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To view it, please visit:=20 https://arn.soundestlink.com/ce/v/66f59766ed7d70230df9f78b/69e67db565142cea= 1a702b60 ************************** Make sure you keep getting our latest offers and add news@twc.health to you= r address book. Unsubscribe=20 https://arn.soundestlink.com/contactsPreferences/v2/unsubscribe/?b=3D6480de= eecefd2884c0f68adb&c=3D66f59766ed7d70230df9f78b&payload=3DfAURbuGh-9mH4SPcr= wV5v0-Wf9rXGlZ5R0Ss-2g7vp1grYCF2UYuPkKB5YzWpnwDKTOLlFvmWs4SjNSGuExKTWungVd8= IAD5XsfI7ANhT1t9xbs-K7MdJ3K65xLkI9RSHvAQ Visit site http://www.twc.health =C2=96 --7d52fd5cb76a45119937f94204336bffbbce0ebee9518cb292558f016c0a Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable Arthritis Breakthrough

= Read why scientists are excited about Ivermectin=E2=80=99s anti-inflammato= ry power

͏ ͏ ͏ ͏ ͏ ͏ &= #847; ͏ ͏ ͏ ͏ ͏ T= 7; ͏ ͏ ͏ ͏ ͏ ͏&= nbsp;͏ ͏ ͏ ͏ ͏ ͏&nbs= p;͏ ͏ ͏ ͏ ͏ ͏ &= #847; ͏ ͏ ͏ ͏ ͏ T= 7; ͏ ͏ ͏ ͏ ͏ ͏&= nbsp;͏ ͏ ͏ ͏ ͏ ͏&nbs= p;͏ ͏ ͏ ͏ ͏ ͏ &= #847; ͏ ͏ ͏ ͏ ͏ T= 7; ͏ ͏ ͏ ͏ ͏ ͏&= nbsp;͏ ͏ ͏ ͏ ͏ ͏&nbs= p;͏ ͏ ͏ ͏ ͏ ͏ &= #847; ͏ ͏ ͏ ͏ ͏ T= 7; ͏ ͏ ͏ ͏ ͏ ͏&= nbsp;͏ ͏ ͏ ͏ ͏ ͏&nbs= p;͏ ͏ ͏ ͏ ͏ ͏ &= #847; ͏ ͏ ͏ ͏ ͏ T= 7; ͏ ͏ ͏ ͏ ͏ ͏&= nbsp;͏ ͏ ͏ ͏ ͏ ͏&nbs= p;͏ ͏ ͏ ͏ ͏ ͏ &= #847; ͏ ͏ ͏ ͏ ͏ T= 7; ͏ ͏ ͏ ͏ ͏ ͏&= nbsp;͏ ͏ ͏ ͏ ͏ ͏&nbs= p; ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ &sh= y; ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ = ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ &sh= y; ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ = ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ &sh= y; ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ = ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ &sh= y; ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ = ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ &sh= y; ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ ­ = ­ ­ ­ ­ ­

= 3D""
=
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Ivermectin & Arthritis: A Surprising Ally Agai= nst Inflammation

3D"I=

If you=E2=80=99ve got arthritis, you already know it= =E2=80=99s not just =E2=80=9Ca little joint pain.=E2=80=9D


It=E2=80=99s a constant, grinding ache =E2=80=94 like= your body is mad at you.

And what=E2=80=99s behind it all? Inflammatio= n. The same kind of inflammation that wreaked havoc in sev= ere COVID-19 cases is also attacking joints in those with rheumatoid arthritis (RA) and osteoarthriti= s (OA).


Swelling. Stiffness. Breakdown. It=E2=80=99s the same= enemy wearing a different mask.

The Cytokine Storm Inside You=

Your body uses chemicals called = cytokines to call for backup when there=E2=80=99s injury o= r infection. But sometimes these chemical messengers go rogue.


They call in the immune system a= s if it were an emergency. So, instead of healing, there is more pain, more= damage, more swelling. Scientists have named the three worst offen= ders: 


TNF-=CE=B1. IL-6. IL-1= =CE=B2.

The =E2=80=9C= Inflammatory Triad=E2=80=9D that hijacks your body=E2=80=99s natural defens= es.


These bad actors flip powerful s= witches inside your cells =E2=80=94 NF-=CE=BAB, MAPK, JAK/STAT =E2=80=94 and set off= chain reactions that cause joints to deteriorate and your body to spiral i= nto chronic inflammation.


In other words, you expe= rience pain all the time.

What If You Could Flip the Sw= itch?

3D"I=

This is where ivermectin rushes in= =2E


Originally developed to fight pa= rasites, ivermectin has shown powerful anti-inflammatory potential. Rese= arch suggests it can help calm the same inflammatory signals that drive art= hritis =E2=80=94 blocking NF-=CE=BAB, the =E2=80=9Cmaster switch=E2=80=9D o= f inflammation, and dialing down pathways like MAPK and JAK/STAT. 


The result? Less swellin= g, reduced tissue breakdown, and relief f= rom persistent joint pain.


For over 30 years, ivermectin has been t= rusted worldwide =E2=80=94 Nobel Prize=E2=80=93winning, FDA-approved, and proven safe for millions.= Now, science is uncovering its broader potential to support inflammation a= nd joint health.


Discover what balanced inflammat= ion feels like.


Start your journey to better joint health today.<= /span>

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Sources:


Chow, Y. Y., & Chin, K. Y. (2020). The role of= inflammation in the pathogenesis of osteoarthritis. Mediators of Infla= mmation, 2020, Article 8293921. https://doi.org/10.1155/2020/8293921

Abcam. (n.d.). Cytokine storm in COVID-19 pathway.= Abcam. Retrieved October 1, 2025, from https://www.abcam.com/en-us/technical-resources/pathways/cytoki= ne-storm-in-covid-19-pathway

 Yang, L., Xie, X., Tu, Z., Fu, J., Xu, D., &= amp; Zhou, Y. (2021). The signal pathways and treatment of cytokine storm i= n COVID-19. Signal Transduction and Targeted Therapy, 6, 255. = ;https://doi.org/10.1038/s41392-021-00679-0

Cell Signaling Technology. (n.d.). Rheumatoid arth= ritis pathogenesis signaling pathway. Cell Signaling Technology. Retrieved = October 1, 2025, from https://www.cellsignal.com/pathways/rheumatoid-arthritis

Yang, L., Xie, X., Tu, Z., Fu, J., Xu, D., & Z= hou, Y. (2021). The signal pathways and treatment of cytokine storm in COVI= D-19. Signal Transduction and Targeted Therapy, 6, 255. https://doi.org/10.1038/s41392-021-00679-0


genic signaling pathways and therapeutic targe= ts. Signal Transduction and Targeted Therapy, 8, Article 169. = ;https://doi.org/10.1038/s41392-023-01330-w

Li, M., Wang, Y., Lin, C., & Liu, H. (2023). S= ignaling pathways in rheumatoid arthritis: Implications for targeted therap= y. Signal Transduction and Targeted Therapy, 8, Article 170. = https://doi.org/10.1038/s41392-023-01331-9

Thermo Fisher Scientific. (n.d.). Pro-inflammatory= cytokines overview. https://www.thermofisher.com/us/en/home/life-science/cell-analy= sis/cell-analysis-learning-center/immunology-at-work/proinflammatory-cytoki= nes-overview.html

Zhao, Y., Liu, J., Yang, C., Zheng, W., & Zhu,= J. (2024). Cytokine network in inflammatory diseases: Current advances and= future perspectives. Frontiers in Immunology, 15, 1330386. <= a style=3D"color:#004D7D" href=3D"https://nas.soundestlink.com/ce/c/66f59766e= d7d70230df9f78b/69e67db565142cea1a702b60/69e77575076dfe5ab4af9f23?signature= =3D7cc4b43bfcacc306c9681bc319d5865aa0cea962dbc210f44357158913d4e02b" target= =3D"_blank">https://www.frontiersin.org/journals/immunology/articles/10.338= 9/fimmu.2024.1330386/full

News Medical. (2021, November 18). Triad of cytoki= nes associated with long COVID. https://www.news-medical.net/news/20211118/Triad-of-cytokines-a= ssociated-with-long-COVID.aspx

Dinarello, C. A. (2010). Proinflammatory cytokines= =2E Chest, 118(2), 503-508. https://pmc.ncbi.nlm.nih.gov/articles/PMC2882124/

Luo, Y., & Zheng, S. (2017). Signaling cross t= alk between TGF-=CE=B2/Smad and other signaling pathways. Signal Transd= uction and Targeted Therapy, 2(1), 17023. https://www.nature.com/articles/sigtrans201723

Assay Genie. (n.d.). MAPK signaling and cytokines = pathways. https://www.assaygenie.com/blog/mapk-signaling-cytokines-pathwa= ys

Chen, L., & Deng, H. (2017). The molecular mec= hanisms of macrophage polarization and phagocytosis. International Revi= ew of Immunology, 36(6), 547-565. https://pmc.ncbi.nlm.nih.gov/articles/PMC3899974/

Liu, C., Wu, J., Zhu, J., Kullak-Ublick, G. A., &a= mp; Lu, Y. (2022). Pharmacological modulation of cytokines in inflammation:= Mechanisms and therapeutic strategies. Frontiers in Pharmacology, 13, 1033674. https://www.frontiersin.org/journals/pharmacology/articles/10.3= 389/fphar.2022.1033674/full

Smyth, L., Williams, L., & Hays, J. (2020). Th= e cytokine profile of COVID-19 patients. Cytokine, 136, 155264.&nb= sp;https://pmc.ncbi.nlm.nih.gov/articles/PMC7539925/

L=C3=B3pez-Collazo, E., & del Fresno, C. (2020= ). Pathogenesis of severe COVID-19: The interplay between the cytokine stor= m and immunosuppression. Cytokine & Growth Factor Reviews, 55,= 1-10. https://pmc.ncbi.nlm.nih.gov/articles/PMC7476419/

Subramaniam, A. V., & Chalmers, J. (2020). Cyt= okines and cardiovascular disease: Updating evidence and standards. Ope= n Heart, 7(2), e001350. https://openheart.bmj.com/content/7/2/e001350

Wu, D., & Yang, X. O. (2021). TH17 responses i= n cytokine storm of COVID-19: An emerging target of JAK2 inhibitor fedratin= ib. Frontiers in Immunology, 12, 620492. https://pmc.ncbi.nlm.nih.gov/articles/PMC8688140/

Martonik, D., Parfieniuk, E., & Szynkiewicz, M= =2E (2020). Cytokine and chemokine patt= erns in COVID-19 and long COVID. F= rontiers in Immunology, 11, 584706. https://pmc.ncbi.nlm.nih.gov/articles/PMC7578741/

Zhang, J., & Zhang, W. (2018). Ivermectin inhi= bits LPS-induced production of inflammatory cytokines and improves LPS-indu= ced survival in mice. Semanticscholar. https://www.semanticscholar.org/paper/Ivermectin-inhibits-LPS-i= nduced-production-of-and-Zhang-Zhang/5db4f9d9e79440a958bba033236b36d4841174= 40

Asghari, A., Ghadiri, M. K., Sayehmiri, F., et al.= (2022). The immunopathological mechanisms of cytokine storm and therapeuti= c approaches for COVID-19. International Immunopharmacology, 112, = 109155. https://pmc.ncbi.nlm.nih.gov/articles/PMC9442455/

Kamal, R., & Kaur, T. (2024). Cytokines: A lin= k between inflammation and cancer. PubMed. https://pubmed.ncbi.nlm.nih.gov/40943574/

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