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ChaseIrons: Retatrutide Plateaus Explained: The REAL Reason You Stopped Losing Weight

Score 0.861 · Account tjphuhs@gmail.com · 2/18/2026, 11:59:11 AM

ChaseIrons: Retatrutide Plateaus Explained: The REAL Reason You Stopped Losing Weight from notifications@rumble.com on 2026-02-18T16:59:11.000Z ChaseIrons: Retatrutide Plateaus Explained: The REAL Reason You Stopped Losing Weight ChaseIrons Your Hourly updates Retatrutide Plateaus Explained: The REAL Reason You Stopped Losing Weight 1 day ago Download our App Rumble Inc. | 444 Gulf of Mexico Dr, Longboat Key, FL, 34228 Unsubscribe from emails for channel "ChaseIrons" Unsubscribe from a

Retatrutide Makes Me Hungrier?

Score 0.738 · Account tjphuhs@gmail.com · 4/29/2026, 6:04:32 PM

Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z a drug. Up to 28.7% at 68 weeks in TRIUMPH-4. That kind of rapid loss triggers a maximal counter-regulatory response. Your body interprets it as starvation and ramps up hunger drive to defend its weight. Lilly hasn't measured ghrelin or leptin in any published retatrutide trial. They don't track "increased appetite" as a reportable side effect. So this whole counter-regulatory mechanism is invisib

Retatrutide Makes Me Hungrier?

Score 0.734 · Account tjphuhs@gmail.com · 4/29/2026, 6:04:32 PM

Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z modest, around r=0.28. That means appetite suppression accounts for less than 10% of the weight-loss variance. So the play is to lean into the protein, the training, HRT, and the lifestyle work. The peptide is doing its job. Your job is to give it the inputs that let the weight loss show up on the scale. Best, Hunter Williams ——————————————————————————— **Further Reading** * [Why Am I So Hungry on

Retatrutide Makes Me Hungrier?

Score 0.734 · Account tjphuhs@gmail.com · 4/29/2026, 6:04:32 PM

Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z more hunger. The TRIUMPH body composition data showed retatrutide doesn't actually preserve lean mass any better than other GLP-1 agents. The "muscle-sparing" marketing around glucagon doesn't hold up in the data. So if you're not training, eating protein, and optimizing your hormones, you'll lose muscle. And your hunger is going to climb. ——————————————————————————— **What I Would Do ** A few thi

Fwd: When Ozempic stops working (and what 10% of users already know)

Score 0.709 · Account tjphuhs@gmail.com · 3/17/2026, 2:05:41 PM

Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z Rate Problem Retatrutide is Eli Lilly's triple agonist (GIP/GLP-1/glucagon). Early results: up to 24.2% weight loss at 48 weeks per the NEJM Phase 2 trial. But buried in the data: dose-dependent increases in heart rate peaking at 24 weeks. The glucagon receptor component is the likely culprit. At the 12mg dose, heart rate elevations were clinically notable. Users report resting

Retatrutide Makes Me Hungrier?

Score 0.703 · Account tjphuhs@gmail.com · 4/29/2026, 6:04:32 PM

Retatrutide Makes Me Hungrier? from huntershealthhacks@mail.beehiiv.com on 2026-04-29T22:04:32.000Z Happy Wednesday! An excellent reader question landed in my inbox this week. It's one I'm hearing more often these days. “_"I've noticed a significant increase in hunger while taking retatrutide, but interestingly, I'm not experiencing weight gain, just not seeing any weight loss either. Is this something you've seen before, and are there ways to improve results in a situation like this?"_“ — The s

Fwd: When Ozempic stops working (and what 10% of users already know)

Score 0.703 · Account tjphuhs@gmail.com · 3/17/2026, 2:05:41 PM

Fwd: When Ozempic stops working (and what 10% of users already know) from tjphuhs@gmail.com on 2026-03-17T18:05:41.000Z to lose even 5% of body weight, the minimum threshold considered clinically meaningful. In the SURMOUNT-2 trial for tirzepatide, 17-21% of participants didn't hit that 5% mark. Why? Variants in the GLP-1 receptor gene affect how strongly the drug signals satiety. Gut microbiome composition also influences response. And if your metabolism is already adapted to caloric restrictio

Fwd: Reta vs. Cancer

Score 0.695 · Account tjphuhs@gmail.com · 2/26/2026, 12:51:09 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z at lower doses, these metabolic changes may be meaningful. Non-Cancer-Favoring Terrain Cancer develops within biological terrain. A body with high fasting glucose A body with elevated insulin A body with systemic inflammation A body with immune dysfunction These conditions create fertile ground for pathological growth. Retatrutide appears to influence multiple pathways simultaneously. It improves glucose regulation, flattens

Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.

Score 0.694 · Account oc.tjphuhs@gmail.com · 3/16/2026, 10:27:30 AM

Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z larger. What Actually Happens When Someone Starts a GLP-1 GLP-1 compounds work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity. The appetite suppression in particular is real and meaningful — most people naturally and significantly reduce how much food they’re eating, often without even trying. Here’s where it gets interest

Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.

Score 0.694 · Account tjphuhs@gmail.com · 3/16/2026, 10:27:30 AM

Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z larger. What Actually Happens When Someone Starts a GLP-1 GLP-1 compounds work by suppressing appetite, slowing gastric emptying, and improving insulin sensitivity. The appetite suppression in particular is real and meaningful — most people naturally and significantly reduce how much food they’re eating, often without even trying. Here’s where it gets interest

Do GLP-1s Kill Your Testosterone?

Score 0.693 · Account tjphuhs@gmail.com · 4/28/2026, 10:43:24 AM

Do GLP-1s Kill Your Testosterone? from derekpruski@substack.com on 2026-04-28T14:43:24.000Z (STEP 1) Tirzepatide: ~21% loss at 72 weeks (SURMOUNT-1) Peptide-R (triple-agonist): ~24% at 48 weeks (phase 2), and 28.7% at 68 weeks in the recent phase 3 TRIUMPH-4 readout. Placebo-adjusted: 26.6%. Once weight loss gets that aggressive, you’re no longer just dropping fat — you’re forcing the body into sustained caloric deficit territory that the HPG axis interprets as famine. And the famine response is

Stuck on Reta?

Score 0.689 · Account tjphuhs@gmail.com · 5/8/2026, 8:19:55 PM

Stuck on Reta? from huntershealthhacks@mail.beehiiv.com on 2026-05-09T00:19:55.000Z biggest topics we get asked about. One listener was on MK-677, sleeping great, but binge eating and worried about insulin resistance. Taylor walks through what she actually recommends for women in this stage, why progesterone is doing more heavy lifting than most people realize, where MK-777 fits in, and the role minerals play that almost nobody talks about. I also get on my soapbox about sunlight, EMFs, and the

Fwd: Reta vs. Cancer

Score 0.688 · Account tjphuhs@gmail.com · 2/26/2026, 12:51:09 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z or appetite suppression. The dose used did not significantly affect body weight, yet tumor growth decreased meaningfully. Retatrutide’s benefits go far beyond cosmetic fat loss. They are metabolic. They are immunologic. They may even profoundly reshape the body's internal terrain. FYI, BioLongevity Labs is running a storewide sale where everything is 30% off. Use code HUNTERW to get an additional 15% off. The Study The resea

Reta vs. Cancer

Score 0.688 · Account tjphuhs@gmail.com · 2/24/2026, 6:06:31 PM

Reta vs. Cancer from huntershealthhacks@mail.beehiiv.com on 2026-02-24T23:06:31.000Z stress without excessive suppression of appetite or energy, that becomes a sustainable strategy. Consistency matters more than intensity. Subtle improvements maintained over the years can compound in powerful ways. ——————————————————————————— **Reta Beyond Fat Loss** For years, I have emphasized that GLP-1 agents are metabolic regulators rather than simple fat loss drugs. Retatrutide extends that concept because

Fwd: Reta vs. Cancer

Score 0.686 · Account tjphuhs@gmail.com · 2/26/2026, 12:56:32 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z improves insulin sensitivity and reduces hyperglycemia. That shift may reduce the availability of fuel and the growth signals that tumors rely on. Even at lower doses, these metabolic changes may be meaningful. Non-Cancer-Favoring Terrain Cancer develops within biological terrain. A body with high fasting glucose A body with elevated insulin A body with systemic inflammation A body with immune dysfunction These conditions cr

Fwd: Reta vs. Cancer

Score 0.685 · Account tjphuhs@gmail.com · 2/26/2026, 12:56:32 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z a frontline immune checkpoint cancer therapy in reducing tumor growth in this model. Interestingly, this study was not centered on dramatic weight loss or appetite suppression. The dose used did not significantly affect body weight, yet tumor growth decreased meaningfully. Retatrutide’s benefits go far beyond cosmetic fat loss. They are metabolic. They are immunologic. They may even profoundly reshape the body's internal ter

Fwd: Reta vs. Cancer

Score 0.681 · Account tjphuhs@gmail.com · 2/26/2026, 12:56:32 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:56:32.000Z broadly influence chronic disease pathways, including those involved in tumor biology. If low-dose retatrutide can meaningfully reduce tumor progression in an aggressive cancer model without causing weight loss, that suggests its metabolic influence runs deeper than body composition changes alone. That opens the door to considering this molecule within a broader longevity framework. Final Thoughts We are still early in the r

Reta vs. Cancer

Score 0.681 · Account tjphuhs@gmail.com · 2/24/2026, 6:06:31 PM

Reta vs. Cancer from huntershealthhacks@mail.beehiiv.com on 2026-02-24T23:06:31.000Z that metabolism and cancer are closely linked. Elevated insulin. Elevated glucose. Chronic inflammation. Visceral adiposity. Impaired immune surveillance. These factors create conditions that favor tumor growth. If a compound improves glucose control, lowers inflammatory tone, enhances insulin sensitivity, and potentially influences immune function, it is reasonable to consider that it could support a less cance

ChaseIrons: Stuck at 15% Body Fat? Do THIS

Score 0.678 · Account tjphuhs@gmail.com · 3/26/2026, 5:51:03 AM

ChaseIrons: Stuck at 15% Body Fat? Do THIS from notifications@rumble.com on 2026-03-26T09:51:03.000Z ChaseIrons: Stuck at 15% Body Fat? Do THIS ChaseIrons Your Hourly updates Stuck at 15% Body Fat? Do THIS 1 day ago Download our App Rumble Inc. | 444 Gulf of Mexico Dr, Longboat Key, FL, 34228 Unsubscribe from emails for channel "ChaseIrons" Unsubscribe from all channel update emails This email was sent for tjphuhs@gmail.com. Sign in and manage your subscriptions here Rumble may receive

Why Peptide Cycles Look Like a Slope, Not a Light Switch

Score 0.676 · Account tjphuhs@gmail.com · 3/29/2026, 9:14:23 PM

Why Peptide Cycles Look Like a Slope, Not a Light Switch from derekpruski@substack.com on 2026-03-30T01:14:23.000Z compounds with extended half-lives Adjust slowly — changes take time to show up Don’t measure results at week one or two; measure at week four or five, after steady state has had a chance to establish Time bloodwork correctly — several weeks in, or several weeks after stopping — not immediately at either end When the cycle ends, treat the washout seriously — especially if doses were

Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.

Score 0.673 · Account oc.tjphuhs@gmail.com · 3/16/2026, 10:27:30 AM

Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z is real and meaningful. The appetite suppression is genuine, the metabolic effects are genuine, and for many researchers the long-term results are significant. The point isn’t to discredit the compounds — it’s to set realistic expectations so people don’t get discouraged when their first week looks different from someone else’s highlight reel. Stop Comparing Y

Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why.

Score 0.673 · Account tjphuhs@gmail.com · 3/16/2026, 10:27:30 AM

Fwd: Nobody Lost 7 Pounds of Fat in Their First Week on a GLP-1. Let's Talk About Why. from tjphuhs@gmail.com on 2026-03-16T14:27:30.000Z is real and meaningful. The appetite suppression is genuine, the metabolic effects are genuine, and for many researchers the long-term results are significant. The point isn’t to discredit the compounds — it’s to set realistic expectations so people don’t get discouraged when their first week looks different from someone else’s highlight reel. Stop Comparing Y

Fwd: Reta vs. Cancer

Score 0.673 · Account tjphuhs@gmail.com · 2/26/2026, 12:51:09 AM

Fwd: Reta vs. Cancer from tjphuhs@gmail.com on 2026-02-26T05:51:09.000Z model without causing weight loss, that suggests its metabolic influence runs deeper than body composition changes alone. That opens the door to considering this molecule within a broader longevity framework. Final Thoughts We are still early in the research. Human data will be essential before drawing firm conclusions. Even so, the data's direction is compelling. Improving metabolic signaling alone influenced tumor biology

Non-GLP Fat Loss Compounds Ranked

Score 0.672 · Account tjphuhs@gmail.com · 5/5/2026, 6:03:45 PM

Non-GLP Fat Loss Compounds Ranked from huntershealthhacks@mail.beehiiv.com on 2026-05-05T22:03:45.000Z Happy Tuesday! Most folks would agree that the GLPs are the kings of fat loss, with retatrutide holding the title belt. But what if GLPs are not on the table for you? What if you are cycling off? What if you want to stack other compounds so you don’t have to crank your GLP dose into the stratosphere? I just dropped a brand-new video and podcast episode where I rank **20 non-GLP-1 fat-loss**** c

Fwd: Stuck on Reta?

Score 0.671 · Account tjphuhs@gmail.com · 5/9/2026, 1:49:02 PM

Fwd: Stuck on Reta? from tjphuhs@gmail.com on 2026-05-09T17:49:02.000Z why I personally only use MT1, why MT2 is more like a tanning bed (use it for an event, not year-round), and how I think about the cancer question for each one. There's also a tangent about tanning beds in the early 2000s that probably explains a lot about a generation of skin issues. > > Perimenopausal Sleep Problems > This is one of the biggest topics we get asked about. One listener was on MK-677, sleeping great, but binge