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[159.112.244.8]) by mx.google.com with UTF8SMTPS id af79cd13be357-8d67dc46e30si698635785a.305.2026.04.06.17.42.35 for (version=TLS1_2 cipher=ECDHE-ECDSA-AES128-GCM-SHA256 bits=128/128); Mon, 06 Apr 2026 17:42:35 -0700 (PDT) Received-SPF: pass (google.com: domain of bounce+91e48a.63af5d-tjphuhs=gmail.com@mg-d0.substack.com designates 159.112.244.8 as permitted sender) client-ip=159.112.244.8; Authentication-Results: mx.google.com; dkim=pass header.i=@mg-d0.substack.com header.s=mailo header.b=oIOCYq7M; dkim=pass header.i=@mailgun.org header.s=mg header.b="L5oyx/50"; spf=pass (google.com: domain of bounce+91e48a.63af5d-tjphuhs=gmail.com@mg-d0.substack.com designates 159.112.244.8 as permitted sender) smtp.mailfrom="bounce+91e48a.63af5d-tjphuhs=gmail.com@mg-d0.substack.com"; dmarc=pass (p=REJECT sp=REJECT dis=NONE) header.from=substack.com DKIM-Signature: a=rsa-sha256; v=1; c=relaxed/relaxed; d=mg-d0.substack.com; q=dns/txt; s=mailo; t=1775522555; x=1775529755; h=List-Unsubscribe-Post: List-Unsubscribe: List-Post: List-Id: List-Archive: List-Owner: Reply-To: In-Reply-To: References: Sender: Sender: Date: Message-Id: To: To: From: From: Subject: Subject: Content-Type: Mime-Version: X-Feedback-Id; bh=/uddjxdfDuzERvkjk//aNTy/FLFQBg/q1jQAy8k7B4E=; b=oIOCYq7M3dHB4I7rMBZKasyP0yv62XOcuiKqlD8nfaDkeQcnyBuRAwb8r+SyAE9jUuVztOnLlrD1Eq+359Hmgbahgz/3E2FLiW0eNEXE0nu5nnKOhj1JbA3Yft6nJXj66LnpWyoILUJhxE6LFT9NP9/oXI9LilJpiFYqTtKQ1no= DKIM-Signature: a=rsa-sha256; v=1; c=relaxed/relaxed; d=mailgun.org; q=dns/txt; s=mg; t=1775522555; x=1775529755; h=List-Unsubscribe-Post: List-Unsubscribe: List-Post: List-Id: List-Archive: List-Owner: Reply-To: In-Reply-To: References: Sender: Sender: Date: Message-Id: To: To: From: From: Subject: Subject: Content-Type: Mime-Version: X-Feedback-Id; bh=/uddjxdfDuzERvkjk//aNTy/FLFQBg/q1jQAy8k7B4E=; b=L5oyx/50IRdMQ+uW+AK77QCha0iRqEeecGUKgOSTHLJHeEa31J9uc7MFWyv21qx0ECSPGyiV5UmA+iUoJ4rgph+s4quIoGnawpx5W18l3Ez0IT0a6xFL3/cWbz8Tou22P/otSCN00NFiKW18N8P/6qgJVP+rmXPJ63BNBRq3yxo= X-Mailgun-Sid: WyJkZWU4NyIsInRqcGh1aHNAZ21haWwuY29tIiwiNjNhZjVkIl0= X-Feedback-Id: postmaster@mg-d0.substack.com:post:6148c7d8a45790427cda307f:mailgun Received: by 048630ec2d3ac53fc9433ee9749221837d3ba66e27188b0ae80f717e1c95f012 with HTTP id 69d452fb05bf5e60b79ecfab; Tue, 07 Apr 2026 00:42:35 GMT X-Mailgun-Sending-Ip: 159.112.244.8 X-Mailgun-Batch-Id: 69d452fb35e5318eb83c322d Mime-Version: 1.0 Content-Type: multipart/alternative; boundary="e21cfac38ee18439b94b510e8c2053b6bae5a79e7c4d28cab99caba8b5a1" Subject: Results from my Feb 23 skin therapy: From: Bryan Johnson from Bryan Johnson To: tjphuhs@gmail.com X-Mailgun-Tag: post X-Mailgun-Track-Clicks: false Message-Id: <20260407004228.3.f6446c51fb351bce@mg-d0.substack.com> Date: Tue, 7 Apr 2026 00:42:28 +0000 Feedback-Id: post-193417404:cat-post:pub-5008442:substack Sender: Bryan Johnson from Bryan Johnson References: In-Reply-To: Reply-To: Bryan Johnson from Bryan Johnson List-Owner: List-Url: List-Archive: List-Id: List-Post: List-Unsubscribe: List-Unsubscribe-Post: List-Unsubscribe=One-Click X-Mailgun-Variables: {"category": "post", "email_generated_at": "1775522553274", "is_freemail": "true", "post_audience": "everyone", "post_id": "193417404", "post_type": "newsletter", "pub_community_enabled": "true", "publication_id": "5008442", "subdomain": "bryanjohns0n", "user_id": "273622398"} --e21cfac38ee18439b94b510e8c2053b6bae5a79e7c4d28cab99caba8b5a1 Content-Type: text/plain; charset="utf-8" Content-Transfer-Encoding: quoted-printable View this post on the web at https://bryanjohns0n.substack.com/p/results-fr= om-my-feb-23-skin-therapy Improvements since treatment: > Brown spots: +71 percentile points (20th =E2=86=92 91st)=E2=9C=85 > Pores: +25 percentile points=E2=9C=85 > Spots: +25 percentile points=E2=9C=85 My skin age is 9 years younger than my chronological age (39 vs 48) and has= n=E2=80=99t aged in five years since starting this project. Effectively a 9= year age reversal. Measured using VISIA multispectral clinical imaging, th= e most validated non-invasive skin analysis system available. Feb 23 treatment summary Technologies > Everesse RF > CoolPeel CO2 laser > BBL Each targeting a different skin depth so repair windows overlap without com= peting. Treatment details Everesse RF (200 pulses, Level 2.5 per cheek), CoolPeel CO2 laser (3.0W, 70= 0 micron spacing), and BBL broadband light. Each targeting a different skin= depth.=20 Everesse drives heat into the dermis at 60-70=C2=B0C, triggering fibroblast= activation and collagen production that peaks 6-8 weeks later (about now),= tightening the structural scaffolding that makes pores visible.=20 CoolPeel ablates the surface layer of skin, physically removing melanin-loa= ded cells and forcing fresh keratinocytes to the surface.=20 BBL destroys residual pigment one layer deeper through selective phototherm= olysis, where melanin absorbs light energy and self-destructs.=20 Porphyrins dropped 13 points, which is expected. The treatments temporarily= disrupt the follicular environment that bacteria need to thrive, and that = recovers within 8-12 weeks.=20 Goal was to do a triple-modality stack so the repair windows overlap withou= t competing (dermis, epidermis, and chromophores). Unsubscribe https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9icnlhbmpvaG5= zMG4uc3Vic3RhY2suY29tL2FjdGlvbi9kaXNhYmxlX2VtYWlsP3Rva2VuPWV5SjFjMlZ5WDJsa0= lqb3lOek0yTWpJek9UZ3NJbkJ2YzNSZmFXUWlPakU1TXpReE56UXdOQ3dpYVdGMElqb3hOemMxT= lRJeU5UVXpMQ0psZUhBaU9qRTRNRGN3TlRnMU5UTXNJbWx6Y3lJNkluQjFZaTAxTURBNE5EUXlJ= aXdpYzNWaUlqb2laR2x6WVdKc1pWOWxiV0ZwYkNKOS5OdDJSU1hZS2pQeDMwZkI0SjNVQVZmZUc= tanBYYkM2RTFOcFI0dkwteXNnIiwicCI6MTkzNDE3NDA0LCJzIjo1MDA4NDQyLCJmIjp0cnVlLC= J1IjoyNzM2MjIzOTgsImlhdCI6MTc3NTUyMjU1MywiZXhwIjoyMDkxMDk4NTUzLCJpc3MiOiJwd= WItMCIsInN1YiI6ImxpbmstcmVkaXJlY3QifQ.IREXm6FVpfdWF7b5cZIRod9zwjX_LYG86bxpO= JDKUxE? --e21cfac38ee18439b94b510e8c2053b6bae5a79e7c4d28cab99caba8b5a1 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable = Results from my Feb 23 skin therapy: 3D""
Improvements since treatment:
͏     ­͏ &= nbsp;   ­͏     ­͏     ­= ;͏     ­͏     ­͏   Q= 99; ­͏     ­͏     ­͏ &n= bsp;   ­͏     ­͏     ­= ͏     ­͏     ­͏   ̳= 9; ­͏     ­͏     ­͏ &nb= sp;   ­͏     ­͏     ­&= #847;     ­͏     ­͏    = ; ­͏     ­͏     ­͏ &nbs= p;   ­͏     ­͏     ­&#= 847;     ­͏     ­͏    = ­͏     ­͏     ­͏  = ;   ­͏     ­͏     ­= 47;     ­͏     ­͏     = ­͏     ­͏     ­͏  =   ­͏     ­͏     ­T= 7;     ­͏     ­͏     &= #173;͏     ­͏     ­͏   =   ­͏     ­͏     ­͏= ;     ­͏     ­͏     &#= 173;͏     ­͏     ­͏   &= #8199; ­͏     ­͏     ­͏=     ­͏     ­͏     = 73;͏     ­͏     ­͏   &#= 8199; ­͏     ­͏     ­͏ =     ­͏     ­͏     = 3;͏     ­͏     ­͏   = 199; ­͏     ­͏     ­͏ &= nbsp;   ­͏     ­͏     ­= ;͏     ­͏     ­͏   Q= 99; ­͏     ­͏     ­͏ &n= bsp;   ­͏     ­͏     ­= ͏     ­͏     ­͏   ̳= 9; ­͏     ­͏     ­͏ &nb= sp;   ­͏     ­͏     ­&= #847;     ­͏     ­͏    = ; ­͏     ­͏     ­͏ &nbs= p;   ­͏     ­͏     ­&#= 847;     ­͏     ­͏    = ­͏     ­͏     ­͏  = ;   ­͏     ­͏     ­= 47;     ­͏     ­͏     = ­͏     ­͏     ­͏  =   ­͏     ­͏     ­T= 7;     ­͏     ­͏     &= #173;͏     ­͏     ­͏   =   ­͏     ­͏     ­͏= ;     ­͏     ­͏     &#= 173;͏     ­͏     ­͏   &= #8199; ­͏     ­͏     ­͏=     ­͏     ­͏     = 73;͏     ­͏     ­͏   &#= 8199; ­͏     ­͏     ­͏ =     ­͏     ­͏     = 3;͏     ­͏     ­͏   = 199; ­͏     ­͏     ­͏ &= nbsp;   ­͏     ­͏     ­= ;͏     ­͏     ­͏   Q= 99; ­͏     ­͏     ­͏ &n= bsp;   ­͏     ­͏     ­= ͏     ­͏     ­͏   ̳= 9; ­͏     ­͏     ­͏ &nb= sp;   ­͏     ­͏     ­&= #847;     ­͏     ­͏    = ; ­͏     ­͏     ­͏ &nbs= p;   ­͏     ­͏     ­&#= 847;     ­͏     ­͏    = ­͏     ­͏     ­͏  = ;   ­͏     ­͏     ­= 47;     ­͏     ­͏     = ­͏     ­͏     ­͏  =   ­͏     ­͏     ­T= 7;     ­͏     ­͏     &= #173;͏     ­͏     ­͏   =   ­
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Improvements since treatment:

> Brown spots: +71 = percentile points (20th → 91st)✅

> Pores: +2= 5 percentile points✅

> Spots: +25 percentile point= s✅

My skin age is 9 years younger than my chron= ological age (39 vs 48) and hasn’t aged in five years since starting = this project. Effectively a 9 year age reversal. Measured using VISIA multi= spectral clinical imaging, the most validated non-invasive skin analysis sy= stem available.

Feb 23 treatment summary=

Technologies
> = Everesse RF
> CoolPeel CO2 laser
> BB= L

Each targeting a different skin depth so repair windo= ws overlap without competing.

Treatmen= t details

Everesse RF (200 pulses, Level 2.5 p= er cheek), CoolPeel CO2 laser (3.0W, 700 micron spacing), and BBL broadband= light. Each targeting a different skin depth.

Everess= e drives heat into the dermis at 60-70°C, triggering fibroblast activa= tion and collagen production that peaks 6-8 weeks later (about now), tighte= ning the structural scaffolding that makes pores visible.

CoolPeel ablates the surface layer of skin, physically removing melanin= -loaded cells and forcing fresh keratinocytes to the surface.
BBL destroys residual pigment one layer deeper through selective ph= otothermolysis, where melanin absorbs light energy and self-destructs.

Porphyrins dropped 13 points, which is expected. The treat= ments temporarily disrupt the follicular environment that bacteria need to = thrive, and that recovers within 8-12 weeks.

Goal was = to do a triple-modality stack so the repair windows overlap without competi= ng (dermis, epidermis, and chromophores).


Bryan Johnson is free today. But if you enjoyed this = post, you can tell Bryan Johnson that their writing is valuable by pledging= a future subscription. You won't be charged unless they enable payments.

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