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Every peptide on this list has legitimate research behind it. They= also have better alternatives that cost about the same and work significan= tly better.=0A=0AThis was actually a harder video to put together than I ex= pected. I get asked about which peptides I think are worthless almost every= single week. So I aggregated all those questions and finally put my list t= ogether.=0A=0AIn today=E2=80=99s email, I wanted to give you a written brea= kdown of each peptide on the list and what I would actually use instead. = =0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=0A=0A**AOD-9604**=0A=0AAOD-9604 is probably the mo= st overrated peptide on this entire list.=0A=0AIn case you're not familiar = with it, AOD is a modified fragment of human growth hormone that spans amin= o acids 177-191. The idea was to isolate the fat-burning effects of growth = hormone without the blood sugar issues or other downstream complications. S= ounds amazing on paper.=0A=0AIt never panned out that way in real life.=0A= =0AMetabolic Pharmaceuticals ran a phase 2B trial with over 500 participant= s. The results were statistically significant but barely noticeable in term= s of actual fat loss. =0A=0AThe company eventually abandoned the program. = =0A=0AI have personally taken AOD as high as one milligram per day. =0A=0AI= f you stack it on top of a GLP-1, a GH peptide, and a mitochondrial compoun= d like MOTS-c, you might get an extra 5 percent boost. But on its own, it j= ust does not move the needle.=0A=0AWhat would I use instead? Tesamorelin or= a GLP-1 agonist. =0A=0ATesamorelin has clinical data showing 15 to 18 perc= ent reductions in trunk fat over 26 weeks. GLP-1s are the gold standard for= overall fat loss. Both options are dramatically more effective dollar for = dollar.=0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**GHRP-2 and GHRP-6**=0A=0AThese wer= e some of the early synthetic growth hormone secretagogues from the ghrelin= mimetic family. =0A=0AThey bind the ghrelin receptor in the pituitary and = stimulate growth hormone release. They were popular in early peptide commun= ities because they were inexpensive and readily available.=0A=0AThe problem= ? =0A=0AGHRP-6 can cause ravenous, near-uncontrollable hunger within 15 to = 20 minutes of injection. That is the opposite of what most people want when= they're trying to manage body composition. =0A=0AIt also significantly ele= vates prolactin and cortisol. GHRP-2 is a little better but still raises co= rtisol meaningfully.=0A=0AThe one case where these can be useful is for som= eone who genuinely struggles to eat and needs help building an appetite bef= ore meals. But most people have the opposite problem.=0A=0AWhat would I use= instead? Ipamorelin paired with CJC-1295 no DAC. =0A=0AYou get all the ben= efits on the pituitary via ghrelin without the prolactin spike, the cortiso= l increase, or the hunger. The growth hormone release is stronger, more sus= tained, and far more selective.=0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**HGH Fragme= nt 176-191**=0A=0AHGH Fragment 176-191 is the unmodified C-terminal fragmen= t of human growth hormone. =0A=0AEssentially, AOD without the tyrosine modi= fication. It gets marketed as the pure fat-burning fragment of growth hormo= ne.=0A=0AI would actually argue this one is worse than AOD-9604.=0A=0AEvery= thing wrong with AOD applies here, but the situation is even worse. AOD at = least had clinical trials backing it up. =0A=0AHGH Frag has almost no human= clinical data. It is basically AOD with even less evidence, yet people are= still buying and selling it.=0A=0AI do not get many questions about this o= ne specifically. But when I was researching the video, I noticed it is stil= l listed on many research sites. People see the words "fat burning fragment= " and pull the trigger without digging deeper.=0A=0AWhat would I use inseta= d? Tesamorelin is going to be the strongest option from the growth hormone = side of fat burning. =0A=0APair that with a GLP-1 agonist if your goal is m= eaningful, sustained fat loss. The difference in results is not even close.= =0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=0A=0A**Sermorelin**=0A=0AThis one is probably my m= ost controversial take on the list.=0A=0ASermorelin is a GHRH analog made u= p of the first 29 amino acids of the 44 amino acid GHRH molecule. It was FD= A-approved in 1997 and became the most commonly prescribed growth hormone s= ecretagogue in anti-aging clinics for years.=0A=0AThe problem is we have so= many better options now.=0A=0ASermorelin does stimulate GH release, and th= ere is real clinical data behind it. But the half-life is very short, and t= he GH pulse it produces is brief and relatively weak. =0A=0AMany users repo= rt underwhelming results even after months of consistent use. It also seems= to lose efficacy over time.=0A=0AI think the reason Sermorelin still hangs= on is that it was FDA-approved at one point. =0A=0AClinics feel comfortabl= e prescribing it, and patients feel comfortable receiving it. =0A=0AWhat wo= uld I use instead? Ipamorelin and CJC-1295 no DAC. =0A=0ABetter GH pulse. B= etter long-term efficacy. You get both the GHRH and GHRP components togethe= r. Same price range. Vastly superior results in basically every category.= =0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=0A=0A**Oral 5-Amino-1MQ Capsules**=0A=0A5-Amino-1M= Q is a small molecule inhibitor of NNMT, an enzyme that gets overexpressed = in the fat tissue of obese individuals. =0A=0AInhibiting NNMT shifts cellul= ar energy balance toward fat oxidation and raises intracellular NAD+ levels= .=0A=0AThe compound is great, but the problem is the delivery form.=0A=0A5-= Amino is a quaternary ammonium compound, which means it carries a permanent= charge. That makes it very difficult to cross biological membranes, includ= ing the intestinal lining. =0A=0AOral bioavailability is likely in the sing= le-digit percentages. Most of the dose gets excreted before it ever reaches= systemic circulation.=0A=0AI tried the oral capsules years ago. Felt somet= hing for two or three weeks and then nothing after that. Clients on standar= d oral dosing rarely report anything meaningful either.=0A=0AWhat I would u= se instead? The injectable version of the exact same compound. =0A=0AI do 1= -2mg per day and feel a massive energy boost along with real fat loss. If y= ou get the injectable and it shows up as an orange powder, that is, in fact= , what it is supposed to look like.=0A=0A=E2=80=94=E2=80=94=E2=80=94=E2=80= =94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94= =E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2= =80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=E2=80=94=0A=0A**Final T= houghts**=0A=0AYou can absolutely get results from every single peptide on = this list. =0A=0AI am not saying these compounds do not work. =0A=0AI am no= t telling you to stop using them if they are working for you. =0A=0AAnd I a= m definitely not telling companies to stop selling them.=0A=0AWhat I am say= ing is that, for most people, better tools are available right now. Same pr= ice range. Better results. Better mechanisms. Better long-term outcomes.=0A= =0AIf you are curious, go test these peptides yourself. Maybe you get a gre= at result and prove me wrong. That is part of the fun of this space. We are= all running our own n =3D 1 experiments.=0A=0AIt truly is a blessing to ge= t to bring this content to you every single week. =0A=0AWhether you're on t= he email list, in the Axion Collective, sharing the podcast with friends, o= r using my code at checkout, just know that I appreciate every bit of it mo= re than you'll ever know!=0A=0ABest,=0A=0AHunter Williams=0A=0A=0A=E2=80=94= =E2=80=94=E2=80=94=0A=0AYou are reading a plain text version of this post. = For the best experience, copy and paste this link in your browser to view t= he post online:=0Ahttps://huntershealthhacks.beehiiv.com/p/the-most-overrat= ed-peptides --IXCocG7iRc61xbv+roKOTQ Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable The Most Overrated Peptides
New video is live! = 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌ ‌ ‌= 60;‌ ‌ ‌ ‌ ‌ ‌=  ‌ ‌ ‌ ‌ ‌ R= 04; ‌ ‌ ‌ ‌ ‌ &= #8204; ‌ ‌ ‌ ‌ ‌= 0;‌ ‌ ‌ ‌ ‌ ‌&= #160;‌ ‌ ‌ ‌ ‌ ̴= 4; ‌ ‌ ‌ ‌ ‌ &#= 8204; ‌ ‌ ‌ ‌ ‌ = ;‌ ‌ ‌ ‌ ‌ ‌&#= 160;‌ ‌ ‌ ‌ ‌ ‌= ; ‌ ‌ ‌ ‌ ‌ = 204; ‌ ‌ ‌ ‌ ‌ = ‌ ‌ ‌ ‌
<= table role=3D"none" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpaddi= ng=3D"0" align=3D"center">

The company eventually abandoned the program.

This one is probably my most controversial take on the = list.

=

April 07, 2026   |   Read online

<= h1 style=3D"text-align:left;font-family:'Trebuchet MS','Lucida Grande',Taho= ma,sans-serif;font-weight:Bold;font-size:32px;color:#2A2A2A;padding:2px 0;l= ine-height:38px;"> The Most Overrated Peptides

New video is live!

 
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 <= a href=3D"https://link.mail.beehiiv.com/v1/c/agS3lO%2FJFq0M9MxS78PkBc01helt= TXQYKdxgdOi2X9j9%2FM8LLf3uyYCyQ7tC%0AZt3iP7mPt0fgTcPEj8N9CXqcroG8i2PE0OixvU= a0%2BX%2FKtIemhnrpUtMv8Twy%0A9jg6vVuqmIl%2BgZ2v9DE2QIG0byNoHdjbYe9ods9dd7hS= CsIYMeY%3D%0A/5be8004830ddda8d" style=3D"text-decoration:none; display:bloc= k;">
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In today=E2=80=99s email, I wanted to give you a wri= tten breakdown of each peptide on the list and what I would actually use in= stead.

Happ= y Tuesday!

I just dropped a = brand new podcast on YouTube and Spotify.

3D""
3D"YouTube

These Peptides Are Overrated (Here's What Actually Works)

This = one might ruffle some feathers.

I break down the five most overrated peptides.

And before anyone gets fired up, this is not a hit = piece. Every peptide on this list has legitimate research behind it. They a= lso have better alternatives that cost about the same and work significantl= y better.

This was actually = a harder video to put together than I expected. I get asked about which pep= tides I think are worthless almost every single week. So I aggregated all t= hose questions and finally put my list together.

 

AOD-9604

AOD-9604 is probably the most overrated peptide on this e= ntire list.

In case you= 9;re not familiar with it, AOD is a modified fragment of human growth hormo= ne that spans amino acids 177-191. The idea was to isolate the fat-burning = effects of growth hormone without the blood sugar issues or other downstrea= m complications. Sounds amazing on paper.

It never panned out that way in real life.

Metabolic Pharmaceuticals ran a phase 2B trial= with over 500 participants. The results were statistically significant but= barely noticeable in terms of actual fat loss.

I have personally taken AOD as hi= gh as one milligram per day.

If you stack it on top of a GLP-1, a GH peptide, and a mitochondrial comp= ound like MOTS-c, you might get an extra 5 percent boost. But on its own, i= t just does not move the needle.

What would I use instead? Tesamorelin or a GLP-1 agonist.

<= /td>

Tesamorelin has clinical data showing 1= 5 to 18 percent reductions in trunk fat over 26 weeks. GLP-1s are the gold = standard for overall fat loss. Both options are dramatically more effective= dollar for dollar.

= = = = =
 

GHRP-2 and GHRP-6

These were some of the early synthet= ic growth hormone secretagogues from the ghrelin mimetic family.

They bind the ghrelin receptor in the= pituitary and stimulate growth hormone release. They were popular in early= peptide communities because they were inexpensive and readily available.

The problem?

GHRP-6 can cause ravenous, near-uncontrolla= ble hunger within 15 to 20 minutes of injection. That is the opposite of wh= at most people want when they're trying to manage body composition.

It also significantly elevates= prolactin and cortisol. GHRP-2 is a little better but still raises cortiso= l meaningfully.

The one case= where these can be useful is for someone who genuinely struggles to eat an= d needs help building an appetite before meals. But most people have the op= posite problem.

What would I= use instead? Ipamorelin paired with CJC-1295 no DAC.

You get all the benefits on the pituitary via gh= relin without the prolactin spike, the cortisol increase, or the hunger. Th= e growth hormone release is stronger, more sustained, and far more selectiv= e.

 

HGH Fragment 176-191

HGH Fragment 176-191 is the unmodified C-terminal fr= agment of human growth hormone.

Essentially, AOD without the tyrosine modification. It gets marketed a= s the pure fat-burning fragment of growth hormone.

I would actually argue this one is worse than AOD-96= 04.

Everything wrong with AO= D applies here, but the situation is even worse. AOD at least had clinical = trials backing it up.

HGH F= rag has almost no human clinical data. It is basically AOD with even less e= vidence, yet people are still buying and selling it.

I do not get many questions about this one specifi= cally. But when I was researching the video, I noticed it is still listed o= n many research sites. People see the words "fat burning fragment"= ; and pull the trigger without digging deeper.

What would I use insetad? Tesamorelin is going to be the= strongest option from the growth hormone side of fat burning.

<= /td>

Pair that with a GLP-1 agonist if your = goal is meaningful, sustained fat loss. The difference in results is not ev= en close.

 

Sermorelin

Sermorelin is a GHRH a= nalog made up of the first 29 amino acids of the 44 amino acid GHRH molecul= e. It was FDA-approved in 1997 and became the most commonly prescribed grow= th hormone secretagogue in anti-aging clinics for years.

The problem is we have so many better options = now.

Sermorelin does stimula= te GH release, and there is real clinical data behind it. But the half-life= is very short, and the GH pulse it produces is brief and relatively weak. =

Many users report underwhel= ming results even after months of consistent use. It also seems to lose eff= icacy over time.

I think the= reason Sermorelin still hangs on is that it was FDA-approved at one point.=

Clinics feel comfortable p= rescribing it, and patients feel comfortable receiving it.

What would I use instead? Ipamorelin and CJ= C-1295 no DAC.

Better GH pu= lse. Better long-term efficacy. You get both the GHRH and GHRP components t= ogether. Same price range. Vastly superior results in basically every categ= ory.

 

Oral 5-Amino-1MQ Capsules

5-Amino-1MQ is a small molecule inhibitor of = NNMT, an enzyme that gets overexpressed in the fat tissue of obese individu= als.

Inhibiting NNMT shifts= cellular energy balance toward fat oxidation and raises intracellular NAD+= levels.

The compound is gre= at, but the problem is the delivery form.

5-Amino is a quaternary ammonium compound, which means it car= ries a permanent charge. That makes it very difficult to cross biological m= embranes, including the intestinal lining.

Oral bioavailability is likely in the single-digit percenta= ges. Most of the dose gets excreted before it ever reaches systemic circula= tion.

I tried the oral capsu= les years ago. Felt something for two or three weeks and then nothing after= that. Clients on standard oral dosing rarely report anything meaningful ei= ther.

What I would use inste= ad? The injectable version of the exact same compound.

I do 1-2mg per day and feel a massive energy bo= ost along with real fat loss. If you get the injectable and it shows up as = an orange powder, that is, in fact, what it is supposed to look like.

 

Final Thoughts

You can absolutely get results from every single peptide on this l= ist.

I am not saying these = compounds do not work.

I am= not telling you to stop using them if they are working for you.

And I am definitely not telling compa= nies to stop selling them.

What I am saying is that, for most people, better tools are available righ= t now. Same price range. Better results. Better mechanisms. Better long-ter= m outcomes.

If you are cur= ious, go test these peptides yourself. Maybe you get a great result and pro= ve me wrong. That is part of the fun of this space. We are all running our = own n =3D 1 experiments.

It = truly is a blessing to get to bring this content to you every single week. =

Whether you're on the e= mail list, in the Axion Collective, sharing the podcast with friends, or us= ing my code at checkout, just know that I appreciate every bit of it more t= han you'll ever know!

Be= st,

Hunter Williams

<= /table>

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