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[69.67.186.32]) by mx.google.com with ESMTPS id d75a77b69052e-51040b4276esi159730521cf.259.2026.05.05.15.03.45 for (version=TLS1_3 cipher=TLS_AES_256_GCM_SHA384 bits=256/256); Tue, 05 May 2026 15:03:45 -0700 (PDT) Received-SPF: pass (google.com: domain of bounces+tjphuhs=gmail.com@bh.mail.beehiiv.com designates 69.67.186.32 as permitted sender) client-ip=69.67.186.32; Authentication-Results: mx.google.com; dkim=pass header.i=@bhmta.beehiiv.com header.s=bh header.b=GbXcMfS0; dkim=pass header.i=@mail.beehiiv.com header.s=bh header.b=Yd1f64CQ; spf=pass (google.com: domain of bounces+tjphuhs=gmail.com@bh.mail.beehiiv.com designates 69.67.186.32 as permitted sender) smtp.mailfrom="bounces+tjphuhs=gmail.com@bh.mail.beehiiv.com"; dmarc=pass (p=REJECT sp=REJECT dis=NONE) header.from=beehiiv.com X-BmtaRef: eyJfQF8iOiJcXF8vIiwicmVjaXBpZW50IjoidGpwaHVoc0BnbWFpbC5jb20iLCJ4X2xpc3RfaWQiOiJmZDQxNjMwZS1lOTFmLTQ2ZDktYTI3NC1iNzQwZGFiNzU2ZDIiLCJ4X3N1YnNjcmliZXJfaWQiOiI5YzQwZDYzOS02ZTFkLTQyOTItYTlkNy0wZTRjYmJiNWQ1ZGIifQ== DKIM-Signature: v=1; a=rsa-sha256; d=bhmta.beehiiv.com; s=bh; c=relaxed/relaxed; bh=68eoxpMy4A/+6hhrqezpjJdjeSBXANBrEARLWrW7zQo=; h=from:subject:mime-version:content-type:content-transfer-encoding: list-unsubcribe:feedback-id:list-unsubscribe-post:reply-to:to:cc: content-type:feedback-id:from:subject:to; t=1778018625; b=GbXcMfS0SEuUaPz8sIUNycAZnSfU+IpsU482ol2Po3USkc2qgE0vnXJrjIwkUG8qryC53qtLO LjCeiZ+ybjZ/4+zxhPZ3eEKd2DJLW/K2ynI8tPFWwFnzjByBTl0P6YcVsMEc2/VFHG+TR25RXU6 Da4auBzbcirYYuY/upM1SpwFAR9sXZiFy1x8nIWAKyeP3GhgMlkzNnO//P2SxSf+5SUfTuL3/vI LyndtMfDSMH+lgYJ/eekvZAFc/mG9iSFrg6LailaDfpYxdBDy6TuQYJ3VpgyNYd3sHakNlkVRO7 fw9hx3jtMYZ/739DpN/6wItHu3Vryf18pNU3lObSs7WA==; DKIM-Signature: v=1; a=rsa-sha256; d=mail.beehiiv.com; s=bh; c=relaxed/relaxed; bh=68eoxpMy4A/+6hhrqezpjJdjeSBXANBrEARLWrW7zQo=; h=from:subject:mime-version:content-type:content-transfer-encoding: list-unsubcribe:feedback-id:list-unsubscribe-post:reply-to:to:cc: content-type:feedback-id:from:subject:to; t=1778018625; b=Yd1f64CQt2rEBjYtLBle9bh4pekhBspzxnd/5LA9KB7qlVTkvlrxTChPuuKyBw0uzfEBrs5LA givToIYzrZxzOJR1XvQhYrUl4WQFbo7Ib4doSy6oOQsp2RaTEmhW1dNcOIUBo7OM3Qp4yxNN7ix k3HOOa7gPcUyZXFJR1VbghG9p1389ih/PkCx+7va46/SGq5jrkXDLeR7DnLYTslMjGL0UfD2wKM HxeQ/BRUjnZQ0QVhPbjMA3rCuq255px0XwLh5IDgBaYn6qUT6XKCxQNL1yY1es/RexL+JVfqRGs sIP3cSMvJFfxKq86UaaACFpcIyTy20jDJgfWE/So794A==; Received: from mail.beehiiv.com by bhmta(mta16) with HTTP id <491b8e2348ce11f19d5f12457269f165> for ; Tue, 05 May 2026 22:03:45 +0000 Content-Type: multipart/alternative; boundary="u4HWCmXeT+aYztS0dSW/Ug" To: "tjphuhs@gmail.com" Feedback-ID: 7d1ff928-ed92-4638-a57f-bca8468c72c6:newsletter:fd41630e-e91f-46d9-a274-b740dab756d2:c8f61fda6a60803 From: Hunter Williams List-Unsubscribe: , List-Unsubscribe-Post: List-Unsubscribe=One-Click Reply-To: =?utf-8?Q?Hunter=27s_Health_Hacks?= Subject: Non-GLP Fat Loss Compounds Ranked X-Batch-Id: 6e9d00b4-f044-4b76-94fe-a0d04b8c99d5 X-Subscriber-ID: 9c40d639-6e1d-4292-a9d7-0e4cbbb5d5db X-Subscription-ID: 663283104 sId: fd41630e-e91f-46d9-a274-b740dab756d2 x-beehiiv-ids: {"account_name":"https://huntershealthhacks.beehiiv.com/","campaign_id":"7d1ff928-ed92-4638-a57f-bca8468c72c6","category":"newsletter","email_generated_at":1778018624,"user_id":"fd41630e-e91f-46d9-a274-b740dab756d2"} x-beehiiv-type: newsletter x-list-id: fd41630e-e91f-46d9-a274-b740dab756d2 x-list-owner: x-newsletter: https://huntershealthhacks.beehiiv.com/p/non-glp-fat-loss-compounds-ranked x-newsletter-id: https://huntershealthhacks.beehiiv.com/ x-newsletter-signup: https://huntershealthhacks.beehiiv.com/subscribe Mime-Version: 1.0 Date: Tue, 5 May 2026 22:03:45 +0000 Message-ID: <20260505.220345.e39e48a5@mta16> --u4HWCmXeT+aYztS0dSW/Ug Content-Type: text/plain; charset="utf-8" Content-Transfer-Encoding: quoted-printable Happy Tuesday! =0A=0AMost folks would agree that the GLPs are the kings of = fat loss, with retatrutide holding the title belt.=0A=0ABut what if GLPs ar= e not on the table for you? What if you are cycling off? What if you want t= o stack other compounds so you don=E2=80=99t have to crank your GLP dose in= to the stratosphere?=0A=0AI just dropped a brand-new video and podcast epis= ode where I rank=C2=A0**20 non-GLP-1 fat-loss**** compounds** from F tier t= o S tier. Most are peptides. A few are small molecules. All of them have a = place in the conversation right now.=0A=0AYoutube: 20 Fat Loss Compounds Ra= nked Worst to Best (No GLP-1s) (https://youtu.be/36E7xjuFVXc)=0A=0AYou can = watch the full video here: [https://youtu.be/36E7xjuFVXc](https://youtu.be/= 36E7xjuFVXc)=0A=0AOr listen on Spotify here: [https://open.spotify.com/epis= ode/3jOsxcgx8n4EaOhhaNCuCv?si=3DTIs_SV5eT6KTmarCWf7cZA](https://open.spotif= y.com/episode/3jOsxcgx8n4EaOhhaNCuCv?si=3DTIs_SV5eT6KTmarCWf7cZA)=0A=0ABelo= w is the breakdown of every compound and why I ranked it where I did.=0A=0A= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=0A=0A_**F Tier (I Don't Use These)**_=0A=0A**Adipotide (= FTPP).** This one targets fat cells by killing the blood vessels that feed = them. Sounds elegant on paper. The problem is that the kidneys are damaged = at the same doses that produce the fat loss. Phase 1 data in obese prostate= cancer patients showed real fat loss but also dose-dependent renal toxicit= y. The risk-to-reward is not there for me. I am sure people are using it. I= just choose not to.=0A=0A**HGH Fragment 176-191.** This is not HGH. It is = a fragment of the HGH amino acid sequence. The human data is weak. AOD9604 = is essentially the same thing with an added tyrosine for stability, and eve= n AOD isn=E2=80=99t great. If you are taking HGH frag, you are wasting your= money.=0A=0A_**D Tier (Weak Use Case)**_=0A=0A**AOD9604.** A 12-week phase= 2 trial showed about 2 kg of fat loss compared with placebo. That is rough= ly 4 to 5 pounds. Not nothing. But not exciting either when GLPs exist. I h= ave used it. The one place it might earn its keep is helping with water ret= ention from growth hormone or GH peptides. As a standalone fat loss tool, s= kip it.=0A=0A_**C Tier (Use Case Exists, But Outclassed)**_=0A=0A**Sermorel= in.** It is a GHRH peptide. It works. It is just the weakest of the GH pept= ide family and has been outclassed by tesamorelin, CJC, and ipamorelin. If = it is what you have, fine. If you are choosing fresh, pick something else.= =0A=0A**Setmelanotide.** An MC4R agonist that absolutely will suppress your= appetite. The problem is the nausea. I took 250 micrograms and felt fine f= or about 6 hours. Then the nausea hit and lasted a day or two. Take the wor= st semaglutide nausea you have ever felt and crank it up. The FDA-approved = dose is 2 to 3 mg daily, and I have no idea how anyone tolerates that. For = people with specific genetic obesity syndromes, it can be life-changing. Fo= r everyone else, it is a glutton-for-punishment compound.=0A=0A_**B Tier (S= olid, Conditional Wins)**_=0A=0A**Tesofensine.** A triple monoamine reuptak= e inhibitor. Phase 3 data in obese Mexican patients showed 8.6 kg of weight= loss vs 1.9 kg placebo over 24 weeks. I love this one for the cognitive li= ft. It feels like a nootropic. About 70% of people do well on it. About 20%= do terribly with insomnia, anxiety, or feeling wired. I run 250 mcg and ge= t great benefits. Watch your heart rate and blood pressure.=0A=0A**SS-31.**= Not a fat loss peptide on paper. But it repairs the mitochondrial hardware= . Fix the mitochondria, and everything works better, including fat loss. I = run 1 to 2 mg for general optimization and 5 to 10 mg for a real metabolic = effect. It earns its place because it improves the rest of your stack.=0A= =0A**Cagrilintide.** A long-acting amylin analog that suppresses appetite t= hrough a completely different mechanism than GLPs. With semaglutide, it pro= duced 20.4% weight loss over 68 weeks. On its own, around 10 to 11% at high= er doses. I do great on it. My wife, Taylor, feels depressed and emotionall= y blunted on it. About half the people I see using it report that. Coin fli= p. Start at 250 mcg and titrate up.=0A=0A**IGF-1 LR3.** This is more of a b= ody recomposition tool than a fat-loss tool. Run alongside HGH or a GH pept= ide for 4 to 6 weeks at 25 to 200 mcg post-workout. Watch your blood sugar.= Always have carbs on hand. Hypoglycemia is the real risk.=0A=0A**Cardarine= (GW501516).** A PPAR agonist that shifts you toward fatty acid oxidation. = By itself, it will not melt fat. Paired with cardio, you get way more out o= f every session. I run 10 mg per day for 4 to 8 weeks. There is a cancer si= gnal in mice (in both directions), which is why I keep doses moderate and c= ycle.=0A=0A_**A Tier (Where Things Get Real)**_=0A=0A**CJC + Ipamorelin.** = Not a fat loss peptide directly. But the downstream effects on sleep, IGF-1= , and recovery move the needle on body composition. Most people tolerate ip= amorelin well. CJC can give some folks reactions. Try them in isolation fir= st before stacking. I would call this an A-minus.=0A=0A**MOTS-c.** A mitoch= ondrial peptide that improves fatty acid oxidation, glucose uptake, and ins= ulin sensitivity. Acts as an exercise mimetic. I run 1 to 2 mg subQ daily, = 5 days on, 2 days off, for 8 weeks on, 8 weeks off. At 1 milligram with 5-A= mino, I felt like a 7-year-old being told to sit still. Solid A or A+.=0A= =0A**5-Amino-1MQ.** An NNMT inhibitor that raises intracellular NAD+ and ma= kes fat cells resistant to lipolysis blockade. Mouse studies show a 30 to 4= 0% reduction in fat cell size with no change in food intake. Injectable wor= ks much better than oral. I run 1 to 2 mg injected daily. Push past 2 milli= grams, and you start to feel burnout. With MOTS-c, I would call the combo a= n A+.=0A=0A**BAM15.** A mitochondrial uncoupler. Your cell burns more fuel = to maintain ATP, and the energy gets dumped as heat. Wider therapeutic wind= ow than DNP. Strong rodent data, no human safety pharmacology yet. I run 50= to 100 mg a day. Above 400 mg, there are diminishing returns.=0A=0A**SLU-P= P-332.** An estrogen-related receptor agonist that drives mitochondrial bio= genesis and fatty acid oxidation. The most studied exercise mimetic in this= class. I prefer 250-750 mcg daily for 8-12 weeks. Higher doses just made m= e feel worse. Oral works fine. Transdermal works great. Injectable in oil m= ight be the best delivery method, but the data isn't clean enough yet to ca= ll it.=0A=0A**ATX-304.** A pan-AMPK activator that does not cross the blood= -brain barrier. Real human data, no appetite suppression, no muscle loss. T= rials used 1,000 milligrams, which is cost-prohibitive for most. I get grea= t results at 300-500 mg daily. Energy is solid, fat loss is real, and water= retention drops. A+.=0A=0A**Mirabegron.** A beta-3 adrenergic agonist. Act= ivates brown fat thermogenesis and improves insulin sensitivity. FDA-approv= ed for overactive bladder. For body comp, 50-100 mg a day. Great for the la= st few weeks of a cut. Watch your heart rate, blood pressure, and urinary r= etention at higher doses.=0A=0A_**S Tier (The Best We Have)**_=0A=0A**Albut= erol.** A beta-2 agonist that activates lipolysis through hormone-sensitive= lipase. Increases resting energy expenditure 3 to 5%. FDA-approved since 1= 981 with decades of safety data. I run 2 to 5 mg orally per day, 2 weeks on= 2 weeks off. The receptors downregulate after about 2 to 3 weeks, which is= why you cycle. The only reason I call it S-minus is that short cycle windo= w. =0A=0A**HGH.** The most underrated fat loss tool we have. Direct GH rece= ptor activation. Increased fatty acid oxidation. Reduced glucose uptake in = fat tissue. Decades of human data. In GH-deficient adults, 4 to 7 kg fat re= duction and 2 to 5 kg lean mass increase over 6 to 12 months. Most men in t= heir 40s, 50s, and 60s probably qualify as deficient. Run 1 to 4 IU daily. = It is not a 2-week shred tool. Over 1 to 2 years, the body just transforms.= =0A=0A**Tesamorelin.** S-tier-plus from a data standpoint. A GHRH that stim= ulates pulsatile pituitary GH release. Phase 3 data in HIV lipodystrophy pa= tients showed about 15% reduction in visceral fat over 6 months, with lean = mass preserved or increased. The only non-GLP-1 fat loss peptide with phase= 3 human data and FDA approval. 1 to 2 mg subQ daily, 5 days on 2 days off,= 8 to 16 weeks on, 4 to 8 weeks off. If you are already lean and chasing si= ngle-digit body fat, the water retention may mask the changes. If you are 2= 5%+ body fat trying to drop into the teens, this works incredibly well.=0A= =0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=0A=0A**Final Thoughts**=0A=0AEvery compound on this l= ist has a place. Even the F-tier ones have a use case for somebody, just no= t for me.=0A=0AThe mistake people make is reaching for one tool and crankin= g the dose until something gives. With everything on this list, you can rot= ate through different mechanisms. =0A=0AAMPK one cycle. Mitochondrial uncou= pling the next. Brown fat thermogenesis the cycle after that. Each pathway = hits differently. Each cycle gives the others a chance to reset.=0A=0AHormo= nes first. Lifestyle second. Compounds third. That order does not change.= =0A=0AAlso, remember this is just my opinion. There are great compounds I l= eft off this list. There are people smarter than me who would rank some of = these differently. I would actually love to hear it. If you think I got som= ething wrong, drop it in the YouTube or Spotify comments. The conversation = is what moves the field forward.=0A=0AIf you want my full reasoning on each= compound, the dosing protocols, and the reactions I have personally seen, = watch the video or listen to the episode. I cover way more than I could fit= in here.=0A=0AAs always, thank you for being here. I have the best audienc= e in the world! =0A=0ABest,=0A=0AHunter Williams=0A=0A=0A=E2=80=94=E2=80=94= =E2=80=94=0A=0AYou are reading a plain text version of this post. For the b= est experience, copy and paste this link in your browser to view the post o= nline:=0Ahttps://huntershealthhacks.beehiiv.com/p/non-glp-fat-loss-compound= s-ranked --u4HWCmXeT+aYztS0dSW/Ug Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Non-GLP Fat Loss Compounds Ranked
New Video is Live!  ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌
=

Happy Tuesday!

Most folks would agree that the GLPs are the kings of fat loss, with r= etatrutide holding the title belt.

But what if GLPs are not on the table for you? What if you are cycli= ng off? What if you want to stack other compounds so you don=E2=80=99t have= to crank your GLP dose into the stratosphere?

I just dropped a brand-new video and podcast episode where I rank=C2=A020 non-GLP-1 fat-loss compounds= from F tier to S tier. Most are peptides. A few are small molecules. All o= f them have a place in the conversation right now.

<= /table><= td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wo= rd-break:break-word;">

F Tier= (I Don't Use These)

<= /tr>

BAM15. = A mitochondrial uncoupler. Your cell burns more fuel to maintain ATP, and t= he energy gets dumped as heat. Wider therapeutic window than DNP. Strong ro= dent data, no human safety pharmacology yet. I run 50 to 100 mg a day. Abov= e 400 mg, there are diminishing returns.

= <= /tr><= td class=3D"dd" align=3D"left" style=3D"padding:0px 15px;text-align:left;wo= rd-break:break-word;">

Hunter Williams

=3D""
= 3D"YouTube

20 Fat Loss C= ompounds Ranked Worst to Best (No GLP-1s)

You can watch the full vide= o here: https:= //youtu.be/36E7xjuFVXc

Or listen on Spotify here: <= a class=3D"link" href=3D"https://link.mail.beehiiv.com/v1/c/IJDcIzJYSxXX9hf= 1JKoXTaGzgH0sxWXeyvLNPxEtaRFXA5R%2B99bjTkxXMeXi%0AIB72SrRpeCGSMlOQAiS%2BKqn= FgfTrZCU1TyVFnftGyYHqqBHdwqIQhvC7vGU3%0AJSQV9%2F5hUYnUCxDaJ9fKkMobqdO7xcWP%= 2FITUoDuqqmX4JXFPifktkrtIvjwv%0A2%2Bf2Pv1DWg1%2FVJubJJlN%2F6QENo19QfnutQ%3D= %3D%0A/9922e31d3b19c1d9" target=3D"_blank" rel=3D"noopener noreferrer nofol= low">https://open.spotify.com/episode/3jOsxcgx8n4EaOhhaNCuCv?si=3DTIs= _SV5eT6KTmarCWf7cZA

Below is the breakdown of every compound and why I ranked it where I did= .

 

Adipotide (FTPP). T= his one targets fat cells by killing the blood vessels that feed them. Soun= ds elegant on paper. The problem is that the kidneys are damaged at the sam= e doses that produce the fat loss. Phase 1 data in obese prostate cancer pa= tients showed real fat loss but also dose-dependent renal toxicity. The ris= k-to-reward is not there for me. I am sure people are using it. I just choo= se not to.

HGH Fragment 1= 76-191. This is not HGH. It is= a fragment of the HGH amino acid sequence. The human data is weak. AOD9604= is essentially the same thing with an added tyrosine for stability, and ev= en AOD isn=E2=80=99t great. If you are taking HGH frag, you are wasting you= r money.

D Tier (Weak Use Case)

<= span style=3D"font-size:1.5rem;">AOD9604. A 12-week phase 2 trial showed about 2 kg of fat loss compar= ed with placebo. That is roughly 4 to 5 pounds. Not nothing. But not exciti= ng either when GLPs exist. I have used it. The one place it might earn its = keep is helping with water retention from growth hormone or GH peptides. As= a standalone fat loss tool, skip it.

C Tier (Use Case Ex= ists, But Outclassed)

Sermorelin. It is a GH= RH peptide. It works. It is just the weakest of the GH peptide family and h= as been outclassed by tesamorelin, CJC, and ipamorelin. If it is what you h= ave, fine. If you are choosing fresh, pick something else.

Setmelanotide. An MC4R agonist that absolutely will suppress your appet= ite. The problem is the nausea. I took 250 micrograms and felt fine for abo= ut 6 hours. Then the nausea hit and lasted a day or two. Take the worst sem= aglutide nausea you have ever felt and crank it up. The FDA-approved dose i= s 2 to 3 mg daily, and I have no idea how anyone tolerates that. For people= with specific genetic obesity syndromes, it can be life-changing. For ever= yone else, it is a glutton-for-punishment compound.

B Tie= r (Solid, Conditional Wins)

Tesofensine. A t= riple monoamine reuptake inhibitor. Phase 3 data in obese Mexican patients = showed 8.6 kg of weight loss vs 1.9 kg placebo over 24 weeks. I love this o= ne for the cognitive lift. It feels like a nootropic. About 70% of people d= o well on it. About 20% do terribly with insomnia, anxiety, or feeling wire= d. I run 250 mcg and get great benefits. Watch your heart rate and blood pr= essure.

SS-31.= Not a fat loss peptide on paper. But it = repairs the mitochondrial hardware. Fix the mitochondria, and everything wo= rks better, including fat loss. I run 1 to 2 mg for general optimization an= d 5 to 10 mg for a real metabolic effect. It earns its place because it imp= roves the rest of your stack.

Cagrilintide. A long-acti= ng amylin analog that suppresses appetite through a completely different me= chanism than GLPs. With semaglutide, it produced 20.4% weight loss over 68 = weeks. On its own, around 10 to 11% at higher doses. I do great on it. My w= ife, Taylor, feels depressed and emotionally blunted on it. About half the = people I see using it report that. Coin flip. Start at 250 mcg and titrate = up.

IGF-1 LR3.= This is more of a body recomposition too= l than a fat-loss tool. Run alongside HGH or a GH peptide for 4 to 6 weeks = at 25 to 200 mcg post-workout. Watch your blood sugar. Always have carbs on= hand. Hypoglycemia is the real risk.

Cardarine (GW501516). A PPAR agonist that shifts you toward fatty acid oxidation. By itself,= it will not melt fat. Paired with cardio, you get way more out of every se= ssion. I run 10 mg per day for 4 to 8 weeks. There is a cancer signal in mi= ce (in both directions), which is why I keep doses moderate and cycle.

A Tier (Where Things Get Real)

CJC + Ipamorelin. Not a fat loss peptide directly. But the downstream effe= cts on sleep, IGF-1, and recovery move the needle on body composition. Most= people tolerate ipamorelin well. CJC can give some folks reactions. Try th= em in isolation first before stacking. I would call this an A-minus.=

MOTS-c. A mitochondrial peptide that improves fatty acid ox= idation, glucose uptake, and insulin sensitivity. Acts as an exercise mimet= ic. I run 1 to 2 mg subQ daily, 5 days on, 2 days off, for 8 weeks on, 8 we= eks off. At 1 milligram with 5-Amino, I felt like a 7-year-old being told t= o sit still. Solid A or A+.

5-Amino-1MQ. An NNMT inhib= itor that raises intracellular NAD+ and makes fat cells resistant to lipoly= sis blockade. Mouse studies show a 30 to 40% reduction in fat cell size wit= h no change in food intake. Injectable works much better than oral. I run 1= to 2 mg injected daily. Push past 2 milligrams, and you start to feel burn= out. With MOTS-c, I would call the combo an A+.

SLU-PP-332. A= n estrogen-related receptor agonist that drives mitochondrial biogenesis an= d fatty acid oxidation. The most studied exercise mimetic in this class. I = prefer 250-750 mcg daily for 8-12 weeks. Higher doses just made me feel wor= se. Oral works fine. Transdermal works great. Injectable in oil might be th= e best delivery method, but the data isn't clean enough yet to call it.=

ATX-304. A pan-AMPK activator that does not cross the = blood-brain barrier. Real human data, no appetite suppression, no muscle lo= ss. Trials used 1,000 milligrams, which is cost-prohibitive for most. I get= great results at 300-500 mg daily. Energy is solid, fat loss is real, and = water retention drops. A+.

Mirabegron. A beta-3 adren= ergic agonist. Activates brown fat thermogenesis and improves insulin sensi= tivity. FDA-approved for overactive bladder. For body comp, 50-100 mg a day= . Great for the last few weeks of a cut. Watch your heart rate, blood press= ure, and urinary retention at higher doses.

S Tier (The B= est We Have)

A= lbuterol. A beta-2 agonist tha= t activates lipolysis through hormone-sensitive lipase. Increases resting e= nergy expenditure 3 to 5%. FDA-approved since 1981 with decades of safety d= ata. I run 2 to 5 mg orally per day, 2 weeks on 2 weeks off. The receptors = downregulate after about 2 to 3 weeks, which is why you cycle. The only rea= son I call it S-minus is that short cycle window.

HGH.= The most underrated fat loss tool we have. Direct GH receptor activation. = Increased fatty acid oxidation. Reduced glucose uptake in fat tissue. Decad= es of human data. In GH-deficient adults, 4 to 7 kg fat reduction and 2 to = 5 kg lean mass increase over 6 to 12 months. Most men in their 40s, 50s, an= d 60s probably qualify as deficient. Run 1 to 4 IU daily. It is not a 2-wee= k shred tool. Over 1 to 2 years, the body just transforms.

Tesamorelin. S-tier-plus from a data standpoint. A GHRH that stimulates= pulsatile pituitary GH release. Phase 3 data in HIV lipodystrophy patients= showed about 15% reduction in visceral fat over 6 months, with lean mass p= reserved or increased. The only non-GLP-1 fat loss peptide with phase 3 hum= an data and FDA approval. 1 to 2 mg subQ daily, 5 days on 2 days off, 8 to = 16 weeks on, 4 to 8 weeks off. If you are already lean and chasing single-d= igit body fat, the water retention may mask the changes. If you are 25%+ bo= dy fat trying to drop into the teens, this works incredibly well.

 

Final Thoughts

Every compound on this list has a place. Even the F-tier ones have a u= se case for somebody, just not for me.

The mistake people make is reaching for one tool and cranking th= e dose until something gives. With everything on this list, you can rotate = through different mechanisms.

AMPK one cycle. Mitochondrial uncoupling the next. Brown fat thermogenes= is the cycle after that. Each pathway hits differently. Each cycle gives th= e others a chance to reset.

Hormones first. Lifestyle second. Compounds third. That order does not cha= nge.

Also, remember this is = just my opinion. There are great compounds I left off this list. There are = people smarter than me who would rank some of these differently. I would ac= tually love to hear it. If you think I got something wrong, drop it in the = YouTube or Spotify comments. The conversation is what moves the field forwa= rd.

If you want my full reas= oning on each compound, the dosing protocols, and the reactions I have pers= onally seen, watch the video or listen to the episode. I cover way more tha= n I could fit in here.

As al= ways, thank you for being here. I have the best audience in the world!

Best,

=

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