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[159.112.244.5]) by mx.google.com with UTF8SMTPS id af79cd13be357-8d0280c9fdbsi23500485a.516.2026.03.27.13.32.05 for (version=TLS1_2 cipher=ECDHE-ECDSA-AES128-GCM-SHA256 bits=128/128); Fri, 27 Mar 2026 13:32:05 -0700 (PDT) Received-SPF: pass (google.com: domain of bounce+30b528.39b08c6-tjphuhs=gmail.com@mg-d1.substack.com designates 159.112.244.5 as permitted sender) client-ip=159.112.244.5; Authentication-Results: mx.google.com; dkim=pass header.i=@mg-d1.substack.com header.s=k1 header.b=BKecy5i4; dkim=pass header.i=@mailgun.org header.s=mg header.b=mS4BKBsr; spf=pass (google.com: domain of bounce+30b528.39b08c6-tjphuhs=gmail.com@mg-d1.substack.com designates 159.112.244.5 as permitted sender) smtp.mailfrom="bounce+30b528.39b08c6-tjphuhs=gmail.com@mg-d1.substack.com"; dmarc=pass (p=REJECT sp=REJECT dis=NONE) header.from=substack.com DKIM-Signature: a=rsa-sha256; v=1; c=relaxed/relaxed; d=mg-d1.substack.com; q=dns/txt; s=k1; t=1774643525; x=1774650725; h=List-Unsubscribe-Post: List-Unsubscribe: List-Post: List-Id: List-Archive: List-Owner: Reply-To: In-Reply-To: References: Sender: Sender: Date: Message-Id: To: To: From: From: Subject: Subject: Content-Type: Mime-Version: X-Feedback-Id; bh=PTOxo5QyA40TyC3Mmb/N0YCgqwxxtyaFit8/s+lwkeg=; b=BKecy5i4nxMNR+I5rBJhgk1J2vMW+yCo3YbF/2tcdNrRFR+WwMJkOd1XUTeBiGIz/YrFqqJIwtUZjbDa/i+xTnZpwLEEjBETRc1B9vQlYJDBWSA0ttVIvRXlEch15z4movcapeLj0DItiY6K/XnhipDunbcHF+4Wwn8wrEMxUuk= DKIM-Signature: a=rsa-sha256; v=1; c=relaxed/relaxed; d=mailgun.org; q=dns/txt; s=mg; t=1774643525; x=1774650725; h=List-Unsubscribe-Post: List-Unsubscribe: List-Post: List-Id: List-Archive: List-Owner: Reply-To: In-Reply-To: References: Sender: Sender: Date: Message-Id: To: To: From: From: Subject: Subject: Content-Type: Mime-Version: X-Feedback-Id; bh=PTOxo5QyA40TyC3Mmb/N0YCgqwxxtyaFit8/s+lwkeg=; b=mS4BKBsrbpco3lUbvbmDs12VBBVC/Z9/wkBs2vSfnbt+NQEnNjpoeunfR7l+fUKzPtOo5fZQEJdMl1bWIDliTPLyQ9eP+6eRSt7Pb+QOE4dGBLQGTysrBGAkSGLrzFXkbJyBFqzUrxLm846D8PNVYAdgXj6B1azWkgpt9vws0Og= X-Mailgun-Sid: WyIxMWU0ZSIsInRqcGh1aHNAZ21haWwuY29tIiwiMzliMDhjNiJd X-Feedback-Id: postmaster@mg-d1.substack.com:post:614a1297c57bbbe25fa40e08:mailgun Received: by cf0ed5bc99ae7ea5c799abff138f5fc3fe5ae13c7b6104f0a6a282425f95b36c with HTTP id 69c6e945fc419e8b5a14c9fc; Fri, 27 Mar 2026 20:32:05 GMT X-Mailgun-Sending-Ip: 159.112.244.5 Mime-Version: 1.0 Content-Type: multipart/alternative; boundary="4251fef8eb1cdafc3513af45e813d55c00f183d4937ff1decd7db9d4bb2b" Subject: NAD+ / MOTS-c / 5-Amino-1MQ: Breaking Down The Blend From: Derek from Peptide Price To: tjphuhs@gmail.com X-Mailgun-Tag: post X-Mailgun-Track-Clicks: false Message-Id: <20260327203144.3.6052092a26a72c8a@mg-d1.substack.com> Date: Fri, 27 Mar 2026 20:31:44 +0000 Feedback-Id: post-192352133:cat-post:pub-3365367:substack Sender: Derek from Peptide Price References: In-Reply-To: Reply-To: Derek from Peptide Price List-Owner: List-Url: List-Archive: List-Id: List-Post: List-Unsubscribe: List-Unsubscribe-Post: List-Unsubscribe=One-Click X-Mailgun-Variables: {"category": "post", "email_generated_at": "1774643525476", "is_freemail": "true", "post_audience": "everyone", "post_id": "192352133", "post_type": "newsletter", "pub_community_enabled": "true", "publication_id": "3365367", "subdomain": "derekpruski", "user_id": "273622398"} --4251fef8eb1cdafc3513af45e813d55c00f183d4937ff1decd7db9d4bb2b Content-Type: text/plain; charset="utf-8" Content-Transfer-Encoding: quoted-printable View this post on the web at https://derekpruski.substack.com/p/nad-mots-c-= 5-amino-1mq-breaking-down For research purposes only. Not for human consumption. A lot of you have been asking about this one, so I figured we=E2=80=99d jus= t walk through each component and explain how it works and whether the comb= ination actually makes sense. By the end of this you=E2=80=99ll have a clea= r picture of what each compound is doing and why they were put together the= way they were. What Is This Blend? Your mitochondria are the power plants inside every cell in your body. Thei= r job is to take the food you eat and convert it into usable energy. When t= hey work well, you feel it =E2=80=94 better energy, better metabolism, bett= er recovery. When they decline, everything suffers. This blend targets mitochondrial function from three different angles at th= e same time. Each compound has its own job, but they work together in a way= that makes the combination more effective than any one of them alone. The Three Compounds =E2=80=94 Plain English NAD+ (the fuel) NAD+ is a molecule your cells absolutely cannot function without. It sits a= t the center of energy production =E2=80=94 without it, your mitochondria c= an=E2=80=99t convert nutrients into ATP (the energy currency your body runs= on). It also activates proteins called sirtuins that are closely tied to c= ellular repair and longevity. The catch: NAD+ levels drop significantly as you age and under metabolic st= ress. Less NAD+ means less efficient energy production across every cell in= your body. MOTS-c (the builder) MOTS-c is a peptide that=E2=80=99s actually encoded inside mitochondrial DN= A =E2=80=94 making it one of the only compounds that originates from the mi= tochondria themselves rather than from the cell=E2=80=99s main nucleus. Thi= nk of it as the mitochondria sending their own distress signal to trigger a= daptation. Its main job is activating AMPK, which is essentially your body=E2=80=99s l= ow-fuel warning system. When AMPK turns on, it signals cells to become more= efficient =E2=80=94 pulling in more glucose, burning more fat, and buildin= g new mitochondria. More mitochondria means more capacity to produce energy= =2E 5-Amino-1MQ (the plug for the leak) There=E2=80=99s an enzyme in the body called NNMT that essentially drains y= our NAD+ supply by siphoning off the raw materials needed to make it. 5-Ami= no-1MQ blocks that enzyme. It=E2=80=99s not adding more NAD+ =E2=80=94 it= =E2=80=99s stopping the leak so the NAD+ you have (and are supplying with t= he first compound) sticks around longer and gets used productively. It also= plays a role in how fat cells behave metabolically. Why These Three Together? On their own, each compound does something useful. Together, they address t= he same system from three directions: NAD+ and 5-Amino-1MQ work as a supply-and-preserve pair. You=E2=80=99re put= ting more NAD+ in while simultaneously slowing the rate it gets degraded. W= ithout addressing the drain, supplementing NAD+ alone is less efficient =E2= =80=94 5-Amino-1MQ closes that loop. MOTS-c and NAD+ reinforce each other at the output level. MOTS-c stimulates= the creation of more mitochondria and activates proteins that require NAD+= to function. So MOTS-c is essentially creating more demand for NAD+ in a p= roductive way =E2=80=94 more mitochondrial machinery that can actually put = the NAD+ to work. MOTS-c and 5-Amino-1MQ both support metabolic flexibility =E2=80=94 the abi= lity to efficiently switch between burning glucose and fat =E2=80=94 but th= ey do it through entirely different pathways. MOTS-c works through the ener= gy-sensing axis. 5-Amino-1MQ works through fat tissue metabolism. They appr= oach the same problem from opposite ends. The short version: NAD+ is the fuel. MOTS-c builds more engines to burn it.= 5-Amino-1MQ stops the fuel from leaking out. A Note on Ratios This blend only makes sense if the ratios make sense for the researcher. Pe= rsonally, I prefer a 20-1-1 ratio by mg =E2=80=94 heavier on the NAD+ relat= ive to the other two. That said, the research-referenced amounts for 5-Amin= o-1MQ are all over the place, which makes dialing in a clean ratio harder t= han it sounds. Given the way the synergy stacks here though, the 10-1-1 breakdown in this = blend is well-reasoned. The NAD+ is doing the heavy lifting as the primary = substrate, MOTS-c and 5-Amino-1MQ are present in amounts that support and p= reserve that without either one dominating the equation. For a pre-blended = vial, this ratio holds up. Reconstitution Vial contents: 100mg NAD+ / 10mg MOTS-c / 10mg 5-Amino-1MQ Add 3ml of bacteriostatic water to the vial. Store reconstituted vial refri= gerated. Each 30-unit (0.3ml) research dose yields 1mg NAD+, 0.1mg MOTS-c, and 0.1mg= 5-Amino-1MQ =E2=80=94 a 10-1-1 ratio that keeps all three compounds propor= tional throughout the vial. Compound Summary NAD+ is the direct energy substrate =E2=80=94 it supplies what mitochondria= need to produce ATP and activates repair proteins that depend on it. MOTS-c is the capacity builder =E2=80=94 it signals the body to create more= mitochondria and become more metabolically efficient, amplifying what NAD+= can do. 5-Amino-1MQ is the preservation mechanism =E2=80=94 it blocks the enzyme th= at degrades NAD+ precursors, extending the effectiveness of the NAD+ being = supplied. Together they cover substrate availability, degradation prevention, and bio= genic capacity. That=E2=80=99s the full stack for mitochondrial support in = a single vial. Research use only. Not for human consumption. Unsubscribe https://substack.com/redirect/2/eyJlIjoiaHR0cHM6Ly9kZXJla3BydXN= raS5zdWJzdGFjay5jb20vYWN0aW9uL2Rpc2FibGVfZW1haWw_dG9rZW49ZXlKMWMyVnlYMmxrSW= pveU56TTJNakl6T1Rnc0luQnZjM1JmYVdRaU9qRTVNak0xTWpFek15d2lhV0YwSWpveE56YzBOa= lF6TlRJMUxDSmxlSEFpT2pFNE1EWXhOemsxTWpVc0ltbHpjeUk2SW5CMVlpMHpNelkxTXpZM0lp= d2ljM1ZpSWpvaVpHbHpZV0pzWlY5bGJXRnBiQ0o5LlQ5ZUE4LUJ1RjhfOUVmTWF0WmlOLWVHNGV= nTkZqaGhONnVRYXNRTFoxdzAiLCJwIjoxOTIzNTIxMzMsInMiOjMzNjUzNjcsImYiOnRydWUsIn= UiOjI3MzYyMjM5OCwiaWF0IjoxNzc0NjQzNTI1LCJleHAiOjIwOTAyMTk1MjUsImlzcyI6InB1Y= i0wIiwic3ViIjoibGluay1yZWRpcmVjdCJ9.-RjZva8_vfW7pIGiUdf9CB0R0ZD6kiv2MaaonsU= ox_k? --4251fef8eb1cdafc3513af45e813d55c00f183d4937ff1decd7db9d4bb2b Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: quoted-printable NAD+ / MOTS-c / 5-Amino-= 1MQ: Breaking Down The Blend3D""
For research purposes only.
͏     ­͏ &nb= sp;   ­͏     ­͏     ­&= #847;     ­͏     ­͏    = ; ­͏     ­͏     ­͏ &nbs= p;   ­͏     ­͏     ­&#= 847;     ­͏     ­͏    = ­͏     ­͏     ­͏  = ;   ­͏     ­͏     ­= 47;     ­͏     ­͏     = ­͏     ­͏     ­͏  =   ­͏     ­͏     ­T= 7;     ­͏     ­͏     &= #173;͏     ­͏     ­͏   =   ­͏     ­͏     ­͏= ;     ­͏     ­͏     &#= 173;͏     ­͏     ­͏   &= #8199; ­͏     ­͏     ­͏=     ­͏     ­͏     = 73;͏     ­͏     ­͏   &#= 8199; ­͏     ­͏     ­͏ =     ­͏     ­͏     = 3;͏     ­͏     ­͏   = 199; ­͏     ­͏     ­͏ &= nbsp;   ­͏     ­͏     ­= ;͏     ­͏     ­͏   Q= 99; ­͏     ­͏     ­͏ &n= bsp;   ­͏     ­͏     ­= ͏     ­͏     ­͏   ̳= 9; ­͏     ­͏     ­͏ &nb= sp;   ­͏     ­͏     ­&= #847;     ­͏     ­͏    = ; ­͏     ­͏     ­͏ &nbs= p;   ­͏     ­͏     ­&#= 847;     ­͏     ­͏    = ­͏     ­͏     ­͏  = ;   ­͏     ­͏     ­= 47;     ­͏     ­͏     = ­͏     ­͏     ­͏  =   ­͏     ­͏     ­T= 7;     ­͏     ­͏     &= #173;͏     ­͏     ­͏   =   ­͏     ­͏     ­͏= ;     ­͏     ­͏     &#= 173;͏     ­͏     ­͏   &= #8199; ­͏     ­͏     ­͏=     ­͏     ­͏     = 73;͏     ­͏     ­͏   &#= 8199; ­͏     ­͏     ­͏ =     ­͏     ­͏     = 3;͏     ­͏     ­͏   = 199; ­͏     ­͏     ­͏ &= nbsp;   ­͏     ­͏     ­= ;͏     ­͏     ­͏   Q= 99; ­͏     ­͏     ­͏ &n= bsp;   ­͏     ­͏     ­= ͏     ­͏     ­͏   ̳= 9; ­͏     ­͏     ­͏ &nb= sp;   ­͏     ­͏     ­&= #847;     ­͏     ­͏    = ; ­͏     ­͏     ­͏ &nbs= p;   ­͏     ­͏     ­&#= 847;     ­͏     ­͏    = ­͏     ­͏     ­͏  = ;   ­͏     ­͏     ­= 47;     ­͏     ­͏     = ­͏     ­͏     ­͏  =   ­͏     ­͏     ­T= 7;     ­͏     ­͏     &= #173;͏     ­͏     ­͏   =   ­͏     ­͏     ­͏= ;     ­͏     ­͏     &#= 173;͏     ­͏     ­͏   &= #8199; ­͏     ­͏     ­͏=     ­͏     ­͏     = 73;͏     ­͏     ­͏   &#= 8199; ­
<= tr>
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3D""=
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READ I= N APP3D""
=  

For research purposes only. Not for human consumption.

<= div style=3D"font-size: 16px;line-height: 26px;">

A lot of you have been asking about this one, so I figured weR= 17;d just walk through each component and explain how it works and whether = the combination actually makes sense. By the end of this you’ll have = a clear picture of what each compound is doing and why they were put togeth= er the way they were.

<= /tr>
3D""
Upgrade to= paid

What Is This Blend?=

Your mitochondria are the power plants inside every cell i= n your body. Their job is to take the food you eat and convert it into usab= le energy. When they work well, you feel it — better energy, better m= etabolism, better recovery. When they decline, everything suffers.

This blend targets mitochondrial function from three different angl= es at the same time. Each compound has its own job, but they work together = in a way that makes the combination more effective than any one of them alo= ne.

<= /div>

The Three Compounds — Plain English

NAD+ (the fuel)

NAD+ is = a molecule your cells absolutely cannot function without. It sits at the ce= nter of energy production — without it, your mitochondria can’t= convert nutrients into ATP (the energy currency your body runs on). It als= o activates proteins called sirtuins that are closely tied to cellular repa= ir and longevity.

The catch: NAD+ levels drop significantly= as you age and under metabolic stress. Less NAD+ means less efficient ener= gy production across every cell in your body.

MOTS-= c (the builder)

MOTS-c is a peptide that’s a= ctually encoded inside mitochondrial DNA — making it one of the only = compounds that originates from the mitochondria themselves rather than from= the cell’s main nucleus. Think of it as the mitochondria sending the= ir own distress signal to trigger adaptation.

Its main job = is activating AMPK, which is essentially your body’s low-fuel warning= system. When AMPK turns on, it signals cells to become more efficient R= 12; pulling in more glucose, burning more fat, and building new mitochondri= a. More mitochondria means more capacity to produce energy.

5-Amino-1MQ (the plug for the leak)

There= ’s an enzyme in the body called NNMT that essentially drains your NAD= + supply by siphoning off the raw materials needed to make it. 5-Amino-1MQ = blocks that enzyme. It’s not adding more NAD+ — it’s stop= ping the leak so the NAD+ you have (and are supplying with the first compou= nd) sticks around longer and gets used productively. It also plays a role i= n how fat cells behave metabolically.

Why These Three= Together?

On their own, each compound does someth= ing useful. Together, they address the same system from three directions:

NAD+ and 5-Amino-1MQ work as a supply-and-preserve pair. You= ’re putting more NAD+ in while simultaneously slowing the rate it get= s degraded. Without addressing the drain, supplementing NAD+ alone is less = efficient — 5-Amino-1MQ closes that loop.

MOTS-c and = NAD+ reinforce each other at the output level. MOTS-c stimulates the creati= on of more mitochondria and activates proteins that require NAD+ to functio= n. So MOTS-c is essentially creating more demand for NAD+ in a productive w= ay — more mitochondrial machinery that can actually put the NAD+ to w= ork.

MOTS-c and 5-Amino-1MQ both support metabolic flexibil= ity — the ability to efficiently switch between burning glucose and f= at — but they do it through entirely different pathways. MOTS-c works= through the energy-sensing axis. 5-Amino-1MQ works through fat tissue meta= bolism. They approach the same problem from opposite ends.

= The short version: NAD+ is the fuel. MOTS-c builds more engines to burn it.= 5-Amino-1MQ stops the fuel from leaking out.

A Note = on Ratios

This blend only makes sense if the ratio= s make sense for the researcher. Personally, I prefer a 20-1-1 ratio by mg = — heavier on the NAD+ relative to the other two. That said, the resea= rch-referenced amounts for 5-Amino-1MQ are all over the place, which makes = dialing in a clean ratio harder than it sounds.

Given the w= ay the synergy stacks here though, the 10-1-1 breakdown in this blend is we= ll-reasoned. The NAD+ is doing the heavy lifting as the primary substrate, = MOTS-c and 5-Amino-1MQ are present in amounts that support and preserve tha= t without either one dominating the equation. For a pre-blended vial, this = ratio holds up.

Reconstitution

Vial contents: 100mg NAD+ / 10mg MOTS-c / 10mg 5-Amino-1MQ

Add 3ml of bacteriostatic water to the vial. Store reconstituted vial = refrigerated.

Each 30-unit (0.3ml) research dose yields 1mg= NAD+, 0.1mg MOTS-c, and 0.1mg 5-Amino-1MQ — a 10-1-1 ratio that keep= s all three compounds proportional throughout the vial.

Compound Summary

NAD+ is the direct energy subs= trate — it supplies what mitochondria need to produce ATP and activat= es repair proteins that depend on it.

MOTS-c is the capacit= y builder — it signals the body to create more mitochondria and becom= e more metabolically efficient, amplifying what NAD+ can do.

Together they cover substrate availability, degra= dation prevention, and biogenic capacity. That’s the full stack for m= itochondrial support in a single vial.

Research use only.= Not for human consumption.

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You're currently a free subscriber to Peptide Price. For the full experience, upgrade your subscription.

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© 2026 Derek Pruski
548 Market Stre= et PMB 72296, San Francisco, CA 94104
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