View
Semantic Search: A New MOTS-c Study Just Dropped — Here's What It Actually Means
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.848
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z View this post on the web at https://derekpruski.substack.com/p/a-new-mots-c-study-just-dropped-heres A new peer-reviewed study on MOTS-c was published January 9th out of the University of Copenhagen, and I’ve seen a little chatter about it online — including Coach Cam touching on it on TikTok. I wanted to give my own read on it for the community, broken down in a way that ac
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.806
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z pages, has described MOTS-c as promoting biogenesis — meaning it helps you grow more mitochondria. This study says that’s not what’s primarily happening. MOTS-c is making your existing mitochondria work better. Same number, higher output. Think of it like tuning an engine rather than adding more cylinders. How Does It Do That? The Two Pathways The researchers found that MOTS-
A New MOTS-c Study Just Dropped — Here's What It Actually Means
Score 0.781
· Account tjphuhs@gmail.com
· 4/4/2026, 9:43:08 PM
A New MOTS-c Study Just Dropped — Here's What It Actually Means from derekpruski@substack.com on 2026-04-05T01:43:08.000Z a number of mitochondrial parameters — including redox handling, mitochondrial integrity, and OXPHOS efficiency — jointly indicating a mechanistic basis for the observed functional improvements. Breaking those terms down: Redox handling — how well the cell manages oxidative stress Mitochondrial integrity — the structural health of the mitochondria themselves OXPHOS efficiency
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.731
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z ---------- Forwarded message ---------- From: Derek from Peptide Price <derekpruski@substack.com> Date: Mar 21, 2026 at 8:24 AM -0400 To: tjphuhs@gmail.com Subject: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown > Not medical advice, not personal advice. > ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria?
Score 0.724
· Account tjphuhs@gmail.com
· 4/5/2026, 1:05:35 PM
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria? from derekpruski@substack.com on 2026-04-05T17:05:35.000Z a well-defined signaling mechanism makes it clearer that SS-31 is filling a different role entirely — structural stabilization at the membrane level that MOTS-c doesn’t address. They’re not competing compounds. They’re targeting different layers of the same problem, which is exactly why they’re frequently discussed together in mitochondrial health research. As always — for resea
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria?
Score 0.719
· Account tjphuhs@gmail.com
· 4/5/2026, 1:05:35 PM
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria? from derekpruski@substack.com on 2026-04-05T17:05:35.000Z View this post on the web at https://derekpruski.substack.com/p/does-ss-31-still-make-sense-if-mots This is a follow-up to my three-part breakdown of the January 9th MOTS-c study out of the University of Copenhagen. A great question came up in the comments after Part 1 — if both MOTS-c and SS-31 improve existing mitochondria rather than building new ones, what’s the point of res
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.712
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z to Research Radar. For the full experience, upgrade your subscription. > Upgrade to paid > > Share > > > Like > Comment > Restack > > © 2026 Derek Pruski > 548 Market Street PMB 72296, San Francisco, CA 94104 > Unsubscribe
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.712
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z to Research Radar. For the full experience, upgrade your subscription. > Upgrade to paid > > Share > > > Like > Comment > Restack > > © 2026 Derek Pruski > 548 Market Street PMB 72296, San Francisco, CA 94104 > Unsubscribe
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.710
· Account tjphuhs@gmail.com
· 3/21/2026, 8:24:20 AM
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from derekpruski@substack.com on 2026-03-21T12:24:20.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-and-morning-workout-timing Not medical advice, not personal advice. For educational purposes only. All use cases discussed are strictly research use only. If a researcher is using MOTS-c and also hitting the gym in the morning, timing matters. Here’s why — broken down in plain language. First, What Is MOTS
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention
Score 0.708
· Account tjphuhs@gmail.com
· 4/20/2026, 9:48:56 AM
MOTS-c on Rest Days: The Scheduling Strategy That's Getting Attention from derekpruski@substack.com on 2026-04-20T13:48:56.000Z View this post on the web at https://derekpruski.substack.com/p/mots-c-on-rest-days-the-scheduling Research use only. This content is intended for educational and informational purposes within a research context. Not for human consumption. Not medical advice. No dosing recommendations are provided or implied. If you’ve been around the research space for any length of ti
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria?
Score 0.707
· Account tjphuhs@gmail.com
· 4/5/2026, 1:05:35 PM
Does SS-31 Still Make Sense If MOTS-C Improves Mitochondria? from derekpruski@substack.com on 2026-04-05T17:05:35.000Z stabilizes it. It’s a physical repair and protection mechanism at the membrane level. The Key Difference Between the Two This is the part that answers the original question. Both MOTS-c and SS-31 improve existing mitochondria and reduce ROS. On the surface that looks redundant. But the way they do it couldn’t be more different: MOTS-c works like software — it sends a signal thro
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.707
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z this needs to be stated clearly because it gets misunderstood constantly. > Activating AMPK does not completely shut off mTOR. It does not eliminate muscle growth. > The relationship between these two pathways is nuanced — it depends on how strongly each is activated, the researcher’s nutrition status, training intensity, recovery, and a range of other factors. A research subje
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.705
· Account tjphuhs@gmail.com
· 3/21/2026, 1:06:18 PM
Fwd: MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from tjphuhs@gmail.com on 2026-03-21T17:06:18.000Z — often called the “powerhouse of the cell.” MOTS-c is essentially a signal that mitochondria send out to communicate with the rest of the body about energy status. > In research, it has shown strong effects on metabolism, insulin sensitivity, fat utilization, and cellular energy regulation. > Two Pathways You Need to Understand > To understand why timing matters, a researcher
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.703
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.703
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z on framing: Everything here is strictly for research use only. These compounds are not for human consumption. Nothing below is medical advice. This is educational content to help you understand what the research literature says about these molecules and how they function at the cellular level. > Upgrade to paid > The 30-Second Version > MOTS-c is a sm
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.695
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z at the signaling layer, NAD+ at the substrate layer. The “anti-aging” framing in marketing is usually oversimplified. The research is more nuanced and mostly preclinical. > Can they be studied together? > Mechanistically they don’t conflict, and there’s some theoretical rationale for why they might be complementary (signal plus substrate). But from a
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.695
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z at the signaling layer, NAD+ at the substrate layer. The “anti-aging” framing in marketing is usually oversimplified. The research is more nuanced and mostly preclinical. > Can they be studied together? > Mechanistically they don’t conflict, and there’s some theoretical rationale for why they might be complementary (signal plus substrate). But from a
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.695
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.695
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z mode. > • > Improves insulin sensitivity in preclinical models, meaning muscle cells pull glucose out of circulation more efficiently. > • > Appears to protect against metabolic stress in rodent studies (high-fat diet models). > • > Levels naturally decline with age, which some researchers think contributes to age-related metabolic dysfunction. > > >
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.694
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 24, 2026 at 1:18 PM -0400 To: tjphuhs@gmail.com Subject: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds > I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one res
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.694
· Account oc.tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z ---------- Forwarded message ---------- From: Derek from Research Radar <derekpruski@substack.com> Date: Apr 24, 2026 at 1:18 PM -0400 To: tjphuhs@gmail.com Subject: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds > I get a lot of questions about MOTS-c versus NAD+, and one of the most common is which one res
😱 GLP-3 (RETA) vs MOTS-C 😱
Score 0.684
· Account tjphuhs@gmail.com
· 2/11/2026, 10:30:15 AM
😱 GLP-3 (RETA) vs MOTS-C 😱 from info@somachems.com on 2026-02-11T15:30:15.000Z Take your metabolic research to the next level This email was sent to you as HTML-only. To view it, please visit: https://qfq.soundestlink.com/ce/v/68a3ebb905e51bffe64c8eaf/698c2a47dd9732c63e198315 ************************** Make sure you keep getting our latest offers and add info@somachems.com to your address book. Unsubscribe https://qfq.soundestlink.com/contactsPreferences/v2/unsubscribe/?b=686794eb7d5d9b4678a0b
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.682
· Account tjphuhs@gmail.com
· 4/24/2026, 1:18:04 PM
MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from derekpruski@substack.com on 2026-04-24T17:18:04.000Z research is more nuanced and mostly preclinical. Can they be studied together? Mechanistically they don’t conflict, and there’s some theoretical rationale for why they might be complementary (signal plus substrate). But from a research design standpoint, studying both at once means you can’t tell which compound is driving any observed effect. One va
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown
Score 0.681
· Account tjphuhs@gmail.com
· 3/21/2026, 8:24:20 AM
MOTS-c & Morning Workout Timing — A Beginner-Friendly Breakdown from derekpruski@substack.com on 2026-03-21T12:24:20.000Z on mTOR. Biologically this makes sense — the body doesn’t want to be building expensive new muscle tissue when it thinks it’s in an energy-deficient state. These two pathways actively suppress each other, which is why administering a potent AMPK activator right before resistance training creates a potential conflict worth thinking about. The Important Nuance Before getting in
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds
Score 0.681
· Account tjphuhs@gmail.com
· 4/24/2026, 1:28:54 PM
Fwd: MOTS-c vs NAD+: The Beginner's Guide to Understanding Two Mitochondrial Research Compounds from tjphuhs@gmail.com on 2026-04-24T17:28:54.000Z > Here’s a walkthrough to help you think about which direction matches your research interests. Read through top to bottom, stop at the first question where the answer is yes. > 1. Is your focus primarily metabolic pathways? (glucose handling, insulin sensitivity, AMPK signaling) > → MOTS-c is more targeted. Focus area: AMPK activation literature. Key