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Semantic Search: Adamax & Adalank: Two Upgrades, Two Very Different Reasons
Adamax & Adalank: Two Upgrades, Two Very Different Reasons
Score 0.850
· Account tjphuhs@gmail.com
· 4/8/2026, 3:54:02 PM
Adamax & Adalank: Two Upgrades, Two Very Different Reasons from derekpruski@substack.com on 2026-04-08T19:54:02.000Z View this post on the web at https://derekpruski.substack.com/p/adamax-and-adalank-two-upgrades-two For research purposes only. Not for human consumption. Adamax and Adalank are often mentioned in the same breath because they’re both “next-gen” derivatives — one built from Semax, one from Selank. But the way each was upgraded is completely different, and that difference matters fo
Adamax & Adalank: Two Upgrades, Two Very Different Reasons
Score 0.823
· Account tjphuhs@gmail.com
· 4/8/2026, 3:54:02 PM
Adamax & Adalank: Two Upgrades, Two Very Different Reasons from derekpruski@substack.com on 2026-04-08T19:54:02.000Z to pass through more readily; more of the compound reaches the brain, at higher concentrations, compared to standard Semax variants; resistance to enzymatic breakdown is also substantially improved The upgrade Adamax represents is pharmacodynamic — meaning the structural change alters what the compound actually does at the receptor level, not only how it is handled in circulation.
Adamax & Adalank: Two Upgrades, Two Very Different Reasons
Score 0.812
· Account tjphuhs@gmail.com
· 4/8/2026, 3:54:02 PM
Adamax & Adalank: Two Upgrades, Two Very Different Reasons from derekpruski@substack.com on 2026-04-08T19:54:02.000Z produces to regulate mood and stress), extending their active window Immune system support — retained from Selank’s origins as a tuftsin analog (tuftsin is a naturally occurring immune peptide), including cytokine regulation (cytokines are signaling proteins that coordinate immune responses) and broader immune system modulation The upgrade Adalank represents is pharmacokinetic — m
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.578
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z TJ Begin forwarded message: From: Derek from Peptide Price <derekpruski@substack.com> Date: March 17, 2026 at 2:35:48 PM EDT To: tjphuhs@gmail.com Subject: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds Reply-To: Derek from Peptide Price <reply+35vwkb&4iwoe6&&9a37b440eaa19e66b34a088ebedada07af9e3dc1f17602c464d22c4118ef1002@mg1.substack.com>
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.578
· Account tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z TJ Begin forwarded message: From: Derek from Peptide Price <derekpruski@substack.com> Date: March 17, 2026 at 2:35:48 PM EDT To: tjphuhs@gmail.com Subject: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds Reply-To: Derek from Peptide Price <reply+35vwkb&4iwoe6&&9a37b440eaa19e66b34a088ebedada07af9e3dc1f17602c464d22c4118ef1002@mg1.substack.com>
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.570
· Account tjphuhs@gmail.com
· 3/17/2026, 2:35:41 PM
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from derekpruski@substack.com on 2026-03-17T18:35:41.000Z same breadth is what drives the more pronounced side effects. Think of it this way: MT1 is a targeted signal to your melanocytes. MT2 is a louder, less specific signal that hits multiple systems at once. What That Looks Like in Practice MT1 produces a gradual, even tan. Existing freckles and moles will darken — this is expected, since those areas already have higher
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.568
· Account tjphuhs@gmail.com
· 3/17/2026, 2:35:41 PM
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from derekpruski@substack.com on 2026-03-17T18:35:41.000Z View this post on the web at https://derekpruski.substack.com/p/melanotan-1-vs-melanotan-2-same-starting For research and educational purposes only. Not medical advice. These two get lumped together constantly. Same name, same origin, similar purpose — so people assume they’re basically the same thing with different numbers. They’re not. Understanding why requires a
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.564
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z compound with more clinical data behind it. It costs more per dose and requires more frequent administration — those are the real tradeoffs. MT2 makes more sense if you want the broader effect profile, if dosing convenience matters, or if you’ve used it before and handle it well. It’s also more cost-effective. Combining them is an option some people use to get the tan
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.564
· Account tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z compound with more clinical data behind it. It costs more per dose and requires more frequent administration — those are the real tradeoffs. MT2 makes more sense if you want the broader effect profile, if dosing convenience matters, or if you’ve used it before and handle it well. It’s also more cost-effective. Combining them is an option some people use to get the tan
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.564
· Account tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z 20.1% weight loss at 48 weeks in Phase 2 — as a standalone drug. Novo Nordisk’s CagriSema combines semaglutide with an amylin agonist for this exact reason. Amylin is a proven target. > Calcitonin > This is the most interesting addition, and the one most worth understanding in depth. > Calcitonin is a hormone your thyroid produces that’s been known for decades primarily
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.564
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 9:42:34 AM
Fwd: Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from tjphuhs@gmail.com on 2026-04-24T13:42:34.000Z 20.1% weight loss at 48 weeks in Phase 2 — as a standalone drug. Novo Nordisk’s CagriSema combines semaglutide with an amylin agonist for this exact reason. Amylin is a proven target. > Calcitonin > This is the most interesting addition, and the one most worth understanding in depth. > Calcitonin is a hormone your thyroid produces that’s been known for decades primarily
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.559
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z of that, the functional impact is minimal. MT2 produces the same tanning effect, plus appetite suppression that some research subjects find significant, plus pro-erectile and libido-related effects driven by MC4R activity. You’re essentially getting multiple systems activated from a single compound. The tradeoff is side effects. Nausea with MT2 is common, particularly
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.559
· Account tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z of that, the functional impact is minimal. MT2 produces the same tanning effect, plus appetite suppression that some research subjects find significant, plus pro-erectile and libido-related effects driven by MC4R activity. You’re essentially getting multiple systems activated from a single compound. The tradeoff is side effects. Nausea with MT2 is common, particularly
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.559
· Account tjphuhs@gmail.com
· 3/17/2026, 2:35:41 PM
Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from derekpruski@substack.com on 2026-03-17T18:35:41.000Z per week MT2: Start: 0.1–0.25mg to assess tolerance Loading: 0.25–0.5mg daily for 1–3 weeks Maintenance: 0.5mg 1–2x per week MT2 achieves a comparable tan at lower doses and less frequent intervals. The convenience advantage is real. Whether it outweighs the side effect profile depends on what you’re optimizing for. How to Choose MT1 makes more sense if tanning is y
The Next Wave of GLP-1s Is Coming
Score 0.559
· Account tjphuhs@gmail.com
· 3/31/2026, 6:05:53 PM
The Next Wave of GLP-1s Is Coming from huntershealthhacks@mail.beehiiv.com on 2026-03-31T22:05:53.000Z fat and energy expenditure benefits that GIP agonism simply does not. Retatrutide is still king on paper. It hits all three receptors and delivers the most weight loss. But survodutide and mazdutide are not far behind. And for people who need an alternative, or who want to cycle compounds to maintain receptor sensitivity, these fill a real gap. ——————————————————————————— **They're Not the Same
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine
Score 0.557
· Account tjphuhs@gmail.com
· 4/24/2026, 9:05:46 AM
Eli Lilly’s Quintuple Agonist: The Next Frontier in Metabolic Medicine from derekpruski@substack.com on 2026-04-24T13:05:46.000Z have better tolerability than incretins, with less nausea Lilly’s eloralintide (a selective amylin agonist) showed up to 20.1% weight loss at 48 weeks in Phase 2 — as a standalone drug. Novo Nordisk’s CagriSema combines semaglutide with an amylin agonist for this exact reason. Amylin is a proven target. Calcitonin This is the most interesting addition, and the one most
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.556
· Account tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z as synthetic analogs of alpha-melanocyte stimulating hormone — α-MSH — a naturally occurring peptide your body already produces. α-MSH plays a central role in regulating pigmentation, appetite, inflammation, and sexual function by binding to a family of receptors called melanocortin receptors (MC1R through MC5R). The researchers weren’t trying to create a tanning pept
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds
Score 0.556
· Account oc.tjphuhs@gmail.com
· 3/17/2026, 2:42:07 PM
Fwd: Melanotan 1 vs Melanotan 2: Same Starting Point, Very Different Compounds from tjphuhs@gmail.com on 2026-03-17T18:42:07.000Z as synthetic analogs of alpha-melanocyte stimulating hormone — α-MSH — a naturally occurring peptide your body already produces. α-MSH plays a central role in regulating pigmentation, appetite, inflammation, and sexual function by binding to a family of receptors called melanocortin receptors (MC1R through MC5R). The researchers weren’t trying to create a tanning pept
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+
Score 0.555
· Account tjphuhs@gmail.com
· 5/11/2026, 10:07:04 AM
NMN vs NR: A Deep Dive For Researchers Who Didn’t Get What They Hoped From NAD+ from derekpruski@substack.com on 2026-05-11T14:07:04.000Z a noisier regulatory history: NMN. They mostly converge. Product Suggestions Here are some good suggestions from products off Amazon. NR: Option 1 [ https://substack.com/redirect/cc11084b-8946-4ee1-92cb-88a534bd1170?j=eyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs ] Option 2 [ https://substack.com/redirect/0d8335b6-57e8-4ebe-b292-16d87ad30def?
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.552
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z you want to start a task, finish a project, or feel rewarded after doing something. GLP-1 compounds can dial down dopamine activity in these areas — not dramatically, but enough that some RS subjects notice a consistent low-grade flatness that doesn’t go away on its own. The same mechanism making the compounds so effective at reducing compulsive eating can also reduce the brai
AMD’s spike reveals CPUs’ importance
Score 0.550
· Account tjphuhs@gmail.com
· 5/7/2026, 6:42:03 AM
AMD’s spike reveals CPUs’ importance from hello@snacks.robinhood.com on 2026-05-07T10:42:03.000Z on the performance of peers, the industry at large. It’s not just AMD: In its fiscal Q4 2026 earnings report last night, Arm Holdings reported a deluge of demand for its data center CPUs, which were launched in late March . “We now have more than $2 billion of customer demand across fiscal 2027 and fiscal 2028, more than double what we stated at launch,” per the press release. “Soon the data center w
Urolithin A: The Most Underrated Compound in Longevity
Score 0.547
· Account tjphuhs@gmail.com
· 5/2/2026, 11:16:56 AM
Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z which collectively drive expression of antioxidant defense genes and reduce oxidative stress. Mechanisms Relevant to Neurodegeneration This is the section that doesn’t get enough attention. UA crosses the blood-brain barrier, and the preclinical neuroprotective data is genuinely impressive across multiple disease models. Alzheimer’s disease (preclinical) In multiple AD mouse models —
Fwd: Urolithin A: The Most Underrated Compound in Longevity
Score 0.544
· Account oc.tjphuhs@gmail.com
· 5/2/2026, 4:58:06 PM
Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z doesn’t get enough attention. UA crosses the blood-brain barrier, and the preclinical neuroprotective data is genuinely impressive across multiple disease models. > Alzheimer’s disease (preclinical) > In multiple AD mouse models — APP/PS1, 3xTgAD, and DNA-repair-deficient ADP mice — UA treatment has been shown to: > > • > Reduce amyloid-beta plaque accumulation > • > Decrease tau hyperp
Fwd: Urolithin A: The Most Underrated Compound in Longevity
Score 0.544
· Account tjphuhs@gmail.com
· 5/2/2026, 4:58:06 PM
Fwd: Urolithin A: The Most Underrated Compound in Longevity from tjphuhs@gmail.com on 2026-05-02T20:58:06.000Z doesn’t get enough attention. UA crosses the blood-brain barrier, and the preclinical neuroprotective data is genuinely impressive across multiple disease models. > Alzheimer’s disease (preclinical) > In multiple AD mouse models — APP/PS1, 3xTgAD, and DNA-repair-deficient ADP mice — UA treatment has been shown to: > > • > Reduce amyloid-beta plaque accumulation > • > Decrease tau hyperp
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend
Score 0.542
· Account tjphuhs@gmail.com
· 3/27/2026, 4:31:44 PM
NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend from derekpruski@substack.com on 2026-03-27T20:31:44.000Z body called NNMT that essentially drains your NAD+ supply by siphoning off the raw materials needed to make it. 5-Amino-1MQ blocks that enzyme. It’s not adding more NAD+ — it’s stopping the leak so the NAD+ you have (and are supplying with the first compound) sticks around longer and gets used productively. It also plays a role in how fat cells behave metabolically. Why These Three Toge