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Subject: He took Retatrutide 40mg and Proved a Point
From: Dave Knapp from On The Pen <onthepen@substack.com>
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View this post on the web at https://onthepen.substack.com/p/he-took-retatr=
utide-40mg-and-proved

Forty milligrams of Retatrutide. That=E2=80=99s the number and the mistake =
that sets the tone for this week=E2=80=99s episode. A 32-year-old man bough=
t the drug online, started at 10 milligrams, quickly escalated to 20, and t=
hen accidentally dosed twice in back-to-back days. You can imagine how that=
 ended, and we break it all down on the podcast.
At the same time, just one month into the Foundayo launch, there=E2=80=99s =
already a reported case of liver failure.=20
Two very different situations, but if you=E2=80=99ve been following On The =
Pen, you=E2=80=99ll start to see the connection. This episode pulls those t=
hreads together and points toward something just as important: how patients=
 can better track, understand, and stay ahead of what=E2=80=99s happening o=
n their own GLP-1 journey.=20
Keep scrolling to check out Shed=E2=80=99s new GLP-1 journey tracking app t=
hat=E2=80=99s available to anyone!
One theme keeps coming up: understanding what=E2=80=99s actually happening =
in your own body matters just as much as following the prescription. It=E2=
=80=99s something we=E2=80=99ve been thinking more about lately, how people=
 track their progress, notice patterns, and make sense of changes in hunger=
, energy, or cravings over time. Tools like Pivot are starting to make that=
 easier, bringing doses, daily habits, and personal feedback into one place=
 so adjustments feel more informed and less like guesswork.
Pivot is a new app offered to anyone, even if you don=E2=80=99t get your pr=
escriptions through Shed.
=E2=80=A2 Track doses, weight, and daily habits in one place
=E2=80=A2 See your full history and compare how you feel across different d=
oses
=E2=80=A2 Connect changes in hunger, energy, and cravings to your medicatio=
n
=E2=80=A2 Weekly success score + insights to guide what to adjust next
It=E2=80=99s a smarter way to stay in tune with your body. If you want to t=
ry it out, you can download it here!

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}
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}</style></head><body class=3D"email-body" style=3D"font-kerning: auto;--im=
age-offset-margin: -120px;"><img src=3D"https://eotrx.substackcdn.com/o/2c3=
b3e74b7236d90/p.gif?token=3DeyJtIjoiPDIwMjYwNTA1MjM0NDE3LjMuNDI0YzZmNzE4MDN=
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width:1px !important;border-width:0 !important;margin-top:0 !important;marg=
in-bottom:0 !important;margin-right:0 !important;margin-left:0 !important;p=
adding-top:0 !important;padding-bottom:0 !important;padding-right:0 !import=
ant;padding-left:0 !important;"/><div class=3D"preview" style=3D"display:no=
ne;font-size:1px;color:#333333;line-height:1px;max-height:0px;max-width:0px=
;opacity:0;overflow:hidden;">Forty milligrams of Retatrutide.</div><div cla=
ss=3D"preview" style=3D"display:none;font-size:1px;color:#333333;line-heigh=
t:1px;max-height:0px;max-width:0px;opacity:0;overflow:hidden;">&#847; &nbsp=
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OYp4oZjkPsXhmhOqPI1AeUIqT4uCpfg8A" style=3D"color: rgb(54,55,55);text-decor=
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r-spacing: .2px;text-decoration: none" href=3D"https://substack.com/@onthep=
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case;letter-spacing: .2px;text-decoration: none" href=3D"https://substack.c=
om/@anncmetz">Ann Metz</a></div></td></tr></tbody></table></td></tr><tr><td=
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Emoji','Segoe UI Symbol';font-weight: 500;text-transform: uppercase;letter-=
spacing: .2px;"><time datetime=3D"2026-05-05T23:44:16.961Z">May 5</time></d=
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</table></td></tr></tbody></table></td></tr><tr height=3D"16"><td height=3D=
"16" style=3D"font-size:0px;line-height:0;">&nbsp;</td></tr></tbody></table=
></div></div><div class=3D"post typography" dir=3D"auto" style=3D"--image-o=
ffset-margin: -120px;padding: 32px 0 0 0;font-size: 16px;line-height: 26px;=
"><div class=3D"body markup" dir=3D"auto" style=3D"text-align: initial;font=
-size: 16px;line-height: 26px;width: 100%;word-break: break-word;margin-bot=
tom: 16px;font-family: 'SF Pro Display', -apple-system, system-ui, BlinkMac=
SystemFont, 'Inter', 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'App=
le Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol';font-weight: 400;"><p =
style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-siz=
e: 16px;margin-top: 0;">Forty milligrams of Retatrutide. That&#8217;s the n=
umber and the mistake that sets the tone for this week&#8217;s episode. A 3=
2-year-old man bought the drug online, started at 10 milligrams, quickly es=
calated to 20, and then accidentally dosed twice in back-to-back days. You =
can imagine how that ended, and we break it all down on the podcast.</p><p =
style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-siz=
e: 16px;">At the same time, just one month into the Foundayo launch, there&=
#8217;s already a reported case of liver failure. </p><p style=3D"margin: 0=
 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;"><span>Tw=
o very different situations, but if you&#8217;ve been following </span><em>=
On The Pen</em><span>, you&#8217;ll start to see the connection. This episo=
de pulls those threads together and points toward something just as importa=
nt: how patients can better track, understand, and stay ahead of what&#8217=
;s happening on their own GLP-1 journey. </span></p><p style=3D"margin: 0 0=
 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;">Keep scrol=
ling to check out Shed&#8217;s new GLP-1 journey tracking app that&#8217;s =
available to anyone!</p><a class=3D"audio-embed-static-outer" href=3D"https=
://substack.com/redirect/1086af1a-c247-4988-b550-a1a3cb5d4c6e?j=3DeyJ1IjoiN=
Gl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs" target=3D"_blank" d=
ata-component-name=3D"AudioEmbedStaticLink" style=3D"text-decoration: none;=
"><table class=3D"audio-embed-static" cellspacing=3D"12" data-component-nam=
e=3D"AudioEmbedStaticTable" style=3D"width: 100%;min-width: 100%;min-height=
: 96px;border: 1px solid rgb(0,0,0,.1);background: rgb(255,255,255);margin:=
 32px 0;border-radius: 12px;"><tbody><tr><td class=3D"thumbnail-container" =
style=3D"padding: 0;margin: 0;width: 88px;height: 88px;border-radius: 12px;=
overflow: hidden;vertical-align: top;"><div class=3D"play-container" style=
=3D"font-size: 16px;line-height: 26px;max-height: 0;position: relative;opac=
ity: 0.999;z-index: 1;"><img class=3D"play" src=3D"https://substackcdn.com/=
image/fetch/$s_!nPrE!,w_72,c_limit,f_auto,q_auto:good,fl_progressive:steep/=
https%3A%2F%2Fsubstack.com%2Fimg%2Fthumbnail-play.png" height=3D"36" width=
=3D"36" style=3D"border: none !important;vertical-align: middle;-ms-interpo=
lation-mode: bicubic;max-width: 100%;display: inline-block;height: 40px;mar=
gin: 24px;width: 40px;"></div><img class=3D"thumbnail" src=3D"https://i.scd=
n.co/image/ab6765630000ba8a797f0259b505e6bd91900b28" height=3D"80" width=3D=
"80" style=3D"border: none !important;vertical-align: middle;display: block=
;-ms-interpolation-mode: bicubic;max-width: 100%;margin: 0 auto;height: 88p=
x;width: 88px;"></td><td class=3D"audio-details" data-component-name=3D"Aud=
ioEmbedStatic" style=3D"font-family: 'SF Pro Display', -apple-system, syste=
m-ui, BlinkMacSystemFont, 'Inter', 'Segoe UI', Roboto, Helvetica, Arial, sa=
ns-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol';-webkit-=
font-smoothing: antialiased;-moz-osx-font-smoothing: antialiased;-webkit-ap=
pearance: optimizelegibility;-moz-appearance: optimizelegibility;appearance=
: optimizelegibility;letter-spacing: -0.012em;text-decoration: none;"><p cl=
ass=3D"title" style=3D"line-height: 20px;margin: 0 0 2px;color: rgb(54,55,5=
5);font-size: 16px;font-weight: 700;">He Took Retatrutide 40mg and Proved a=
 Point</p><p class=3D"subtitle" style=3D"font-family: 'SF Pro Display',-app=
le-system-headline,system-ui,-apple-system,BlinkMacSystemFont,'Segoe UI',Ro=
boto,Helvetica,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji','Segoe=
 UI Symbol';-webkit-font-smoothing: antialiased;-moz-osx-font-smoothing: an=
tialiased;-webkit-appearance: optimizelegibility;-moz-appearance: optimizel=
egibility;appearance: optimizelegibility;font-weight: 400;margin: 0 0 2px;c=
olor: rgb(119,119,119);line-height: 20px;font-size: 14px;">Dave Knapp GLP-1=
 Industry Insider</p><p class=3D"metadata" style=3D"line-height: 20px;margi=
n: 0 0 2px;color: rgb(119,119,119);font-size: 14px;font-weight: 400;">Episo=
de</p></td></tr></tbody></table></a><p style=3D"margin: 0 0 20px 0;color: r=
gb(54,55,55);line-height: 26px;font-size: 16px;"><span>One theme keeps comi=
ng up: understanding </span><strong>what&#8217;s actually happening in your=
 own body matters</strong><span> just as much as following the prescription=
=2E It&#8217;s something we&#8217;ve be=
en thinking more about lately, how peo=
ple track their progress, notice patterns, and make sense of changes in hun=
ger, energy, or cravings over time. Tools like </span><strong>Pivot</strong=
><span> are starting to make that easier, bringing doses, daily habits, and=
 personal feedback into one place so adjustments feel more informed and les=
s like guesswork.</span></p><div class=3D"captioned-image-container-static"=
 style=3D"font-size: 16px;line-height: 26px;margin: 32px auto;"><figure sty=
le=3D"width: 100%;margin: 0 auto;"><table class=3D"image-wrapper" width=3D"=
100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0" data-component-name=
=3D"Image2ToDOMStatic" style=3D"mso-padding-alt: 1em 0 1.6em;"><tbody><tr><=
td style=3D"text-align: center;"></td><td class=3D"content" align=3D"left" =
width=3D"350" style=3D"text-align: center;"><a class=3D"image-link" target=
=3D"_blank" href=3D"https://substack.com/redirect/edb9a5a1-9c3e-4369-9291-2=
cd58a19253d?j=3DeyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifR=
B-Zs" style=3D"position: relative;flex-direction: column;align-items: cente=
r;padding: 0;width: auto;height: auto;border: none;text-decoration: none;di=
splay: block;margin: 0;"><img data-attrs=3D"{&quot;src&quot;:&quot;https://=
substack-post-media.s3.amazonaws.com/public/images/d1a5748d-c9be-4792-aea2-=
07ba78345c6c_3963x6173.png&quot;,&quot;srcNoWatermark&quot;:null,&quot;full=
screen&quot;:null,&quot;imageSize&quot;:null,&quot;height&quot;:2268,&quot;=
width&quot;:1456,&quot;resizeWidth&quot;:350,&quot;bytes&quot;:3650560,&quo=
t;alt&quot;:&quot;&quot;,&quot;title&quot;:null,&quot;type&quot;:&quot;imag=
e/png&quot;,&quot;href&quot;:null,&quot;belowTheFold&quot;:false,&quot;topI=
mage&quot;:true,&quot;internalRedirect&quot;:&quot;https://onthepen.substac=
k.com/i/196597630?img=3Dhttps%3A%2F%2Fsubstack-post-media.s3.amazonaws.com%=
2Fpublic%2Fimages%2Fd1a5748d-c9be-4792-aea2-07ba78345c6c_3963x6173.png&quot=
;,&quot;isProcessing&quot;:false,&quot;align&quot;:null,&quot;offset&quot;:=
false}" alt=3D"" title=3D"" width=3D"350" height=3D"545.1923076923077" src=
=3D"https://substackcdn.com/image/fetch/$s_!GTt_!,w_350,c_limit,f_auto,q_au=
to:good,fl_progressive:steep/https%3A%2F%2Fsubstack-post-media.s3.amazonaws=
=2Ecom%2Fpublic%2Fimages%2Fd1a5748d-c9b=
e-4792-aea2-07ba78345c6c_3963x6173.png=
" style=3D"border: none !important;vertical-align: middle;display: block;-m=
s-interpolation-mode: bicubic;height: auto;margin-bottom: 0;width: auto !im=
portant;max-width: 100% !important;margin: 0 auto;"></a></td><td style=3D"t=
ext-align: center;"></td></tr></tbody></table></figure></div><p style=3D"ma=
rgin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;"><=
strong>Pivot</strong><span> is a new app offered to anyone, even if you don=
&#8217;t get your prescriptions through Shed.</span></p><p style=3D"margin:=
 0 0 20px 0;color: rgb(54,55,55);line-height: 26px;font-size: 16px;"><span>=
&#8226; Track doses, weight, and daily habits in one place</span><br><span>=
&#8226; See your full history and compare how you feel across different dos=
es</span><br><span>&#8226; Connect changes in hunger, energy, and cravings =
to your medication</span><br><span>&#8226; Weekly success score + insights =
to guide what to adjust next</span></p><p style=3D"margin: 0 0 20px 0;color=
: rgb(54,55,55);line-height: 26px;font-size: 16px;">It&#8217;s a smarter wa=
y to stay in tune with your body. If you want to try it out, you can downlo=
ad it here!</p><p class=3D"button-wrapper" data-attrs=3D"{&quot;url&quot;:&=
quot;https://tr.ee/rr_BXB9CgP&quot;,&quot;text&quot;:&quot;PIVOT APP&quot;,=
&quot;action&quot;:null,&quot;class&quot;:null}" data-component-name=3D"But=
tonCreateButton" style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-heig=
ht: 26px;font-size: 16px;text-align: center;cursor: pointer;border-radius: =
4px;"><a class=3D"button primary" href=3D"https://substack.com/redirect/01d=
a3c40-fa23-4b19-a60e-bfe3f7d496fe?j=3DeyJ1IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdam=
Y0krRXGMy3p768BWtuZifRB-Zs" style=3D"font-family: system-ui,-apple-system,B=
linkMacSystemFont,'Segoe UI',Roboto,Helvetica,Arial,sans-serif,'Apple Color=
 Emoji','Segoe UI Emoji','Segoe UI Symbol';display: inline-block;box-sizing=
: border-box;cursor: pointer;border: none;border-radius: 8px;font-size: 14p=
x;line-height: 20px;font-weight: 600;text-align: center;margin: 0;opacity: =
1;outline: none;white-space: nowrap;color: #ffffff !important;text-decorati=
on: none !important;background-color: #f34dc9;padding: 12px 20px;height: au=
to;"><span style=3D"color: #ffffff;text-decoration: none;">PIVOT APP</span>=
</a></p><div class=3D"captioned-image-container-static" style=3D"font-size:=
 16px;line-height: 26px;margin: 32px auto;"><figure style=3D"width: 100%;ma=
rgin: 0 auto;"><table class=3D"image-wrapper" width=3D"100%" border=3D"0" c=
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" style=3D"mso-padding-alt: 1em 0 1.6em;"><tbody><tr><td style=3D"text-alig=
n: center;"></td><td class=3D"content" align=3D"left" width=3D"350" style=
=3D"text-align: center;"><a class=3D"image-link" target=3D"_blank" href=3D"=
https://substack.com/redirect/568e3fce-80c9-45b4-bcd1-23484d0d1735?j=3DeyJ1=
IjoiNGl3b2U2In0.sVDxRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs" style=3D"posit=
ion: relative;flex-direction: column;align-items: center;padding: 0;width: =
auto;height: auto;border: none;text-decoration: none;display: block;margin:=
 0;"><img data-attrs=3D"{&quot;src&quot;:&quot;https://substack-post-media.=
s3.amazonaws.com/public/images/f882dc9d-bb59-47af-9cac-edbdba073f10_3852x70=
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quot;imageSize&quot;:&quot;normal&quot;,&quot;height&quot;:2668,&quot;width=
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ic%2Fimages%2Ff882dc9d-bb59-47af-9cac-edbdba073f10_3852x7059.png" style=3D"=
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tion-mode: bicubic;height: auto;margin-bottom: 0;width: auto !important;max=
-width: 100% !important;margin: 0 auto;"></a></td><td style=3D"text-align: =
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