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Semantic Search: A neuroscientist’s secret to relationships that last
A neuroscientist’s secret to relationships that last
Score 0.849
· Account tjphuhs@gmail.com
· 5/12/2026, 4:15:25 PM
A neuroscientist’s secret to relationships that last from support@email.masterclass.com on 2026-05-12T20:15:25.000Z A neuroscientist’s secret to relationships that last Dr. Amir Levine reveals what it takes to get the relationship you’ve always wanted.͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
A neuroscientist’s secret to relationships that last
Score 0.745
· Account tjphuhs@gmail.com
· 5/12/2026, 4:15:25 PM
A neuroscientist’s secret to relationships that last from support@email.masterclass.com on 2026-05-12T20:15:25.000Z <https://x.com/masterclass> If you no longer want to receive updates on the MasterClass membership, you can unsubscribe at any time by clicking "unsubscribe" below. Support <https://www.masterclass.com/help-center> | Gifts <https://www.masterclass.com/gift?utm_content=gift_footer> | MasterClass at Work <https://www.masterclass.com/for-business?utm_content=atwork_footer> Privacy <ht
5-Bullet Friday — Art Thieves, At-Home Brain Stimulation, Dwarkesh’s Origin Story, and Tide Shifts
Score 0.624
· Account tjphuhs@gmail.com
· 5/8/2026, 7:51:46 PM
5-Bullet Friday — Art Thieves, At-Home Brain Stimulation, Dwarkesh’s Origin Story, and Tide Shifts from tim@fourhourbody.com on 2026-05-08T23:51:46.000Z ( https://click.fourhourmail.com/4zu36wwe44tehpem92zixh699qn49h5h704/z2hghnhexq576obp/aHR0cHM6Ly9hcmNoaXZlLmlzL1dXcGZ3 ).) One excerpt from the latter: “Various efforts within the psychopharmacology society aim to make deprescribing part of regular medical practice. One group is proposing the creation of a new insurance code so that doctors
NEW: Stop falling for the same red flags
Score 0.617
· Account tjphuhs@gmail.com
· 5/8/2026, 5:42:36 PM
NEW: Stop falling for the same red flags from support@email.masterclass.com on 2026-05-08T21:42:36.000Z to someone might be a warning sign. Learn to spot unhealthy patterns in your relationships. START LEARNING <https://www.masterclass.com/course/499> <https://www.masterclass.com/course/499> Why can’t I let anyone in? <https://www.masterclass.com/course/499> If letting someone in feels hard, this class shows you what triggers the distance so you can change your patterns. START LEARNING <https://
Open Tab: Esther Perel
Score 0.597
· Account tjphuhs@gmail.com
· 5/12/2026, 12:04:35 PM
Open Tab: Esther Perel from on+open-tab@substack.com on 2026-05-12T16:04:35.000Z Esther: There are so many ways to answer this. I have never worked for anyone. I’ve worked for clinics, I’ve worked in hospitals, but I’ve never been a full-time employee somewhere. And I always said, I can tolerate the lack of security better than I can tolerate the lack of freedom. This was the life of the therapist. You do it all by yourself. And that’s part of why at some point I feel like I want more, I want so
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System
Score 0.594
· Account tjphuhs@gmail.com
· 3/20/2026, 10:11:53 AM
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System from tjphuhs@gmail.com on 2026-03-20T14:11:53.000Z — or 9-Me-BC — is a naturally occurring compound in the beta-carboline family. Beta-carbolines are found in small amounts in certain foods and even produced endogenously (your body makes trace amounts of them). 9-Me-BC specifically has been the subject of growing research interest because of what it appears to do to dopaminergic neurons — the cells in your brain responsible
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System
Score 0.594
· Account oc.tjphuhs@gmail.com
· 3/20/2026, 10:11:53 AM
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System from tjphuhs@gmail.com on 2026-03-20T14:11:53.000Z — or 9-Me-BC — is a naturally occurring compound in the beta-carboline family. Beta-carbolines are found in small amounts in certain foods and even produced endogenously (your body makes trace amounts of them). 9-Me-BC specifically has been the subject of growing research interest because of what it appears to do to dopaminergic neurons — the cells in your brain responsible
NEW: Stop falling for the same red flags
Score 0.592
· Account tjphuhs@gmail.com
· 5/8/2026, 5:42:36 PM
NEW: Stop falling for the same red flags from support@email.masterclass.com on 2026-05-08T21:42:36.000Z NEW: Stop falling for the same red flags Get 50% off for Mother’s Day—ends soon.͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System
Score 0.591
· Account tjphuhs@gmail.com
· 3/20/2026, 8:11:11 AM
9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System from derekpruski@substack.com on 2026-03-20T12:11:11.000Z View this post on the web at https://derekpruski.substack.com/p/9-me-bc-the-nootropic-that-wakes Let’s start with a question. Have you ever had a week where coffee just... stopped working? You drink it and feel nothing. No lift. No focus. Just the ritual of drinking something hot so your brain doesn’t scream at you. That’s not a caffeine problem. That’s a dopamine problem
Fwd: Do Semax and Selank Need to Be Cycled?
Score 0.582
· Account oc.tjphuhs@gmail.com
· 3/19/2026, 2:29:56 PM
Fwd: Do Semax and Selank Need to Be Cycled? from tjphuhs@gmail.com on 2026-03-19T18:29:56.000Z enhancing focus, cognition, and mental clarity in research subjects. Selank works on the GABAergic system and has anxiolytic effects — it reduces stress and anxiety markers in RS without sedation. > Neither works like a stimulant where you see an immediate on/off effect. The benefits build gradually and compound over time. That’s important context for understanding how to structure research protocols.
Fwd: Do Semax and Selank Need to Be Cycled?
Score 0.582
· Account tjphuhs@gmail.com
· 3/19/2026, 2:29:56 PM
Fwd: Do Semax and Selank Need to Be Cycled? from tjphuhs@gmail.com on 2026-03-19T18:29:56.000Z enhancing focus, cognition, and mental clarity in research subjects. Selank works on the GABAergic system and has anxiolytic effects — it reduces stress and anxiety markers in RS without sedation. > Neither works like a stimulant where you see an immediate on/off effect. The benefits build gradually and compound over time. That’s important context for understanding how to structure research protocols.
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System
Score 0.581
· Account oc.tjphuhs@gmail.com
· 3/20/2026, 10:11:53 AM
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System from tjphuhs@gmail.com on 2026-03-20T14:11:53.000Z so dopamine and serotonin linger longer and bind to receptors more fully. > • > MAO-A primarily breaks down serotonin and norepinephrine. MAO-B is more specific to dopamine. 9-Me-BC inhibits both, giving the full spectrum of monoamine neurotransmitters a longer window of activity. > • > Simple version: your brain releases dopamine and serotonin, but normally an enzyme quick
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System
Score 0.581
· Account tjphuhs@gmail.com
· 3/20/2026, 10:11:53 AM
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System from tjphuhs@gmail.com on 2026-03-20T14:11:53.000Z so dopamine and serotonin linger longer and bind to receptors more fully. > • > MAO-A primarily breaks down serotonin and norepinephrine. MAO-B is more specific to dopamine. 9-Me-BC inhibits both, giving the full spectrum of monoamine neurotransmitters a longer window of activity. > • > Simple version: your brain releases dopamine and serotonin, but normally an enzyme quick
Semax, Selank & SSRIs: What the Research Says About Combining Them
Score 0.580
· Account tjphuhs@gmail.com
· 3/23/2026, 12:50:25 PM
Semax, Selank & SSRIs: What the Research Says About Combining Them from derekpruski@substack.com on 2026-03-23T16:50:25.000Z View this post on the web at https://derekpruski.substack.com/p/semax-selank-and-ssris-what-the-research For research and educational purposes only. Not for human consumption. Not medical advice. I get asked about SSRIs constantly. Every nootropic peptide post, every Q&A, every comment section. “Can I use this on an SSRI?” “Will this interact with my antidepressant?” “Is i
The Brain Peptide You Don't Know About
Score 0.578
· Account tjphuhs@gmail.com
· 1/27/2026, 6:09:49 PM
The Brain Peptide You Don't Know About from huntershealthhacks@mail.beehiiv.com on 2026-01-27T23:09:49.000Z plasticity. Mechanistically, it is associated with pathways like JAK/STAT3, MAPK, and PI3K/Akt, which are heavily involved in how neurons adapt and survive under stress. One of the signature concepts around P21 is LIF inhibition, meaning it interferes with leukemia inhibitory factor signaling. LIF signaling can suppress aspects of neurogenesis, and P21 appears to reduce that brake, allowin
9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System
Score 0.577
· Account tjphuhs@gmail.com
· 3/20/2026, 8:11:11 AM
9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System from derekpruski@substack.com on 2026-03-20T12:11:11.000Z around lower-light periods or take precautions with sun exposure. MAO inhibition carries interaction considerations. Because 9-Me-BC slows the breakdown of serotonin and dopamine, stacking it carelessly with other compounds that also raise those neurotransmitters can push levels too high. This is especially relevant for anyone whose RS is using SSRIs, other MAOIs, or sero
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System
Score 0.576
· Account oc.tjphuhs@gmail.com
· 3/20/2026, 10:11:53 AM
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System from tjphuhs@gmail.com on 2026-03-20T14:11:53.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 20, 2026 at 8:14 AM -0400 To: tjphuhs@gmail.com Subject: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System > Let’s start with a question. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System
Score 0.576
· Account tjphuhs@gmail.com
· 3/20/2026, 10:11:53 AM
Fwd: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System from tjphuhs@gmail.com on 2026-03-20T14:11:53.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 20, 2026 at 8:14 AM -0400 To: tjphuhs@gmail.com Subject: 9-Me-BC: The Nootropic That Wakes Up Your Brain's Own Reward System > Let’s start with a question. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Fwd: Semax, Selank & SSRIs: What the Research Says About Combining Them
Score 0.575
· Account tjphuhs@gmail.com
· 3/23/2026, 1:16:56 PM
Fwd: Semax, Selank & SSRIs: What the Research Says About Combining Them from tjphuhs@gmail.com on 2026-03-23T17:16:56.000Z start here, with the two nootropic peptides I get this question about the most: Semax and Selank. They’re the most studied nootropic peptides in this category, they both interact with the serotonin system in some capacity, and they’re genuinely different from each other in ways that matter for this conversation. > This is not medical advice. Do not make changes to any prescr
Bryan’s deep sleep protocol
Score 0.575
· Account tjphuhs@gmail.com
· 4/3/2026, 10:15:47 AM
Bryan’s deep sleep protocol from hello@bryanjohnson.com on 2026-04-03T14:15:47.000Z (rapid eye movement) REM sleep and deep sleep. [Bryan Johnson’s sleep quality data](https://blueprint.bryanjohnson.com/) [Bryan Johnson's sleep quality data](https://blueprint.bryanjohnson.com/) What happens in the body during restorative sleep: - + brain cleaning: During early night deep sleep, glial cells shrink by up to 60%. These are cells that support and protect nerve cells. When they shrink, they create tu
Urolithin A: The Most Underrated Compound in Longevity
Score 0.575
· Account tjphuhs@gmail.com
· 5/2/2026, 11:16:56 AM
Urolithin A: The Most Underrated Compound in Longevity from derekpruski@substack.com on 2026-05-02T15:16:56.000Z which collectively drive expression of antioxidant defense genes and reduce oxidative stress. Mechanisms Relevant to Neurodegeneration This is the section that doesn’t get enough attention. UA crosses the blood-brain barrier, and the preclinical neuroprotective data is genuinely impressive across multiple disease models. Alzheimer’s disease (preclinical) In multiple AD mouse models —
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching
Score 0.574
· Account tjphuhs@gmail.com
· 4/4/2026, 8:24:03 PM
GLP-1 Mental Flatness & Anhedonia — Peptides Worth Researching from derekpruski@substack.com on 2026-04-05T00:24:03.000Z like a ceiling being lifted than a noticeable acute change. Research in this area is still relatively early but the underlying mechanism is well-supported in the preclinical literature. Oxytocin Most people know oxytocin as the “bonding hormone” — associated with trust, connection, and intimacy. But its role in the brain’s reward system is broader than that. It’s deeply tied t
Fwd: Brain fog isn't normal—here's what fixes it
Score 0.572
· Account tjphuhs@gmail.com
· 3/17/2026, 2:05:19 PM
Fwd: Brain fog isn't normal—here's what fixes it from tjphuhs@gmail.com on 2026-03-17T18:05:19.000Z for Sleep and Cognition How to restore deep sleep, mental sharpness, and protect against cognitive aging Does this sound familiar? You sleep 7-8 hours but wake up exhausted Brain fog slows you down at work Recovery takes longer than it used to Mental sharpness isn't what it was Sleep quality has quietly declined Here's the issue: as you age, your brain's repair pathways break down. Neurons can't r
Do Semax and Selank Need to Be Cycled?
Score 0.572
· Account tjphuhs@gmail.com
· 3/19/2026, 2:13:47 PM
Do Semax and Selank Need to Be Cycled? from derekpruski@substack.com on 2026-03-19T18:13:47.000Z View this post on the web at https://derekpruski.substack.com/p/do-semax-and-selank-need-to-be-cycled I get this question constantly, so let’s address it directly. The short answer: it depends on the research protocol and administration frequency. Every research subject is going to respond a little differently. But here’s the framework that makes sense for most protocols. What these compounds actuall
Fwd: Dihexa Deep Dive
Score 0.571
· Account tjphuhs@gmail.com
· 3/24/2026, 6:19:34 PM
Fwd: Dihexa Deep Dive from tjphuhs@gmail.com on 2026-03-24T22:19:34.000Z the blood-brain barrier when taken orally. Most neurotrophic factors can't do that. Dihexa can, thanks to its engineered lipophilicity and small molecular size. > One more interesting detail. The half-life is around 12 to 13 days. That's extraordinarily long. It means you get a cumulative effect when dosing regularly. It also means you probably don't need to take it every single day. > > Studies > A 2021 study out of China