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Semantic Search: Fwd: Retatrutide Is Too Good… And That’s The Problem
Fwd: Retatrutide Is Too Good… And That’s The Problem
Score 0.816
· Account tjphuhs@gmail.com
· 3/24/2026, 10:14:11 PM
Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z quickly on multiple fronts. > We break it all down in this week’s episode, what’s changing, what it could mean for you, and what to keep an eye on next. > The Throttling of Compounded GLP-1sFDA vs Telehealth, What’s Really HappeningThe Truth About “Research Peptides”The Rule That Created the Black Market If You Rely on This, Here’s What’s ComingWhy They Want You Back on Branded DrugsRetatrutid
Fwd: Retatrutide Is Too Good… And That’s The Problem
Score 0.816
· Account oc.tjphuhs@gmail.com
· 3/24/2026, 10:14:11 PM
Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z quickly on multiple fronts. > We break it all down in this week’s episode, what’s changing, what it could mean for you, and what to keep an eye on next. > The Throttling of Compounded GLP-1sFDA vs Telehealth, What’s Really HappeningThe Truth About “Research Peptides”The Rule That Created the Black Market If You Rely on This, Here’s What’s ComingWhy They Want You Back on Branded DrugsRetatrutid
Fwd: Retatrutide Is Too Good… And That’s The Problem
Score 0.788
· Account oc.tjphuhs@gmail.com
· 3/24/2026, 10:14:11 PM
Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 24, 2026 at 9:24 PM -0400 To: tjphuhs@gmail.com Subject: Retatrutide Is Too Good… And That’s The Problem > There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. > ͏ ͏ ͏ ͏ ͏
Fwd: Retatrutide Is Too Good… And That’s The Problem
Score 0.788
· Account tjphuhs@gmail.com
· 3/24/2026, 10:14:11 PM
Fwd: Retatrutide Is Too Good… And That’s The Problem from tjphuhs@gmail.com on 2026-03-25T02:14:11.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 24, 2026 at 9:24 PM -0400 To: tjphuhs@gmail.com Subject: Retatrutide Is Too Good… And That’s The Problem > There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. > ͏ ͏ ͏ ͏ ͏
Retatrutide Is Too Good… And That’s The Problem
Score 0.742
· Account tjphuhs@gmail.com
· 3/24/2026, 9:24:24 PM
Retatrutide Is Too Good… And That’s The Problem from onthepen@substack.com on 2026-03-25T01:24:24.000Z View this post on the web at https://onthepen.substack.com/p/retatrutide-is-too-good-and-thats There’s a lot shifting right now in the world of GLP-1s, and if you rely on compounded or research-grade options, this week’s updates may feel especially important. From new signals out of Washington that could impact access, to powerful new data on next-generation treatments like retatrutide, to wher
Retatrutide Makes Me Hungrier?
Score 0.693
· Account tjphuhs@gmail.com
· 4/29/2026, 6:04:32 PM
Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z more hunger. The TRIUMPH body composition data showed retatrutide doesn't actually preserve lean mass any better than other GLP-1 agents. The "muscle-sparing" marketing around glucagon doesn't hold up in the data. So if you're not training, eating protein, and optimizing your hormones, you'll lose muscle. And your hunger is going to climb. ——————————————————————————— **What I Would Do ** A few thi
Retatrutide Makes Me Hungrier?
Score 0.676
· Account tjphuhs@gmail.com
· 4/29/2026, 6:04:32 PM
Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z modest, around r=0.28. That means appetite suppression accounts for less than 10% of the weight-loss variance. So the play is to lean into the protein, the training, HRT, and the lifestyle work. The peptide is doing its job. Your job is to give it the inputs that let the weight loss show up on the scale. Best, Hunter Williams ——————————————————————————— **Further Reading** * [Why Am I So Hungry on
Fwd: Reta vs. Cancer
Score 0.674
· Account tjphuhs@gmail.com
· 2/26/2026, 12:56:32 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z broadly influence chronic disease pathways, including those involved in tumor biology. If low-dose retatrutide can meaningfully reduce tumor progression in an aggressive cancer model without causing weight loss, that suggests its metabolic influence runs deeper than body composition changes alone. That opens the door to considering this molecule within a broader longevity framework. Final Thoughts We are still early in the r
Fwd: Reta vs. Cancer
Score 0.672
· Account tjphuhs@gmail.com
· 2/26/2026, 12:51:09 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z or appetite suppression. The dose used did not significantly affect body weight, yet tumor growth decreased meaningfully. Retatrutide’s benefits go far beyond cosmetic fat loss. They are metabolic. They are immunologic. They may even profoundly reshape the body's internal terrain. FYI, BioLongevity Labs is running a storewide sale where everything is 30% off. Use code HUNTERW to get an additional 15% off. The Study The resea
Fwd: Reta vs. Cancer
Score 0.666
· Account tjphuhs@gmail.com
· 2/26/2026, 12:51:09 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z at lower doses, these metabolic changes may be meaningful. Non-Cancer-Favoring Terrain Cancer develops within biological terrain. A body with high fasting glucose A body with elevated insulin A body with systemic inflammation A body with immune dysfunction These conditions create fertile ground for pathological growth. Retatrutide appears to influence multiple pathways simultaneously. It improves glucose regulation, flattens
Fwd: Reta vs. Cancer
Score 0.664
· Account tjphuhs@gmail.com
· 2/26/2026, 12:56:32 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z a frontline immune checkpoint cancer therapy in reducing tumor growth in this model. Interestingly, this study was not centered on dramatic weight loss or appetite suppression. The dose used did not significantly affect body weight, yet tumor growth decreased meaningfully. Retatrutide’s benefits go far beyond cosmetic fat loss. They are metabolic. They are immunologic. They may even profoundly reshape the body's internal ter
Fwd: Reta vs. Cancer
Score 0.663
· Account tjphuhs@gmail.com
· 2/26/2026, 12:56:32 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z improves insulin sensitivity and reduces hyperglycemia. That shift may reduce the availability of fuel and the growth signals that tumors rely on. Even at lower doses, these metabolic changes may be meaningful. Non-Cancer-Favoring Terrain Cancer develops within biological terrain. A body with high fasting glucose A body with elevated insulin A body with systemic inflammation A body with immune dysfunction These conditions cr
Fwd: Reta vs. Cancer
Score 0.663
· Account tjphuhs@gmail.com
· 2/26/2026, 12:56:32 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z TJ Begin forwarded message: From: TJ Bourdeau <tjphuhs@gmail.com> Date: February 26, 2026 at 12:51:11 AM EST To: uncontrolledtrial@gmail.com Subject: Fwd: Reta vs. Cancer TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: February 24, 2026 at 6:06:32 PM EST To: tjphuhs@gmail.com Subject: Reta vs. Cancer Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Reta vs. Cancer 96 New stud
Fwd: Reta vs. Cancer
Score 0.660
· Account tjphuhs@gmail.com
· 2/26/2026, 12:51:09 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z TJ Begin forwarded message: From: Hunter Williams <huntershealthhacks@mail.beehiiv.com> Date: February 24, 2026 at 6:06:32 PM EST To: tjphuhs@gmail.com Subject: Reta vs. Cancer Reply-To: Hunter's Health Hacks <hunter@zeroats.com> Reta vs. Cancer 96 New study just released
Retatrutide Makes Me Hungrier?
Score 0.659
· Account tjphuhs@gmail.com
· 4/29/2026, 6:04:32 PM
Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z a drug. Up to 28.7% at 68 weeks in TRIUMPH-4. That kind of rapid loss triggers a maximal counter-regulatory response. Your body interprets it as starvation and ramps up hunger drive to defend its weight. Lilly hasn't measured ghrelin or leptin in any published retatrutide trial. They don't track "increased appetite" as a reportable side effect. So this whole counter-regulatory mechanism is invisib
Fwd: Stuck on Reta?
Score 0.652
· Account oc.tjphuhs@gmail.com
· 5/9/2026, 1:49:02 PM
Fwd: Stuck on Reta? from tjphuhs@gmail.com on 2026-05-09T17:49:02.000Z why I personally only use MT1, why MT2 is more like a tanning bed (use it for an event, not year-round), and how I think about the cancer question for each one. There's also a tangent about tanning beds in the early 2000s that probably explains a lot about a generation of skin issues. > > Perimenopausal Sleep Problems > This is one of the biggest topics we get asked about. One listener was on MK-677, sleeping great, but binge
Fwd: Stuck on Reta?
Score 0.652
· Account tjphuhs@gmail.com
· 5/9/2026, 1:49:02 PM
Fwd: Stuck on Reta? from tjphuhs@gmail.com on 2026-05-09T17:49:02.000Z why I personally only use MT1, why MT2 is more like a tanning bed (use it for an event, not year-round), and how I think about the cancer question for each one. There's also a tangent about tanning beds in the early 2000s that probably explains a lot about a generation of skin issues. > > Perimenopausal Sleep Problems > This is one of the biggest topics we get asked about. One listener was on MK-677, sleeping great, but binge
Orforglipron: Does It Work? Yes. Is It Better Than Subq? Not Even Close.
Score 0.651
· Account tjphuhs@gmail.com
· 4/23/2026, 2:51:24 PM
Orforglipron: Does It Work? Yes. Is It Better Than Subq? Not Even Close. from derekpruski@substack.com on 2026-04-23T18:51:24.000Z Versus Retatrutide (Triple Agonist) This is where the gap becomes absurd. Subq retatrutide at 12 mg delivered 28.7% weight loss at 68 weeks in TRIUMPH-4. Break that down further: 58.6% of participants on 12 mg achieved at least 25% weight loss 39.4% achieved at least 30% 23.7% achieved at least 35% Orforglipron 36 mg: 12.4%. Retatrutide is in a different universe — r
Reta vs. Cancer
Score 0.651
· Account tjphuhs@gmail.com
· 2/24/2026, 6:06:31 PM
Reta vs. Cancer from huntershealthhacks@mail.beehiiv.com on 2026-02-24T23:06:31.000Z that metabolism and cancer are closely linked. Elevated insulin. Elevated glucose. Chronic inflammation. Visceral adiposity. Impaired immune surveillance. These factors create conditions that favor tumor growth. If a compound improves glucose control, lowers inflammatory tone, enhances insulin sensitivity, and potentially influences immune function, it is reasonable to consider that it could support a less cance
Retatrutide Makes Me Hungrier?
Score 0.650
· Account tjphuhs@gmail.com
· 4/29/2026, 6:04:32 PM
Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z Happy Wednesday! An excellent reader question landed in my inbox this week. It's one I'm hearing more often these days. “_"I've noticed a significant increase in hunger while taking retatrutide, but interestingly, I'm not experiencing weight gain, just not seeing any weight loss either. Is this something you've seen before, and are there ways to improve results in a situation like this?"_“ — The s
Fwd: When Ozempic stops working (and what 10% of users already know)
Score 0.647
· Account tjphuhs@gmail.com
· 3/17/2026, 2:05:41 PM
Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z Rate Problem Retatrutide is Eli Lilly's triple agonist (GIP/GLP-1/glucagon). Early results: up to 24.2% weight loss at 48 weeks per the NEJM Phase 2 trial. But buried in the data: dose-dependent increases in heart rate peaking at 24 weeks. The glucagon receptor component is the likely culprit. At the 12mg dose, heart rate elevations were clinically notable. Users report resting
Fwd: Reta vs. Cancer
Score 0.645
· Account tjphuhs@gmail.com
· 2/26/2026, 12:51:09 AM
Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z model without causing weight loss, that suggests its metabolic influence runs deeper than body composition changes alone. That opens the door to considering this molecule within a broader longevity framework. Final Thoughts We are still early in the research. Human data will be essential before drawing firm conclusions. Even so, the data's direction is compelling. Improving metabolic signaling alone influenced tumor biology
Reta vs. Cancer
Score 0.644
· Account tjphuhs@gmail.com
· 2/24/2026, 6:06:31 PM
Reta vs. Cancer from huntershealthhacks@mail.beehiiv.com on 2026-02-24T23:06:31.000Z stress without excessive suppression of appetite or energy, that becomes a sustainable strategy. Consistency matters more than intensity. Subtle improvements maintained over the years can compound in powerful ways. ——————————————————————————— **Reta Beyond Fat Loss** For years, I have emphasized that GLP-1 agents are metabolic regulators rather than simple fat loss drugs. Retatrutide extends that concept because
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.639
· Account tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z sits well behind all of these. > ═══════════════════════════════ > WHY TIME IS THE KEY VARIABLE > Here’s what matters most for anyone following this story. The excitement is warranted, but the timeline is not short. > If animal data drops at ADA in 5 weeks, that’s mouse data. From mouse preclinical to approved human drug is historically 8-12 years. Even in this accelerat
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.639
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z sits well behind all of these. > ═══════════════════════════════ > WHY TIME IS THE KEY VARIABLE > Here’s what matters most for anyone following this story. The excitement is warranted, but the timeline is not short. > If animal data drops at ADA in 5 weeks, that’s mouse data. From mouse preclinical to approved human drug is historically 8-12 years. Even in this accelerat