/2026, 6:06:24 PM

Women and Testosterone from huntershealthhacks@mail.beehiiv.com on 2026-04-23T22:06:24.000Z also got paired blood work at baseline and 12 weeks. The protocol was simple. Start with a blood test, administer a low physiologic dose, retest, and then adjust. Then target the upper end of the premenopausal range, 25 to 50 ng/dL total testosterone (still too low in my opinion, but better than nothing). Delivery options were topical cream, oral troches, or subcutaneous injections. Women rated change acr

Women and Testosterone

Score 0.771 · Account tjphuhs@gmail.com · 4/23/2026, 6:06:24 PM

Women and Testosterone from huntershealthhacks@mail.beehiiv.com on 2026-04-23T22:06:24.000Z Happy Thursday! “FYI, in case you missed it, I launched a giveaway yesterday to celebrate 100,000 active newsletter readers. You can register to [win here](https://hunterwilliamshealth.com/giveaway) (apologies for the tech issues yesterday, the website crashed in the first 30 minutes). [https://hunterwilliamshealth.com/giveaway](https://hunterwilliamshealth.com/giveaway)“ — Let me tell you about a convers

Fwd: Women and Testosterone

Score 0.763 · Account tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z 5.4% of women reported significant improvement in quality of life. > At greater than 12 months, 51.5% did. And not a single woman in the 12+ month group reported no change. > The benefits compound. > Most published trials on testosterone in women run 12 to 24 weeks. The study authors specifically called this out as a problem. These are trial windows that cut off just as the deeper benefits are starting to show. > If y

Fwd: Women and Testosterone

Score 0.763 · Account oc.tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z 5.4% of women reported significant improvement in quality of life. > At greater than 12 months, 51.5% did. And not a single woman in the 12+ month group reported no change. > The benefits compound. > Most published trials on testosterone in women run 12 to 24 weeks. The study authors specifically called this out as a problem. These are trial windows that cut off just as the deeper benefits are starting to show. > If y

Women and Testosterone

Score 0.761 · Account tjphuhs@gmail.com · 4/23/2026, 6:06:24 PM

Women and Testosterone from huntershealthhacks@mail.beehiiv.com on 2026-04-23T22:06:24.000Z still feel off, ask for a testosterone panel that INCLUDES free testosterone. Don't accept "normal for your age" as an answer without seeing a number. A woman at 50 with the testosterone of a 50-year-old is a woman running on half of what she had at 25. That's not normal! I favor injections, but in this study, the other delivery mechanisms worked too. Pick what fits your lifestyle best. Testosterone is fo

Women and Testosterone

Score 0.751 · Account tjphuhs@gmail.com · 4/23/2026, 6:06:24 PM

Women and Testosterone from huntershealthhacks@mail.beehiiv.com on 2026-04-23T22:06:24.000Z month. They didn't show meaningful improvement until the 4 to 6-month mark. Why? Because brain tissue takes longer to remodel than energy metabolism does. Testosterone supports hippocampal neurogenesis and BDNF expression, but growing new neurons is not a 30-day process. This is the reason so many women try TRT for 12 weeks, don't feel a cognitive shift, and quit. They stopped three months before the brai

Fwd: Women and Testosterone

Score 0.716 · Account tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z > Peptide Cheat Sheet > > 👉All my daily essentials on Amazon > > • > Amazon Storefront > > 👉Get discounts on your favorite peptides and research chemicals: > > • > PEPTIDES > • > BioLongevity Labs (use code hunterw for 15% off): https://biolongevitylabs.com/ > > 👉10% off the BEST workout supplements from Unmatched Supps (pre-workout, whey protein, creatine, EAAs, electrolytes - use code HUNTERW at checkout): > > •

Fwd: Women and Testosterone

Score 0.716 · Account oc.tjphuhs@gmail.com · 4/24/2026, 9:43:00 AM

Fwd: Women and Testosterone from tjphuhs@gmail.com on 2026-04-24T13:43:00.000Z > Peptide Cheat Sheet > > 👉All my daily essentials on Amazon > > • > Amazon Storefront > > 👉Get discounts on your favorite peptides and research chemicals: > > • > PEPTIDES > • > BioLongevity Labs (use code hunterw for 15% off): https://biolongevitylabs.com/ > > 👉10% off the BEST workout supplements from Unmatched Supps (pre-workout, whey protein, creatine, EAAs, electrolytes - use code HUNTERW at checkout): > > •

Fwd: Men vs. Women Peptide Dosing

Score 0.677 · Account tjphuhs@gmail.com · 2/26/2026, 1:00:26 AM

Fwd: Men vs. Women Peptide Dosing from tjphuhs@gmail.com on 2026-02-26T06:00:26.000Z TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: January 28, 2026 at 6:03:38 PM EST To: tjphuhs@gmail.com Subject: Men vs. Women Peptide Dosing Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Men vs. Women Peptide Dosing 96 Does your gender matter? ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌ ‌

Fwd: Men vs. Women Peptide Dosing

Score 0.670 · Account tjphuhs@gmail.com · 2/26/2026, 1:00:26 AM

Fwd: Men vs. Women Peptide Dosing from tjphuhs@gmail.com on 2026-02-26T06:00:26.000Z dosing.” Pharmacokinetics Many people assume that women and men metabolize substances differently. Sometimes that’s true with specific oral drugs, especially when liver enzyme differences matter. But most popular peptides are injected (or nasal), and they’re cleared by pathways that don’t reliably split by sex in a way that forces dosing differences. Instead, what matters more is stuff like: injection route and

Fwd: Men vs. Women Peptide Dosing

Score 0.670 · Account tjphuhs@gmail.com · 2/26/2026, 1:00:26 AM

Fwd: Men vs. Women Peptide Dosing from tjphuhs@gmail.com on 2026-02-26T06:00:26.000Z your fuel tank, whereas peptides are more like tune-ups for every other area of your car. They bind to receptors, activate a signal, and trigger downstream cascades. Once you understand that, the unisex dosing makes a lot more sense. So today, I’ll break down the real reason protocols often look identical across men and women, and then I’ll give you the exceptions so you don’t walk away thinking it’s always one-

Do GLP-1s Kill Your Testosterone?

Score 0.665 · Account tjphuhs@gmail.com · 4/28/2026, 10:43:24 AM

Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z The Ranger and Marine studies show 20-60% increases. So even if total testosterone looks “fine” on paper, free testosterone — the active fraction — can be dramatically lower because more of the total is bound up. If your RS pulls labs and only checks total T, the picture looks better than it is. Always pull total T, free T, and SHBG together. Otherwise you’re guessing. Section 5: Why it’s not just hormone

Do GLP-1s Kill Your Testosterone?

Score 0.664 · Account tjphuhs@gmail.com · 4/28/2026, 10:43:24 AM

Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z View this post on the web at https://derekpruski.substack.com/p/do-glp-1s-kill-your-testosterone Got a great question in the inbox this week that deserves a full walkthrough. The framing was something like: “My RS is on a heavy weight-loss compound, lost a ton of weight, and now reports profound lethargy and zero libido. Is this anhedonia, or is testosterone actually crashing from the metabolic burn?” The

Hematocrit on HRT

Score 0.656 · Account tjphuhs@gmail.com · 3/10/2026, 6:05:09 PM

Hematocrit on HRT from huntershealthhacks@mail.beehiiv.com on 2026-03-10T22:05:09.000Z that creates huge peaks. Maybe they have untreated sleep apnea. Maybe they are inflamed and insulin-resistant. Maybe they got their labs after sauna and cardio and came in dehydrated. Those are the kinds of things I would want to address first. I would much rather adjust the testosterone protocol, improve metabolic health, and get more consistent lab conditions before I default to pulling blood out of the body

Hematocrit on HRT

Score 0.642 · Account tjphuhs@gmail.com · 3/10/2026, 6:05:09 PM

Hematocrit on HRT from huntershealthhacks@mail.beehiiv.com on 2026-03-10T22:05:09.000Z Happy Tuesday! I want to start today’s email with a quick announcement: “If you have attempted to view/listen to [my videos on Spotify](https://open.spotify.com/show/5aVo13w6OaaGoZzqoJpBkT?si=5lfkP_J5SvW3FaAtM9G18g) in the last 24 hours, you probably noticed they disappeared. Yesterday, my podcast was terminated from Spotify for “harmful and dangerous information.” Fortunately, my team of lawyers and experts s

Do GLP-1s Kill Your Testosterone?

Score 0.637 · Account tjphuhs@gmail.com · 4/28/2026, 10:43:24 AM

Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z None of this is medical advice. Anyone running these compounds in any human capacity should be working with a clinician monitoring full labs (total T, free T, LH, FSH, SHBG, estradiol, prolactin, fasting insulin, cortisol, full thyroid panel). If your RS is obese and on a moderate dose The data suggests testosterone will likely improve as weight comes off. The intervention is mostly hands-off: stay the co

Do GLP-1s Kill Your Testosterone?

Score 0.637 · Account tjphuhs@gmail.com · 4/28/2026, 10:43:24 AM

Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z then signals back to the hypothalamus to slow GnRH release, suppressing the whole axis from the top. Insulin resistance. Impairs Leydig cell function and HPG signaling. Chronic inflammation. Adipose tissue releases inflammatory cytokines that further suppress the axis. This is the population the GLP-1 trials are studying. So the starting line for these studies is already low T, and the question becomes: d

Hematocrit on HRT

Score 0.636 · Account tjphuhs@gmail.com · 3/10/2026, 6:05:09 PM

Hematocrit on HRT from huntershealthhacks@mail.beehiiv.com on 2026-03-10T22:05:09.000Z the testosterone protocol itself. Short-acting injectables and protocols that produce larger peaks are associated with greater erythrocytosis than steadier delivery methods. Sometimes the smartest move is not donating blood. Sometimes it is lowering the dose, splitting injections more frequently, or changing the route of administration. ——————————————————————————— **Final Thoughts** If a man is on a true thera

Do GLP-1s Kill Your Testosterone?

Score 0.635 · Account tjphuhs@gmail.com · 4/28/2026, 10:43:24 AM

Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z (STEP 1) Tirzepatide: ~21% loss at 72 weeks (SURMOUNT-1) Peptide-R (triple-agonist): ~24% at 48 weeks (phase 2), and 28.7% at 68 weeks in the recent phase 3 TRIUMPH-4 readout. Placebo-adjusted: 26.6%. Once weight loss gets that aggressive, you’re no longer just dropping fat — you’re forcing the body into sustained caloric deficit territory that the HPG axis interprets as famine. And the famine response is