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Semantic Search: BREAKING: Two Stories That Impact Compounded GLP-1
BREAKING: Two Stories That Impact Compounded GLP-1
Score 0.735
· Account tjphuhs@gmail.com
· 4/30/2026, 10:32:22 PM
BREAKING: Two Stories That Impact Compounded GLP-1 from onthepen@substack.com on 2026-05-01T02:32:22.000Z The Reality for Patients Patients did not turn to compounded GLP-1s because they wanted a workaround. They turned to them because the branded medications were out of stock, out of reach, imprecisely dosed, or excluded by their insurance. Compounding was not a loophole. For hundreds of thousands of people, it was the only path forward. The FDA’s position is now clear. Affordability is not a c
The GLP-1 Moment Is Breaking the Healthcare System Wide Open
Score 0.731
· Account tjphuhs@gmail.com
· 3/18/2026, 6:27:27 PM
The GLP-1 Moment Is Breaking the Healthcare System Wide Open from onthepen@substack.com on 2026-03-18T22:27:27.000Z View this post on the web at https://onthepen.substack.com/p/the-glp-1-moment-is-breaking-the I’ve said this a number of times, but it keeps proving itself out. GLP-1 medications are not just transforming lives, they’re transforming our healthcare system in a way we haven’t seen in decades, and it’s happening faster than most people realize. What started as a shortage story, and on
The Last Time It “Worked” Before GLP-1
Score 0.719
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z the moment life got complicated, then you already understand why that matters. What is the moment where things fell apart for you, even when you were doing everything right? Unsubscribe https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9vbnRoZXBlbi5zdWJzdGFjay5jb20vYWN0aW9uL2Rpc2FibGVfZW1haWw_dG9rZW49ZXlKMWMyVnlYMmxrSWpveU56TTJNakl6T1Rnc0luQnZjM1JmYVdRaU9qRTVNemt3T1RJd05pd2lhV0YwSWpveE56YzFPVE16T0RNMExD
BREAKING: Two Stories That Impact Compounded GLP-1
Score 0.708
· Account tjphuhs@gmail.com
· 4/30/2026, 10:32:22 PM
BREAKING: Two Stories That Impact Compounded GLP-1 from onthepen@substack.com on 2026-05-01T02:32:22.000Z on compounded GLP-1’s, this week proposing not to include semaglutide, tirzepatide, or liraglutide on the 503B Bulks List. That is the list that determines which substances outsourcing facilities can compound from at scale. The agency was explicit about its reasoning. It stated that there is no clinical need for outsourcing facilities to compound these drugs from bulk substances. It stated t
BREAKING: Two Stories That Impact Compounded GLP-1
Score 0.707
· Account tjphuhs@gmail.com
· 4/30/2026, 10:32:22 PM
BREAKING: Two Stories That Impact Compounded GLP-1 from onthepen@substack.com on 2026-05-01T02:32:22.000Z View this post on the web at https://onthepen.substack.com/p/breaking-two-stories-that-impact A federal judge just handed Eli Lilly a mixed ruling in its lawsuit against Empower Pharmacy. At almost the same time, the FDA quietly proposed something that could matter even more long term: formally declaring that there is no “clinical need” to compound semaglutide, tirzepatide, or liraglutide at
The Last Time It “Worked” Before GLP-1
Score 0.700
· Account tjphuhs@gmail.com
· 4/11/2026, 2:56:58 PM
The Last Time It “Worked” Before GLP-1 from onthepen@substack.com on 2026-04-11T18:56:58.000Z in the middle of the night and went home. I say “finally” because it seems like every weigh loss story has a “finally”… This is the part right before the wheels come off. My wife ended up in the hospital for a full week, passing kidney stones one after another. I stayed with her the entire time. Inducing early labor was the big concern, so it was a terrifying time for us. The hospital was about an hour
The GLP-1 Moment Is Breaking the Healthcare System Wide Open
Score 0.693
· Account tjphuhs@gmail.com
· 3/18/2026, 6:27:27 PM
The GLP-1 Moment Is Breaking the Healthcare System Wide Open from onthepen@substack.com on 2026-03-18T22:27:27.000Z are doing at the individual level is just as profound. They are increasingly looking like longevity drugs, fewer heart attacks and strokes, less inflammation, reduced cancer risk signals, meaningful diabetes improvement, and the list keeps growing. The impact of that alone is massively transformative and cannot be overstated. I’ve been digging into this more in recent conversations
Fwd: Compound Tirzepatide & Semaglutide Updates!
Score 0.691
· Account tjphuhs@gmail.com
· 3/17/2026, 5:51:48 PM
Fwd: Compound Tirzepatide & Semaglutide Updates! from tjphuhs@gmail.com on 2026-03-17T21:51:48.000Z exclusive DDC list explained Novo’s lab findings 302% dose shocker Catalent’s contamination mess Lilly’s B12 tirzepatide bombshell Is the molecule changing? New oral GLP-1 contender MASSIVE: Compound Tirzepatide and Semaglutide Updates! Dave Knapp GLP-1 Industry Insider Episode Do you trust compounded GLP-1s based on real-world experience, or do findings like the ones discussed today change your p
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.688
· Account tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In
Score 0.688
· Account oc.tjphuhs@gmail.com
· 4/7/2026, 1:00:10 PM
Fwd: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In from tjphuhs@gmail.com on 2026-04-07T17:00:10.000Z ---------- Forwarded message ---------- From: Dave Knapp from On The Pen <onthepen@substack.com> Date: Mar 28, 2026 at 1:38 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1 Pregnancy Fears vs Reality… The First Real Data Is In > If you’re currently on a GLP-1, or if you’ve been on one long enough to feel your body experience massive changes, you already understand why this conversatio
GLP-1s vs. Addiction
Score 0.688
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z Happy Monday! I recently [read a very large study published in ](https://www.bmj.com/content/392/bmj-2025-086886)_[The BMJ](https://www.bmj.com/content/392/bmj-2025-086886)_ that provided the strongest signal yet that something tangible may be happening in the brain on GLP-1s. The study analyzed health records from more than 600,000 U.S. veterans with type 2 diabetes to examine whether GLP-1 drugs influence
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.681
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z > The compounds where this PK shift becomes noteworthy in the published literature are the ones where timing of the peak is part of the mechanism, or where a sharp Cmax is what produces the intended effect: > Fast-onset agents where the curve shape is the effect — the onset profile changes, and the shifted Tmax can create the impression that something isn’t working wh
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.681
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z > The compounds where this PK shift becomes noteworthy in the published literature are the ones where timing of the peak is part of the mechanism, or where a sharp Cmax is what produces the intended effect: > Fast-onset agents where the curve shape is the effect — the onset profile changes, and the shifted Tmax can create the impression that something isn’t working wh
The Next Wave of GLP-1s Is Coming
Score 0.679
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z the GLP-1 world. They're not retatrutide. But they're not far off. And they fill important gaps that tirzepatide and semaglutide can't address. Whether you use them as a primary GLP-1, an alternative for people who don't tolerate retatrutide well, or a rotation compound to maintain receptor sensitivity, I think they're worth researching. Remember to check out the video for the full breakdown. A
GLP-1s vs. Addiction
Score 0.678
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z what it does and does not prove. The research is observational. That means it identifies associations between GLP-1 drugs and addiction outcomes. It does not prove that the drugs directly caused the reduction in addiction risk. The study population also consisted mostly of older male veterans with type 2 diabetes. That population may not perfectly represent the broader public. Researchers also cannot fully
GLP-1s vs. Addiction
Score 0.678
· Account tjphuhs@gmail.com
· 3/11/2026, 6:07:04 PM
GLP-1s vs. Addiction from huntershealthhacks@mail.beehiiv.com on 2026-03-11T22:07:04.000Z addiction medicine, it is rare to see a single intervention associated with improvements across multiple substances at the same time! ——————————————————————————— **What’s Going on in the Brain** To understand why these drugs might influence addiction, we have to look at where GLP-1 receptors exist in the body. Most people think of GLP-1 as a gut hormone. It is released after eating and helps regulate blood
GLP-1 Access State of the Union
Score 0.673
· Account tjphuhs@gmail.com
· 4/7/2026, 4:01:22 PM
GLP-1 Access State of the Union from onthepen@substack.com on 2026-04-07T20:01:22.000Z View this post on the web at https://onthepen.substack.com/p/glp-1-access-state-of-the-union If you just look at the headlines, things look great for access to GLP-1 medications but for some of those already using these medications things are changing and getting tighter. Listen in as Dave breaks down the news of the week and puts it all in context. Watch or listen to this week’s podcast on Spotify! If you pre
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.671
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most cases — preserved. > This article is for research and educational purposes only. The compounds and protocols discussed are intended for in vitro and laboratory research use. Nothing in this article constitutes medical advice, clinical guidance, or
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.671
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most cases — preserved. > This article is for research and educational purposes only. The compounds and protocols discussed are intended for in vitro and laboratory research use. Nothing in this article constitutes medical advice, clinical guidance, or
Massive GLP-1 Data From ECO 2026
Score 0.671
· Account tjphuhs@gmail.com
· 5/13/2026, 10:52:49 AM
Massive GLP-1 Data From ECO 2026 from onthepen@substack.com on 2026-05-13T14:52:49.000Z weeks. Two cohorts: those coming off Zepbound and those coming off Wegovy. 376 participants total. They started orforglipron at 12mg and titrated up every four weeks, targeting a maximum of 36mg. A rescue protocol allowed escalation or a switch from placebo to orforglipron after week 24 for anyone who regained more than half their original loss. One detail to keep in mind: there was a two-week screening gap b
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.670
· Account oc.tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 2:01 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption > One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — i
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.670
· Account tjphuhs@gmail.com
· 4/25/2026, 9:08:09 PM
Fwd: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from tjphuhs@gmail.com on 2026-04-26T01:08:09.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 25, 2026 at 2:01 PM -0400 To: tjphuhs@gmail.com Subject: GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption > One of the most underappreciated mechanisms of GLP-1 receptor agonists isn’t the appetite suppression or the glucose control — i
The Next Wave of GLP-1s Is Coming
Score 0.668
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z Happy Tuesday! There are two peptides quietly making waves in the clinical space that will demand all of our attention over the next 24 months. They don't work like semaglutide, they don't work like tirzepatide, and the clinical data is turning heads. I just dropped a brand new video breaking down survodutide and mazdutide. Survodutide & Mazdutide | The GLP-1/Glucagon Duo That Could Rival Reta:
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.667
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z and produce mood-adjacent effects through its central mechanism. Dosing being explored runs 500 mcg – 2 mg per research administration, administered 1–2 hours before the relevant observation window. Most community research starts at the lower end — 500 mcg to 1 mg — to assess tolerance before titrating up. Frequency is kept to a maximum of 2–3x per week to avoid the receptors
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption
Score 0.666
· Account tjphuhs@gmail.com
· 4/25/2026, 2:00:53 PM
GLP-1s and Slowed Gastric Emptying: What It Means for Compound Absorption from derekpruski@substack.com on 2026-04-25T18:00:53.000Z onset to be delayed, expect peaks to be softer, and don’t interpret a delayed onset as a failure of the protocol. The compound is in circulation. It’s just taking a longer path to get there. Understanding the mechanism is the difference between confusion and clarity here. The gastric emptying effect is real, the PK shift is real, and the total exposure is — in most