Subject: How To Build Peptide Protocols
From: Hunter Williams <[email-masked]>
To: "[email-masked]" <[email-masked]>
Date: Wed, 8 Apr 2026 22:02:55 +0000

Happy Wednesday!

Taylor and I just sat down with Drew Donaldson on The DDT Method Podcast.

Youtube: The 5 Buckets That Cover 95% of Every Peptide Protocol (https://youtu.be/B-uyRj81THU)

This one covers a lot of ground.

We went deep on what's actually working right now in the peptide and optimization space. No hype, no fluff, just the protocols and products we're using with ourselves and our coaching clients.

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**Here's what we covered:**

* Why peptide fatigue is real and how to stop stacking 40 things at once

* The 5 buckets framework for building a protocol that actually works

* Why injectable testosterone for women is finally having its moment

* P21 and PE 22-28 for cognition, focus, and anxiety 

* Injectable bioregulators that nobody talks about 

* Transdermal peptides and small molecules that actually work

* MK-777 vs MK-677 and why the new version might be a game changer

* How to pick between Tirzepatide and Retatrutide based on the client

* The SS-31 plus MOTS-c sequencing we use for mitochondrial support

* SLU-PP-332 dosing debate

* Why ATX deserves way more love than it gets

* Jardiance, Metformin, and why SGLT2 inhibitors might make Metformin obsolete

* ACE-167, an oral compound that could change the TRT conversation

* IGF-1 LR3 and why we think people are still sleeping on it

If any of that hits, go watch the full episode.

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**A quick word on Drew.**

Drew is one of the few people in this space doing long-form content the right way. He goes deep. He asks the questions that actually matter. He doesn't chase clicks or oversimplify complex topics to fit a 60-second reel.

If you care about peptides, HRT, PEDs, and biohacking done with real depth, please subscribe to [The DDT Method Podcast](https://www.youtube.com/channel/UC9pFnidHL3PnqyL9Lwf8H2w). 

Drew brings on quality guests and knows exactly what questions to ask to make an engaging podcast. 

You'll learn more from one of his episodes than from a month of scrolling Instagram! 

Best,

Hunter Williams 

P.S. Drew also runs a Skool group with tons of insider content and coaching calls for only $10 per month. You can check it out [here](https://www.skool.com/ddtmethod/about). 

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