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charset="utf-8" Content-Transfer-Encoding: quoted-printable Happy Wednesday!=0A=0AI want to deviate from scheduled peptide and hormone = programming today to talk about one of my favorite OTC supplements. =0A=0AH= ave you ever wanted the focus and energy that caffeine gives you, without t= he jitters, the 2 pm crash, or the tolerance creep where last week's dose s= tops working?=0A=0AIf so, you may be a fan of a compound called theacrine.= =0A=0AI've been taking it daily for cognitive performance for years, and I = want to walk you through what the research actually shows, how I use it, an= d why it deserves more attention than it gets.=0A=0A=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A= =0A**What is Theacrine?**=0A=0ATheacrine is a purine alkaloid found in kuch= a tea, certain coffee species, and cupua=C3=A7u fruit. =0A=0AIt looks simil= ar to caffeine at the molecular level and works through some of the same pa= thways. =0A=0ABut the way it behaves in the body is different in a few impo= rtant ways.=0A=0AIt hits both the adenosine system (which caffeine blocks t= o make you feel awake) and the dopamine system (which drives motivation and= focus). That dual mechanism is part of why people describe theacrine as cl= ean energy with a slight mood boost.=0A=0AThe half-life is also much longer= than caffeine. Caffeine clears in about 5 to 6 hours. Theacrine sticks aro= und for 20+ hours. That sounds bad on paper, but in practice, the subjectiv= e stimulation tapers smoothly. No crash.=0A=0A=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**M= y Protocol**=0A=0AI take theacrine in the morning along with my coffee.=0A= =0AThe research suggests the two work better together than either alone, an= d that's been my real-world experience, too.=0A=0AThe reason I stack them i= s simple. Caffeine kicks in fast. Theacrine has a slower onset, around 90-1= 20 minutes. So by the time my coffee is wearing off, the theacrine is hitti= ng its stride. I get clean focus through the early afternoon without needin= g a second cup.=0A=0ATypically, I do not use it after about 11 am. =0A=0AEv= en though I don't feel it as a stimulant late in the day, the half-life is = long enough that I want to respect my sleep.=0A=0A=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A= **Research**=0A=0AThere are some pretty cool small-scale studies on theacri= ne. =0A=0A**Acute energy, focus, and motivation.** The Habowski 2014 pilot = trial tested a single 200 mg dose in healthy adults using a randomized, dou= ble-blind, crossover design. Subjective energy, focus, concentration, and m= otivation to exercise all increased compared with placebo. 200 mg outperfor= med both 100 mg and 400 mg, which suggests a sweet spot rather than more be= ing better.=0A=0A**Cognitive performance with caffeine.** Kuhman, Joyner, a= nd Bloomer ran a crossover study comparing a theacrine-containing supplemen= t, caffeine alone, and a placebo. The theacrine product produced cognitive = and mood effects without the hemodynamic spike you sometimes see with caffe= ine. =0A=0A**8-week safety and no tolerance.** This is the big one. Taylor = and colleagues at the University of Mary Hardin-Baylor enrolled 60 healthy = adults who received a placebo, 200 mg, or 300 mg of theacrine daily for 8 w= eeks. Heart rate, blood pressure, liver and kidney markers, lipids, and blo= od counts all remained within normal ranges. And critically, the subjective= benefits did not fade across the 8 weeks. No tolerance. No tachyphylaxis. = _They also saw a small drop in LDL and total cholesterol_, which was a seco= ndary finding worth noting but not the main point.=0A=0A**Caffeine combinat= ion pharmacokinetics.** A small 8-subject study found that taking theacrine= with caffeine increases theacrine's bioavailability and effect size compar= ed to taking it alone. Heart rate and blood pressure were not affected by t= he combination. This is part of why I stack them.=0A=0A**Endurance performa= nce.** Bello and colleagues at Rutgers ran 24 high-level soccer players thr= ough a 90-minute simulated treadmill match across four conditions (theacrin= e, caffeine, both, placebo). Time-to-exhaustion improved 27 to 38% with the= acrine versus placebo. The combination with caffeine produced the best cogn= itive results.=0A=0A**Tactical and stress performance.** A 2025 study out o= f South Carolina tested 20 tactically trained subjects on 300 mg caffeine, = 150 mg caffeine + 150 mg theacrine, or placebo before and after high-intens= ity interval exercise. Both active conditions outperformed the placebo. The= caffeine-theacrine combo had additional cognitive benefits beyond caffeine= alone, at half the caffeine dose.=0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**Final T= houghts**=0A=0AI think theacrine is one of the more underrated cognitive to= ols out there. =0A=0AThe non-habituation piece is the part I care most abou= t. With caffeine, most people see tolerance creep up over the years. With t= heacrine, the 8-week data show the subjective benefits remained steady thro= ughout. That matches my experience.=0A=0AFor daily cognitive demand, it's w= orked well for me, and it's worked well for many of the high performers I k= now.=0A=0AIf you want to try it, the cleanest way I've found is **NAD Regen= ** from BioStack Labs. =0A=0AIt contains theacrine as part of their NAD3 co= mplex (theacrine, wasabi extract, cuprous niacin), along with niacinamide, = resveratrol, and spermidine. =0A=0AYou get the cognitive lift from theacrin= e plus full NAD+ support, mitochondrial support, and longevity signaling in= two capsules a day.=0A=0AHere is the link: **[Try NAD Regen here](https://= biostacklabs.com/pages/nad-regen-triple?ref=3Dhunter&utm_campaign=3Dhunter&= utm_medium=3Daffiliate)**=0A=0AThank you for your continued support as a re= ader! =0A=0ABest, =0A=0AHunter Williams=0A=0A=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**Furt= her reading**=0A=0A* [The effects of TeaCrine, a nature-identical purine al= kaloid, on subjective measures of cognitive function, psychometric and hemo= dynamic indices in healthy humans](https://pmc.ncbi.nlm.nih.gov/articles/PM= C4271659/).=0A=0A* [Performance and Mood Following Ingestion of a Theacrine= -Containing Dietary Supplement, Caffeine, or Placebo by Young Men and Women= ](https://pmc.ncbi.nlm.nih.gov/articles/PMC4663612/). =0A=0A* [Safety of Te= aCrine, a non-habituating, naturally-occurring purine alkaloid over eight w= eeks of continuous use](https://pubmed.ncbi.nlm.nih.gov/26766930/).=0A=0A* = [The effects of TeaCrine and caffeine on endurance and cognitive performanc= e during a simulated match in high-level soccer players](https://pmc.ncbi.n= lm.nih.gov/articles/PMC6472067/). =0A=0A* [A caffeine and theacrine combina= tion improves cognitive performance in tactical personnel under physically = fatiguing conditions](https://pmc.ncbi.nlm.nih.gov/articles/PMC12284986/). = =0A=0A=0A=E2=80=94=E2=80=94=E2=80=94=0A=0AYou are reading a plain text vers= ion of this post. For the best experience, copy and paste this link in your= browser to view the post online:=0Ahttps://huntershealthhacks.beehiiv.com/= p/my-favorite-caffeine-alternative --R4kTpldVTJuerrQ2nJe/Bg Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable My Favorite Caffeine Alternative
Analysis of Theacrine  ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌
<= /tr>

May 13, = 2026   |   Read online=

My Favorite Caffeine Alternative

Analys= is of Theacrine

<= tr>
=
3D"share
 
3D"share
 
3D"share
 =
3D"share
3D""
<= td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wo= rd-break:break-word;">

What is Theacrine?

Theacrine is a purine alkaloid found in kucha tea, c= ertain coffee species, and cupua=C3=A7u fruit.

It looks similar to caffeine at the molecular level and= works through some of the same pathways.

= = =

Final Thoughts

Happy Wednesday!

I want t= o deviate from scheduled peptide and hormone programming today to talk abou= t one of my favorite OTC supplements.

Have you ever wanted the focus and energy that caffeine gives yo= u, without the jitters, the 2 pm crash, or the tolerance creep where last w= eek's dose stops working?

If so, you may be a fan of a compound called theacrine.

I've been taking it daily for cognitive p= erformance for years, and I want to walk you through what the research actu= ally shows, how I use it, and why it deserves more attention than it gets.<= /span>

 

But the way it behaves in the body is different in a few imp= ortant ways.

It hits both t= he adenosine system (which caffeine blocks to make you feel awake) and the = dopamine system (which drives motivation and focus). That dual mechanism is= part of why people describe theacrine as clean energy with a slight mood b= oost.

The half-life is also = much longer than caffeine. Caffeine clears in about 5 to 6 hours. Theacrine= sticks around for 20+ hours. That sounds bad on paper, but in practice, th= e subjective stimulation tapers smoothly. No crash.

 

= My Protocol

I take theac= rine in the morning along with my coffee.

The research suggests the two work better together than eithe= r alone, and that's been my real-world experience, too.

The reason I stack them is simple. Caffeine= kicks in fast. Theacrine has a slower onset, around 90-120 minutes. So by = the time my coffee is wearing off, the theacrine is hitting its stride. I g= et clean focus through the early afternoon without needing a second cup.

Typically, I do not use it aft= er about 11 am.

Even though= I don't feel it as a stimulant late in the day, the half-life is long = enough that I want to respect my sleep.

=  

Research

There are some pretty coo= l small-scale studies on theacrine.

Acute energy, focus, and motivation. The Habowski 2014 pilot trial tested a single 200 mg dos= e in healthy adults using a randomized, double-blind, crossover design. Sub= jective energy, focus, concentration, and motivation to exercise all increa= sed compared with placebo. 200 mg outperformed both 100 mg and 400 mg, whic= h suggests a sweet spot rather than more being better.

Cognitive performance with caffeine. Kuhman, Joyner, and Bloomer ran a cros= sover study comparing a theacrine-containing supplement, caffeine alone, an= d a placebo. The theacrine product produced cognitive and mood effects with= out the hemodynamic spike you sometimes see with caffeine.

8-week safety and no tolerance. This is the big one. Taylor and collea= gues at the University of Mary Hardin-Baylor enrolled 60 healthy adults who= received a placebo, 200 mg, or 300 mg of theacrine daily for 8 weeks. Hear= t rate, blood pressure, liver and kidney markers, lipids, and blood counts = all remained within normal ranges. And critically, the subjective benefits = did not fade across the 8 weeks. No tolerance. No tachyphylaxis. They also saw a small drop in LDL and tot= al cholesterol, which was a se= condary finding worth noting but not the main point.

Caffeine combination pharmacokinetics. A small 8-subject study found that tak= ing theacrine with caffeine increases theacrine's bioavailability and e= ffect size compared to taking it alone. Heart rate and blood pressure were = not affected by the combination. This is part of why I stack them.

Endurance performance.= Bello and colleagues at Rutgers ran 24 h= igh-level soccer players through a 90-minute simulated treadmill match acro= ss four conditions (theacrine, caffeine, both, placebo). Time-to-exhaustion= improved 27 to 38% with theacrine versus placebo. The combination with caf= feine produced the best cognitive results.

Tactical and stress performance. A 2025 study out of South Carolina tested 20 tacticall= y trained subjects on 300 mg caffeine, 150 mg caffeine + 150 mg theacrine, = or placebo before and after high-intensity interval exercise. Both active c= onditions outperformed the placebo. The caffeine-theacrine combo had additi= onal cognitive benefits beyond caffeine alone, at half the caffeine dose.

 

I think theacrine is one of the more underrated cognitive too= ls out there.

The non-habit= uation piece is the part I care most about. With caffeine, most people see = tolerance creep up over the years. With theacrine, the 8-week data show the= subjective benefits remained steady throughout. That matches my experience= .

For daily cognitive demand= , it's worked well for me, and it's worked well for many of the hig= h performers I know.

If you = want to try it, the cleanest way I've found is NAD Regen = from BioStack Labs.

It cont= ains theacrine as part of their NAD3 complex (theacrine, wasabi extract, cu= prous niacin), along with niacinamide, resveratrol, and spermidine. =

You get the cognitive lift from th= eacrine plus full NAD+ support, mitochondrial support, and longevity signal= ing in two capsules a day.

Here is the link: Try = NAD Regen here

Thank you for your continued support as a reader!

Best,

Hunter Williams

 

Further reading

=
=
=3D"ig"3D"yt"<= /td>
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=F0=9F=91=89Join my priva= te coaching group, The AXION Collective:

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