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Semantic Search: Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.883
· Account oc.tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z TJ Begin forwarded message: From: Derek from Peptide Price <derekpruski@substack.com> Date: March 16, 2026 at 10:25:49 AM EDT To: tjphuhs@gmail.com Subject: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. Reply-To: Derek from Peptide Price <reply+35so0v&4iwoe6&&82edb6be5b009f85c0744544f02d4a5269faf369ed1e663207a198ec47c9f0d9@m
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.883
· Account tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z TJ Begin forwarded message: From: Derek from Peptide Price <derekpruski@substack.com> Date: March 16, 2026 at 10:25:49 AM EDT To: tjphuhs@gmail.com Subject: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. Reply-To: Derek from Peptide Price <reply+35so0v&4iwoe6&&82edb6be5b009f85c0744544f02d4a5269faf369ed1e663207a198ec47c9f0d9@m
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.875
· Account oc.tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z is real and meaningful. The appetite suppression is genuine, the metabolic effects are genuine, and for many researchers the long-term results are significant. The point isn’t to discredit the compounds — it’s to set realistic expectations so people don’t get discouraged when their first week looks different from someone else’s highlight reel. Stop Comparing Y
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.875
· Account tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z is real and meaningful. The appetite suppression is genuine, the metabolic effects are genuine, and for many researchers the long-term results are significant. The point isn’t to discredit the compounds — it’s to set realistic expectations so people don’t get discouraged when their first week looks different from someone else’s highlight reel. Stop Comparing Y
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.875
· Account tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z larger. What Actually Happens When Someone Starts a GLP-1 GLP-1 compounds work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity. The appetite suppression in particular is real and meaningful — most people naturally and significantly reduce how much food they’re eating, often without even trying. Here’s where it gets interest
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.875
· Account oc.tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z larger. What Actually Happens When Someone Starts a GLP-1 GLP-1 compounds work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity. The appetite suppression in particular is real and meaningful — most people naturally and significantly reduce how much food they’re eating, often without even trying. Here’s where it gets interest
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.851
· Account oc.tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z and claim they “gained 7 pounds of fat back” in days. Both narratives are spreading fast, and both are doing real damage to people who are quietly comparing their experience and wondering what’s wrong with them. Nothing is wrong with them. The scale is just lying, and nobody is explaining why. Let’s fix that. Upgrade to paid You Cannot Lose 7 Pounds of Fat in
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.
Score 0.851
· Account tjphuhs@gmail.com
· 3/16/2026, 10:27:30 AM
Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z and claim they “gained 7 pounds of fat back” in days. Both narratives are spreading fast, and both are doing real damage to people who are quietly comparing their experience and wondering what’s wrong with them. Nothing is wrong with them. The scale is just lying, and nobody is explaining why. Let’s fix that. Upgrade to paid You Cannot Lose 7 Pounds of Fat in
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.731
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.731
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Non-GLP Fat Loss Compounds Ranked
Score 0.718
· Account tjphuhs@gmail.com
· 5/5/2026, 6:03:45 PM
Non-GLP Fat Loss Compounds Ranked from huntershealthhacks@mail.beehiiv.com on 2026-05-05T22:03:45.000Z Happy Tuesday! Most folks would agree that the GLPs are the kings of fat loss, with retatrutide holding the title belt. But what if GLPs are not on the table for you? What if you are cycling off? What if you want to stack other compounds so you don’t have to crank your GLP dose into the stratosphere? I just dropped a brand-new video and podcast episode where I rank **20 non-GLP-1 fat-loss**** c
Massive GLP-1 Data From ECO 2026
Score 0.711
· Account tjphuhs@gmail.com
· 5/13/2026, 10:52:49 AM
Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z Wegovy and thinking about switching to Foundayo, the data is quite encouraging. If you are on Zepbound, the picture is still positive, but expect some drift and definitely factor that into the conversation with your doctor. On tolerability, the transition went relatively smoothly. GI effects were mild to moderate, discontinuation rates were low across all arms, and (perhaps most importantly) no liver safety c
GLP-1 Shaming
Score 0.709
· Account tjphuhs@gmail.com
· 4/20/2026, 6:03:00 PM
GLP-1 Shaming from huntershealthhacks@mail.beehiiv.com on 2026-04-20T22:03:00.000Z 1 to 7 measuring whether she cheated or took a shortcut, diet-and-exercise Evette scored around 1.2. GLP-1 Evette scored over 3._ Essentially, she was over 100% more disliked. _ The researchers then traced how that one belief rippled outward. People who thought Evette took a shortcut also rated her as less likable. They wanted more social distance from her. They blamed her more for being fat in the first place. Th
Fwd: When Ozempic stops working (and what 10% of users already know)
Score 0.704
· Account tjphuhs@gmail.com
· 3/17/2026, 2:05:41 PM
Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z to lose even 5% of body weight, the minimum threshold considered clinically meaningful. In the SURMOUNT-2 trial for tirzepatide, 17-21% of participants didn't hit that 5% mark. Why? Variants in the GLP-1 receptor gene affect how strongly the drug signals satiety. Gut microbiome composition also influences response. And if your metabolism is already adapted to caloric restrictio
Fwd: When Ozempic stops working (and what 10% of users already know)
Score 0.698
· Account tjphuhs@gmail.com
· 3/17/2026, 2:05:41 PM
Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z Rate Problem Retatrutide is Eli Lilly's triple agonist (GIP/GLP-1/glucagon). Early results: up to 24.2% weight loss at 48 weeks per the NEJM Phase 2 trial. But buried in the data: dose-dependent increases in heart rate peaking at 24 weeks. The glucagon receptor component is the likely culprit. At the 12mg dose, heart rate elevations were clinically notable. Users report resting
GLP-1 Shaming
Score 0.693
· Account tjphuhs@gmail.com
· 4/20/2026, 6:03:00 PM
GLP-1 Shaming from huntershealthhacks@mail.beehiiv.com on 2026-04-20T22:03:00.000Z and it shortens lives. ——————————————————————————— **Final Thoughts** If there is anyone who is a proponent of intelligent GLP-1 use, it’s me. I always say, these peptides should be used as a catalyst, then stack the rest of the lifestyle work to enhance results. Resistance training to protect lean mass. Protein intake high enough to keep you metabolically strong through the weight loss phase. Sleep well. Handle S
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.692
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 2:01 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption > One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — i
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.692
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 2:01 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption > One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — i
The Last Time It “Worked” Before GLP-1
Score 0.692
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z View this post on the web at https://onthepen.substack.com/p/the-last-time-it-worked-before-glp I’ve battled obesity my entire adult life. Not in a casual way, and not in a “I should probably lose a few pounds” kind of way, but in a way where it becomes part of how you think, how you plan your day, and how the world and people around you start to see you and treat you. I remember the last time my weight
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.691
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z of trying everything else. For many others, it was the first real hope offered, after the promises of metabolic surgeries failed to deliver as promised. > That is exactly why pregnancy can add such a complex layer to the journey, because the same medication that helped restore metabolic health is also restoring ovulation in ways many women using GLP-1 therapies did not necessarily
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.691
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z of trying everything else. For many others, it was the first real hope offered, after the promises of metabolic surgeries failed to deliver as promised. > That is exactly why pregnancy can add such a complex layer to the journey, because the same medication that helped restore metabolic health is also restoring ovulation in ways many women using GLP-1 therapies did not necessarily
The Last Time It “Worked” Before GLP-1
Score 0.690
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z in the middle of the night and went home. I say “finally” because it seems like every weigh loss story has a “finally”… This is the part right before the wheels come off. My wife ended up in the hospital for a full week, passing kidney stones one after another. I stayed with her the entire time. Inducing early labor was the big concern, so it was a terrifying time for us. The hospital was about an hour
Do GLP-1s Kill Your Testosterone?
Score 0.689
· Account tjphuhs@gmail.com
· 4/28/2026, 10:43:24 AM
Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z (STEP 1) Tirzepatide: ~21% loss at 72 weeks (SURMOUNT-1) Peptide-R (triple-agonist): ~24% at 48 weeks (phase 2), and 28.7% at 68 weeks in the recent phase 3 TRIUMPH-4 readout. Placebo-adjusted: 26.6%. Once weight loss gets that aggressive, you’re no longer just dropping fat — you’re forcing the body into sustained caloric deficit territory that the HPG axis interprets as famine. And the famine response is
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This.
Score 0.689
· Account tjphuhs@gmail.com
· 3/18/2026, 4:18:18 PM
Fwd: Waking Up at 2–3am While Researching a GLP-1? Read This. from tjphuhs@gmail.com on 2026-03-18T20:18:18.000Z overthink it — just make sure there’s enough fuel in the tank before lights out. > As always, this is for research purposes only. All compounds are research use only, not for human consumption. > Drop any questions below — happy to help you troubleshoot. > Upgrade to paid > You're currently a free subscriber to Peptide Price. For the full experience, upgrade your subscription. > Upgra
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors?
Score 0.689
· Account oc.tjphuhs@gmail.com
· 3/15/2026, 2:45:56 PM
Fwd: How Long Does It Actually Take To Resensitize Your GLP-1 Receptors? from tjphuhs@gmail.com on 2026-03-15T18:45:56.000Z > Upgrade to paid > First, Why Do Receptors Desensitize In The First Place? > GLP-1 receptors aren’t just in your stomach - they’re distributed throughout your gut, brain, and nervous system. When a long-acting GLP-1 compound is being administered week after week, those receptors are receiving a continuous, sustained signal. Over time the body does what it always does - it