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Semantic Search: Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.898
· Account tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z wanted it badly enough, you’d find your way out eventually. Sound familiar? > If you’ve lived inside the obesity fight, you know this cycle all too well. The same cycle of white knuckle effort and utter disappointment. The same medical shrug. The same story that put the weight of a biological condition squarely on the shoulders of the person carrying it. Two different
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.898
· Account oc.tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z wanted it badly enough, you’d find your way out eventually. Sound familiar? > If you’ve lived inside the obesity fight, you know this cycle all too well. The same cycle of white knuckle effort and utter disappointment. The same medical shrug. The same story that put the weight of a biological condition squarely on the shoulders of the person carrying it. Two different
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.890
· Account tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: May 1, 2026 at 7:34 AM -0400 To: tjphuhs@gmail.com Subject: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention > Anecdotes are slowly becoming science > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.890
· Account oc.tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: May 1, 2026 at 7:34 AM -0400 To: tjphuhs@gmail.com Subject: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention > Anecdotes are slowly becoming science > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.885
· Account tjphuhs@gmail.com
· 5/1/2026, 7:31:47 AM
Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from onthepen@substack.com on 2026-05-01T11:31:47.000Z View this post on the web at https://onthepen.substack.com/p/semaglutide-and-alcohol-a-new-study There’s a particular kind of exhaustion that comes with alcohol use disorder. Not just the physical kind, though that’s real too. I’m talking the kind that settles into your bones after years of trying, having minimal success, and trying again. After being told, in ways spo
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.878
· Account tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z condition that accounts for 5% of deaths worldwide every year. Those medications help some people, and that certainly matters. It matters in the same way that phentermine and orlistat mattered to obesity. A useful way to think about how well a treatment works is something called the number needed to treat, which captures how many people have to take the drug for one p
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.878
· Account oc.tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z condition that accounts for 5% of deaths worldwide every year. Those medications help some people, and that certainly matters. It matters in the same way that phentermine and orlistat mattered to obesity. A useful way to think about how well a treatment works is something called the number needed to treat, which captures how many people have to take the drug for one p
Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.863
· Account tjphuhs@gmail.com
· 5/1/2026, 7:31:47 AM
Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from onthepen@substack.com on 2026-05-01T11:31:47.000Z not only having fewer heavy drinking days. They were also drinking less per drinking day, reporting significantly less craving, showing improved liver enzyme numbers, and losing considerably more weight than the placebo group. For decades, the FDA has approved exactly three medications for alcohol use disorder: disulfiram, acamprosate, and naltrexone. Three medications
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.853
· Account oc.tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z study population that was predominantly White. The researchers themselves are careful to say that larger, more diverse studies are needed before anyone should consider using this drug off-label for AUD. > Upgrade to paid > This is just the beginning. Eli Lilly has a dual GLP-1/GIP co-agonist called brenipatide that is being looked at for a whole host of nueralogical d
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.853
· Account tjphuhs@gmail.com
· 5/1/2026, 9:18:21 AM
Fwd: Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from tjphuhs@gmail.com on 2026-05-01T13:18:21.000Z study population that was predominantly White. The researchers themselves are careful to say that larger, more diverse studies are needed before anyone should consider using this drug off-label for AUD. > Upgrade to paid > This is just the beginning. Eli Lilly has a dual GLP-1/GIP co-agonist called brenipatide that is being looked at for a whole host of nueralogical d
Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention
Score 0.832
· Account tjphuhs@gmail.com
· 5/1/2026, 7:31:47 AM
Semaglutide and Alcohol: A New Study in The Lancet is Worthy of Attention from onthepen@substack.com on 2026-05-01T11:31:47.000Z with constipation, reflux, and fatigue at higher rates than the placebo group. Most of those effects were temporary and mild to moderate, but this is not a medication that asks nothing of your body. And it bears repeating that this was one trial, 108 people, in one city in Denmark, with a study population that was predominantly White. The researchers themselves are car
Fwd: Compound Tirzepatide & Semaglutide Updates!
Score 0.712
· Account tjphuhs@gmail.com
· 3/17/2026, 5:51:48 PM
Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z exclusive DDC list explained Novo’s lab findings 302% dose shocker Catalent’s contamination mess Lilly’s B12 tirzepatide bombshell Is the molecule changing? New oral GLP-1 contender MASSIVE: Compound Tirzepatide and Semaglutide Updates! Dave Knapp GLP-1 Industry Insider Episode Do you trust compounded GLP-1s based on real-world experience, or do findings like the ones discussed today change your p
Can BPC-157 Blunt the Effects of Alcohol? The Angiogenesis Angle
Score 0.708
· Account tjphuhs@gmail.com
· 5/14/2026, 11:46:54 AM
Can BPC-157 Blunt the Effects of Alcohol? The Angiogenesis Angle from derekpruski@substack.com on 2026-05-14T15:46:54.000Z then into acetate, which gets cleared from the body. The speed and efficiency of this entire process depends heavily on blood flow. The liver needs strong, consistent blood perfusion to filter alcohol efficiently. The stomach and gut need healthy vasculature to manage absorption without taking damage. And the brain — which is where you actually feel intoxication — is affecte
Can BPC-157 Blunt the Effects of Alcohol? The Angiogenesis Angle
Score 0.707
· Account tjphuhs@gmail.com
· 5/14/2026, 11:46:54 AM
Can BPC-157 Blunt the Effects of Alcohol? The Angiogenesis Angle from derekpruski@substack.com on 2026-05-14T15:46:54.000Z View this post on the web at https://derekpruski.substack.com/p/can-bpc-157-blunt-the-effects-of Research use only. Not for human consumption. The following is educational discussion of research compounds and anecdotal observations from the research community. Nothing here constitutes medical advice or dosing guidance. Saw an interesting question come through the community r
Can BPC-157 Blunt the Effects of Alcohol? The Angiogenesis Angle
Score 0.695
· Account tjphuhs@gmail.com
· 5/14/2026, 11:46:54 AM
Can BPC-157 Blunt the Effects of Alcohol? The Angiogenesis Angle from derekpruski@substack.com on 2026-05-14T15:46:54.000Z on Reddit and one researcher’s observation don’t constitute evidence. Subjective alcohol effects are notoriously influenced by tolerance, hydration, food intake, sleep, and dozens of other variables that easily confound this kind of pattern. Animal studies on alcohol protection don’t translate directly. Most of the alcohol-protective research on BPC-157 looks at organ-level
Fwd: Compound Tirzepatide & Semaglutide Updates!
Score 0.691
· Account tjphuhs@gmail.com
· 3/17/2026, 5:51:48 PM
Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z TJ Begin forwarded message: From: Dave Knapp from On The Pen <onthepen@substack.com> Date: March 17, 2026 at 4:03:57 PM EDT To: tjphuhs@gmail.com Subject: Compound Tirzepatide & Semaglutide Updates! Reply-To: Dave Knapp from On The Pen <reply+35w1tf&4iwoe6&&9985d0eabdad8d3ee001e8d18022b7e3ec1f9e03481cf6e0f518cbf32ac3e62e@mg1.substack.com> Compound Tirzepatide & Semaglutide Updates! Happy Spring Br
What Happened with Compounded Oral Semaglutide? Read the Breakdown
Score 0.680
· Account tjphuhs@gmail.com
· 2/13/2026, 12:25:59 PM
What Happened with Compounded Oral Semaglutide? Read the Breakdown from autumn-americanpeptide.co@shared1.ccsend.com on 2026-02-13T17:25:59.000Z Email from American Peptide Association You don't want to miss this. The American Peptide Association | 151 NW 1st Ave Delray Beach, FL 33444 | Delray Beach, FL 33444 US Unsubscribe | Update Profile | Constant Contact Data Notice
Fwd: When Ozempic stops working (and what 10% of users already know)
Score 0.667
· Account tjphuhs@gmail.com
· 3/17/2026, 2:05:41 PM
Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z to lose even 5% of body weight, the minimum threshold considered clinically meaningful. In the SURMOUNT-2 trial for tirzepatide, 17-21% of participants didn't hit that 5% mark. Why? Variants in the GLP-1 receptor gene affect how strongly the drug signals satiety. Gut microbiome composition also influences response. And if your metabolism is already adapted to caloric restrictio
Fwd: Semax, Selank & SSRIs: What the Research Says About Combining Them
Score 0.667
· Account tjphuhs@gmail.com
· 3/23/2026, 1:16:56 PM
Fwd: Semax, Selank & SSRIs: What the Research Says About Combining Them from tjphuhs@gmail.com on 2026-03-23T17:16:56.000Z a risk worth taking. > More SSRI + nootropic peptide breakdowns coming. If there’s a specific compound you want covered next, drop it in the comments. > — Derek > All content is for educational and research purposes only. Research subjects in all discussed contexts are non-human. Nothing here constitutes medical advice or a recommendation to change, add, or discontinue any m
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.665
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 30, 2026 at 10:19 AM -0400 To: tjphuhs@gmail.com Subject: New Study Worth Knowing About: GLP-1s and Alzheimer's > A new research review just came out in Molecular and Cellular Neuroscience (April 2026) looking at how GLP-1 drugs — the same class as Ozempic, Wegovy, Mounjaro, and T
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.665
· Account tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 30, 2026 at 10:19 AM -0400 To: tjphuhs@gmail.com Subject: New Study Worth Knowing About: GLP-1s and Alzheimer's > A new research review just came out in Molecular and Cellular Neuroscience (April 2026) looking at how GLP-1 drugs — the same class as Ozempic, Wegovy, Mounjaro, and T
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.663
· Account tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z actually does. > GLP-1 (Glucagon-Like Peptide-1) > This is the backbone of every modern weight loss drug, from semaglutide forward. GLP-1 stimulates insulin release when blood sugar is high, suppresses glucagon (preventing unnecessary sugar release from the liver), and slows gastric emptying so you feel full longer. It also acts directly on the brain’s appetite centers i
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.663
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z actually does. > GLP-1 (Glucagon-Like Peptide-1) > This is the backbone of every modern weight loss drug, from semaglutide forward. GLP-1 stimulates insulin release when blood sugar is high, suppresses glucagon (preventing unnecessary sugar release from the liver), and slows gastric emptying so you feel full longer. It also acts directly on the brain’s appetite centers i
Fwd: Semax, Selank & SSRIs: What the Research Says About Combining Them
Score 0.658
· Account tjphuhs@gmail.com
· 3/23/2026, 1:16:56 PM
Fwd: Semax, Selank & SSRIs: What the Research Says About Combining Them from tjphuhs@gmail.com on 2026-03-23T17:16:56.000Z start here, with the two nootropic peptides I get this question about the most: Semax and Selank. They’re the most studied nootropic peptides in this category, they both interact with the serotonin system in some capacity, and they’re genuinely different from each other in ways that matter for this conversation. > This is not medical advice. Do not make changes to any prescr
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's
Score 0.657
· Account oc.tjphuhs@gmail.com
· 4/30/2026, 11:00:22 AM
Fwd: New Study Worth Knowing About: GLP-1s and Alzheimer's from tjphuhs@gmail.com on 2026-04-30T15:00:22.000Z That’s about 73% showing plaque reduction and 63% showing tangle reduction. In research terms, that’s a strong, consistent signal — not a one-off finding. > By drug: > > • > Liraglutide — the most studied of the four. The most consistent. Reduced both plaques AND tangles across multiple models. > • > Dulaglutide — fewer studies, but consistent. Reduced both plaques and tangles, and impro