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Subject: =?UTF-8?q?Retatrutide_Is_Too_Good=E2=80=A6_And_That=E2=80=99s_The_Problem?=
From: Dave Knapp from On The Pen <onthepen@substack.com>
To: tjphuhs@gmail.com
Message-Id: <20260325012424.3.242c528b02270fcd@mg-d1.substack.com>
Date: Wed, 25 Mar 2026 01:24:24 +0000
Feedback-Id: post-192017047:cat-post:pub-4808993:substack
Sender: Dave Knapp from On The Pen <onthepen@substack.com>
References: <post-192017047@substack.com>
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Reply-To: Dave Knapp from On The Pen
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View this post on the web at https://onthepen.substack.com/p/retatrutide-is=
-too-good-and-thats

There=E2=80=99s a lot shifting right now in the world of GLP-1s, and if you=
 rely on compounded or research-grade options, this week=E2=80=99s updates =
may feel especially important.
From new signals out of Washington that could impact access, to powerful ne=
w data on next-generation treatments like retatrutide, to where drug compan=
ies are heading next=E2=80=A6things are moving quickly on multiple fronts.
We break it all down in this week=E2=80=99s episode, what=E2=80=99s changin=
g, what it could mean for you, and what to keep an eye on next.
The Throttling of Compounded GLP-1sFDA vs Telehealth, What=E2=80=99s Really=
 HappeningThe Truth About =E2=80=9CResearch Peptides=E2=80=9DThe Rule That =
Created the Black Market If You Rely on This, Here=E2=80=99s What=E2=80=99s=
 ComingWhy They Want You Back on Branded DrugsRetatrutide Might Be the Most=
 Powerful YetThe Data That Changes Everything (Diabetes + Weight Loss)What =
Comes After GLP-1s, The Next Wave

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}</style></head><body class=3D"email-body" style=3D"font-kerning: auto;--im=
age-offset-margin: -120px;"><img src=3D"https://eotrx.substackcdn.com/open?=
token=3DeyJtIjoiPDIwMjYwMzI1MDEyNDI0LjMuMjQyYzUyOGIwMjI3MGZjZEBtZy1kMS5zdWJ=
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ght=3D"1" border=3D"0" style=3D"height:1px !important;width:1px !important;=
border-width:0 !important;margin-top:0 !important;margin-bottom:0 !importan=
t;margin-right:0 !important;margin-left:0 !important;padding-top:0 !importa=
nt;padding-bottom:0 !important;padding-right:0 !important;padding-left:0 !i=
mportant;"/><div class=3D"preview" style=3D"display:none;font-size:1px;colo=
r:#333333;line-height:1px;max-height:0px;max-width:0px;opacity:0;overflow:h=
idden;">There&#8217;s a lot shifting right now in the world of GLP-1s, and =
if you rely on compounded or research-grade options, this week&#8217;s upda=
tes may feel especially important.</div><div class=3D"preview" style=3D"dis=
play:none;font-size:1px;color:#333333;line-height:1px;max-height:0px;max-wi=
dth:0px;opacity:0;overflow:hidden;">&#847; &nbsp; &#8199; &#173;&#847; &nbs=
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3;&#847; &nbsp; &#8199; &#173;&#847; &nbsp; &#8199; &#173;&#847; &nbsp; &#8=
199; &#173;</div><table class=3D"email-body-container" role=3D"presentation=
" width=3D"100%" border=3D"0" cellspacing=3D"0" cellpadding=3D"0"><tbody><t=
r><td></td><td class=3D"content" width=3D"550"></td><td></td></tr><tr><td><=
/td><td class=3D"content" width=3D"550" align=3D"left"><div style=3D"font-s=
ize: 16px;line-height: 26px;max-width: 550px;width: 100%;margin: 0 auto;ove=
rflow-wrap: break-word;"><table role=3D"presentation" width=3D"100%" border=
=3D"0" cellspacing=3D"0" cellpadding=3D"0"><tbody><tr><td align=3D"right" s=
tyle=3D"height:20px;"><table role=3D"presentation" width=3D"auto" border=3D=
"0" cellspacing=3D"0" cellpadding=3D"0"><tbody><tr><td style=3D"vertical-al=
ign:middle;"><span class=3D"pencraft pc-reset reset-IxiVJZ tw-font-body tw-=
text-ssm tw-text-substack-secondary" style=3D"font-family: SF Pro Text, -ap=
ple-system, system-ui, BlinkMacSystemFont, Inter, Segoe UI, Roboto, Helveti=
ca, Arial, sans-serif, Apple Color Emoji, Segoe UI Emoji, Segoe UI Symbol;f=
ont-size: 13px;color: unset;list-style: none;text-decoration: unset;margin:=
 0;"><div class=3D"pencraft pc-reset align-right-VJbKw5 size-12-mmZ61m rese=
t-IxiVJZ" style=3D"list-style: none;color: unset;text-align: right;font-siz=
e: 12px;line-height: 16px;text-decoration: unset;margin: 0;"><span class=3D=
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jb20vc3Vic2NyaWJlP3V0bV9zb3VyY2U9ZW1haWwmdXRtX2NhbXBhaWduPWVtYWlsLXN1YnNjcm=
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CUyRnJldGF0cnV0aWRlLWlzLXRvby1nb29kLWFuZC10aGF0cyIsInAiOjE5MjAxNzA0NywicyI6=
NDgwODk5MywiZiI6dHJ1ZSwidSI6MjczNjIyMzk4LCJpYXQiOjE3NzQ0MDE4NzQsImV4cCI6MjA=
4OTk3Nzg3NCwiaXNzIjoicHViLTAiLCJzdWIiOiJsaW5rLXJlZGlyZWN0In0.BJyccxc7ob723U=
e8dROUTH_y4QMaAB5NVp6AlBhANSY?" style=3D"list-style: none;color: unset;text=
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</td></tr></tbody></table></td></tr></tbody></table><div class=3D"post typo=
graphy" dir=3D"auto" style=3D"--image-offset-margin: -120px;padding: 32px 0=
 0 0;font-size: 16px;line-height: 26px;"><div class=3D"post-header" role=3D=
"region" aria-label=3D"Post header" style=3D"font-size: 16px;line-height: 2=
6px;"><h1 class=3D"post-title published title-X77sOw" dir=3D"auto" style=3D=
"direction: auto;text-align: start;unicode-bidi: isolate;color: rgb(54,55,5=
5);font-family: 'SF Pro Display', -apple-system, system-ui, BlinkMacSystemF=
ont, 'Inter', 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Colo=
r Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol';font-weight: 900;-webkit-font=
-smoothing: antialiased;-moz-osx-font-smoothing: antialiased;-webkit-appear=
ance: optimizelegibility;-moz-appearance: optimizelegibility;appearance: op=
timizelegibility;margin: 0;line-height: 36px;font-size: 32px;"><a href=3D"h=
ttps://substack.com/app-link/post?publication_id=3D4808993&post_id=3D192017=
047&utm_source=3Dpost-email-title&utm_campaign=3Demail-post-title&isFreemai=
l=3Dtrue&r=3D4iwoe6&token=3DeyJ1c2VyX2lkIjoyNzM2MjIzOTgsInBvc3RfaWQiOjE5MjA=
xNzA0NywiaWF0IjoxNzc0NDAxODc0LCJleHAiOjE3NzY5OTM4NzQsImlzcyI6InB1Yi00ODA4OT=
kzIiwic3ViIjoicG9zdC1yZWFjdGlvbiJ9.QWu6MwJmfqTgQ9JA0N6VUpEP30a-3ziwAj4qchRR=
Ln4" style=3D"color: rgb(54,55,55);text-decoration: none;">Retatrutide Is T=
oo Good&#8230; And That&#8217;s The Problem</a></h1><table class=3D"post-me=
ta" role=3D"presentation" width=3D"100%" border=3D"0" cellspacing=3D"0" cel=
lpadding=3D"0" style=3D"margin: 1em 0;height: 20px;align-items: center;"><t=
body><tr><td><table role=3D"presentation" width=3D"auto" border=3D"0" cells=
pacing=3D"0" cellpadding=3D"0"><tbody><tr><td><table role=3D"presentation" =
width=3D"auto" border=3D"0" cellspacing=3D"0" cellpadding=3D"0"><tbody><tr>=
<td style=3D"vertical-align:middle;"><div class=3D"pencraft pc-reset color-=
primary-zABazT line-height-20-t4M0El font-meta-MWBumP size-11-NuY2Zx weight=
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SF Compact',-apple-system,system-ui,-apple-system,BlinkMacSystemFont,'Segoe=
 UI',Roboto,Helvetica,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji'=
,'Segoe UI Symbol';font-weight: 500;text-transform: uppercase;letter-spacin=
g: .2px;"><a class=3D"pencraft pc-reset color-primary-zABazT line-height-20=
-t4M0El font-meta-MWBumP size-11-NuY2Zx weight-medium-fw81nC transform-uppe=
rcase-yKDgcq reset-IxiVJZ meta-EgzBVA" style=3D"list-style: none;color: rgb=
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pact',-apple-system,system-ui,-apple-system,BlinkMacSystemFont,'Segoe UI',R=
oboto,Helvetica,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji','Sego=
e UI Symbol';font-weight: 500;text-transform: uppercase;letter-spacing: .2p=
x;text-decoration: none" href=3D"https://substack.com/@onthepen">On The Pen=
 GLP-1 News</a></div></td></tr></tbody></table></td></tr><tr><td><table rol=
e=3D"presentation" width=3D"auto" border=3D"0" cellspacing=3D"0" cellpaddin=
g=3D"0"><tbody><tr><td style=3D"vertical-align:middle;"><div class=3D"pencr=
aft pc-reset color-secondary-ls1g8s line-height-20-t4M0El font-meta-MWBumP =
size-11-NuY2Zx weight-medium-fw81nC transform-uppercase-yKDgcq reset-IxiVJZ=
 meta-EgzBVA" style=3D"list-style: none;font-size: 11px;line-height: 20px;t=
ext-decoration: unset;color: rgb(119,119,119);margin: 0;font-family: 'SF Co=
mpact',-apple-system,system-ui,-apple-system,BlinkMacSystemFont,'Segoe UI',=
Roboto,Helvetica,Arial,sans-serif,'Apple Color Emoji','Segoe UI Emoji','Seg=
oe UI Symbol';font-weight: 500;text-transform: uppercase;letter-spacing: .2=
px;"><time datetime=3D"2026-03-25T01:24:24.690Z">Mar 25</time></div></td></=
tr></tbody></table></td></tr></tbody></table></td><td align=3D"right"><tabl=
e role=3D"presentation" width=3D"auto" border=3D"0" cellspacing=3D"0" cellp=
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le=3D"box-sizing: border-box;max-width: 550px;border: none;vertical-align: =
middle;width: 40px;height: 40px;min-width: 40px;min-height: 40px;object-fit=
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ing=3D"0" cellpadding=3D"0"><tbody><tr><td align=3D"center"><a class=3D"ema=
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on: none;color: rgb(119,119,119);"><div class=3D"email-button-spacer" style=
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ext" style=3D"vertical-align: middle;margin-right: 4px">READ IN APP</span><=
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!ET-_!,w_36,c_scale,f_png,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsu=
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y></table></td></tr></tbody></table></td></tr></tbody></table></td></tr><tr=
 height=3D"16"><td height=3D"16" style=3D"font-size:0px;line-height:0;">&nb=
sp;</td></tr></tbody></table></div></div><div class=3D"post typography" dir=
=3D"auto" style=3D"--image-offset-margin: -120px;padding: 32px 0 0 0;font-s=
ize: 16px;line-height: 26px;"><div class=3D"body markup" dir=3D"auto" style=
=3D"text-align: initial;font-size: 16px;line-height: 26px;width: 100%;word-=
break: break-word;margin-bottom: 16px;font-family: 'SF Pro Display', -apple=
-system, system-ui, BlinkMacSystemFont, 'Inter', 'Segoe UI', Roboto, Helvet=
ica, Arial, sans-serif, 'Apple Color Emoji', 'Segoe UI Emoji', 'Segoe UI Sy=
mbol';font-weight: 400;"><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55=
);line-height: 26px;font-size: 16px;margin-top: 0;">There&#8217;s a lot shi=
fting right now in the world of GLP-1s, and if you rely on compounded or re=
search-grade options, this week&#8217;s updates may feel especially importa=
nt.</p><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);line-height: 26p=
x;font-size: 16px;">From new signals out of Washington that could impact ac=
cess, to powerful new data on next-generation treatments like retatrutide, =
to where drug companies are heading next&#8230;things are moving quickly on=
 multiple fronts.</p><p style=3D"margin: 0 0 20px 0;color: rgb(54,55,55);li=
ne-height: 26px;font-size: 16px;">We break it all down in this week&#8217;s=
 episode, what&#8217;s changing, what it could mean for you, and what to ke=
ep an eye on next.</p><a class=3D"youtube-wrap" href=3D"https://substack.co=
m/redirect/189b9098-ccb9-4179-a658-e8f518e99d51?j=3DeyJ1IjoiNGl3b2U2In0.sVD=
xRtmZ85v8kfdamY0krRXGMy3p768BWtuZifRB-Zs" target=3D"_blank" data-component-=
name=3D"Youtube2ToDOMStatic" style=3D"display: block;margin: 32px 0;"><img =
src=3D"https://substackcdn.com/image/youtube/w_728,c_limit/l_youtube_play_q=
yqt8q,w_120/ILVI0WU4AEQ" style=3D"border: none !important;vertical-align: m=
iddle;-ms-interpolation-mode: bicubic;max-width: 100%;height: auto;margin: =
0 auto;display: block;width: 100%;"></a><p style=3D"margin: 0 0 20px 0;colo=
r: rgb(54,55,55);line-height: 26px;font-size: 16px;">The Throttling of Comp=
ounded GLP-1sFDA vs Telehealth, What&#8217;s Really HappeningThe Truth Abou=
t &#8220;Research Peptides&#8221;The Rule That Created the Black Market If =
You Rely on This, Here&#8217;s What&#8217;s ComingWhy They Want You Back on=
 Branded DrugsRetatrutide Might Be the Most Powerful YetThe Data That Chang=
es Everything (Diabetes + Weight Loss)What Comes After GLP-1s, The Next Wav=
e</p><a class=3D"audio-embed-static-outer" href=3D"https://substack.com/red=
irect/ca95bb32-3cd6-44fc-8aae-a5143a0e321e?j=3DeyJ1IjoiNGl3b2U2In0.sVDxRtmZ=
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=3D"AudioEmbedStaticLink" style=3D"text-decoration: none;"><table class=3D"=
audio-embed-static" cellspacing=3D"12" data-component-name=3D"AudioEmbedSta=
ticTable" style=3D"width: 100%;min-width: 100%;min-height: 96px;border: 1px=
 solid rgb(0,0,0,.1);background: rgb(255,255,255);margin: 32px 0;border-rad=
ius: 12px;"><tbody><tr><td class=3D"thumbnail-container" style=3D"padding: =
0;margin: 0;width: 88px;height: 88px;border-radius: 12px;overflow: hidden;v=
ertical-align: top;"><div class=3D"play-container" style=3D"font-size: 16px=
;line-height: 26px;max-height: 0;position: relative;opacity: 0.999;z-index:=
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E!,w_72,c_limit,f_auto,q_auto:good,fl_progressive:steep/https%3A%2F%2Fsubst=
ack.com%2Fimg%2Fthumbnail-play.png" height=3D"36" width=3D"36" style=3D"bor=
der: none !important;vertical-align: middle;-ms-interpolation-mode: bicubic=
;max-width: 100%;display: inline-block;height: 40px;margin: 24px;width: 40p=
x;"></div><img class=3D"thumbnail" src=3D"https://i.scdn.co/image/ab6765630=
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ode: bicubic;max-width: 100%;margin: 0 auto;height: 88px;width: 88px;"></td=
><td class=3D"audio-details" data-component-name=3D"AudioEmbedStatic" style=
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Font, 'Inter', 'Segoe UI', Roboto, Helvetica, Arial, sans-serif, 'Apple Col=
or Emoji', 'Segoe UI Emoji', 'Segoe UI Symbol';-webkit-font-smoothing: anti=
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