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[149.72.240.244]) by mx.google.com with ESMTPS id af79cd13be357-8d028035c7dsi892651585a.220.2026.03.30.12.30.23 for (version=TLS1_3 cipher=TLS_AES_128_GCM_SHA256 bits=128/128); Mon, 30 Mar 2026 12:30:24 -0700 (PDT) Received-SPF: pass (google.com: domain of bounces+35285666-9e1b-tjphuhs=gmail.com@mail.blueprint.bryanjohnson.com designates 149.72.240.244 as permitted sender) client-ip=149.72.240.244; Authentication-Results: mx.google.com; dkim=pass header.i=@blueprint.bryanjohnson.com header.s=kl2 header.b=t0T11dUz; dkim=pass header.i=@sendgrid.info header.s=smtpapi header.b=G6k5iWBt; spf=pass (google.com: domain of bounces+35285666-9e1b-tjphuhs=gmail.com@mail.blueprint.bryanjohnson.com designates 149.72.240.244 as permitted sender) smtp.mailfrom="bounces+35285666-9e1b-tjphuhs=gmail.com@mail.blueprint.bryanjohnson.com"; dmarc=pass (p=QUARANTINE sp=QUARANTINE dis=NONE) header.from=bryanjohnson.com DKIM-Signature: v=1; a=rsa-sha256; c=relaxed/relaxed; d=blueprint.bryanjohnson.com; h=content-type:date:from:mime-version:subject:feedback-id: list-unsubscribe:list-unsubscribe-post:to:cc:content-type:date:feedback-id:from: subject:to; s=kl2; t=1774899022; bh=1khZqvo8whcYLW9FV1HxJbX8J8CFjCjUuH0fmnFmARQ=; b=t0T11dUzuxJbN+OXjgvr/ef+4eSqRVnMx8FrzkCud8bvTLMPXhXaX4r8TPqx45MxBHJI 4qPMztoy3dXHvEny9TAu2UmnT2rrF22x5Xz53A1oHSREvVIal2QZ/5JMehPIb8FdwAHZ3h UfLhXsVappaSZeBSSRvNuOu1SZeRJ3+Z/E7o5ZleHOJu2xmQZdJiw0cGiouNt0ni2lZHdF IEm2JOSV2/xToHbE8YhWFkNeU8/Aq+zBpw8A5sf8E/dHwB1qnEUjcoVjKcq2rGH2Rj6rwF 5gfxsjuvPvTqSHuArbWDvvsRyTYNCubaUVOBgs5Raq71MD4DwlOmZ2bmmKrxiGUQ== DKIM-Signature: v=1; a=rsa-sha256; c=relaxed/relaxed; d=sendgrid.info; h=content-type:date:from:mime-version:subject:feedback-id: list-unsubscribe:list-unsubscribe-post:to:cc:content-type:date:feedback-id:from: subject:to; s=smtpapi; t=1774899022; bh=1khZqvo8whcYLW9FV1HxJbX8J8CFjCjUuH0fmnFmARQ=; b=G6k5iWBtF4DTOJUnGBHFCUpbyZToBymjKae5z0pr+EDctzrWdTejCWT3CD3Twkt/vZAa 1SEEheQiNkSU4ywWwL3Lx6/Ca8tpSLt07gyTXptJWZUNZgIs535Osb4eur1kBRLzwx7rLk n71wB830weObbjoNz1quJcIUJNpQBidYY= Received: by recvd-6f8dfb459c-zcdh8 with SMTP id recvd-6f8dfb459c-zcdh8-1-69CACF4E-12A 2026-03-30 19:30:22.775877354 +0000 UTC m=+1815335.994101350 Received: from MzUyODU2NjY (unknown) by geopod-ismtpd-28 (SG) with HTTP id 8zSZdmzeR9-OhwVtEnNniQ Mon, 30 Mar 2026 19:30:22.755 +0000 (UTC) Content-Type: multipart/alternative; boundary=034e07048d43feea36da74f8de992ca9eee508375a9f73edf61932554117 Date: Mon, 30 Mar 2026 19:30:22 +0000 (UTC) From: Blueprint Mime-Version: 1.0 Message-ID: <8zSZdmzeR9-OhwVtEnNniQ@geopod-ismtpd-28> Subject: 5 protocols that claim to regrow hair Feedback-ID: 01KMR1S4GNRMAXPF4MP3DKRBFS:UDtiqU:27885238018:kl List-Unsubscribe: =?us-ascii?Q?=3Chttps=3A=2F=2Fmanage=2Ekmail-lists=2Ecom=2Fsubscriptions=2Funsubscribe=3Fa=3DUD?= =?us-ascii?Q?tiqU&c=3D01KJT9DP2RVS1CVFD3BD75ZESG&k=3D450?= =?us-ascii?Q?25595cf22049e7e57727e73cdc99b&m=3D01KMR1S?= =?us-ascii?Q?4MMGGW4D8RQCX3MNGZT&r=3D01KN02V1C6F3RAHQV?= =?us-ascii?Q?EYY7W4EVX=3E?= List-Unsubscribe-Post: List-Unsubscribe=One-Click X-Kmail-Account: UDtiqU X-Kmail-Message: 01KMR1S4MMGGW4D8RQCX3MNGZT X-Kmail-Ops: 01KJT9DP2RVS1CVFD3BD75ZESG X-Report-Abuse: Please report any spam or abuse to: abuse@klaviyo.com X-SG-EID: =?us-ascii?Q?u001=2ErwwAcwTVl5FiHopKoi3e3izGJyprtbNNCMj9bxLvQV2d87N2EKv6drBAB?= =?us-ascii?Q?f+gAXoQOcNUv3wHRVA3ny9nLsmEjHMJ6PLUl=2Fhq?= =?us-ascii?Q?UUZc5pxlj=2F8NDTvndAOpIduNtdYxnOVKnGg9SaY?= =?us-ascii?Q?FEpWZSCyCIO7SxwZSuktaogbMaxZjz3CxB47i6v?= =?us-ascii?Q?bI1ylQp5ZCrc8Wh1DC6q1sCIFpSr4iS38U2V+TF?= =?us-ascii?Q?SKtEh2rKmhzUEHo2tmDlyESswupkTaG+MAYxpim?= =?us-ascii?Q?Xt3e?= X-SG-ID: =?us-ascii?Q?u001=2ESdBcvi+Evd=2FbQef8eZF3BiU3Zi1S53GtqGa3TWBmqe75yn5aYrkvkfG+Z?= =?us-ascii?Q?GKrHRvqCI1cV9HjBz0XvSghBglTQltvhoA8bXxy?= =?us-ascii?Q?HibePBmuHY9dYowZ3YKEvrkeqsmVouILX2JWEeW?= =?us-ascii?Q?QqXPiLwXe+dHF2TW3W7wNZiwmniDSjB+rT3+y9g?= =?us-ascii?Q?lGDUJ015=2FIgXsrJNUGK47B6hxA9NpKp9SRCjoWc?= =?us-ascii?Q?S80ikp1XnIR80DOcXO+PvYPeboE0Qiy8GGW7v1L?= =?us-ascii?Q?UUEHhCZawl=2FDVgdu3s3akbnpkrSqOp7GCYxeVuY?= =?us-ascii?Q?EBXlg+hsEtWja7MQ65xXDdrcGlM+hqUOy9=2FIVeS?= =?us-ascii?Q?qPKLandpUQdcvgncwL4JZqO4A+6zMzTVl6HcXBH?= =?us-ascii?Q?JyzBbAnKh31x6Sa?= To: tjphuhs@gmail.com X-Entity-ID: u001.jUcd5nuE7bFtshTLUhoRtg== --034e07048d43feea36da74f8de992ca9eee508375a9f73edf61932554117 Content-Transfer-Encoding: quoted-printable Content-Type: text/plain; charset=utf-8 Mime-Version: 1.0 [Blueprint Homepage](https://blueprint.bryanjohnson.com) Hi friend, =C2=A0 Up to 50% of hair loss goes unnoticed.=C2=A0 =C2=A0 It=E2=80=99s not a problem that announces itself. It advances quietly for y= ears before it's visible. By age 20, ~20% of men have some visible hair los= s. By age 50, up to 40% of women have noticeable hair loss.=C2=A0 =C2=A0 Many people start addressing hair loss after the best window for interventi= on has already passed.=C2=A0 https://blueprint.bryanjohnson.com/collections/haircare https://blueprint.bryanjohnson.com/collections/haircare In this email: - + why hair falls out + 5 interventions with strong clinical evidence + side effects + timelines + what to look for when building a protocol Why hair falls out =C2=A0 Each hair follicle cycles through a growth phase (anagen), a transition pha= se (catagen), and a resting phase (telogen) before shedding (exogen) and re= starting.=C2=A0 =C2=A0 In androgenetic alopecia (the most common form of hair loss in both men and= women), the hormone DHT (dihydrotestosterone) binds to receptors in hair f= ollicles and progressively shortens the anagen phase. Follicles miniaturize= over time and eventually stop producing hair. =C2=A0 The window matters. Once a follicle fully miniaturizes, regrowth becomes si= gnificantly harder. Interventions work best when you start early. #1. Topical minoxidil Topical minoxidil is a widely studied hair loss intervention. It works by w= idening scalp blood vessels and extending the anagen phase, keeping more fo= llicles in the growth cycle. - + side effects: Itching, scalp irritation, and potential initial shedding= in first ~12 weeks (a sign the cycle is resetting) - + timeline: It usually takes 6-12 months to see hair regrowth.=C2=A0 - + note: Stopping topical minoxidil typically leads to reversal of gains w= ithin 3-4 months. - + availability: Topical minoxidil is broadly available at study-level dos= es without a prescription. - + Bryan=E2=80=99s protocol: Bryan uses a custom topical formulation that = contains minoxidil. #2. Oral minoxidil=C2=A0 Low doses of oral minoxidil (<5 mg daily) can treat hair loss. Note: it=E2=80=99s not FDA-approved for this use. It=E2=80=99s approved as = a blood pressure medication, but is often prescribed off-label to regrow ha= ir.=C2=A0 =C2=A0 In a double-blind, placebo-controlled RCT of 90 men with androgenetic alope= cia, oral minoxidil at 5 mg daily produced similar results to topical minox= idil (5% solution, applied twice daily) after 24 weeks. - + side effects: Hypertrichosis (unwanted body hair growth), headaches, an= d in rare cases fluid retention - + timeline: Typically 2-4 months for initial changes - + availability: Oral minoxidil requires a prescription. As an off-label u= se, it can only be prescribed for hair regrowth at a provider=E2=80=99s dis= cretion. It is not available through Blueprint=E2=80=A6 yet. =C2=A0 - + Bryan=E2=80=99s protocol: Bryan takes oral minoxidil daily. #3. Low-level laser light therapy (LLLT) LLLT is an FDA-cleared technology that delivers low-level red laser light d= irectly to the scalp. Wavelengths of 650 nm have been shown to increase hai= r follicle blood flow and cellular metabolism, extend the anagen phase, and= promote visibly thicker hair with pattern hair loss. - + side effects: Minimal. Some users report scalp warmth during early use. - + timeline: Visible results in ~4 months with consistent daily use. - + availability: The [Blueprint 302 Laser Cap](https://blueprint.bryanjohn= son.com/products/laser-cap) has 302 individual laser diodes (not LEDs), and= is designed to regrow hair in 16 weeks with 6 min of daily use. - + note: Laser diodes and LEDs are not the same. Many =E2=80=9Cred light= =E2=80=9D devices use LEDs only, or a combination of LEDs and lasers. Studi= es show that laser therapy is more successful at stimulating hair growth th= an LEDs and lasers combined. - + Bryan=E2=80=99s protocol: Bryan wears the 302 Laser Cap for 6 min a day= , after using [Peptide Shampoo](https://blueprint.bryanjohnson.com/products= /hair-peptide-shampoo) and [Peptide Hair Serum](https://blueprint.bryanjohn= son.com/products/hair-peptide-serum).=C2=A0 #4. Biomimetic peptide serums =C2=A0 Peptides like sh-Polypeptide-86, sh-Polypeptide-59, and copper tripeptide-1= support the appearance of stronger, healthier-looking hair. =C2=A0 Effective delivery depends on a formulation that can actually penetrate the= scalp barrier. - + side effects: Minimal. Scalp sensitivity possible. - + availability: There are a growing number of peptide hair serums on the = market. Look for one with a nanoliposome delivery system to deliver ingredi= ents to the scalp and follicles. The [Blueprint Peptide Hair Serum](https:/= /blueprint.bryanjohnson.com/products/hair-peptide-serum) has 8 advanced pep= tides with a nanoliposome delivery system. - + Bryan=E2=80=99s protocol: Bryan uses the Peptide Hair Serum on a dry sc= alp, after the shampoo and before the laser cap.=C2=A0 #5. DHT blockers: finasteride and dutasteride Finasteride and dutasteride block an enzyme called 5-alpha reductase, reduc= ing DHT at the follicle level. Both medications are only available on presc= ription. =C2=A0 Bryan does not currently include either medication in his protocol due to s= ide effects. A small percentage of users report sexual dysfunction. The ris= k-benefit calculation is a personal one that should involve a physician. What to look for =C2=A0 Whether you buy from [Blueprint](https://blueprint.bryanjohnson.com/) or el= sewhere: - + start early: Intervene before loss is visible. Many people wait too lon= g. It may be easier to prevent hair loss than to regrow hair, though hair r= egrowth is possible. - + layer mechanisms: Minoxidil and LLLT target different pathways. - + for laser devices: Confirm laser diodes (not LEDs), wavelength between = 630-670 nm, and full scalp coverage including hairline, temples, and crown. - + for serums: Look for a delivery system designed to cross the skin barri= er, not just a list of ingredients. - + be consistent: Every intervention requires consistent use. Gaps reset p= rogress. Be well, Blueprint [Blueprint](https://blueprint.bryanjohnson.com/) Most emails suck. We're trying not to. What did you think of this email? 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3D""=
Hi friend,
 
Up to 50% of hair loss goes unnoticed= . 
 
It=E2=80=99s not a problem that annou= nces itself. It advances quietly for years before it's visible. By age 20, = ~20% of men have some visible hair loss. By age 50, up to 40% of women have= noticeable hair loss. 
 
Many people start addressing hair los= s after the best window for intervention has already passed. 
3D""
3D""
In this email:
  • + why hair fa= lls out
    + 5 interventions with strong clinical evidence
    + side effect= s
    + timelines
    + what to look for when building a protocol
= Why hair falls out
 
Each hai= r follicle cycles through a growth phase (anagen), a transition phase (cata= gen), and a resting phase (telogen) before shedding (exogen) and restarting= . 
 
In andro= genetic alopecia (the most common form of hair loss in both men and women),= the hormone DHT (dihydrotestosterone) binds to receptors in hair follicles= and progressively shortens the anagen phase. Follicles miniaturize over ti= me and eventually stop producing hair.
 
The wind= ow matters. Once a follicle fully miniaturizes, regrowth becomes significan= tly harder. Interventions work best when you start early.


#1. Topical minoxidil

Topical minoxidil is a= widely studied hair loss intervention. It works by widening scalp blood ve= ssels and extending the anagen phase, keeping more follicles in the growth = cycle.
  • + sid= e effects: Itching, scalp irritation, and potential initial sheddi= ng in first ~12 weeks (a sign the cycle is resetting)
  • + tim= eline: It usually takes 6-12 months to see hair regrowth. 
  • + not= e: Stopping topical minoxidil typically leads to reversal of gains= within 3-4 months.
  • + ava= ilability: Topical minoxidil is broadly available at study-level d= oses without a prescription.
  • + Bry= an=E2=80=99s protocol: Bryan uses a custom topical formulation tha= t contains minoxidil.

#2. Oral minoxidil 

Low doses of oral minoxidil (<5 mg= daily) can treat hair loss.

Note: it=E2=80=99s not FDA-approv= ed for this use. It=E2=80=99s approved as a blood pressure medication, but = is often prescribed off-label to regrow hair. 
 
In a double-blind, placebo-controlled= RCT of 90 men with androgenetic alopecia, oral minoxidil at 5 mg daily pro= duced similar results to topical minoxidil (5% solution, applied twice dail= y) after 24 weeks.
  • + sid= e effects: Hypertrichosis (unwanted body hair growth), headaches, = and in rare cases fluid retention
  • + tim= eline: Typically 2-4 months for initial changes
  • + ava= ilability: Oral minoxidil requires a prescription. As an off-label= use, it can only be prescribed for hair regrowth at a provider=E2=80=99s d= iscretion. It is not available through Blueprint=E2=80=A6 yet.  
  • + Bry= an=E2=80=99s protocol: Bryan takes oral minoxidil daily.

#3. Low-level laser light ther= apy (LLLT)

LLLT is = an FDA-cleared technology that delivers low-level red laser light directly = to the scalp. Wavelengths of 650 nm have been shown to increase hair follic= le blood flow and cellular metabolism, extend the anagen phase, and promote= visibly thicker hair with pattern hair loss.
  • + sid= e effects: Minimal. Some users report scalp warmth during early us= e.
  • + tim= eline: Visible results in ~4 months with consistent daily use.
  • + ava= ilability: The Bluepri= nt 302 Laser Cap has 302 individual laser diodes (not LEDs), and is des= igned to regrow hair in 16 weeks with 6 min of daily use.
  • + not= e: Laser diodes and LEDs are not the same. Many =E2=80=9Cred light= =E2=80=9D devices use LEDs only, or a combination of LEDs and lasers. Studi= es show that laser therapy is more successful at stimulating hair growth th= an LEDs and lasers combined.
  • = Peptide Shampoo and Peptide= Hair Serum. 

#4. Biomimetic peptide serums<= /strong>
 
Peptides= like sh-Polypeptide-86, sh-Polypeptide-59, and copper tripeptide-1 support= the appearance of stronger, healthier-looking hair.
 
Effectiv= e delivery depends on a formulation that can actually penetrate the scalp b= arrier.
  • + sid= e effects: Minimal. Scalp sensitivity possible.
  • + ava= ilability: There are a growing number of peptide hair serums on th= e market. Look for one with a nanoliposome delivery system to deliver ingre= dients to the scalp and follicles. The Blueprint Peptide Hair Serum has 8 advanced= peptides with a nanoliposome delivery system.
  • + Bry= an=E2=80=99s protocol: Bryan uses the Peptide Hair Serum on a dry = scalp, after the shampoo and before the laser cap. 

= #5. DHT blockers: finasteride and dutasteride

Finaster= ide and dutasteride block an enzyme called 5-alpha reductase, reducing DHT = at the follicle level. Both medications are only available on prescription.=
 
Bryan do= es not currently include either medication in his protocol due to side effe= cts. A small percentage of users report sexual dysfunction. The risk-benefi= t calculation is a personal one that should involve a physician.
What to look for
 
Whether you buy from Blueprint or elsewhere:
  • + sta= rt early: Intervene before loss is visible. Many people wait too l= ong. It may be easier to prevent hair loss than to regrow hair, though hair= regrowth is possible.
  • + lay= er mechanisms: Minoxidil and LLLT target different pathways.
  • + for= laser devices: Confirm laser diodes (not LEDs), wavelength betwee= n 630-670 nm, and full scalp coverage including hairline, temples, and crow= n.
  • + for= serums: Look for a delivery system designed to cross the skin bar= rier, not just a list of ingredients.
  • + be = consistent: Every intervention requires consistent use. Gaps reset= progress.
Be well,
Blueprint
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Disclaimer: This content is for educational = purposes only and is not intended as medical advice. You should consult a q= ualified healthcare provider before starting any treatment or making change= s to your health regimen.
 
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